The sperm of mice homozygous for the abnormal spermatozoon head shape mutation (azh) have a characteristic ladle shape and up to 40% lack a flagella. However, most male mice do breed and litter sizes are more than half as large as those of unaffected litter mates. There are defects in sperm-head packaging of the chromatin as well as acrosomal and flagellar development. Slight but significant reductions in measurements of sperm motility occur. In vitro, sperm from homozygous mutant mice fail to fertilize ova with intact zonae pellucidae, but are successful in fertilizing zona-free ova. Further analysis of these mice reveal defects in the microtubular manchette which surrounds the nucleus.
|Allele Name||abnormal spermatazoon head shape|
|Allele Type||Radiation induced|
|Gene Symbol and Name||Hook1, hook microtubule tethering protein 1|
|Strain of Origin||C57BL/6J x SWR/J|
|Molecular Note||The azh mutation has been identified as a deletion of exons 10 and 11. The genomic deletion was an estimated 2021 bp in size.|
When using the abnormal spermatazoon head shape mouse strain in a publication, please cite the originating article(s) and include JAX stock #002009 in your Materials and Methods section.