80% of mice homozygous for the eyeless 2 Jackson mutation were reported to have anophthalmia, and those with intact globes have microphthalmia and are often found to have congenital corneal perforations and collapse of the anterior chamber (Chang et al., 2005).
The eyless 2 Jackson mutation arose spontaneously on the Lystbg-10J-bearing mutant subline of LT.MA-Glob/J. The eyeless 2 Jackson mutant male was crossed to a (C57BL/6J x C3FeLe.B6-a/a)F1 female and their offspring were intercrossed to generate homozygotes in the F2 generation. This line was maintained by sibling breeding eyl2/eyl2 a/a nonagouti eyeless mutants and at generation F16 embryos were generated for cryopreservation from homozygous females bred to homozygous males.
|Allele Name||eyeless 2 Jackson|
|Allele Synonym(s)||Eyeless 2|
|Gene Symbol and Name||eyl2, eyeless 2 Jackson|
|Strain of Origin||LT.MA-Glo1b H2d/J|
|General Note||The eyless 2 Jackson mutation arose spontaneously on the Lystbg-10J-bearing mutant subline of LT.MA-Glob/J.|
|Molecular Note||This spontaneous mutation was found in a colony at The Jackson Laboratory.|