These mice carry a spontaneous mutation at the Atcay locus characterized by smaller size and hesitant walking motion.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Atcay | ataxia, cerebellar, Cayman type |
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Mice homozygous for the hesitant spontaneous mutation (Atcayji-hes) can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, the hindlimbs of homozygous mutant mice hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced.
The hesitant (Atcayji-hes) mutation arose spontaneously on the C3H/HeJ-Tyrc-a background at The Jackson Laboratory in 1987. It was backcrossed twice to C3HeB/FeJ, using ovarian transplanted females crossed to C3HeB/FeJ males, then maintained by sibling breeding until F48 when another ovarian transplant and cross to C3HeB/FeJ was done, then sibling breeding resumed. It is maintained by breeding homozygous females with heterozygous males. In March 2003 this strain reached N2F48N1F4.
Allele Name | jittery hesitant |
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Allele Type | Spontaneous |
Allele Synonym(s) | hes; jihes |
Gene Symbol and Name | Atcay, ataxia, cerebellar, Cayman type |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ-Tyrc-a |
Chromosome | 10 |
General Note | Homozygotes can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, mutants' hindlimbs hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced(J:1771). |
Molecular Note | The mutation in the hesitant mouse has been identified as an IAP insertion in intron 1 that results in large aberrant transcripts and small amounts of normal transcript. |
When using the jittery hesitant mouse strain in a publication, please cite the originating article(s) and include JAX stock #001904 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Atcay<ji-hes> |
Frozen Mouse Embryo | C3H-Atcay<ji-hes>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H-Atcay<ji-hes>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H-Atcay<ji-hes>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C3H-Atcay<ji-hes>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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