Jackson Laboratory SEARCH FOR MICE
CFW-Em/J
Stock No: 001998
  • Spontaneous Mutation
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Overview

Mice with the spontaneous dominant mutation Emory cataract (Em) develop late-onset bilateral lens opacities starting at 6-8 months of age. The phenotype resembles human age-related (senile) cataract in timing and pathology.

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Genetic overview

Genetic Background Generation
F10+71
(2020-04-23 00:00:00)

Em

Allele Type Gene Symbol Gene Name
Spontaneous Em Emory cataract
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Research Applications

  • Sensorineural Research
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Base Price

Starting at:

$205.90 Domestic price for female
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Details

Detailed Description

Emory cataract (Em) is an autosomal dominant mutation, which arose spontaneously in a CFW inbred strain colony. Mice with the mutation develop late-onset bilateral lens opacities starting at 6-8 months of age. Cataracts from aged mice (548 days) have large vacuoles and degenerated lens substance in the subcapsular region. Females develop cataracts more rapidly than males beginning at 6 months of age, however, after 13 months of age both sexes present with cataracts of equivalent severity (Grade 5). The phenotype resembles human age-related (senile) cataract in timing and pathology.

Development

Emory cataract (Em) is an autosomal dominant mutation, which arose spontaneously in a CFW inbred strain colony held by Dr. Kathryn Kuck at Emory University. The mutation was first observed in a single male that developed bilateral cataracts at 11 months of age. Descendants from this male were selectively bred for the cataract phenotype. Em mice were imported into The Jackson Laboratory from Tufts University in 1992. The mutation is maintained on its' original background by sibling mating.

Control Suggestions

  • None Available

Additional Information

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Genetics

Em

Allele Symbol: Em

Allele Name Emory cataract
Allele Type Spontaneous
Allele Synonym(s)
Gene Symbol and Name Em, Emory cataract
Gene Synonym(s)
Strain of Origin CFW
Chromosome UN

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Em related

  • Sensorineural Research
    • Cataracts
      • cortical

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Em/?
CFW-Em

vision/eye phenotype

  • cataract
    • after 6 months of age, female mice develop more severe cataracts than male mice
    • (MGI Ref ID J:79371)
    • lens opacities appear as early as 6 to 8 months in mutant mice and progress to a dense opaque central zone, with a shrunken appearance and loss of wet and dry weight of the lens mice exhibit bilateral cataracts
    • (MGI Ref ID J:6825)
    • severity of cataracts developed is decreased in mice fed a calorie restricted diet
    • (MGI Ref ID J:24254)
    • cataracts development is associated with the conversion of soluble to insoluble proteins, with lower total protein and lower glutathione than in wild-type mice
    • (MGI Ref ID J:7009)

References

Additional - Em related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Mating System

    • Homozygote x Homozygote
  • Appearance

    • albino, cataract, vascular cornea
      Related Genotype: Tyrc/Tyrc Em/Em
  • Citation

    When using the CFW-Em/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001998 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
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Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

Service/Product Description Price
Homozygous for Tyr<c> Homozygous for Em, 1 pair minimum

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Phone: 207-288-6470
Email: TechTran@jax.org

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