C3H-Atcay^ji-hes/J

Stock number: 001904
Product name: jittery hesitant
Research areas: Developmental Biology Research, Mouse/Human Gene Homologs, Neurobiology Research

Description

These mice carry a spontaneous mutation at the Atcay locus characterized by smaller size and hesitant walking motion.

Detailed description

Mice homozygous for the hesitant spontaneous mutation (Atcay^ji-hes) can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, the hindlimbs of homozygous mutant mice hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced.

Development

The hesitant (Atcay^ji-hes) mutation arose spontaneously on the C3H/HeJ-Tyr^c-a background at The Jackson Laboratory in 1987. It was backcrossed twice to C3HeB/FeJ, using ovarian transplanted females crossed to C3HeB/FeJ males, then maintained by sibling breeding until F48 when another ovarian transplant and cross to C3HeB/FeJ was done, then sibling breeding resumed. It is maintained by breeding homozygous females with heterozygous males. In March 2003 this strain reached N2F48N1F4.

Allele

Symbol: Atcay^ji-hes
Name: jittery hesitant
MGI accession ID: MGI:1856898
Generation method: Spontaneous
Marker symbol: Atcay
Marker name: ataxia, cerebellar, Cayman type
Chromosome: 10
Strain of origin: C3H/HeJ-Tyr^c-a
Molecular note: The mutation in the hesitant mouse has been identified as an IAP insertion in intron 1 that results in large aberrant transcripts and small amounts of normal transcript.
General note: Homozygotes can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, mutants' hindlimbs hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced(J:1771).