Jackson Laboratory SEARCH FOR MICE
C3A.Cg-Pde6b+ Prph2Rd2/J
Stock No: 001979
  • Congenic
  • Spontaneous Mutation
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    • Mammalian Phenotype Terms by Genotype
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Overview

Rd2 or retinal degeneration slow (rds) is a dominant spontaneous mutation in Prph2 (peripherin 2), mutant mice are characterized by slow degeneration of the outer nuclear layer of the retina beginning at 5 weeks, and eventual loss of retinal rod and cone cells by 12 months of age. This strain may be useful for studying human retinopathies.

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Genetic overview

Genetic Background Generation
N20F98
(2020-04-23 00:00:00)

Prph2Rd2

Allele Type Gene Symbol Gene Name
Spontaneous Prph2 peripherin 2

Pde6b+

Allele Type Gene Symbol Gene Name
Not Applicable Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
View Genetics

Research Applications

  • Research Tools
  • Mouse/Human Gene Homologs
  • Sensorineural Research
View All Research Applications

Base Price

Starting at:

$135.09 Domestic price for female
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Details

Detailed Description

Prph2 (peripherin 2) encodes a tetraspanning membrane protein found in the outer segment of both rod and cone photoreceptor cells, which is involved in photoreceptor disc morphogenesis. In this congenic strain, the retinal degeneration 2 (Prph2Rd2) allele was transferred from strain O20/A to C3A.BLiA-Pde6b+ (wild-type for retinal degeneration 1 - rd1).
Rd2 or retinal degeneration slow (rds) is a dominant spontaneous mutation characterized by slow degeneration of the outer nuclear layer of the retina beginning at 5 weeks, loss of retinal rod cells by 7-10 months, loss of cone cells and all visual cell structures by 12 months of age, loss of some pigment epithelial cells and increased density of Muller cells accompanied by fibrillary tangles. This strain may be useful for studying human retinopathies.

Development

This strain was developed in the laboratory of Dr. Willem J. De Grit at Erasmus Universiteit, Rotterdam, the Netherlands. The Prph2Rd2 allele was transferred from strain O20/A to C3A.BLiA-Pde6b+ via more than 20 backcross-intercross cycles (Schalken et al. 1990; S. Sanyal, personal communication). C3A.BLiA-Pde6b+ is a congenic strain having the wildtype Pde6b allele of C57BL/LiA on the C3Hf/HeA background. Since its arrival at The Jackson Laboratory, Stock No. 001979 has been maintained by sibling mating of mice homozygous for both Pde6b+ and Prph2Rd2.

Expression Data

Expressed Gene Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.

Control Suggestions

  • 001912 C3A.BLiA-Pde6b+/J

Additional Information

  • Considerations for Choosing Controls

Selected References

  • Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9PubMed: 2137350MGI: J:109932
View All References

Genetics

Prph2Rd2

Allele Symbol: Prph2Rd2

Allele Name retinal degeneration 2
Allele Type Spontaneous
Allele Synonym(s) Prph2Rds; Rd-2; Rds; rds-; RdsRd2; retinal degeneration slow
Gene Symbol and Name Prph2, peripherin 2
Gene Synonym(s)
Strain of Origin O20/A
Chromosome 17
Molecular Note The mutation is an insertion of approximately 10 kb in the gene after nucleotide 899 (numbering of the encoded mRNA), disrupting the protein coding sequence in exon 2. The inserted DNA was similar to both the TSE of mice, repeated elements found in the H2 complex, and to the mouse early transposon (ETn). Northern blot analysis demonstrated that an aberrant 12 kb transcript was produced from this allele, although at reduced levels compared to wild-type. This allele is predicted to encode a truncated protein with its carboxy terminal 116 amino acids replaced by 35 amino acids from sequences in the insertion. Mutant mice doubly homozygous for two retinal degeneration mutations (Pde6brd1 and RdsRd2) shows an intermediate level of mRNAs for the beta subunit of cGMP-PDE and for several other phototransduction related proteins, suggesting an interaction between Pde6brd1 and RdsRd2.

Pde6b+

Allele Symbol: Pde6b+

Allele Name wild type
Allele Type Not Applicable
Allele Synonym(s)
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)
Expressed GenePde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory
Site of ExpressionRetina.
Strain of Origin Not Applicable
Chromosome 5

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

  • retinitis pigmentosa 7

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Prph2Rd2 related

  • Research Tools
    • Sensorineural Research
      • retinal degeneration
  • Sensorineural Research
    • Retinal Degeneration
  • Mouse/Human Gene Homologs
    • retinal degeneration, slow

Genotype: Pde6b+ related

  • Mouse/Human Gene Homologs
    • retinitis pigmentosa, wildtype
  • Sensorineural Research
    • Retinal Degeneration
      • wild-type

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain

Genotype: Prph2Rd2/Prph2+
involves: O20/A

nervous system phenotype

  • short photoreceptor outer segment
    • outer segment layers are thinner
    • (MGI Ref ID J:215646)
  • abnormal photoreceptor outer segment disc membrane morphology
    • highly abnormal membrane swirls in the outer segment
    • (MGI Ref ID J:215646)

vision/eye phenotype

  • decreased a-wave amplitude
    • scotopic a wave amplitude is reduced at P30 and P180
    • (MGI Ref ID J:215646)
  • decreased b-wave amplitude
    • scotopic b wave amplitude is reduced at P30 and P180
    • (MGI Ref ID J:215646)
    • Normal - however, phototopic b wave amplitudes are similar to wild-type mice at P30
    • (MGI Ref ID J:215646)
  • abnormal ocular fundus morphology
    • 2/10 eyes exhibit very mild signs of flecking in the fundus at P180
    • (MGI Ref ID J:215646)
  • abnormal photoreceptor outer segment disc membrane morphology
    • highly abnormal membrane swirls in the outer segment
    • (MGI Ref ID J:215646)
  • short photoreceptor outer segment
    • outer segment layers are thinner
    • (MGI Ref ID J:215646)
  • abnormal rod electrophysiology
    • scotopic ERG responses are reduced at P30 and P180
    • (MGI Ref ID J:215646)
  • retinal outer nuclear layer degeneration
    • the outer nuclear layer is thinner by P180 but not at P30
    • (MGI Ref ID J:215646)

Genotype: Prph2Rd2/Prph2+
either: (involves: BALB/c * O20/A) or (involves: GR/A * O20/A) or (involves: O20/A * STS/A)

vision/eye phenotype

  • thin retinal outer nuclear layer
    • maximal outer nuclear layer thickness is only 50-60% of wild-type
    • (MGI Ref ID J:25582)
    • thinning of the outer nuclear layer is first seen in the peripheral retina and later seen in the central retina
    • (MGI Ref ID J:25582)
    • at 18 months, outer nuclear layer thickness is markedly decreased
    • (MGI Ref ID J:25582)
  • abnormal retinal photoreceptor morphology
    • at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
    • (MGI Ref ID J:25582)
  • abnormal photoreceptor outer segment morphology
    • these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
    • (MGI Ref ID J:25582)
    • at 18 months, outer segments become reduced and somewhat patchy
    • (MGI Ref ID J:25582)
    • outer segments are delayed in development but eventually appear throughout the retinal surface
    • (MGI Ref ID J:25582)
    • outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
    • (MGI Ref ID J:25582)
  • abnormal retinal pigment epithelium morphology
    • peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period
    • (MGI Ref ID J:25582)
    • pigment epithelial cells contain larger and more numerous phagosomes
    • (MGI Ref ID J:25582)
  • abnormal eye development
    • at P14, considerable portions of the retinal surface have fewer outer segments and those present have disc structures that are irregularly oriented
    • (MGI Ref ID J:25582)
  • abnormal photoreceptor inner segment morphology
    • occasional inner segments with swollen endoplasmic reticuli and vacuoles
    • (MGI Ref ID J:25582)
  • abnormal retinal layer morphology
      (MGI Ref ID J:25582)
  • increased retinal cone cell number
    • the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
    • (MGI Ref ID J:25582)

nervous system phenotype

  • abnormal photoreceptor outer segment morphology
    • outer segments are delayed in development but eventually appear throughout the retinal surface
    • (MGI Ref ID J:25582)
    • outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes
    • (MGI Ref ID J:25582)
    • these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated
    • (MGI Ref ID J:25582)
    • at 18 months, outer segments become reduced and somewhat patchy
    • (MGI Ref ID J:25582)
  • abnormal retinal photoreceptor morphology
    • at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons
    • (MGI Ref ID J:25582)
  • abnormal photoreceptor inner segment morphology
    • occasional inner segments with swollen endoplasmic reticuli and vacuoles
    • (MGI Ref ID J:25582)
  • increased retinal cone cell number
    • the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina
    • (MGI Ref ID J:25582)

pigmentation phenotype

  • abnormal retinal pigment epithelium morphology
    • pigment epithelial cells contain larger and more numerous phagosomes
    • (MGI Ref ID J:25582)
    • peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period
    • (MGI Ref ID J:25582)

Genotype: Prph2Rd2/Prph2Rd2
O20/A-Prph2

cardiovascular system phenotype

  • retinal neovascularization
    • extensive vascularization at 12 months of age
    • (MGI Ref ID J:6432)

pigmentation phenotype

  • abnormal retinal pigment epithelium morphology
    • at 12 months of age the pigment epithelium appears patchy with normal appearing areas adjacent to areas lacking pigment epithelial cells
    • (MGI Ref ID J:6432)
    • phagosomes containing debris from the outer nuclear layer are absent
    • (MGI Ref ID J:25582)

hematopoietic system phenotype

  • abnormal macrophage morphology
    • at 12 months of age only a few small macrophages remain in the outer aspect of the inner nuclear layer
    • (MGI Ref ID J:6432)
    • as the outer nuclear layer thins, fewer macrophages are detected in this layer of the retina
    • (MGI Ref ID J:6432)
    • at P11 macrophages in the retina remain large and display high levels of glucosaminidase activity
    • (MGI Ref ID J:6432)

vision/eye phenotype

  • abnormal retinal pigment epithelium morphology
    • at 12 months of age the pigment epithelium appears patchy with normal appearing areas adjacent to areas lacking pigment epithelial cells
    • (MGI Ref ID J:6432)
    • phagosomes containing debris from the outer nuclear layer are absent
    • (MGI Ref ID J:25582)
  • retinal degeneration
    • at 18-24 months of age continuing degeneration results in further distortion and thinning of the retina
    • (MGI Ref ID J:6432)
    • by 28 days of age thinning of the photoreceptor and outer plexiform layers is seen
    • (MGI Ref ID J:6432)
    • degeneration slowly progresses until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
    • (MGI Ref ID J:6051)
    • detectable at P14 as a decrease in the thickness of the outer nuclear layer
    • (MGI Ref ID J:6432)
    • at 9 months of age extensive areas of the retina completely lack visual cells
    • (MGI Ref ID J:6432)
    • at 12 months of age, all visual cell structures are gone and degenerative changes are observed in other layers of the retina
    • (MGI Ref ID J:6432)
    • slight degenerative changes are seen in the outer nuclear layer starting at 5 weeks
    • (MGI Ref ID J:6051)
  • thin retinal outer nuclear layer
    • at 2 months of age thickness is reduced by about 50%
    • (MGI Ref ID J:6432)(MGI Ref ID J:7600)
    • progressive reduction in thickness of the ONL starting at P14
    • (MGI Ref ID J:6432)
  • abnormal retina morphology
    • thin with distorted structure at 12 months of age
    • (MGI Ref ID J:6432)
  • abnormal retinal cone cell morphology
    • at 2 months of age the percentage of cones is higher in the periphery compared to wild-type controls
    • (MGI Ref ID J:6432)
    • the percentage of cones in the periphery further increases up until 6 months of age
    • (MGI Ref ID J:6432)
  • abnormal retinal development
    • decrease in growth of retinal thickness from P7 onwards
    • (MGI Ref ID J:6432)
    • morphological differences from controls are clearly recognizable by P14
    • (MGI Ref ID J:6432)
  • abnormal retinal outer nuclear layer morphology
    • maximal thickness is detected on P7 compared to P11 in wild-type controls
    • (MGI Ref ID J:6432)
    • lei are seen in the outer layer
    • (MGI Ref ID J:6432)
    • at 9 months of age a single row of outer nuclei is present in the centrally located region surrounding the optic nerve head and in the most outlying region approaching the periphery, while in areas lying between these two regions, two or three rows of nuclei are seen in the outer layer
    • (MGI Ref ID J:6432)
  • abnormal retinal photoreceptor layer morphology
    • at 9 months of age in some areas this layer is absent
    • (MGI Ref ID J:6432)
    • retarded growth of the photoreceptor layer is visible from P7 onwards
    • (MGI Ref ID J:6432)
    • growth continues until P21 but by P28 a reduction in photoreceptor layer thickness is seen
    • (MGI Ref ID J:6432)
  • thin retinal outer plexiform layer
    • detectable at P28 and slowly progresses with age
    • (MGI Ref ID J:6432)
    • thinning is more conspicuous in peripheral areas at P28
    • (MGI Ref ID J:6432)
  • abnormal eye electrophysiology
    • absence of detectable a-wave at all intensities tested at 6-7 and 13 months of age
    • (MGI Ref ID J:7600)
    • smaller a-wave and b-wave amplitudes at all intensities tested at 1 and 2-3 months of age compared to age matched controls
    • (MGI Ref ID J:7600)
    • time to peak of the waves is increased at 2-3 months of age but not at 1 month of age compared to age matched controls
    • (MGI Ref ID J:7600)
    • b-wave amplitudes are reduced but still detectable at higher intensities at 6-7 months of age
    • (MGI Ref ID J:7600)
  • abnormal retinal photoreceptor morphology
    • at 9 months of age extensive areas of the retina completely lack visual cells
    • (MGI Ref ID J:6432)
    • at 12 months of age, all visual cell structures are gone
    • (MGI Ref ID J:6432)
    • at 2 months of age the extreme margins of the retina lack visual cells
    • (MGI Ref ID J:6432)
  • absent retinal rod cells
    • at 7-10 months rods are absent
    • (MGI Ref ID J:6051)
    • at 12 months of age
    • (MGI Ref ID J:6432)
  • decreased total retina thickness
    • observed at 12 months of age
    • (MGI Ref ID J:6432)
  • retinal neovascularization
    • extensive vascularization at 12 months of age
    • (MGI Ref ID J:6432)
  • absent photoreceptor outer segment
    • retinal photoreceptor cells lack outer segments
    • (MGI Ref ID J:75095)
  • retinal outer nuclear layer degeneration
    • degeneration of the outer nuclear cell (ONL) layer is seen as early as 2 weeks of age
    • (MGI Ref ID J:75095)
    • slow degeneration beginning at 5 weeks and progressing until at 7-10 months rods are absent and the photoreceptor cell nuclei are reduced to 1 row
    • (MGI Ref ID J:6051)
  • absent retinal cone cells
    • at 12 months of age
    • (MGI Ref ID J:6432)
  • abnormal retinal rod cell outer segment morphology
    • the layer of rod outer segments fails to develop
    • (MGI Ref ID J:6432)
  • abnormal retinal neuronal layer morphology
    • at 9 months of age in some areas the outermost row of the inner nuclear layer has merged with the outer nuclear layer
    • (MGI Ref ID J:6432)

immune system phenotype

  • abnormal macrophage morphology
    • at 12 months of age only a few small macrophages remain in the outer aspect of the inner nuclear layer
    • (MGI Ref ID J:6432)
    • as the outer nuclear layer thins, fewer macrophages are detected in this layer of the retina
    • (MGI Ref ID J:6432)
    • at P11 macrophages in the retina remain large and display high levels of glucosaminidase activity
    • (MGI Ref ID J:6432)

nervous system phenotype

  • abnormal retinal cone cell morphology
    • the percentage of cones in the periphery further increases up until 6 months of age
    • (MGI Ref ID J:6432)
    • at 2 months of age the percentage of cones is higher in the periphery compared to wild-type controls
    • (MGI Ref ID J:6432)
  • abnormal retinal photoreceptor morphology
    • at 12 months of age, all visual cell structures are gone
    • (MGI Ref ID J:6432)
    • at 9 months of age extensive areas of the retina completely lack visual cells
    • (MGI Ref ID J:6432)
    • at 2 months of age the extreme margins of the retina lack visual cells
    • (MGI Ref ID J:6432)
  • absent retinal rod cells
    • at 12 months of age
    • (MGI Ref ID J:6432)
    • at 7-10 months rods are absent
    • (MGI Ref ID J:6051)
  • absent retinal cone cells
    • at 12 months of age
    • (MGI Ref ID J:6432)
  • absent photoreceptor outer segment
    • retinal photoreceptor cells lack outer segments
    • (MGI Ref ID J:75095)
  • abnormal retinal rod cell outer segment morphology
    • the layer of rod outer segments fails to develop
    • (MGI Ref ID J:6432)

Genotype: Prph2Rd2/Prph2Rd2
either: C.O20-Prph2 or C3.O20-Prph2

nervous system phenotype

  • abnormal Muller cell morphology
    • at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased
    • (MGI Ref ID J:27850)
    • at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
    • (MGI Ref ID J:27850)
    • at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
    • (MGI Ref ID J:27850)
    • at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
    • (MGI Ref ID J:27850)

vision/eye phenotype

  • abnormal Muller cell morphology
    • at 9 months of age the density of Muller cells, fibrillar tangles, and horizontal fibers in the plexiform layers is further increased
    • (MGI Ref ID J:27850)
    • at P28 the number of Muller cells is increased, the cells tend to be unevenly distributed, and occasional fibrillar tangles are seen in the inner plexiform layer
    • (MGI Ref ID J:27850)
    • at P11 small numbers of Muller cells and radial fibers are found in the outer plexiform layer
    • (MGI Ref ID J:27850)
    • at 2 months of age the density of Muller cells has increased dramatically, in the periphery these cells have fibers that penetrate the outer nuclear layer and cover it externally, and the number of fibrillar tangles is increased
    • (MGI Ref ID J:27850)
  • thin retinal outer nuclear layer
    • at 18 months, no recognizable outer nuclear layer is seen
    • (MGI Ref ID J:27850)
    • at 9 months, the outer nuclear layer is reduced to 2 to 3 rows
    • (MGI Ref ID J:27850)

Genotype: Prph2Rd2/Prph2+
either: C.O20-Prph2 or C3.O20-Prph2

nervous system phenotype

  • abnormal Muller cell morphology
    • at 16 months, the density of Muller cells is increased compared to 2 months
    • (MGI Ref ID J:27850)
    • at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
    • (MGI Ref ID J:27850)

vision/eye phenotype

  • abnormal Muller cell morphology
    • at 2 months, high numbers of Muller cells and lower numbers of fibrillar tangles and horizontal fibers are seen relative to homozygous mice
    • (MGI Ref ID J:27850)
    • at 16 months, the density of Muller cells is increased compared to 2 months
    • (MGI Ref ID J:27850)
  • thin retinal outer nuclear layer
    • at 16 months, the outer nuclear layer is reduced to 3 to 4 rows
    • (MGI Ref ID J:27850)

Genotype: Prph2Rd2/Prph2Rd2
involves: O20/A

nervous system phenotype

  • retinal photoreceptor degeneration
    • photoreceptor degeneration is severe by P180
    • (MGI Ref ID J:215646)

vision/eye phenotype

  • abnormal rod electrophysiology
    • scotopic responses are reduced at P30 and P180, with no mice exhibiting an a-wave above the limit of detection
    • (MGI Ref ID J:215646)
  • retinal photoreceptor degeneration
    • photoreceptor degeneration is severe by P180
    • (MGI Ref ID J:215646)
  • decreased b-wave amplitude
    • photopic b wave amplitude is reduced at P30 and P180
    • (MGI Ref ID J:215646)
    • scotopic b wave amplitude is reduced at P30 and P180
    • (MGI Ref ID J:215646)
  • abnormal cone electrophysiology
    • photopic ERG responses are lower
    • (MGI Ref ID J:215646)
  • abnormal ocular fundus morphology
    • widespread yellow flecks are seen in the fundus at P180
    • (MGI Ref ID J:215646)
    • Normal - however, no changes in retinal vasculature are seen at P180
    • (MGI Ref ID J:215646)
  • decreased a-wave amplitude
    • absent scotopic a-wave amplitude
    • (MGI Ref ID J:215646)
  • retinal outer nuclear layer degeneration
    • small reduction in the outer nuclear layer thickness at P30 and by P180, the outer nuclear layer is thin in the central retina and almost absent in the periphery
    • (MGI Ref ID J:215646)

Genotype: Prph2Rd2/Prph2Rd2
involves: BALB/c * O20/A

vision/eye phenotype

  • abnormal eye electrophysiology
    • at 4 months, a small-amplitude b-wave is recorded
    • (MGI Ref ID J:76490)
  • retinal degeneration
    • mice exhibit 8 or 9 rows of photoreceptor nuclei at 1 months and 3 or 4 rows at 4 months
    • (MGI Ref ID J:76490)
The following phenotype relates to a compound genotype created using this strain

Genotype: Prph2Rd2/Prph2+
either: (involves: C3H * O20/A) or (involves: C57BL/LiA * O20/A)

nervous system phenotype

  • abnormal photoreceptor outer segment morphology
    • Background Sensitivity - in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated
    • (MGI Ref ID J:25582)

vision/eye phenotype

  • abnormal photoreceptor outer segment morphology
    • Background Sensitivity - in pigmented heterozygous mice outer segments resemble those in albino mice but have more disc membranes that appear more tightly packed and less vacuolated
    • (MGI Ref ID J:25582)

References

  • Schalken JJ; Janssen JJ; Sanyal S; Hawkins RK; de Grip WJ. 1990. Development and degeneration of retina in rds mutant mice: immunoassay of the rod visual pigment rhodopsin. Biochim Biophys Acta 1033(1):103-9PubMed: 2137350MGI: J:109932

Additional References

  • Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25PubMed: 11853768MGI: J:75095

Additional - Pde6b+ related

Additional - Prph2Rd2 related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Standard PCR:Prph2
    • Standard PCR:Generic Pde6b Alternate1
    • Probe:Pde6b Probe
    • Genotyping resources and troubleshooting
  • Mating System

    • Homozygote x Homozygote
  • Appearance

    • agouti
      Related Genotype: A/A
  • Citation

    When using the C3A.Cg-Pde6b+ Prph2Rd2/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001979 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
  • Domestic
  • International

Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

Service/Product Description Price
Homozygous for Prph2<Rd2>, 1 pair minimum

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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Phone: 207-288-6470
Email: TechTran@jax.org

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