Mice with the spontaneous dominant mutation Emory cataract (Em) develop late-onset bilateral lens opacities starting at 6-8 months of age. The phenotype resembles human age-related (senile) cataract in timing and pathology.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Em | Emory cataract |
Emory cataract (Em) is an autosomal dominant mutation, which arose spontaneously in a CFW inbred strain colony. Mice with the mutation develop late-onset bilateral lens opacities starting at 6-8 months of age. Cataracts from aged mice (548 days) have large vacuoles and degenerated lens substance in the subcapsular region. Females develop cataracts more rapidly than males beginning at 6 months of age, however, after 13 months of age both sexes present with cataracts of equivalent severity (Grade 5). The phenotype resembles human age-related (senile) cataract in timing and pathology.
Emory cataract (Em) is an autosomal dominant mutation, which arose spontaneously in a CFW inbred strain colony held by Dr. Kathryn Kuck at Emory University. The mutation was first observed in a single male that developed bilateral cataracts at 11 months of age. Descendants from this male were selectively bred for the cataract phenotype. Em mice were imported into The Jackson Laboratory from Tufts University in 1992. The mutation is maintained on its' original background by sibling mating.
When using the CFW-Em/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001998 in your Materials and Methods section.
Service/Product | Description | Price |
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Homozygous for Tyr<c> Homozygous for Em, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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