BXSB.B6-Yaa+ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). As such, BXSB.B6-Yaa+ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.Read More +
This BXSB strain carries the wild-type allele of the Yaa gene from C57BL/6 and serves as a control strain for BXSB/MpJ Yaa (Stock No. 000740). BXSB/MpJ Yaa mice develop spontaneous autoimmune disease characterized by moderate lymph node and spleen enlargement, hemolytic anemia, hypergammaglobulinemia, and immune complex glomerulonephritis.
BXSB/MpJ inbred females (Stock No. 000740) were bred to C57BL/6J inbred males (Stock No. 000664). Each successive generation, male offspring with the C57BL/6J-derived Y chromosome were bred with BXSB/MpJ inbred females. The congenic strain after ten generations of backcrossing is BXSB.B6-Yaa+/J (N10; Stock No. 000742).
Around 1998, Drs. Larry E. Mobraaten and Derry C. Roopenian (The Jackson Laboratory) obtained some BXSB.B6-Yaa+/J males from The Jackson Laboratory Repository and continued the backcrossing for additional generations.
The congenic strain here was backcrossed to N24 to significantly reduce the probability of any introduced C57BL/6J autosomal genes.
Dr. Derry Roopenian continued backcrossing and at generation N40 provided mice to The Jackson Laboratory Repository to establish the consomic BXSB.B6-Yaa+/MobJDcrJ strain (#021330).