Overview

Also Known As:juvenile bare

These mice carry the spontaneous jb mutation and are characterized by juvenile hair loss. in which the hair follicle follows irregular pathways to the surface and mutants generally become dystrophic when about 23 days of age.

Genetic overview

Genetic Background	Generation
000664 C57BL/6J

jb

Allele Type	Gene Symbol	Gene Name
Spontaneous	jb	juvenile bare

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Research Applications

Dermatology Research

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

jb/jbfemales breed but tend to have small litters. Only some breeding jb/jbfemales develop overgrown incisors with a tendency to break, resulting in undernourishment and inability to nurse. An occasional jb/jbmouse of either sex will convulse upon handling. Genetic background impacts the expression of the jbmutation. jb "is expressed on strains C57BL/6J, ABP/Le, and MEV/1Ty and C.B-17-Prkdc^scid/Prkdc^scid, but seldom expressed on C3HeB/FeJ, A/J, and CAST/Ei, and only partially expressed on the C57BL/6J x C3HeB/FeJLe-a/a hybrid (Lane et al., 1998). This strain does NOT show the seizure phenotype seen in 001510.

jb/jbhomozygotes are identifiable by phenotype between 15 and 21 days of age preweaning hair loss. Heterozygotes are distinguishable from wild type littermates only by test crossing.

Development

jb occurred spontaneously in 1984 in The Mouse Mutant Stock Center (MMSC) at The Jackson Laboratory in B6C3Fe-a/a-hyh, a stock then maintained by crossing to (C57BL/6J x C3FeLe.B6-a/a)F1 mice. The hyh mutation was being transferred from C57BL/10 onto the B6C3Fe a/a background. hyh arose spontaneously on the C57BL/10J background, was sibling mated by progeny tested heterozygote x heterozygote for 11 generations, and was then maintained by outcrossing to (C57BL/6J x C3FeLe.B6-a/a)F1 mice at every other generation (through outcross-intercross breeding). At N3 of this outcross the jb mutation arose. Microsatellite marker testing has shown that the jb mutation arose on the C3HeB/FeJLe-a/a derived DNA. jb was initially identified in a male that had loss of hair at an early age. This male was bred to a normal sibling and then four affected pairs of progeny were mated, and all of the offspring exhibited the hair loss phenotype. 001510, STOCK a/a jb, a homozygous inbred jb/jb strain was generated beginning with these four pairs (Lane et al. 1998). A backcross was done from the homozygous STOCK a/a jb colony, 001510, at F15 onto C57BL/6J resulting in 001959, B6.Cg-jb. (The nclf mutation was discovered in 1991 in STOCK a/a jb from which the present 002648, STOCK a/a +jb/+ nclf/nclf , was bred. The F8 frozen stock of 001510 have the nclf mutation, but this mutation has been bred out of the 001510 that remains on the shelf)

Control Suggestions

+/? untyped from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Genetics

jb

Allele Symbol: jb

Allele Name	juvenile bare
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	jb, juvenile bare
Gene Synonym(s)
Strain of Origin	(C57BL/6J x C3HeB/FeJ-a-Napa^hyh)F1
Chromosome	7

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: jb related

Dermatology Research
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: jb/jb
involves: C3HeB/FeJ * C57BL/6J

behavior/neurological phenotype

ataxia

convulsive seizures
- convulsions are seen occasionally when the mutants are disturbed, such as when transfered between cages, and after these convulsions the mice are described as unusually nervous

nervous system phenotype

convulsive seizures
- convulsions are seen occasionally when the mutants are disturbed, such as when transfered between cages, and after these convulsions the mice are described as unusually nervous

reproductive system phenotype

decreased litter size

skeleton phenotype

abnormal incisor morphology
- breeding females, but not males or virgin females, are prone to incisor overgrowth and breakage, possibly due to poor mineralization

long incisors

craniofacial phenotype

abnormal incisor morphology
- breeding females, but not males or virgin females, are prone to incisor overgrowth and breakage, possibly due to poor mineralization

long incisors

growth/size/body region phenotype

abnormal incisor morphology
- breeding females, but not males or virgin females, are prone to incisor overgrowth and breakage, possibly due to poor mineralization

long incisors

weight loss
- in some breeding females, likely associated with bad incisors

integument phenotype

abnormal hair growth
- Background Sensitivity - ales have a slightly sparce coat, which becomes more sparse with age
- Background Sensitivity - at 14 to 15 days of age hair loss begins and progresses from rump forward, stopping by 20 to 21 days of age at a line on the head between the ears. After this the hair regrows from the head forward to the rump and males have an almost nomral coat and females have a slightly sparce coat, which becomes more sparse with age

abnormal hair shedding

disheveled coat
- Background Sensitivity - in females after regrowth of the coat

premature hair loss

sparse hair

The following phenotype relates to a compound genotype created using this strain

Genotype: jb/jb
B6.Cg-jb/J

endocrine/exocrine gland phenotype

abnormal gland physiology
- Background Sensitivity - skin transplants from the C57BL/6J host background onto albino scid hosts do not show the hair loss indicating that the site of action of this mutation is not localized to the hair follicle but rather is systemic

integument phenotype

abnormal hair cycle
- Background Sensitivity - at 19, 23, and 26 days of age hair follciles are severely distorted and the dermis becomes thickened, but by 26 days of age the skin begins to return to normal

abnormal hair growth
- Background Sensitivity - ales have a slightly sparce coat, which becomes more sparce with age
- Background Sensitivity - at 14 to 15 days of age hair loss begins and progresses from rump forward, stopping by 20 to 21 days of age at a line on the head between the ears, after which the hair regrows from the head forward to the rump and males have an almost normal coat and females have a slightly sparce coat, which becomes more sparce with age
- Background Sensitivity - phenotypic expression is found on the C57BL/6J, ABP/Le, MEV/1Ty and C.B17-Prkdc backgrounds but has low expression on the C3HeB/FeJ, A/J, and CAST/Ei backgrounds and partial expression on the (B6 x C3HeB/FeJ) segregating background

References

Additional References

Lane PW; Bronson RT; Cook SA; Ward-Bailey P; Donahue LR; Davisson MT. 1998. Juvenile bare: a new hair loss mutation on chromosome 7 of the mouse. J Hered 89(3):254-7PubMed: 9656467 MGI: J:39707

Additional - jb related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

When maintaining a live colony, homozygous mice may be bred together.
- Additional Breeding and Husbandry Support
Appearance
- black, preweaning hair loss
  Related Genotype: a/a jb/jb
  
  black, unaffected
  Related Genotype: a/a +/?
Citation
When using the juvenile bare mouse strain in a publication, please cite the originating article(s) and include JAX stock #001959 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous or Homozygous for jb, 1 pair minimum

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Also Known As:juvenile bare

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

jb

Allele Symbol: jb

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: jb related

Mammalian Phenotype Terms by Genotype

Genotype: jb/jbinvolves: C3HeB/FeJ * C57BL/6J

behavior/neurological phenotype

nervous system phenotype

reproductive system phenotype

skeleton phenotype

craniofacial phenotype

growth/size/body region phenotype

integument phenotype

Genotype: jb/jbB6.Cg-jb/J

endocrine/exocrine gland phenotype

integument phenotype

References

Additional References

Additional - jb related

Genotyping Protocols

Breeding Considerations

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Genotype: jb/jb
involves: C3HeB/FeJ * C57BL/6J

Genotype: jb/jb
B6.Cg-jb/J