JAX Mouse Strain Datasheet - 001800

FVB/NJ

Stock No:: 001800

Inbred Strain

Readily Available

Overview

Also Known As: FVB, Friend Virus B NIH Jackson

FVB/NJ are a widely used multipurpose inbred strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of Pde6b^rd1, resulting in blindness by wean age.

Genetic overview

Genetic Background	Generation
	F95pF100 (14-AUG-14)

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Research Applications

Research Tools
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research

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Base Price

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$20.89 Domestic price for male 3-week

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

FVB/NJ was inbred for the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2^q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6b^rd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma. For more information, please refer to Michael Festing's Index of Inbred Strain Characteristics.

Development

In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1^b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87.

Selected References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci U S A 88(6):2065-9. PubMed: 1848692 MGI: J:11068

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Genetics

Disc1^del

Allele Symbol: Disc1^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	Disc1^129S6; Disc1^delta6
Gene Symbol and Name	Disc1, disrupted in schizophrenia 1
Gene Synonym(s)	C1orf136; SCZD9
Strain of Origin	various
Chromosome	8
General Note	This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note	A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	EX33; GPCR4
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	C5; C5; C5D; C5a; C5b; CPAMD4; ECLZB; He; He
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	mt-Atp8^FVB/NJ
Gene Symbol and Name	mt-Atp8, mitochondrially encoded ATP synthase 8
Gene Synonym(s)	ATPase8; MTATP8; URFA6L
Strain of Origin	FVB/NJ
Chromosome	MT
Molecular Note	A G to T transversion is located at nucleotide 7778 resulting in an aspartic acid to tyrosine substitution in the fifth amino acid of the conserved N-terminus of the protein. This substitution has been reported in the FVB/NJ strain.

Fv1

Marker Symbol: Fv1

Marker Synonym(s)	Fv-1; Fv-1; Rauscher leukemia virus susceptibility 1; Rv-1; Rv-1; Rv1; Rv1
Chromosome(s)	4

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- General Purpose
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Production of Transgenic Mice, large pronuclei
- Infectious Disease
  - Salmonella
Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Phenotype Information

Body Weight Information - JAX^® Mice Strain FVB/NJ (001800)

References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci U S A 88(6):2065-9. PubMed: 1848692 MGI: J:11068

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768 MGI: J:75095
Hennings H; Glick AB; Lowry DT; Krsmanovic LS; Sly LM; Yuspa SH. 1993. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14(11):2353-8. PubMed: 8242866 MGI: J:16333
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37(8):835-43. PubMed: 15995705 MGI: J:100159
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. PubMed: 16971002 MGI: J:138682
Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. PubMed: 12626335 MGI: J:84265
Zhu W; Gilmour MI. 2009. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. Immunogenetics 61(3):199-207. PubMed: 19224206 MGI: J:146790

Additional - Disc1^del related

Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :. MGI: J:118317
Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. PubMed: 16751659 MGI: J:111837
Ji B; Higa KK; Kim M; Zhou L; Young JW; Geyer MA; Zhou X. 2014. Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet 23(21):5683-705. PubMed: 24908665 MGI: J:214737
Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. PubMed: 16484369 MGI: J:107244
Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. PubMed: 21903668 MGI: J:177560
Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. PubMed: 23563120 MGI: J:195189
Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. PubMed: 21595826 MGI: J:185685

Additional - Gpr84^del related

Perez CJ; Dumas A; Vallieres L; Guenet JL; Benavides F. 2013. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. J Hered 104(4):565-71. PubMed: 23616478 MGI: J:237405

Additional - Hc⁰ related

Actor JK; Breij E; Wetsel RA; Hoffmann H; Hunter RL Jr; Jagannath C. 2001. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis. Scand J Immunol 53(5):464-74. PubMed: 11309154 MGI: J:103981
Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol 175(3):1894-902. PubMed: 16034133 MGI: J:107269
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. PubMed: 16428769 MGI: J:104987
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties. Eur J Immunol 31(12):3595-601. PubMed: 11745379 MGI: J:151748
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A 111(4):1503-8. PubMed: 24474777 MGI: J:206648
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis. Arthritis Rheum 50(11):3721-8. PubMed: 15529344 MGI: J:94347
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. PubMed: 19805369 MGI: J:153217
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One 7(11):e50327. PubMed: 23189195 MGI: J:194784
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol 177(3):1872-8. PubMed: 16849499 MGI: J:138026
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Scand J Immunol 62(2):123-30. PubMed: 16101818 MGI: J:114316
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun 7:10346. PubMed: 26831747 MGI: J:236291
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. J Exp Med 120:897-924. PubMed: 14247728 MGI: J:13003
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice. J Appl Physiol 85(5):1676-83. PubMed: 9804569 MGI: J:51187
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol 81(11):5518-26. PubMed: 17360740 MGI: J:153322
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. PubMed: 16261419 MGI: J:102639
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. J Lab Clin Med 143(6):358-65. PubMed: 15192652 MGI: J:101948
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. J Immunol 177(7):4688-98. PubMed: 16982908 MGI: J:139313
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. Int J Mol Med 16(4):605-8. PubMed: 16142393 MGI: J:107581
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. PLoS One 8(11):e81341. PubMed: 24260573 MGI: J:209669
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. J Immunol 176(6):3516-24. PubMed: 16517720 MGI: J:129509
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells. J Immunol 165(7):3689-94. PubMed: 11034373 MGI: J:151749
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis. FASEB J 22(10):3483-90. PubMed: 18587006 MGI: J:140250
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood 101(11):4472-8. PubMed: 12543861 MGI: J:151744
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. PubMed: 10449528 MGI: J:108724
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology 144(1):149-57. PubMed: 25039245 MGI: J:220131
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. Immunity 11(2):163-71. PubMed: 10485651 MGI: J:151750
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644-54. PubMed: 14660741 MGI: J:86845
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37(8):835-43. PubMed: 15995705 MGI: J:100159
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis. J Exp Med 194(3):321-30. PubMed: 11489951 MGI: J:70882
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 1(3):221-6. PubMed: 10973279 MGI: J:108211
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. PubMed: 11836529 MGI: J:151747
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med 197(8):1007-16. PubMed: 12707300 MGI: J:151743
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. PubMed: 15379984 MGI: J:92933
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol 176(7):4315-22. PubMed: 16547268 MGI: J:129872
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. Leukemia 26(1):106-16. PubMed: 21769103 MGI: J:181063
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood 112(4):1109-19. PubMed: 18524992 MGI: J:138410
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. PubMed: 16301658 MGI: J:122156
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest 122(6):2234-8. PubMed: 22585573 MGI: J:190492
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. J Appl Physiol 87(6):2357-61. PubMed: 10601189 MGI: J:103341
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. Leukemia 23(11):2052-62. PubMed: 19657368 MGI: J:154482
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. PubMed: 20033053 MGI: J:158026
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. PLoS One 8(12):e84802. PubMed: 24386419 MGI: J:209840
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. Shock 12(5):340-9. PubMed: 10565608 MGI: J:59655
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 166(4):2479-86. PubMed: 11160308 MGI: J:111000
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role. Mol Immunol 33(14):1135-7. PubMed: 9047380 MGI: J:38592
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. Cell Immunol 162(2):326-32. PubMed: 7743560 MGI: J:25289
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113(12):2684-94. PubMed: 19136662 MGI: J:146538
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Additional - Pde6b^rd1 related

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Also Known As: FVB, Friend Virus B NIH Jackson

Genetic overview

Research Applications

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Detailed Description

Development

Selected References

Disc1del

Allele Symbol: Disc1del

Gpr84del

Allele Symbol: Gpr84del

Hc0

Allele Symbol: Hc0

Pde6brd1

Allele Symbol: Pde6brd1

mt-Atp8m1

Allele Symbol: mt-Atp8m1

Fv1

Marker Symbol: Fv1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Hc0 related

Genotype: Pde6brd1 related

Phenotype Information

References

Additional References

Additional - Disc1del related

Additional - Gpr84del related

Additional - Hc0 related

Additional - mt-Atp8m1 related

Additional - Pde6brd1 related

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Disc1^del

Allele Symbol: Disc1^del

Gpr84^del

Allele Symbol: Gpr84^del

Hc⁰

Allele Symbol: Hc⁰

Pde6b^rd1

Allele Symbol: Pde6b^rd1

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Genotype: Hc⁰ related

Genotype: Pde6b^rd1 related

Additional - Disc1^del related

Additional - Gpr84^del related

Additional - Hc⁰ related

Additional - mt-Atp8^m1 related

Additional - Pde6b^rd1 related