TThese mice carry a mutation of the Cat gene induced by X-irradiation and are characterized by a deficiency in blood catalase.
Allen Gates, University of Rochester
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Radiation induced | Cat | catalase |
This strain is homozygous for the retinal degeneration allele Pde6brd1.
TThese mice carry a mutation of the Cat gene induced by X-irradiation and are characterized by a deficiency in blood catalase.
The Catb allele arose in the randomly mated progeny of a male that had been exposed to X-irradiation at Oak Ridge National Laboratory. The male was an F1 from a cross between 101 and C3H. He was bred to a female from a recessive test stock that was homozygous for the following seven alleles: a, Tyrp1b, Tyr c-ch, p, Myo5ad, Bmp5se, and Ednrbs. This test stock was derived from the breeding of NB stock, which contained the first six alleles, with a non-inbred stock that was homozygous for Ednrbs and three of the other six alleles (Russell, WL, 1951. Cold Spring Symp. Quant. Biol. 16, 327-336). A female was identified with a blood catalase level of 40 PU/ml. She was bred to a wild type male and the offspring also had lower than normal blood catalase activity. One of these F1 males was backcrossed to its mother and a strain described as acatalasemic derived from this. While the history of this strain began at Oak Ridge National Laboratory, it moved to RN Feinstein at The Argonne National Laboratory and was backcrossed to C3HfB/Anl for 8 generations, reaching N8 in approximately 1968, and was then inbred. It was transferred from RN Feinstein to Allen H. Gates at The University of Rochester in 1975 when it was at N8F13. In 1986 this strain was at N8F13+30. The N8F13+44 generation of this strain was received by The Jackson Laboratory in July, 1991 from Allen H. Gates. It was sibling mated and frozen as embryos at N8 F13+44+2. (Gates, AH, Mouse News Lett. 1987. 79:17)
Allele Name | acatalasemia |
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Allele Type | Radiation induced |
Allele Synonym(s) | Csb; M1 |
Gene Symbol and Name | Cat, catalase |
Gene Synonym(s) | |
Strain of Origin | (101 x C3H)F1 |
Chromosome | 2 |
Molecular Note | This allele corresponds to a mutation located in the first alpha helix in the amino terminal arm of the catalase subunit. The substitution of G to T results in an amino acid substitution that replaces glutamine with histidine at position 11. |
When using the acatalasemia mouse strain in a publication, please cite the originating article(s) and include JAX stock #001906 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for Cat<b>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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