Overview

Also Known As: Friend Virus B NIH Jackson, FVB

FVB/NJ are a widely used multipurpose inbred strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of Pde6b^rd1, resulting in blindness by wean age.

Genetic overview

Genetic Background	Generation
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Research Applications

Research Tools
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research
Mouse/Human Gene Homologs

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

FVB/NJ was inbred for the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2^q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6b^rd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma. For more information, please refer to Michael Festing's Index of Inbred Strain Characteristics.

Development

In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1^b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87.

Selected References

Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci U S A 88(6):2065-9PubMed: 1848692 MGI: J:11068
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. Genome Biol 17(1):167PubMed: 27480531 MGI: J:262923
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

View All References

Genetics

Bfsp2^Dundee

Allele Symbol: Bfsp2^Dundee

Allele Name	Dundee
Allele Type	Spontaneous
Allele Synonym(s)	Bfsp2^Dundee; Dundee
Gene Symbol and Name	Bfsp2, beaded filament structural protein 2, phakinin
Gene Synonym(s)	CP47; CP49; CTRCT12; LIFL-L; expressed sequence AI448593; PHAKOSIN; AI448593
Strain of Origin	129X1/SvJ
Chromosome	9
Molecular Note	A deletion of ~6 kb within intron B was identified in the 129X1/SvJ background. The deleted region included 24 bp of the exon 2 splice acceptor site. RT-PCR analysis identified transcript in which exon 2 is skipped and exon 1 splices directly to exon 3. The aberrant splicing generates a frameshift and ultimately a premature stop codon at position 2 of exon 3. Neither normal protein nor truncated fragments were detected by Western blot analysis. This mutation has been detected in 129S1/SvImJ, 129S2/SvPas, 129S4/SvJae, FVB/N, NZB/BlNJ, and NZW/LacJ backgrounds but not in C3H or C57BL/6J backgrounds.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)	deletion; Gpr84^del
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	GPCR4; EX33
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	deficient; Hc⁰
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	He; CPAMD4; ECLZB; C5b; He; C5; C5a; C5D; C5; Hfib2; hepatic fibrogenesis 2; Hfib2
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, I/LnJ, KK/HlJ, MOLF/EiJ, NZB/B1NJ, RF/J, ST/bJ SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Disc1^del

Allele Symbol: Disc1^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	deletion; Disc1^del
Gene Symbol and Name	Disc1, disrupted in schizophrenia 1
Gene Synonym(s)	SCZD9; C1orf136
Strain of Origin	various
Chromosome	8
General Note	This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note	A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

Mx1^s1

Allele Symbol: Mx1^s1

Allele Name	myxovirus susceptibility 1
Allele Type	Spontaneous
Allele Synonym(s)	Mx1^s1; myxovirus susceptibility 1
Gene Symbol and Name	Mx1, MX dynamin-like GTPase 1
Gene Synonym(s)	Mx; Mx-1; Mx; Mx-1; AI893580; myxovirus (influenza) resistance 1 polypeptide; expressed sequence AI893580; IFI-78K; MxA; MX; IFI78; MXB
Strain of Origin	multiple strains
Chromosome	16
General Note	The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Resistance is specific for the orthomyxoviruses (J:6265). It is dependent on the presence of interferon-alpha and -beta but not -gamma (J:7365). The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Susceptibility alleles do not produce the protein (J:8273). The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). The MX-1 protein is a GTPase containing a GTP binding domain (J:1417) and this binding core is also necessary (J:21243). Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1^r. The Mx1^r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1^s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1^r allele. This large deletion apparently renders the protein incapable of providing resistance to influenza. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1^s2 allele in which there is a nonsense mutation (J:9452). Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892).
Molecular Note	Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	retinal degeneration 1; Pde6b^rd1
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	rd; rd1; Pdeb; r; rd; rd10; nmf137; r; retinal degeneration; retinal degeneration 1; retinal degeneration 10; CSNB3; CSNBAD2; rd1; rd-1; rd10; PDEB; RP40; phosphodiesterase, cGMP, rod receptor, beta polypeptide; Pdeb; GMP-PDEbeta
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Tyro3^m1

Allele Symbol: Tyro3^m1

Allele Name	mutation 1
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	mutation 1; Tyro3^m1
Gene Symbol and Name	Tyro3, TYRO3 protein tyrosine kinase 3
Gene Synonym(s)	brain tyrosine kinase; Dtk; BYK; Brt; Tif; Sky; RSE; AI323366; Etk-2; expressed sequence AI323366; Brt; Rek; Rse
Strain of Origin	various
Chromosome	2
Molecular Note	A single C to T transiton in the signal sequence causes an arginine to tryptophan substitution at amino acid 7.

Cox7a2l^l

Allele Symbol: Cox7a2l^l

Allele Name	long
Allele Type	Not Applicable (Not Specified)
Allele Synonym(s)	Cox7a2l^l; long
Gene Symbol and Name	Cox7a2l, cytochrome c oxidase subunit 7A2 like
Gene Synonym(s)	COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1
Strain of Origin	multiple strains
Chromosome	17
General Note	Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T⁺ Itpr3^tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.
Molecular Note	This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	mutation 1; mt-Atp8^m1
Gene Symbol and Name	mt-Atp8, mitochondrially encoded ATP synthase 8
Gene Synonym(s)	URFA6L; ATPase8; MTATP8
Strain of Origin	FVB/NJ
Chromosome	MT
Molecular Note	A G to T transversion is located at nucleotide 7778 resulting in an aspartic acid to tyrosine substitution in the fifth amino acid of the conserved N-terminus of the protein. This substitution has been reported in the FVB/NJ strain.

Fv1

Marker Symbol: Fv1

Marker Synonym(s)	Rv-1; Fv-1; Fv-1; Rv-1; Rv1; Rv1; Rauscher leukemia virus susceptibility 1
Chromosome(s)	4

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- General Purpose
- Genetics Research
  - Mutagenesis and Transgenesis: Production of Transgenic Mice, large pronuclei
  - Mutagenesis and Transgenesis
- Infectious Disease
  - Salmonella
Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration
Mouse/Human Gene Homologs
- retinitis pigmentosa, autosomal recessive

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci U S A 88(6):2065-9PubMed: 1848692 MGI: J:11068
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. Genome Biol 17(1):167PubMed: 27480531 MGI: J:262923
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37(8):835-43PubMed: 15995705 MGI: J:100159
Wahlsten D; Bachmanov A; Finn DA; Crabbe JC. 2006. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103(44):16364-9PubMed: 17053075 MGI: J:115640
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Berglund ED; Li CY; Poffenberger G; Ayala JE; Fueger PT; Willis SE; Jewell MM; Powers AC; Wasserman DH. 2008. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 57(7):1790-9PubMed: 18398139 MGI: J:138229
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20PubMed: 16971002 MGI: J:138682
Zhu W; Gilmour MI. 2009. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. Immunogenetics 61(3):199-207PubMed: 19224206 MGI: J:146790
Srivastava B; Blazejewska P; Hessmann M; Bruder D; Geffers R; Mauel S; Gruber AD; Schughart K. 2009. Host genetic background strongly influences the response to influenza a virus infections. PLoS One 4(3):e4857PubMed: 19293935 MGI: J:147356
Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
Hennings H; Glick AB; Lowry DT; Krsmanovic LS; Sly LM; Yuspa SH. 1993. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14(11):2353-8PubMed: 8242866 MGI: J:16333
Murray SA; Morgan JL; Kane C; Sharma Y; Heffner CS; Lake J; Donahue LR. 2010. Mouse gestation length is genetically determined. PLoS One 5(8)PubMed: 20811634 MGI: J:163994
Sinke AP; Caputo C; Tsaih SW; Yuan R; Ren D; Deen PM; Korstanje R. 2011. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics 43(5):265-70PubMed: 21177381 MGI: J:171768
Zombeck JA; Swearingen SP; Rhodes JS. 2010. Acute locomotor responses to cocaine in adolescents vs. adults from four divergent inbred mouse strains. Genes Brain Behav 9(8):892-8PubMed: 20662938 MGI: J:178207
Crowley JJ; Kim Y; Szatkiewicz JP; Pratt AL; Quackenbush CR; Adkins DE; van den Oord E; Bogue MA; Yang H; Wang W; Threadgill DW; de Villena FP; McLeod HL; Sullivan PF. 2012. Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. Mamm Genome 23(5-6):322-35PubMed: 22207321 MGI: J:179972
Yuan R; Meng Q; Nautiyal J; Flurkey K; Tsaih SW; Krier R; Parker MG; Harrison DE; Paigen B. 2012. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A 109(21):8224-9PubMed: 22566614 MGI: J:184775
Lightfoot JT; Leamy L; Pomp D; Turner MJ; Fodor AA; Knab A; Bowen RS; Ferguson D; Moore-Harrison T; Hamilton A. 2010. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol 109(3):623-34PubMed: 20538847 MGI: J:185928
Harrill AH; Desmet KD; Wolf KK; Bridges AS; Eaddy JS; Kurtz CL; Hall JE; Paine MF; Tidwell RR; Watkins PB. 2012. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci 130(2):416-26PubMed: 22940726 MGI: J:192655
Leduc MS; Hageman RS; Meng Q; Verdugo RA; Tsaih SW; Churchill GA; Paigen B; Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9(5):823-36PubMed: 20735370 MGI: J:201869
Pani AK; Jiao Y; Sample KJ; Smeyne RJ. 2014. Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice. PLoS One 9(3):e92422PubMed: 24642754 MGI: J:215077
Yuan R; Tsaih SW; Petkova SB; Marin de Evsikova C; Xing S; Marion MA; Bogue MA; Mills KD; Peters LL; Bult CJ; Rosen CJ; Sundberg JP; Harrison DE; Churchill GA; Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8(3):277-87PubMed: 19627267 MGI: J:216124
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607PubMed: 26067236 MGI: J:223755
Wiltshire T; Ervin RB; Duan H; Bogue MA; Zamboni WC; Cook S; Chung W; Zou F; Tarantino LM. 2015. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains. Genes Brain Behav 14(3):271-80PubMed: 25727211 MGI: J:235925
Sundberg JP; Berndt A; Sundberg BA; Silva KA; Kennedy V; Bronson R; Yuan R; Paigen B; Harrison D; Schofield PN. 2011. The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice. Pathobiol Aging Age Relat Dis 1PubMed: 22953031 MGI: J:236844
Van Der Kraak L; Langlais D; Jothy S; Beauchemin N; Gros P. 2016. Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice. Mamm Genome 27(5-6):213-24PubMed: 26979842 MGI: J:242437
Bopp SE; Rodrigo E; Gonzalez-Paez GE; Frazer M; Barnes SW; Valim C; Watson J; Walker JR; Schmedt C; Winzeler EA. 2013. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J 12:316PubMed: 24025732 MGI: J:244519
Van Hede D; Polese B; Humblet C; Wilharm A; Renoux V; Dortu E; de Leval L; Delvenne P; Desmet CJ; Bureau F; Vermijlen D; Jacobs N. 2017. Human papillomavirus oncoproteins induce a reorganization of epithelial-associated gammadelta T cells promoting tumor formation. Proc Natl Acad Sci U S A 114(43):E9056-E9065PubMed: 29073102 MGI: J:252911
Lu Y; Cao X; Zhang X; Kovalovsky D. 2015. PLZF Controls the Development of Fetal-Derived IL-17+Vgamma6+ gammadelta T Cells. J Immunol 195(9):4273-81PubMed: 26408661 MGI: J:262271
Panksepp JB; Rodriguez ED; Ryabinin AE. 2017. Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice. Genes Brain Behav 16(3):369-383PubMed: 27706910 MGI: J:263201
Boon AC; Finkelstein D; Zheng M; Liao G; Allard J; Klumpp K; Webster R; Peltz G; Webby RJ. 2011. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. MBio 2(5)PubMed: 21896679 MGI: J:267274
Xue J; Schoenrock SA; Valdar W; Tarantino LM; Ideraabdullah FY. 2016. Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations. Clin Epigenetics 8:107PubMed: 27777636 MGI: J:268179
Yoneyama N; Crabbe JC; Ford MM; Murillo A; Finn DA. 2008. Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 42(3):149-60PubMed: 18358676 MGI: J:268914
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Feinberg TY; Zheng H; Liu R; Wicha MS; Yu SM; Weiss SJ. 2018. Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs. Dev Cell 47(2):145-160.e6PubMed: 30269950 MGI: J:272388
Bumgardner SA; Zhou Y; Jiang Z; Coe EJ; Yakaitis CL; Xiao Y; Pazdro R. 2018. Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. Exp Gerontol 104:9-16PubMed: 29355703 MGI: J:272690
Linehan JL; Harrison OJ; Han SJ; Byrd AL; Vujkovic-Cvijin I; Villarino AV; Sen SK; Shaik J; Smelkinson M; Tamoutounour S; Collins N; Bouladoux N; Dzutsev A; Rosshart SP; Arbuckle JH; Wang CR; Kristie TM; Rehermann B; Trinchieri G; Brenchley JM; O'Shea JJ; Belkaid Y. 2018. Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell 172(4):784-796.e18PubMed: 29358051 MGI: J:272693
Chella Krishnan K; Kurt Z; Barrere-Cain R; Sabir S; Das A; Floyd R; Vergnes L; Zhao Y; Che N; Charugundla S; Qi H; Zhou Z; Meng Y; Pan C; Seldin MM; Norheim F; Hui S; Reue K; Lusis AJ; Yang X. 2018. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6(1):103-115.e7PubMed: 29361464 MGI: J:272734
Roberts A; Pardo-Manuel de Villena F; Wang W; McMillan L; Threadgill DW. 2007. The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome 18(6-7):473-81PubMed: 17674098 MGI: J:274826
Adebayo Michael AO; Ko S; Tao J; Moghe A; Yang H; Xu M; Russell JO; Pradhan-Sundd T; Liu S; Singh S; Poddar M; Monga JS; Liu P; Oertel M; Ranganathan S; Singhi A; Rebouissou S; Zucman-Rossi J; Ribback S; Calvisi D; Qvartskhava N; Gorg B; Haussinger D; Chen X; Monga SP. 2019. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by beta-Catenin Mutations. Cell Metab 29(5):1135-1150.e6PubMed: 30713111 MGI: J:274941
Zimmerman H; Yin Z; Zou F; Everett ET. 2019. Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping. Front Genet 10:291PubMed: 31001328 MGI: J:275176
Geuther BQ; Deats SP; Fox KJ; Murray SA; Braun RE; White JK; Chesler EJ; Lutz CM; Kumar V. 2019. Robust mouse tracking in complex environments using neural networks. Commun Biol 2:124PubMed: 30937403 MGI: J:275426
Byers SL; Payson SJ; Taft RA. 2006. Performance of ten inbred mouse strains following assisted reproductive technologies (ARTs). Theriogenology 65(9):1716-26PubMed: 16271754 MGI: J:275449
O'Leary TP; Savoie V; Brown RE. 2011. Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze. Behav Brain Res 216(2):531-42PubMed: 20801160 MGI: J:275452
Brown RE; Wong AA. 2007. The influence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem 14(3):134-44PubMed: 17351136 MGI: J:275455
Savov JD; Whitehead GS; Wang J; Liao G; Usuka J; Peltz G; Foster WM; Schwartz DA. 2004. Ozone-induced acute pulmonary injury in inbred mouse strains. Am J Respir Cell Mol Biol 31(1):69-77PubMed: 14975936 MGI: J:275715
Liu X; Gershenfeld HK. 2003. An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross. Brain Res Bull 60(3):223-31PubMed: 12754084 MGI: J:275778
Bolivar VJ. 2009. Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis. Neurobiol Learn Mem 92(2):206-14PubMed: 19496240 MGI: J:275782
Frick A; Fedoriw Y; Richards K; Damania B; Parks B; Suzuki O; Benton CS; Chan E; Thomas RS; Wiltshire T. 2015. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med 8:81-98PubMed: 25897258 MGI: J:275938
Benton CS; Miller BH; Skwerer S; Suzuki O; Schultz LE; Cameron MD; Marron JS; Pletcher MT; Wiltshire T. 2012. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl) 221(2):297-315PubMed: 22113448 MGI: J:275939
Vinyard CJ; Payseur BA. 2008. Of mice and mammals: utilizing classical inbred mice to study the genetic architecture of function and performance in mammals. Integr Comp Biol 48(3):324-37PubMed: 21669795 MGI: J:275940
Tomasini-Johansson B; Mosher DF. 2009. Plasma fibronectin concentration in inbred mouse strains. Thromb Haemost 102(6):1278-80PubMed: 19967162 MGI: J:275941
Thomsen M; Ralph RJ; Caine SB. 2011. Psychomotor stimulation by dopamine D(1)-like but not D(2)-like agonists in most mouse strains. Exp Clin Psychopharmacol 19(5):342-60PubMed: 21843011 MGI: J:275942
Thomsen M; Caine SB. 2011. Psychomotor stimulant effects of cocaine in rats and 15 mouse strains. Exp Clin Psychopharmacol 19(5):321-41PubMed: 21843010 MGI: J:275943
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Wooley CM; Xing S; Burgess RW; Cox GA; Seburn KL. 2009. Age, experience and genetic background influence treadmill walking in mice. Physiol Behav 96(2):350-61PubMed: 19027767 MGI: J:275950
Bradford BU; Lock EF; Kosyk O; Kim S; Uehara T; Harbourt D; DeSimone M; Threadgill DW; Tryndyak V; Pogribny IP; Bleyle L; Koop DR; Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-17PubMed: 21135412 MGI: J:275951
Maroteaux G; Loos M; van der Sluis S; Koopmans B; Aarts E; van Gassen K; Geurts A; Largaespada DA; Spruijt BM; Stiedl O; Smit AB; Verhage M. 2012. High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. Genes Brain Behav 11(7):772-84PubMed: 22846151 MGI: J:275952
Tsuchiya M; Ji C; Kosyk O; Shymonyak S; Melnyk S; Kono H; Tryndyak V; Muskhelishvili L; Pogribny IP; Kaplowitz N; Rusyn I. 2012. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology 56(1):130-9PubMed: 22307928 MGI: J:275956
Metten P; Crabbe JC. 2005. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci 119(4):911-25PubMed: 16187819 MGI: J:276057
Ishiwatari Y; Bachmanov AA. 2012. NaCl taste thresholds in 13 inbred mouse strains. Chem Senses 37(6):497-508PubMed: 22293936 MGI: J:276118
Lad HV; Liu L; Paya-Cano JL; Parsons MJ; Kember R; Fernandes C; Schalkwyk LC. 2010. Behavioural battery testing: evaluation and behavioural outcomes in 8 inbred mouse strains. Physiol Behav 99(3):301-16PubMed: 19931548 MGI: J:276120
Bolivar VJ; Caldarone BJ; Reilly AA; Flaherty L. 2000. Habituation of activity in an open field: A survey of inbred strains and F1 hybrids. Behav Genet 30(4):285-93PubMed: 11206083 MGI: J:67085
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25PubMed: 11853768 MGI: J:75095
Bouwknecht JA; Paylor R. 2002. Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains. Behav Brain Res 136(2):489-501PubMed: 12429412 MGI: J:80397
Bachmanov AA; Beauchamp GK; Tordoff MG. 2002. Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet 32(6):445-57PubMed: 12467342 MGI: J:80489
Bachmanov AA; Reed DR; Beauchamp GK; Tordoff MG. 2002. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32(6):435-43PubMed: 12467341 MGI: J:80495
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159
Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42PubMed: 12626335 MGI: J:84265

Additional - Bfsp2^Dundee related

Additional - Cox7a2l^l related

Additional - Disc1^del related

Additional - Fv1 related

Additional - Gpr84^del related

Additional - Hc⁰ related

Additional - mt-Atp8^m1 related

Additional - Mx1^s1 related

Additional - Pde6b^rd1 related

Additional - Tyro3^m1 related

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is an exceptional breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: A/A Tyr^c/Tyr^c
Citation
When using the FVB/NJ mouse strain in a publication, please include JAX stock #001800 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Pricing & Availability

Readily Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Volume Pricing Details

QUANTITY	VOLUME PRICING

Volume Pricing Program
Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached
Sexes: Sexes of the same strain may be combined to reach minimum quantity levels to receive the volume pricing
Shipment: All shipping destinations qualify

Cryorecovery - Pricing

Service	Genotype	Price
	Inbred, 1 pair minimum will be supplied

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: Friend Virus B NIH Jackson, FVB

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Important Note

Detailed Description

Development

Selected References

Bfsp2Dundee

Allele Symbol: Bfsp2Dundee

Gpr84del

Allele Symbol: Gpr84del

Hc0

Allele Symbol: Hc0

Disc1del

Allele Symbol: Disc1del

Mx1s1

Allele Symbol: Mx1s1

Pde6brd1

Allele Symbol: Pde6brd1

Tyro3m1

Allele Symbol: Tyro3m1

Cox7a2ll

Allele Symbol: Cox7a2ll

mt-Atp8m1

Allele Symbol: mt-Atp8m1

Fv1

Marker Symbol: Fv1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Hc0 related

Genotype: Pde6brd1 related

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Additional - Bfsp2Dundee related

Additional - Cox7a2ll related

Additional - Disc1del related

Additional - Fv1 related

Additional - Gpr84del related

Additional - Hc0 related

Additional - mt-Atp8m1 related

Additional - Mx1s1 related

Additional - Pde6brd1 related

Additional - Tyro3m1 related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Volume Pricing Details

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Bfsp2^Dundee

Allele Symbol: Bfsp2^Dundee

Gpr84^del

Allele Symbol: Gpr84^del

Hc⁰

Allele Symbol: Hc⁰

Disc1^del

Allele Symbol: Disc1^del

Mx1^s1

Allele Symbol: Mx1^s1

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Tyro3^m1

Allele Symbol: Tyro3^m1

Cox7a2l^l

Allele Symbol: Cox7a2l^l

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Genotype: Hc⁰ related

Genotype: Pde6b^rd1 related

Additional - Bfsp2^Dundee related

Additional - Cox7a2l^l related

Additional - Disc1^del related

Additional - Gpr84^del related

Additional - Hc⁰ related

Additional - mt-Atp8^m1 related

Additional - Mx1^s1 related

Additional - Pde6b^rd1 related

Additional - Tyro3^m1 related