JAX
Mouse Strain Datasheet - 001924
B6EiC3Sn a/A-Ts(1716)65Dn/J
Also Known As: Ts65Dn
Ts65Dn mice are trisomic for about two-thirds of the genes orthologous to human chromosome 21 and are a well-characterized model for studying Down Syndrome.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
N?+N12
(08-FEB-10) |
Ts(1716)65Dn
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Radiation induced | Ts(1716)65Dn | trisomy, Chr 16 translocation to Chr 17, Davisson 65 |
Base Price
Starting at:
| $247.50 Domestic price for female |
| $425.50 Domestic price for breeder pair |
Important Note
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind. Stock No. 005252 is an alternative strain, with a virtually identical genetic background except that it is wild-type for Pde6brd1.
Detailed Description
Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are homologues of human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation.
Neural cognitive deficits and behavioral abnormalities have been noted in Ts65Dn mice. They have spatial learning and memory defects as assessed in the Morris water maze and the radial arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior. They perform similar to controls in visual placing, balance, prehensile reflex and traction on a horizontal bar, motor coordination, swimming ability and olfaction orienting. They also show altered noradrenergic transmission in the hippocampus and cerebral cortex and degeneration of basal forebrain cholinergic neurons by 6 months of age. Trisomic females are smaller and produce fewer, smaller litters than euploid females while trisomic males are effectively sterile with hypospermia.
The precise locations of the Chr 16 and Chr 17 breakpoints are 84,351,351 bp and 9,426,822 bp, respectively. The Chr 16 segment contains about two thirds of the human Chr 21 homologues in the mouse, from mitochondrial ribosomal protein L39 (Mrpl39) gene to the distal telomere. These data were used to generate a PCR genotyping assay for Ts65Dn (Reinholdt et al., 2011), replacing the previous methods of chromosome analysis or qPCR. For comparison of segments conserved in human Chr 21 with mouse Chrs 16, 17, 10 and genetic definition of Ts65Dn, see the Human - Mouse Orthology Map. Northern and Western blotting, enzyme activity assays and reverse phase protein arrays (RPPA) demonstrate that some but not all genes in the translocation product are expressed at elevated levels in segmentally trisomic animals. RPPA shows a loss of correlation among some brain proteins (Ahmed et al., 2012).
Please see the Down Syndrome and Cytogenetics Models Resource for more information.
Development
Cesium irradiation was used to produce a reciprocal translocation, T (16;17) 65Dn. One of the translocation chromosomes is a small marker chromosome, comprised of the centromere and proximal end of Chr 17 (~9.5Mb) and the distal end of mouse Chr 16 (~34Mb). Translocation heterozygous females produced progeny trisomic for this small translocation product and a stock was established in which Ts65Dn mice are trisomic for the genes carried in the small translocation chromosome, symbolized Ts(1716)65Dn.
Control Suggestions
Selected References
- Ahmed MM; Sturgeon X; Ellison M; Davisson MT; Gardiner KJ. 2012. Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome. J Proteome Res 11(2):1251-63. PubMed: 22214338MGI: J:180732
- Reeves RH; Irving NG; Moran TH; Wohn A; Kitt C; Sisodia SS; Schmidt C; Bronson RT; Davisson MT. 1995. A mouse model for Down syndrome exhibits learning and behaviour deficits [see comments] Nat Genet 11(2):177-84. PubMed: 7550346MGI: J:29232
- Reinholdt LG; Ding Y; Gilbert GT; Czechanski A; Solzak JP; Roper RJ; Johnson MT; Donahue LR; Lutz C; Davisson MT. 2011. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm Genome 22(11-12):685-91. PubMed: 21953412MGI: J:178871
Ts(1716)65Dn
Allele Symbol: Ts(1716)65Dn
| Allele Name | trisomy, Chr 16 translocation to Chr 17, Davisson 65 |
|---|---|
| Allele Type | Radiation induced |
| Allele Synonym(s) | T(16C3-4;17A2)65Dn; Ts16; Ts65Dn |
| Gene Symbol and Name | Ts(1716)65Dn, trisomy, Chr 16 translocation to Chr 17, Davisson 65 |
| Gene Synonym(s) | Ts65Dn; trisomy 16 |
| Strain of Origin | DBA/2J |
| Chromosome | 16 |
| Molecular Note | About 15% of the distal end of chromosome 16 is fused to less than 10% of the centromeric end of chromosome 17 to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Down syndrome
Mammalian Phenotype Terms by Genotype
Genotype: Ts(1716)65Dn/0
B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
growth/size/body region phenotype
- decreased body length
- the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference (MGI Ref ID J:153579)
- decreased body weight
- (MGI Ref ID J:153579)
behavior/neurological phenotype
- abnormal learning/memory/conditioning
- in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test (MGI Ref ID J:153579)
- abnormal spatial learning
- (MGI Ref ID J:153579)
- decreased grip strength
- output of a grip strength meter shows reduced grip force relative to controls (MGI Ref ID J:153579)
- hyperactivity
- although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls (MGI Ref ID J:153579)
- impaired contextual conditioning behavior
- (MGI Ref ID J:153579)
- impaired cued conditioning behavior
- (MGI Ref ID J:153579)
- increased stereotypic behavior
- significantly increased dark cycle horizontal and vertical stereotypic activity (MGI Ref ID J:153579)
- increased vertical activity
- significantly increased dark cycle rearing (MGI Ref ID J:153579)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Ts(1716)65Dn/0
involves: C3H/HeJ * C57BL/6JEi * DBA/2J
nervous system phenotype
- abnormal Purkinje cell morphology
- Purkinje cell linear density is decreased compared to in wild-type mice (MGI Ref ID J:91221)
Genotype: Ts(1716)65Dn/0
involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
cellular phenotype
- abnormal male germ cell morphology
- significantly more sperm with head abnormalities (MGI Ref ID J:117029)
- oligozoospermia
- sperm concentration was significantly reduced below controls (MGI Ref ID J:117029)
reproductive system phenotype
- abnormal Sertoli cell morphology
- only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells (MGI Ref ID J:96650)
- abnormal male germ cell morphology
- significantly more sperm with head abnormalities (MGI Ref ID J:117029)
- abnormal sperm motility
- significantly reduced frequencies of sperm with progressive motility (MGI Ref ID J:117029)
- abnormal spermatogenesis
- abnormal testis morphology
- Leydig cells are clustered loosely in expanded interstitial compartment (MGI Ref ID J:96650)
- arrest of male meiosis
- many tubules contain germ cells in arrested at meiotic metaphase 1 (MGI Ref ID J:117029)
- decreased testis weight
- male infertility
- oligozoospermia
- sperm concentration was significantly reduced below controls (MGI Ref ID J:117029)
growth/size/body region phenotype
- decreased body size
- mice are ~20% smaller in size compared to normal littermates postnatally (MGI Ref ID J:96650)
- decreased body weight
- (MGI Ref ID J:94569)
nervous system phenotype
- abnormal CNS synapse formation
- 18% of dendritic spines are enlarged and display irregular heads or a globular shape (MGI Ref ID J:94569)
- average synapse length is increased 34% in the hippocampus and 25% in the cortex (MGI Ref ID J:94569)
- glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines (MGI Ref ID J:94569)
- in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex (MGI Ref ID J:94569)
- the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex (MGI Ref ID J:94569)
- abnormal cerebellar granule cell morphology
- dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice (MGI Ref ID J:94569)
- abnormal dendrite morphology
- abnormal neuron morphology
- in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls (MGI Ref ID J:96650)
endocrine/exocrine gland phenotype
- abnormal Sertoli cell morphology
- only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells (MGI Ref ID J:96650)
- abnormal testis morphology
- Leydig cells are clustered loosely in expanded interstitial compartment (MGI Ref ID J:96650)
Genotype: Ts(1716)65Dn/0
involves: C3H/HeJ * C57BL/6 * DBA/2J
nervous system phenotype
- abnormal cerebellar granule cell morphology
- granule cell density is reduced to 76% of that in control mice (MGI Ref ID J:121764)
- decreased Purkinje cell number
- Purkinje cell density is reduced to 90% of that in control mice (MGI Ref ID J:121764)
- increased brain size
- (MGI Ref ID J:121764)
- small cerebellum
- cerebellar volume is reduced to 88% of that in control mice (MGI Ref ID J:121764)
behavior/neurological phenotype
- abnormal spatial learning
- mice show impairment in a Morris water maze test (MGI Ref ID J:121764)
growth/size/body region phenotype
- decreased body weight
- (MGI Ref ID J:121764)
Genotype: Ts(1716)65Dn/0
involves: C3H * C57BL/6 * DBA/2J
craniofacial phenotype
- abnormal incisor morphology
- mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice (MGI Ref ID J:73800)
- abnormal mandibular angle morphology
- reduced in size compared to in wild-type mice (MGI Ref ID J:73800)
- abnormal mandibular coronoid process morphology
- reduced in size compared to in wild-type mice (MGI Ref ID J:73800)
- decreased cranium height
- mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice (MGI Ref ID J:73800)
- small mandible
- (MGI Ref ID J:73800)
skeleton phenotype
- abnormal incisor morphology
- mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice (MGI Ref ID J:73800)
- abnormal mandibular angle morphology
- reduced in size compared to in wild-type mice (MGI Ref ID J:73800)
- abnormal mandibular coronoid process morphology
- reduced in size compared to in wild-type mice (MGI Ref ID J:73800)
- decreased cranium height
- mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice (MGI Ref ID J:73800)
- small mandible
- (MGI Ref ID J:73800)
growth/size/body region phenotype
- abnormal incisor morphology
- mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice (MGI Ref ID J:73800)
Genotype: Ts(1716)65Dn/0
involves: DBA/2J
craniofacial phenotype
- abnormal neurocranium morphology
- cranial vault is enlarged (MGI Ref ID J:93223)
- small cranium
- size difference was most pronounced along the rostralcaudal axis (MGI Ref ID J:93223)
- small mandible
- mice show a Down's Syndrome-like pattern of mandible reduction (MGI Ref ID J:93223)
limbs/digits/tail phenotype
- short femur
- (MGI Ref ID J:93223)
skeleton phenotype
- abnormal neurocranium morphology
- cranial vault is enlarged (MGI Ref ID J:93223)
- short femur
- (MGI Ref ID J:93223)
- small cranium
- size difference was most pronounced along the rostralcaudal axis (MGI Ref ID J:93223)
- small mandible
- mice show a Down's Syndrome-like pattern of mandible reduction (MGI Ref ID J:93223)
Genotype: Ts(1716)65Dn/0
involves: C3H/HeJ * C57BL/6J * DBA/2J
neoplasm
- increased follicular lymphoma incidence
- splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma (MGI Ref ID J:174270)
- increased lymphoma incidence
- increased malignant tumor incidence
- some mutants exhibit malignant tumors of liver, colon, or lung (MGI Ref ID J:174270)
immune system phenotype
- abnormal spleen B cell follicle morphology
- splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (MGI Ref ID J:174270)
- abnormal spleen red pulp morphology
- splenic red pulp is largely obliterated (MGI Ref ID J:174270)
hematopoietic system phenotype
- abnormal spleen B cell follicle morphology
- splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (MGI Ref ID J:174270)
- abnormal spleen red pulp morphology
- splenic red pulp is largely obliterated (MGI Ref ID J:174270)
Genotype: Ts(1716)65Dn/0
involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J
mortality/aging
- postnatal lethality, incomplete penetrance
- (MGI Ref ID J:185269)
cardiovascular system phenotype
- abnormal QRS complex
- fragmented time-course with decreased S wave amplitude (MGI Ref ID J:185269)
- abnormal heart electrocardiography waveform feature
- flecainide-treated mice exhibit a specific electrophysiologic signature as compare to wild-type mice (MGI Ref ID J:185269)
- abnormal heart morphology
- great vessel and cardiac malformation in 1 of 18 mice that died postnatally (MGI Ref ID J:185269)
- decreased P wave amplitude
- in the frontal plane (MGI Ref ID J:185269)
- decreased QRS amplitude
- (MGI Ref ID J:185269)
- decreased heart rate
- (MGI Ref ID J:185269)
- prolonged PR interval
- (MGI Ref ID J:185269)
- prolonged QRS complex duration
- (MGI Ref ID J:185269)
- prolonged QT interval
- larger QT and QTc (MGI Ref ID J:185269)
- prolonged RR interval
- (MGI Ref ID J:185269)
- retroesophageal right subclavian artery
- aberrant right subclavian artery arising from the distal part of the aortic arch (MGI Ref ID J:185269)
- ventricular septal defect
- 1 in 18 newborns exhibit an upper communication of the ventricles, indication a septation defect of the ventricles (MGI Ref ID J:185269)
References
- Ahmed MM; Sturgeon X; Ellison M; Davisson MT; Gardiner KJ. 2012. Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome. J Proteome Res 11(2):1251-63. PubMed: 22214338MGI: J:180732
- Reeves RH; Irving NG; Moran TH; Wohn A; Kitt C; Sisodia SS; Schmidt C; Bronson RT; Davisson MT. 1995. A mouse model for Down syndrome exhibits learning and behaviour deficits [see comments] Nat Genet 11(2):177-84. PubMed: 7550346MGI: J:29232
- Reinholdt LG; Ding Y; Gilbert GT; Czechanski A; Solzak JP; Roper RJ; Johnson MT; Donahue LR; Lutz C; Davisson MT. 2011. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm Genome 22(11-12):685-91. PubMed: 21953412MGI: J:178871
Additional References
- Belichenko NP; Belichenko PV; Kleschevnikov AM; Salehi A; Reeves RH; Mobley WC. 2009. The 'Down syndrome critical region' is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci 29(18):5938-48. PubMed: 19420260MGI: J:148478
- Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. PubMed: 17050550MGI: J:117029
- Davisson MT; Bechtel LJ; Akeson EC; Fortna A; Slavov D; Gardiner K. 2001. Evolutionary breakpoints on human chromosome 21. Genomics 78(1/2):99-106. PubMed: 11707078MGI: J:69673
- Dierssen M; Vallina IF; Baamonde C; Garcia-Calatayud S; Lumbreras MA; Florez J. 1997. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res 749(2):238-44. PubMed: 9138724MGI: J:39408
- Hill JM; Ades AM; McCune SK; Sahir N; Moody EM; Abebe DT; Crnic LS; Brenneman DE. 2003. Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. Exp Neurol 183(1):56-65. PubMed: 12957488MGI: J:85337
- Holtzman DM; Santucci D; Kilbridge J; Chua-Couzens J; Fontana DJ; Daniels SE; Johnson RM; Chen K; Sun Y; Carlson E; Alleva E; Epstein CJ; Mobley WC. 1996. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A 93(23):13333-8. PubMed: 8917591MGI: J:36555
- Liu DP; Schmidt C; Billings T; Davisson MT. 2003. Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome. Biotechniques 35(6):1170-4, 1176, 1178 passim. PubMed: 14682051MGI: J:112549
Additional - Ts(1716)65Dn related
- Adorno M; Sikandar S; Mitra SS; Kuo A; Nicolis Di Robilant B; Haro-Acosta V; Ouadah Y; Quarta M; Rodriguez J; Qian D; Reddy VM; Cheshier S; Garner CC; Clarke MF. 2013. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature 501(7467):380-4. PubMed: 24025767MGI: J:206099
- Akeson EC; Lambert JP; Narayanswami S; Gardiner K; Bechtel LJ; Davisson MT. 2001. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet 93(3-4):270-6. PubMed: 11528125MGI: J:71031
- Alldred MJ; Lee SH; Petkova E; Ginsberg SD. 2015. Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. J Comp Neurol 523(1):61-74. PubMed: 25131634MGI: J:238190
- Altafaj X; Martin ED; Ortiz-Abalia J; Valderrama A; Lao-Peregrin C; Dierssen M; Fillat C. 2013. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 52:117-27. PubMed: 23220201MGI: J:197665
- Arriagada C; Bustamante M; Atwater I; Rojas E; Caviedes R; Caviedes P. 2010. Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Neurosci Lett 470(1):81-5. PubMed: 20043975MGI: J:156873
- Ash JA; Velazquez R; Kelley CM; Powers BE; Ginsberg SD; Mufson EJ; Strupp BJ. 2014. Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis 70:32-42. PubMed: 24932939MGI: J:218355
- Aso S; Miyabara S; Sugihara H; Winking H. 2001. Comparative study of mouse trisomy 16 and bis-diamine treated fetuses: Discrimination of possible contribution of neural crest cells to malformations Cong Anom 41:169-176. MGI: J:104833
- Ayberk Kurt M; Ilker Kafa M; Dierssen M; Ceri Davies D. 2004. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res 1022(1-2):101-9. PubMed: 15353219MGI: J:92543
- Baek KH; Zaslavsky A; Lynch RC; Britt C; Okada Y; Siarey RJ; Lensch MW; Park IH; Yoon SS; Minami T; Korenberg JR; Folkman J; Daley GQ; Aird WC; Galdzicki Z; Ryeom S. 2009. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459(7250):1126-30. PubMed: 19458618MGI: J:150286
- Bambrick LL; Yarowsky PJ; Krueger BK. 2003. Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. J Neurosci Res 73(1):89-94. PubMed: 12815712MGI: J:173986
- Baxter LL; Moran TH; Richtsmeier JT; Troncoso J; Reeves RH. 2000. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet 9(2):195-202. PubMed: 10607830MGI: J:59886
- Bearer EL; Zhang X; Jacobs RE. 2007. Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. Neuroimage 37(1):230-42. PubMed: 17566763MGI: J:173981
- Begenisic T; Sansevero G; Baroncelli L; Cioni G; Sale A. 2015. Early environmental therapy rescues brain development in a mouse model of Down syndrome. Neurobiol Dis 82:409-19. PubMed: 26244989MGI: J:227677
- Begenisic T; Spolidoro M; Braschi C; Baroncelli L; Milanese M; Pietra G; Fabbri ME; Bonanno G; Cioni G; Maffei L; Sale A. 2011. Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome. Front Cell Neurosci 5:29. PubMed: 22207837MGI: J:190265
- Belichenko PV; Kleschevnikov AM; Masliah E; Wu C; Takimoto-Kimura R; Salehi A; Mobley WC. 2009. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol 512(4):453-66. PubMed: 19034952MGI: J:173987
- Belichenko PV; Kleschevnikov AM; Salehi A; Epstein CJ; Mobley WC. 2007. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 504(4):329-45. PubMed: 17663443MGI: J:132525
- Belichenko PV; Masliah E; Kleschevnikov AM; Villar AJ; Epstein CJ; Salehi A; Mobley WC. 2004. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol 480(3):281-98. PubMed: 15515178MGI: J:94569
- Berg BM; Croom J; Fernandez JM; Spears JW; Eisen EJ; Taylor IL; Daniel LR; Coles BA; Boeheim F; Mannon PJ. 2000. Peptide YY administration decreases brain aluminum in the Ts65Dn Down syndrome mouse model Growth Dev Aging 64(1-2):3-19. PubMed: 10969882MGI: J:63856
- Berndt A; Sundberg BA; Silva KA; Kennedy VE; Richardson MA; Li Q; Bronson RT; Uitto J; Sundberg JP. 2014. Phenotypic characterization of the KK/HlJ inbred mouse strain. Vet Pathol 51(4):846-57. PubMed: 24009271MGI: J:227536
- Best TK; Cho-Clark M; Siarey RJ; Galdzicki Z. 2008. Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons. Neurosci Lett 438(3):356-61. PubMed: 18490108MGI: J:173980
- Best TK; Cramer NP; Chakrabarti L; Haydar TF; Galdzicki Z. 2012. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp Neurol 233(2):749-57. PubMed: 22178330MGI: J:182047
- Best TK; Siarey RJ; Galdzicki Z. 2007. Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J Neurophysiol 97(1):892-900. PubMed: 17093127MGI: J:135917
- Bhutta MF; Cheeseman MT; Herault Y; Yu YE; Brown SD. 2013. Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. Mamm Genome :. PubMed: 24068166MGI: J:201811
- Bianchi P; Bettini S; Guidi S; Ciani E; Trazzi S; Stagni F; Ragazzi E; Franceschini V; Bartesaghi R. 2014. Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome. Exp Neurol 251:1-11. PubMed: 24192151MGI: J:206601
- Bianchi P; Ciani E; Contestabile A; Guidi S; Bartesaghi R. 2010. Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. Brain Pathol 20(1):106-18. PubMed: 19298631MGI: J:173984
- Bimonte-Nelson HA; Hunter CL; Nelson ME; Granholm AC. 2003. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav Brain Res 139(1-2):47-57. PubMed: 12642175MGI: J:95711
- Blank M; Fuerst PG; Stevens B; Nouri N; Kirkby L; Warrier D; Barres BA; Feller MB; Huberman AD; Burgess RW; Garner CC. 2011. The Down Syndrome Critical Region Regulates Retinogeniculate Refinement. J Neurosci 31(15):5764-5776. PubMed: 21490218MGI: J:170968
- Blazek JD; Abeysekera I; Li J; Roper RJ. 2015. Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. Hum Mol Genet 24(20):5687-96. PubMed: 26206885MGI: J:226041
- Blazek JD; Billingsley CN; Newbauer A; Roper RJ. 2010. Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome. Dev Dyn 239(6):1645-53. PubMed: 20503361MGI: J:160592
- Blazek JD; Gaddy A; Meyer R; Roper RJ; Li J. 2011. Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice. Bone 48(2):275-80. PubMed: 20870049MGI: J:170199
- Blazek JD; Malik AM; Tischbein M; Arbones ML; Moore CS; Roper RJ. 2014. Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Mech Dev :. PubMed: 25556111MGI: J:217672
- Casas C; Martinez S; Pritchard MA; Fuentes JJ; Nadal M; Guimera J; Arbones M; Florez J; Soriano E; Estivill X; Alcantara S. 2001. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev 101(1-2):289-92. PubMed: 11231093MGI: J:68156
- Cataldo AM; Petanceska S; Peterhoff CM; Terio NB; Epstein CJ; Villar A; Carlson EJ; Staufenbiel M; Nixon RA. 2003. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23(17):6788-92. PubMed: 12890772MGI: J:84685
- Cefalu JA; Croom WJ Jr; Eisen EJ; Jones EE; Daniel LR; Taylor IL. 1998. Jejunal function and plasma amino acid concentrations in the segmental trisomic Ts65Dn mouse. Growth Dev Aging 62(1-2):47-59. PubMed: 9666356MGI: J:48496
- Chakrabarti L; Best TK; Cramer NP; Carney RS; Isaac JT; Galdzicki Z; Haydar TF. 2010. Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci 13(8):927-34. PubMed: 20639873MGI: J:163767
- Chakrabarti L; Galdzicki Z; Haydar TF. 2007. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci 27(43):11483-95. PubMed: 17959791MGI: J:127045
- Chang Q; Gold PE. 2008. Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol Learn Mem 89(2):167-77. PubMed: 17644430MGI: J:128851
- Chen Y; Dyakin VV; Branch CA; Ardekani B; Yang D; Guilfoyle DN; Peterson J; Peterhoff C; Ginsberg SD; Cataldo AM; Nixon RA. 2009. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiol Aging 30(9):1453-65. PubMed: 18180075MGI: J:152960
- Choi JH; Berger JD; Mazzella MJ; Morales-Corraliza J; Cataldo AM; Nixon RA; Ginsberg SD; Levy E; Mathews PM. 2009. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem 110(6):1818-27. PubMed: 19619138MGI: J:152489
- Chrast R; Scott HS; Papasavvas MP; Rossier C; Antonarakis ES; Barras C; Davisson MT; Schmidt C; Estivill X; Dierssen M; Pritchard M; Antonarakis SE. 2000. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of down syndrome (Ts65Dn) and normals Genome Res 10(12):2006-21. PubMed: 11116095MGI: J:66235
- Colas D; Valletta JS; Takimoto-Kimura R; Nishino S; Fujiki N; Mobley WC; Mignot E. 2008. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis 30(1):1-7. PubMed: 18282758MGI: J:136520
- Contestabile A; Fila T; Bartesaghi R; Ciani E. 2009. Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. Brain Pathol 19(2):224-37. PubMed: 18482164MGI: J:174271
- Contestabile A; Fila T; Bartesaghi R; Contestabile A; Ciani E. 2006. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J Neurochem 97(2):515-26. PubMed: 16539660MGI: J:109560
- Contestabile A; Fila T; Cappellini A; Bartesaghi R; Ciani E. 2009. Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. Cell Prolif 42(2):171-81. PubMed: 19317805MGI: J:173979
- Contestabile A; Fila T; Ceccarelli C; Bonasoni P; Bonapace L; Santini D; Bartesaghi R; Ciani E. 2007. Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus 17(8):665-78. PubMed: 17546680MGI: J:173985
- Contestabile A; Greco B; Ghezzi D; Tucci V; Benfenati F; Gasparini L. 2013. Lithium rescues synaptic plasticity and memory in Down syndrome mice. J Clin Invest 123(1):348-61. PubMed: 23202733MGI: J:194179
- Cooper JD; Salehi A; Delcroix JD; Howe CL; Belichenko PV; Chua-Couzens J; Kilbridge JF; Carlson EJ; Epstein CJ; Mobley WC. 2001. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 98(18):10439-44. PubMed: 11504920MGI: J:95716
- Costa AC; Grybko MJ. 2005. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neurosci Lett 382(3):317-22. PubMed: 15925111MGI: J:99714
- Costa AC; Scott-McKean JJ; Stasko MR. 2008. Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 33(7):1624-32. PubMed: 17700645MGI: J:173990
- Costa AC; Stasko MR; Schmidt C; Davisson MT. 2010. Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206(1):52-62. PubMed: 19720087MGI: J:153579
- Costa AC; Walsh K; Davisson MT. 1999. Motor dysfunction in a mouse model for Down syndrome. Physiol Behav 68(1-2):211-20. PubMed: 10627083MGI: J:95719
- Coussons-Read ME; Crnic LS. 1996. Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field. Behav Genet 26(1):7-13. PubMed: 8852727MGI: J:173989
- Cramer NP; Xu X; F Haydar T; Galdzicki Z. 2015. Altered intrinsic and network properties of neocortical neurons in the Ts65Dn mouse model of Down syndrome. Physiol Rep 3(12):. PubMed: 26702072MGI: J:229599
- Das D; Medina B; Baktir MA; Mojabi FS; Fahimi A; Ponnusamy R; Salehi A. 2015. Increased incidence of intermittent hypoxemia in the Ts65Dn mouse model of Down syndrome. Neurosci Lett 604:91-6. PubMed: 26240993MGI: J:228441
- Das I; Park JM; Shin JH; Jeon SK; Lorenzi H; Linden DJ; Worley PF; Reeves RH. 2013. Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med 5(201):201ra120. PubMed: 24005160MGI: J:213460
- Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. PubMed: 17050550MGI: J:117029
- Davisson MT. 2005. Mouse models of Down syndrome Drug Discov Today 2(2):103-109. MGI: J:173982
- Davisson MT; Costa ACS. 1999. Mouse models of Down Syndrome Adv Neurochem 9:297-327. MGI: J:174349
- Davisson MT; Schmidt C; Reeves RH; Irving NG; Akeson EC; Harris BS; Bronson RT. 1993. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res 384:117-33. PubMed: 8115398MGI: J:30229
- Deidda G; Parrini M; Naskar S; Bozarth IF; Contestabile A; Cancedda L. 2015. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome. Nat Med 21(4):318-26. PubMed: 25774849MGI: J:228180
- Demas GE; Nelson RJ; Krueger BK; Yarowsky PJ. 1998. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav Brain Res 90(2):199-201. PubMed: 9521551MGI: J:95722
- Demas GE; Nelson RJ; Krueger BK; Yarowsky PJ. 1996. Spatial memory deficits in segmental trisomic Ts65Dn mice. Behav Brain Res 82(1):85-92. PubMed: 9021073MGI: J:173988
- Di Filippo M; Tozzi A; Ghiglieri V; Picconi B; Costa C; Cipriani S; Tantucci M; Belcastro V; Calabresi P. 2010. Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome. Biol Psychiatry 67(7):666-71. PubMed: 19818432MGI: J:173983
- Dierssen M; Benavides-Piccione R; Martinez-Cue C; Estivill X; Florez J; Elston GN; DeFelipe J. 2003. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb Cortex 13(7):758-64. PubMed: 12816891MGI: J:102148
- Dierssen M; Vallina IF; Baamonde C; Garcia-Calatayud S; Lumbreras MA; Florez J. 1997. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res 749(2):238-44. PubMed: 9138724MGI: J:39408
- Dorard E; Gorisse-Hussonnois L; Guihenneuc-Jouyaux C; Albac C; Potier MC; Allinquant B. 2016. Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice. Neurobiol Aging 46:43-8. PubMed: 27460148MGI: J:239427
- Dowdy-Sanders NC; Wenger GR. 2006. Working memory in the Ts65Dn mouse, a model for Down syndrome. Behav Brain Res 168(2):349-52. PubMed: 16386318MGI: J:174273
- Driscoll LL; Carroll JC; Moon J; Crnic LS; Levitsky DA; Strupp BJ. 2004. Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. Behav Neurosci 118(6):1196-205. PubMed: 15598129MGI: J:174344
- Duchon A; Raveau M; Chevalier C; Nalesso V; Sharp AJ; Herault Y. 2011. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome. Mamm Genome 22(11-12):674-84. PubMed: 21953411MGI: J:178872
- Dutka T; Hallberg D; Reeves RH. 2015. Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice. Mech Dev 135:68-80. PubMed: 25511459MGI: J:217683
- Escorihuela RM; Fernandez-Teruel A; Vallina IF; Baamonde C; Lumbreras MA; Dierssen M; Tobena A; Florez J. 1995. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neurosci Lett 199(2):143-6. PubMed: 8584244MGI: J:174275
- Escorihuela RM; Vallina IF; Martinez-Cue C; Baamonde C; Dierssen M; Tobena A; Florez J; Fernandez-Teruel A. 1998. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 247(2-3):171-4. PubMed: 9655620MGI: J:95721
- Faizi M; Bader PL; Tun C; Encarnacion A; Kleschevnikov A; Belichenko P; Saw N; Priestley M; Tsien RW; Mobley WC; Shamloo M. 2011. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of beta(1)-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis 43(2):397-413. PubMed: 21527343MGI: J:173180
- Fedoriw AM; Menon D; Kim Y; Mu W; Magnuson T. 2015. Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes. Development 142(17):2972-80. PubMed: 26209650MGI: J:239795
- Fernandez F; Garner CC. 2008. Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. Behav Brain Res 188(1):233-7. PubMed: 17950473MGI: J:130535
- Fernandez F; Trinidad JC; Blank M; Feng DD; Burlingame AL; Garner CC. 2009. Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome. J Neurochem 110(1):157-69. PubMed: 19453946MGI: J:150749
- Fortress AM; Hamlett ED; Vazey EM; Aston-Jones G; Cass WA; Boger HA; Granholm AC. 2015. Designer receptors enhance memory in a mouse model of down syndrome. J Neurosci 35(4):1343-53. PubMed: 25632113MGI: J:218976
- Fowler TW; McKelvey KD; Akel NS; Vander Schilden J; Bacon AW; Bracey JW; Sowder T; Skinner RA; Swain FL; Hogue WR; Leblanc DB; Gaddy D; Wenger GR; Suva LJ. 2012. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment. PLoS One 7(8):e42967. PubMed: 22916188MGI: J:190052
- Fuchs C; Ciani E; Guidi S; Trazzi S; Bartesaghi R. 2012. Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression. Lab Invest 92(11):1648-60. PubMed: 22890555MGI: J:189812
- Galdzicki Z; Siarey R; Pearce R; Stoll J; Rapoport SI. 2001. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Brain Res Rev 35(2):115-45. PubMed: 11336779MGI: J:69888
- Galdzicki Z; Siarey RJ. 2003. Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav 2(3):167-78. PubMed: 12931790MGI: J:104907
- Giacomini A; Stagni F; Trazzi S; Guidi S; Emili M; Brigham E; Ciani E; Bartesaghi R. 2015. Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 82:385-96. PubMed: 26254735MGI: J:227674
- Gotti S; Chiavegatto S; Sica M; Viglietti-Panzica C; Nelson RJ; Panzica G. 2004. Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. Neurobiol Dis 16(3):563-71. PubMed: 15262268MGI: J:91857
- Granholm AC; Ford KA; Hyde LA; Bimonte HA; Hunter CL; Nelson M; Albeck D; Sanders LA; Mufson EJ; Crnic LS. 2002. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiol Behav 77(2-3):371-85. PubMed: 12419414MGI: J:95714
- Granholm AC; Sanders LA; Crnic LS. 2000. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp Neurol 161(2):647-63. PubMed: 10686084MGI: J:60959
- Guedj F; Pereira PL; Najas S; Barallobre MJ; Chabert C; Souchet B; Sebrie C; Verney C; Herault Y; Arbones M; Delabar JM. 2012. DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis 46(1):190-203. PubMed: 22293606MGI: J:182294
- Gutierrez-Castellanos N; Winkelman BH; Tolosa-Rodriguez L; Devenney B; Reeves RH; De Zeeuw CI. 2013. Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment. J Neurosci 33(39):15408-13. PubMed: 24068809MGI: J:202685
- Hampton TG; Stasko MR; Kale A; Amende I; Costa AC. 2004. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav 82(2-3):381-9. PubMed: 15276802MGI: J:95704
- Han F; Yu H; Zhang J; Tian C; Schmidt C; Nava C; Davisson MT; Zheng QY. 2009. Otitis media in a mouse model for Down syndrome. Int J Exp Pathol 90(5):480-8. PubMed: 19765102MGI: J:154717
- Hanson JE; Blank M; Valenzuela RA; Garner CC; Madison DV. 2007. The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. J Physiol 579(Pt 1):53-67. PubMed: 17158177MGI: J:140845
- Harashima C; Jacobowitz DM; Stoffel M; Chakrabarti L; Haydar TF; Siarey RJ; Galdzicki Z. 2006. Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model. Cell Mol Neurobiol 26(4-6):719-34. PubMed: 16783527MGI: J:174334
- Harashima C; Jacobowitz DM; Witta J; Borke RC; Best TK; Siarey RJ; Galdzicki Z. 2006. Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. J Comp Neurol 494(5):815-33. PubMed: 16374808MGI: J:174347
- Herrera F; Chen Q; Fischer WH; Maher P; Schubert DR. 2009. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. Cell Death Differ 16(6):910-20. PubMed: 19282871MGI: J:164187
- Hijazi M; Fillat C; Medina JM; Velasco A. 2013. Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome. Exp Neurol 239:229-34. PubMed: 23124096MGI: J:196990
- Hill CA; Reeves RH; Richtsmeier JT. 2007. Effects of aneuploidy on skull growth in a mouse model of Down syndrome. J Anat 210(4):394-405. PubMed: 17428201MGI: J:129637
- Hill JM; Ades AM; McCune SK; Sahir N; Moody EM; Abebe DT; Crnic LS; Brenneman DE. 2003. Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. Exp Neurol 183(1):56-65. PubMed: 12957488MGI: J:85337
- Holtzman DM; Santucci D; Kilbridge J; Chua-Couzens J; Fontana DJ; Daniels SE; Johnson RM; Chen K; Sun Y; Carlson E; Alleva E; Epstein CJ; Mobley WC. 1996. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A 93(23):13333-8. PubMed: 8917591MGI: J:36555
- Huang W; Galdzicki Z; van Gelderen P; Balbo A; Chikhale EG; Schapiro MB; Rapoport SI. 2000. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport 11(3):445-8. PubMed: 10718292MGI: J:103600
- Hunter CL; Bimonte HA; Granholm AC. 2003. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behav Brain Res 138(2):121-31. PubMed: 12527443MGI: J:95712
- Hunter CL; Bimonte-Nelson HA; Nelson M; Eckman CB; Granholm AC. 2004. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol Aging 25(7):873-84. PubMed: 15212841MGI: J:95707
- Hunter CL; Isacson O; Nelson M; Bimonte-Nelson H; Seo H; Lin L; Ford K; Kindy MS; Granholm AC. 2003. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res 45(4):437-45. PubMed: 12657457MGI: J:95710
- Hyde LA; Crnic LS. 2001. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behav Neurosci 115(6):1239-46. PubMed: 11770055MGI: J:174345
- Hyde LA; Crnic LS. 2002. Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. Brain Res 945(1):26-30. PubMed: 12113948MGI: J:78188
- Hyde LA; Frisone DF; Crnic LS. 2001. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav Brain Res 118(1):53-60. PubMed: 11163633MGI: J:95717
- Incerti M; Horowitz K; Roberson R; Abebe D; Toso L; Caballero M; Spong CY. 2012. Prenatal treatment prevents learning deficit in Down syndrome model. PLoS One 7(11):e50724. PubMed: 23209818MGI: J:194780
- Insausti AM; Megias M; Crespo D; Cruz-Orive LM; Dierssen M; Vallina IF; Insausti R; Florez J. 1998. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neurosci Lett 253(3):175-8. PubMed: 9792239MGI: J:95720
- Jiang Y; Rigoglioso A; Peterhoff CM; Pawlik M; Sato Y; Bleiwas C; Stavrides P; Smiley JF; Ginsberg SD; Mathews PM; Levy E; Nixon RA. 2016. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging 39:90-8. PubMed: 26923405MGI: J:234508
- Kahlem P; Sultan M; Herwig R; Steinfath M; Balzereit D; Eppens B; Saran NG; Pletcher MT; South ST; Stetten G; Lehrach H; Reeves RH; Yaspo ML. 2004. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res 14(7):1258-67. PubMed: 15231742MGI: J:95706
- Kida E; Rabe A; Walus M; Albertini G; Golabek AA. 2013. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. Exp Neurol 240:178-89. PubMed: 23201095MGI: J:196979
- Kirsammer G; Jilani S; Liu H; Davis E; Gurbuxani S; Le Beau MM; Crispino JD. 2008. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111(2):767-75. PubMed: 17901249MGI: J:130041
- Klein SL; Kriegsfeld LJ; Hairston JE; Rau V; Nelson RJ; Yarowsky PJ. 1996. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav 60(4):1159-64. PubMed: 8884947MGI: J:174274
- Kleschevnikov AM; Belichenko PV; Gall J; George L; Nosheny R; Maloney MT; Salehi A; Mobley WC. 2012. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 45(2):683-91. PubMed: 22062771MGI: J:182052
- Kleschevnikov AM; Belichenko PV; Villar AJ; Epstein CJ; Malenka RC; Mobley WC. 2004. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24(37):8153-60. PubMed: 15371516MGI: J:95702
- Kurt MA; Davies DC; Kidd M; Dierssen M; Florez J. 2000. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res 858(1):191-7. PubMed: 10700614MGI: J:95718
- Laguna A; Barallobre MJ; Marchena MA; Mateus C; Ramirez E; Martinez-Cue C; Delabar JM; Castelo-Branco M; de la Villa P; Arbones ML. 2013. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet 22(14):2775-84. PubMed: 23512985MGI: J:198546
- Lane AA; Chapuy B; Lin CY; Tivey T; Li H; Townsend EC; van Bodegom D; Day TA; Wu SC; Liu H; Yoda A; Alexe G; Schinzel AC; Sullivan TJ; Malinge S; Taylor JE; Stegmaier K; Jaffe JD; Bustin M; te Kronnie G; Izraeli S; Harris MH; Stevenson KE; Neuberg D; Silverman LB; Sallan SE; Bradner JE; Hahn WC; Crispino JD; Pellman D; Weinstock DM. 2014. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet 46(6):618-23. PubMed: 24747640MGI: J:212324
- Letourneau A; Santoni FA; Bonilla X; Sailani MR; Gonzalez D; Kind J; Chevalier C; Thurman R; Sandstrom RS; Hibaoui Y; Garieri M; Popadin K; Falconnet E; Gagnebin M; Gehrig C; Vannier A; Guipponi M; Farinelli L; Robyr D; Migliavacca E; Borel C; Deutsch S;Feki A; Stamatoyannopoulos JA; Herault Y; van Steensel B; Guigo R; Antonarakis SE. 2014. Domains of genome-wide gene expression dysregulation in Down's syndrome. Nature 508(7496):345-50. PubMed: 24740065MGI: J:208833
- Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. PubMed: 19041304MGI: J:174270
- Liu DP; Schmidt C; Billings T; Davisson MT. 2003. Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome. Biotechniques 35(6):1170-4, 1176, 1178 passim. PubMed: 14682051MGI: J:112549
- Llorens-Martin MV; Rueda N; Tejeda GS; Florez J; Trejo JL; Martinez-Cue C. 2010. Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome. Neuroscience 171(4):1228-40. PubMed: 20875841MGI: J:170195
- Lockrow J; Prakasam A; Huang P; Bimonte-Nelson H; Sambamurti K; Granholm AC. 2009. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol 216(2):278-89. PubMed: 19135442MGI: J:147308
- Lomoio S; Scherini E; Necchi D. 2009. Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice. Brain Res 1297:198-206. PubMed: 19703431MGI: J:157413
- Lorandeau CG; Hakkinen LA; Moore CS. 2011. Cardiovascular development and survival during gestation in the Ts65Dn mouse model for down syndrome. Anat Rec (Hoboken) 294(1):93-101. PubMed: 21157920MGI: J:173508
- Lorenzi HA; Reeves RH. 2006. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res 1104(1):153-9. PubMed: 16828061MGI: J:111633
- Lorenzo LP; Shatynski KE; Clark S; Yarowsky PJ; Williams MS. 2013. Defective thymic progenitor development and mature T-cell responses in a mouse model for Down syndrome. Immunology 139(4):447-58. PubMed: 23432468MGI: J:202187
- Lu S; Yin X. 2016. Overexpression of Dyrk1A regulates cardiac troponin T splicing in cells and mice. Biochem Biophys Res Commun 473(4):993-8. PubMed: 27049307MGI: J:234953
- Lyle R; Gehrig C; Neergaard-Henrichsen C; Deutsch S; Antonarakis SE. 2004. Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res 14(7):1268-74. PubMed: 15231743MGI: J:95705
- Lysenko LV; Kim J; Henry C; Tyrtyshnaia A; Kohnz RA; Madamba F; Simon GM; Kleschevnikova NE; Nomura DK; Ezekowitz RA; Kleschevnikov AM. 2014. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. PLoS One 9(12):e114521. PubMed: 25474204MGI: J:225685
- Martinez-Cue C; Baamonde C; Lumbreras M; Paz J; Davisson MT; Schmidt C; Dierssen M; Florez J. 2002. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134(1-2):185-200. PubMed: 12191805MGI: J:95715
- Martinez-Cue C; Baamonde C; Lumbreras MA; Vallina IF; Dierssen M; Florez J. 1999. A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport 10(5):1119-22. PubMed: 10321494MGI: J:174342
- Martinez-Cue C; Rueda N; Garcia E; Davisson MT; Schmidt C; Florez J. 2005. Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav Brain Res 163(2):174-85. PubMed: 15941601MGI: J:100647
- Martinez-Cue C; Rueda N; Garcia E; Florez J. 2006. Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. Genes Brain Behav 5(5):413-22. PubMed: 16879635MGI: J:123653
- Megias M; Verduga R; Dierssen M; Florez J; Insausti R; Crespo D. 1997. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport 8(16):3475-8. PubMed: 9427310MGI: J:103727
- Meraviglia V; Ulivi AF; Boccazzi M; Valenza F; Fratangeli A; Passafaro M; Lecca D; Stagni F; Giacomini A; Bartesaghi R; Abbracchio MP; Ceruti S; Rosa P. 2016. SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation. Glia 64(8):1437-60. PubMed: 27270750MGI: J:232996
- Mitra A; Blank M; Madison DV. 2012. Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome. Brain Res 1440:1-8. PubMed: 22284618MGI: J:181873
- Moore CS. 2006. Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mamm Genome 17(10):1005-12. PubMed: 17019652MGI: J:115042
- Moore CS; Hawkins C; Franca A; Lawler A; Devenney B; Das I; Reeves RH. 2010. Increased male reproductive success in Ts65Dn 'Down syndrome' mice. Mamm Genome 21(11-12):543-9. PubMed: 21110029MGI: J:166752
- Moran TH; Capone GT; Knipp S; Davisson MT; Reeves RH; Gearhart JD. 2002. The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav 77(2-3):403-9. PubMed: 12419416MGI: J:95713
- Necchi D; Lomoio S; Scherini E. 2008. Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse. Brain Res 1238:181-8. PubMed: 18755166MGI: J:147643
- Necchi D; Lomoio S; Scherini E. 2011. Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice. Exp Neurol 232(2):114-8. PubMed: 21867700MGI: J:178390
- Netzer WJ; Powell C; Nong Y; Blundell J; Wong L; Duff K; Flajolet M; Greengard P. 2010. Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. PLoS One 5(6):e10943. PubMed: 20532168MGI: J:161812
- Ng AP; Hu Y; Metcalf D; Hyland CD; Ierino H; Phipson B; Wu D; Baldwin TM; Kauppi M; Kiu H; Di Rago L; Hilton DJ; Smyth GK; Alexander WS. 2015. Early lineage priming by trisomy of erg leads to myeloproliferation in a down syndrome model. PLoS Genet 11(5):e1005211. PubMed: 25973911MGI: J:224794
- Ng AP; Hyland CD; Metcalf D; Carmichael CL; Loughran SJ; Di Rago L; Kile BT; Alexander WS. 2010. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 115(19):3966-9. PubMed: 20007548MGI: J:160280
- Noll C; Planque C; Ripoll C; Guedj F; Diez A; Ducros V; Belin N; Duchon A; Paul JL; Badel A; de Freminville B; Grattau Y; Blehaut H; Herault Y; Janel N; Delabar JM. 2009. DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One 4(10):e7540. PubMed: 19844572MGI: J:154042
- Nosheny RL; Belichenko PV; Busse BL; Weissmiller AM; Dang V; Das D; Fahimi A; Salehi A; Smith SJ; Mobley WC. 2015. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiol Dis 77:173-90. PubMed: 25753471MGI: J:221127
- O'Leary DA; Pritchard MA; Xu D; Kola I; Hertzog PJ; Ristevski S. 2004. Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS. Biochim Biophys Acta 1739(1):81-7. PubMed: 15607120MGI: J:95701
- Olmos-Serrano JL; Kang HJ; Tyler WA; Silbereis JC; Cheng F; Zhu Y; Pletikos M; Jankovic-Rapan L; Cramer NP; Galdzicki Z; Goodliffe J; Peters A; Sethares C; Delalle I; Golden JA; Haydar TF; Sestan N. 2016. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron 89(6):1208-22. PubMed: 26924435MGI: J:230856
- Olmos-Serrano JL; Tyler WA; Cabral HJ; Haydar TF. 2016. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol 279:40-56. PubMed: 26854932MGI: J:230863
- Olson LE; Richtsmeier JT; Leszl J; Reeves RH. 2004. A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science 306(5696):687-90. PubMed: 15499018MGI: J:93223
- Olson LE; Roper RJ; Baxter LL; Carlson EJ; Epstein CJ; Reeves RH. 2004. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230(3):581-9. PubMed: 15188443MGI: J:91221
- Olson LE; Roper RJ; Sengstaken CL; Peterson EA; Aquino V; Galdzicki Z; Siarey R; Pletnikov M; Moran TH; Reeves RH. 2007. Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Hum Mol Genet 16(7):774-82. PubMed: 17339268MGI: J:121764
- Palminiello S; Kida E; Kaur K; Walus M; Wisniewski KE; Wierzba-Bobrowicz T; Rabe A; Albertini G; Golabek AA. 2008. Increased levels of carbonic anhydrase II in the developing Down syndrome brain. Brain Res 1190:193-205. PubMed: 18083150MGI: J:130837
- Paz-Miguel JE; Flores R; Sanchez-Velasco P; Ocejo-Vinyals G; Escribano de Diego J; Lopez de Rego J; Leyva-Cobian F. 1999. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome. J Immunol 163(10):5399-410. PubMed: 10553065MGI: J:58452
- Paz-Miguel JE; Pardo-Manuel de Villena F; Sanchez-Velasco P; Leyva-Cobian F. 2001. H2-haplotype-dependent unequal transmission of the 17(16) translocation chromosome from Ts65Dn females. Mamm Genome 12(1):83-5. PubMed: 11178750MGI: J:68688
- Peiris H; Duffield MD; Fadista J; Jessup CF; Kashmir V; Genders AJ; McGee SL; Martin AM; Saiedi M; Morton N; Carter R; Cousin MA; Kokotos AC; Oskolkov N; Volkov P; Hough TA; Fisher EM; Tybulewicz VL; Busciglio J; Coskun PE; Becker A; Belichenko PV; Mobley WC; Ryan MT; Chan JY; Laybutt DR; Coates PT; Yang S; Ling C; Groop L; Pritchard MA; Keating DJ. 2016. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to beta-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet 12(5):e1006033. PubMed: 27195491MGI: J:231889
- Peng S; Garzon DJ; Marchese M; Klein W; Ginsberg SD; Francis BM; Mount HT; Mufson EJ; Salehi A; Fahnestock M. 2009. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci 29(29):9321-9. PubMed: 19625522MGI: J:151795
- Polk RC; Gergics P; Steimle JD; Li H; Moskowitz IP; Camper SA; Reeves RH. 2015. The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol 15:30. PubMed: 26208718MGI: J:224143
- Pollonini G; Gao V; Rabe A; Palminiello S; Albertini G; Alberini CM. 2008. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 156(1):99-106. PubMed: 18703118MGI: J:140854
- Powers BE; Kelley CM; Velazquez R; Ash JA; Strawderman MS; Alldred MJ; Ginsberg SD; Mufson EJ; Strupp BJ. 2017. Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring. Neuroscience 340:501-514. PubMed: 27840230MGI: J:238270
- Rachidi M; Lopes C. 2007. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 59(4):349-69. PubMed: 17897742MGI: J:128743
- Rachubinski AL; Maclean KN; Evans JR; Bjugstad KB. 2012. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Exp Gerontol 47(9):723-33. PubMed: 22776132MGI: J:203590
- Ramakrishna N; Meeker HC; Li S; Brown WT; Rao R; El Idrissi A. 2009. Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain. Neuroscience 161(2):451-8. PubMed: 19328224MGI: J:152941
- Raveau M; Lignon JM; Nalesso V; Duchon A; Groner Y; Sharp AJ; Dembele D; Brault V; Herault Y. 2012. The app-runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a down syndrome mouse model. PLoS Genet 8(5):e1002724. PubMed: 22693452MGI: J:185269
- Richtsmeier JT; Baxter LL; Reeves RH. 2000. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217(2):137-45. PubMed: 10706138MGI: J:60229
- Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. PubMed: 11840489MGI: J:73800
- Roper RJ; Baxter LL; Saran NG; Klinedinst DK; Beachy PA; Reeves RH. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc Natl Acad Sci U S A 103(5):1452-6. PubMed: 16432181MGI: J:105996
- Roper RJ; St John HK; Philip J; Lawler A; Reeves RH. 2006. Perinatal Loss of Ts65Dn Down Syndrome Mice. Genetics 172(1):437-43. PubMed: 16172497MGI: J:105157
- Roper RJ; VanHorn JF; Cain CC; Reeves RH. 2009. A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mech Dev 126(3-4):212-9. PubMed: 19056491MGI: J:145541
- Rueda N; Florez J; Martinez-Cue C. 2008. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav Brain Res 188(2):355-67. PubMed: 18178265MGI: J:131326
- Rueda N; Florez J; Martinez-Cue C. 2008. Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 433(1):22-7. PubMed: 18226451MGI: J:174272
- Rueda N; Mostany R; Pazos A; Florez J; Martinez-Cue C. 2005. Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci Lett 380(1-2):197-201. PubMed: 15854777MGI: J:97980
- Ruiz de Azua I; Lumbreras MA; Zalduegui A; Baamonde C; Dierssen M; Florez J; Salles J. 2001. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. J Neurosci Res 66(4):540-50. PubMed: 11746373MGI: J:174277
- Sago H; Carlson EJ; Smith DJ; Rubin EM; Crnic LS; Huang TT; Epstein CJ. 2000. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48(5):606-13. PubMed: 11044479MGI: J:86822
- Sahir N; Brenneman DE; Hill JM. 2006. Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation. J Mol Neurosci 30(3):329-40. PubMed: 17401158MGI: J:174343
- Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC. 2006. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29-42. PubMed: 16815330MGI: J:122937
- Salehi A; Faizi M; Colas D; Valletta J; Laguna J; Takimoto-Kimura R; Kleschevnikov A; Wagner SL; Aisen P; Shamloo M; Mobley WC. 2009. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med 1(7):7ra17. PubMed: 20368182MGI: J:167886
- Sanders NC; Williams DK; Wenger GR. 2009. Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for Down syndrome, change as they age? Behav Brain Res 203(1):137-42. PubMed: 19409933MGI: J:149835
- Saran NG; Pletcher MT; Natale JE; Cheng Y; Reeves RH. 2003. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet 12(16):2013-9. PubMed: 12913072MGI: J:95709
- Schewe M; Franken PF; Sacchetti A; Schmitt M; Joosten R; Bottcher R; van Royen ME; Jeammet L; Payre C; Scott PM; Webb NR; Gelb M; Cormier RT; Lambeau G; Fodde R. 2016. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell 19(1):38-51. PubMed: 27292189MGI: J:238240
- Scott-McKean JJ; Chang B; Hurd RE; Nusinowitz S; Schmidt C; Davisson MT; Costa AC. 2010. The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci 51(6):3300-8. PubMed: 20130276MGI: J:164105
- Seo H; Isacson O. 2005. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp Neurol 193(2):469-80. PubMed: 15869949MGI: J:99662
- Shetty HU; Siarey RJ; Galdzicki Z; Stoll J; Rapoport SI. 2000. Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochem Res 25(4):431-5. PubMed: 10823574MGI: J:174335
- Shichiri M; Yoshida Y; Ishida N; Hagihara Y; Iwahashi H; Tamai H; Niki E. 2011. alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome. Free Radic Biol Med 50(12):1801-11. PubMed: 21447382MGI: J:172069
- Siarey RJ; Carlson EJ; Epstein CJ; Balbo A; Rapoport SI; Galdzicki Z. 1999. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 38(12):1917-20. PubMed: 10608287MGI: J:86821
- Siarey RJ; Coan EJ; Rapoport SI; Galdzicki Z. 1997. Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice. Neurosci Lett 232(3):131-4. PubMed: 9310297MGI: J:174280
- Siarey RJ; Kline-Burgess A; Cho M; Balbo A; Best TK; Harashima C; Klann E; Galdzicki Z. 2006. Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome. J Neurochem 98(4):1266-77. PubMed: 16895585MGI: J:119275
- Siarey RJ; Stoll J; Rapoport SI; Galdzicki Z. 1997. Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology 36(11-12):1549-54. PubMed: 9517425MGI: J:174279
- Siddiqui A; Lacroix T; Stasko MR; Scott-McKean JJ; Costa AC; Gardiner KJ. 2008. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav 7(7):810-20. PubMed: 19125866MGI: J:151137
- Singh N; Dutka T; Devenney BM; Kawasaki K; Reeves RH; Richtsmeier JT. 2015. Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology. Dis Model Mech 8(3):271-9. PubMed: 25540129MGI: J:219589
- Singh N; Dutka T; Reeves RH; Richtsmeier JT. 2016. Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice. Dev Dyn 245(2):114-22. PubMed: 26509735MGI: J:229168
- Souchet B; Guedj F; Sahun I; Duchon A; Daubigney F; Badel A; Yanagawa Y; Barallobre MJ; Dierssen M; Yu E; Herault Y; Arbones M; Janel N; Creau N; Delabar JM. 2014. Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. Neurobiol Dis 69:65-75. PubMed: 24801365MGI: J:214001
- Spellman C; Ahmed MM; Dubach D; Gardiner KJ. 2013. Expression of trisomic proteins in Down syndrome model systems. Gene 512(2):219-25. PubMed: 23103828MGI: J:192164
- Stagni F; Giacomini A; Emili M; Trazzi S; Guidi S; Sassi M; Ciani E; Rimondini R; Bartesaghi R. 2016. Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neuroscience 333:277-301. PubMed: 27457036MGI: J:238238
- Stagni F; Giacomini A; Guidi S; Ciani E; Ragazzi E; Filonzi M; De Iasio R; Rimondini R; Bartesaghi R. 2015. Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice. Neurobiol Dis 74:204-18. PubMed: 25497735MGI: J:219354
- Stagni F; Magistretti J; Guidi S; Ciani E; Mangano C; Calza L; Bartesaghi R. 2013. Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome. PLoS One 8(4):e61689. PubMed: 23620781MGI: J:200637
- Stasko MR; Costa AC. 2004. Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behav Brain Res 154(1):1-17. PubMed: 15302106MGI: J:95703
- Stasko MR; Scott-McKean JJ; Costa AC. 2006. Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. Neuroreport 17(8):837-41. PubMed: 16708025MGI: J:174341
- Stewart LS; Persinger MA; Cortez MA; Snead OC 3rd. 2007. Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome. Behav Genet 37(2):388-98. PubMed: 17146725MGI: J:147556
- Strovel J; Stamberg J; Yarowsky PJ. 1999. Interphase FISH for rapid identification of a down syndrome animal model. Cytogenet Cell Genet 86(3-4):285-7. PubMed: 10575227MGI: J:174278
- Sussan TE; Yang A; Li F; Ostrowski MC; Reeves RH. 2008. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451(7174):73-5. PubMed: 18172498MGI: J:131046
- Tlili A; Noll C; Middendorp S; Duchon A; Jouan M; Benabou E; Herault Y; Paul JL; Delabar JM; Janel N. 2013. DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels. Mol Genet Metab 110(3):371-7. PubMed: 23920041MGI: J:205302
- Toiber D; Azkona G; Ben-Ari S; Toran N; Soreq H; Dierssen M. 2010. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis 40(1):348-359. PubMed: 20600907MGI: J:163008
- Trazzi S; Fuchs C; De Franceschi M; Mitrugno VM; Bartesaghi R; Ciani E. 2014. APP-dependent alteration of GSK3beta activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 67:24-36. PubMed: 24636797MGI: J:211994
- Trazzi S; Mitrugno VM; Valli E; Fuchs C; Rizzi S; Guidi S; Perini G; Bartesaghi R; Ciani E. 2011. APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. Hum Mol Genet 20(8):1560-73. PubMed: 21266456MGI: J:170123
- Turner CA; Presti MF; Newman HA; Bugenhagen P; Crnic L; Lewis MH. 2001. Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice. Behav Genet 31(4):393-400. PubMed: 11720125MGI: J:72690
- Tyler WA; Haydar TF. 2013. Multiplex genetic fate mapping reveals a novel route of neocortical neurogenesis, which is altered in the Ts65Dn mouse model of Down syndrome. J Neurosci 33(12):5106-19. PubMed: 23516277MGI: J:231261
- Usowicz MM; Garden CL. 2012. Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. Brain Res 1465:10-7. PubMed: 22627164MGI: J:186437
- Velazquez R; Ash JA; Powers BE; Kelley CM; Strawderman M; Luscher ZI; Ginsberg SD; Mufson EJ; Strupp BJ. 2013. Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 58C:92-101. PubMed: 23643842MGI: J:197983
- Vidal V; Garcia S; Martinez P; Corrales A; Florez J; Rueda N; Sharma A; Martinez-Cue C. 2012. Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. Neuroscience 220:158-68. PubMed: 22728103MGI: J:192516
- Villar AJ; Belichenko PV; Gillespie AM; Kozy HM; Mobley WC; Epstein CJ. 2005. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16(2):79-90. PubMed: 15859352MGI: J:96650
- Vorbrodt AW; Li S; Brown WT; Ramakrishna N. 2008. Increased expression of beta-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome. Brain Cell Biol 36(5-6):203-11. PubMed: 19132532MGI: J:174346
- Voronov SV; Frere SG; Giovedi S; Pollina EA; Borel C; Zhang H; Schmidt C; Akeson EC; Wenk MR; Cimasoni L; Arancio O; Davisson MT; Antonarakis SE; Gardiner K; De Camilli P; Di Paolo G. 2008. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A 105(27):9415-20. PubMed: 18591654MGI: J:137826
- Walus M; Kida E; Rabe A; Albertini G; Golabek AA. 2016. Widespread cerebellar transcriptome changes in Ts65Dn Down syndrome mouse model after lifelong running. Behav Brain Res 296:35-46. PubMed: 26304719MGI: J:227533
- Wang X; Zhao Y; Zhang X; Badie H; Zhou Y; Mu Y; Loo LS; Cai L; Thompson RC; Yang B; Chen Y; Johnson PF; Wu C; Bu G; Mobley WC; Zhang D; Gage FH; Ranscht B; Zhang YW; Lipton SA; Hong W; Xu H. 2013. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med 19(4):473-80. PubMed: 23524343MGI: J:198375
- Wenger GR; Schmidt C; Davisson MT. 2004. Operant conditioning in the Ts65Dn mouse: learning. Behav Genet 34(1):105-19. PubMed: 14739701MGI: J:95708
- Williams AD; Mjaatvedt CH; Moore CS. 2008. Characterization of the cardiac phenotype in neonatal Ts65Dn mice. Dev Dyn 237(2):426-35. PubMed: 18161058MGI: J:130989
- Wiseman FK; Alford KA; Tybulewicz VL; Fisher EM. 2009. Down syndrome--recent progress and future prospects. Hum Mol Genet 18(R1):R75-83. PubMed: 19297404MGI: J:156661
- Xu JC; Dawson VL; Dawson TM. 2013. Usp16: key controller of stem cells in Down syndrome. EMBO J 32(21):2788-9. PubMed: 24076652MGI: J:202008
- Xu W; Weissmiller AM; White JA 2nd; Fang F; Wang X; Wu Y; Pearn ML; Zhao X; Sawa M; Chen S; Gunawardena S; Ding J; Mobley WC; Wu C. 2016. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest 126(5):1815-33. PubMed: 27064279MGI: J:234942
- Yan J; Ginsberg SD; Powers B; Alldred MJ; Saltzman A; Strupp BJ; Caudill MA. 2014. Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice. FASEB J 28(10):4312-23. PubMed: 24963152MGI: J:217837
- Yang A; Reeves RH. 2011. Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome. Cancer Res 71(10):3573-81. PubMed: 21467166MGI: J:171978
- Zhang L; Fu D; Belichenko PV; Liu C; Kleschevnikov AM; Pao A; Liang P; Clapcote SJ; Mobley WC; Yu YE. 2012. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs 3(1):8-12. PubMed: 22126738MGI: J:196862