FVB/NJ

Stock No:: 001800

Also Known As: FVB, Friend Virus B NIH Jackson

FVB/NJ are a widely used multipurpose inbred strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of Pde6b^rd1, resulting in blindness by wean age.

Genetic overview

Genetic Background	Generation

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Research Applications

Immunology, Inflammation and Autoimmunity Research
Research Tools
Sensorineural Research

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

FVB/NJ was inbred for the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2^q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6b^rd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma. For more information, please refer to Michael Festing's Index of Inbred Strain Characteristics.

Development

In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1^b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1^b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87.

Selected References

Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. (6): 2065-9. PubMed: 1848692 MGI: 11056
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. (34): 9158-9163. PubMed: 28784771 MGI: 245385
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. (1): 167. PubMed: 27480531 MGI: 289628

View All References

Genetics

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	rd; rd1; Pdeb; r; rd; rd10; nmf137; r; retinal degeneration; retinal degeneration 1; retinal degeneration 10; CSNB3; CSNBAD2; rd1; rd-1; rd10; PDEB; RP40; phosphodiesterase, cGMP, rod receptor, beta polypeptide; Pdeb; GMP-PDEbeta
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; Hc^Hfib2; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	He; CPAMD4; ECLZB; C5b; He; C5; C5a; C5D; C5; Hfib2; hepatic fibrogenesis 2; Hfib2
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, I/LnJ, KK/HlJ, MOLF/EiJ, NZB/B1NJ, RF/J, ST/bJ SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Disc1^del

Allele Symbol: Disc1^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	Disc1^129S6; Disc1^delta6
Gene Symbol and Name	Disc1, disrupted in schizophrenia 1
Gene Synonym(s)	SCZD9; C1orf136
Strain of Origin	various
Chromosome	8
General Note	This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note	A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	mt-Atp8^FVB/NJ
Gene Symbol and Name	mt-Atp8, mitochondrially encoded ATP synthase 8
Gene Synonym(s)	URFA6L; ATPase8; MTATP8
Strain of Origin	FVB/NJ
Chromosome	MT
Molecular Note	A G to T transversion is located at nucleotide 7778 resulting in an aspartic acid to tyrosine substitution in the fifth amino acid of the conserved N-terminus of the protein. This substitution has been reported in the FVB/NJ strain.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	GPCR4; EX33
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Bfsp2^Dundee

Allele Symbol: Bfsp2^Dundee

Allele Name	Dundee
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Bfsp2, beaded filament structural protein 2, phakinin
Gene Synonym(s)	CP47; CP49; CTRCT12; LIFL-L; expressed sequence AI448593; PHAKOSIN; AI448593
Strain of Origin	129X1/SvJ
Chromosome	9
Molecular Note	A deletion of ~6 kb within intron B was identified in the 129X1/SvJ background. The deleted region included 24 bp of the exon 2 splice acceptor site. RT-PCR analysis identified transcript in which exon 2 is skipped and exon 1 splices directly to exon 3. The aberrant splicing generates a frameshift and ultimately a premature stop codon at position 2 of exon 3. Neither normal protein nor truncated fragments were detected by Western blot analysis. This mutation has been detected in 129S1/SvImJ, 129S2/SvPas, 129S4/SvJae, FVB/N, NZB/BlNJ, and NZW/LacJ backgrounds but not in C3H or C57BL/6J backgrounds.

Fv1

Marker Symbol: Fv1

Marker Synonym(s)
Chromosome(s)	4

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1
Research Tools
- General Purpose
- Infectious Disease
  - Salmonella
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Production of Transgenic Mice, large pronuclei

Mammalian Phenotype Terms by Genotype

Phenotype Information

Body Weight Information - JAX^® Mice Strain FVB/NJ (001800)

References

Taketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. (6): 2065-9. PubMed: 1848692 MGI: 11056
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. (5): 902-11. PubMed: 15081119 MGI: 90283
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. (34): 9158-9163. PubMed: 28784771 MGI: 245385
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. (1): 167. PubMed: 27480531 MGI: 289628

Additional References

Hennings H; Glick AB; Lowry DT; Krsmanovic LS; Sly LM; Yuspa SH. 1993. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. (11): 2353-8. PubMed: 8242866 MGI: 16218
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. (4): 517-25. PubMed: 11853768 MGI: 76050
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. (8): 835-43. PubMed: 15995705 MGI: 101186
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. (1): 4-20. PubMed: 16971002 MGI: 139775
Bouwknecht JA; Paylor R. 2002. Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains. (2): 489-501. PubMed: 12429412 MGI: 81358
Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. (1): L32-42. PubMed: 12626335 MGI: 85242
Zhu W; Gilmour MI. 2009. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. (3): 199-207. PubMed: 19224206 MGI: 147883
Van Hede D; Polese B; Humblet C; Wilharm A; Renoux V; Dortu E; de Leval L; Delvenne P; Desmet CJ; Bureau F; Vermijlen D; Jacobs N. 2017. Human papillomavirus oncoproteins induce a reorganization of epithelial-associated gammadelta T cells promoting tumor formation. (43): E9056-E9065. PubMed: 29073102 MGI: 261794
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. e05607. PubMed: 26067236 MGI: 224852
Lu Y; Cao X; Zhang X; Kovalovsky D. 2015. PLZF Controls the Development of Fetal-Derived IL-17+Vgamma6+ gammadelta T Cells. (9): 4273-81. PubMed: 26408661 MGI: 286367
Panksepp JB; Rodriguez ED; Ryabinin AE. 2017. Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice. (3): 369-383. PubMed: 27706910 MGI: 285542

Additional - Bfsp2^Dundee

Sandilands A; Wang X; Hutcheson AM; James J; Prescott AR; Wegener A; Pekny M; Gong X; Quinlan RA. 2004. Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. (4): 875-89. PubMed: 15037121 MGI: 86221
Sandilands A; Wang X; Hutcheson AM; James J; Prescott AR; Wegener A; Pekny M; Gong X; Quinlan RA. 2004. Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. (1): 109-23. PubMed: 14667833 MGI: 86303
Simirskii VN; Lee RS; Wawrousek EF; Duncan MK. 2006. Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens. (11): 4931-4. PubMed: 17065509 MGI: 124180
Nowak RB; Fowler VM. 2012. Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex. (6): 414-27. PubMed: 22473940 MGI: 197935
Fan J; Dong L; Mishra S; Chen Y; FitzGerald P; Wistow G. 2012. A role for gammaS-crystallin in the organization of actin and fiber cell maturation in the mouse lens. (16): 2892-904. PubMed: 22715935 MGI: 202128
Cheng C; Nowak RB; Gao J; Sun X; Biswas SK; Lo WK; Mathias RT; Fowler VM. 2015. Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells. (10): C835-47. PubMed: 25740157 MGI: 225258
Sindhu Kumari S; Gupta N; Shiels A; FitzGerald PG; Menon AG; Mathias RT; Varadaraj K. 2015. Role of Aquaporin 0 in lens biomechanics. (4): 339-45. PubMed: 25960294 MGI: 229555
Logan CM; Rajakaruna S; Bowen C; Radice GL; Robinson ML; Menko AS. 2017. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. (1): 118-134. PubMed: 28552735 MGI: 254056
Kumari S; Gao J; Mathias RT; Sun X; Eswaramoorthy A; Browne N; Zhang N; Varadaraj K. 2017. Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins. (14): 6006-6019. PubMed: 29196765 MGI: 275411
Logan CM; Bowen CJ; Menko AS. 2017. Induction of Immune Surveillance of the Dysmorphogenic Lens. (1): 16235. PubMed: 29176738 MGI: 272539

Additional - Disc1^del

Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. (10): 3693-7. PubMed: 16484369 MGI: 108318
Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. (4): 2407-10. PubMed: 16751659 MGI: 112921
Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 . MGI: 119406
Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. (23): 4666-83. PubMed: 21903668 MGI: 178656
Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. (5): 615-24. PubMed: 21595826 MGI: 186781
Ritchie DJ; Clapcote SJ. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. (3): 162-7. PubMed: 23563120 MGI: 196285
Ji B; Higa KK; Kim M; Zhou L; Young JW; Geyer MA; Zhou X. 2014. Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. (21): 5683-705. PubMed: 24908665 MGI: 215834
Gomez-Sintes R; Kvajo M; Gogos JA; Lucas JJ. 2014. Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders. 253. PubMed: 25126062 MGI: 265155
Baan M; Krentz KJ; Fontaine DA; Davis DB. 2016. Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice. (6): 847-854. PubMed: 27515175 MGI: 252105
Dittrich L; Petese A; Jackson WS. 2017. The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. (1): 5665. PubMed: 28720848 MGI: 258100
Cipriani C; Ricceri L; Matteucci C; De Felice A; Tartaglione AM; Argaw-Denboba A; Pica F; Grelli S; Calamandrei G; Sinibaldi Vallebona P; Balestrieri E. 2018. High expression of Endogenous Retroviruses from intrauterine life to adulthood in two mouse models of Autism Spectrum Disorders. (1): 629. PubMed: 29330412 MGI: 281813

Additional - Gpr84^del

Perez CJ; Dumas A; Vallieres L; Guenet JL; Benavides F. 2013. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. (4): 565-71. PubMed: 23616478 MGI: 238497

Additional - Hc⁰

Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. (1): 1-16. PubMed: 4959665 MGI: 5005
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. (5735): 207-8. PubMed: 492335 MGI: 6203
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. 897-924. PubMed: 14247728 MGI: 12956
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. (5): 1442-7. PubMed: 3572304 MGI: 8678
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. (5): 2435-40. PubMed: 2303408 MGI: 24109
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. (2): 326-32. PubMed: 7743560 MGI: 25397
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role. (14): 1135-7. PubMed: 9047380 MGI: 38781
Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. (6656): 172-5. PubMed: 9367154 MGI: 44499
Wang Y; Kristan J; Hao L; Lenkoski CS; Shen Y; Matis LA. 2000. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. (8): 4340-7. PubMed: 10754334 MGI: 62530
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. (3): 425-35. PubMed: 18328742 MGI: 134035
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis. (3): 321-30. PubMed: 11489951 MGI: 71833
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. (2): 163-71. PubMed: 10485651 MGI: 152843
Zal T; Weiss S; Mellor A; Stockinger B. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. (17): 9102-7. PubMed: 8799161 MGI: 152846
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. (11): 1644-54. PubMed: 14660741 MGI: 87827
Niculescu T; Weerth S; Niculescu F; Cudrici C; Rus V; Raine CS; Shin ML; Rus H. 2004. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. (9): 5702-6. PubMed: 15100315 MGI: 90671
Mullick A; Elias M; Picard S; Bourget L; Jovcevski O; Gauthier S; Tuite A; Harakidas P; Bihun C; Massie B; Gros P. 2004. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. (10): 5868-76. PubMed: 15385488 MGI: 94122
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis. (11): 3721-8. PubMed: 15529344 MGI: 95338
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. (7): 835-46. PubMed: 15466618 MGI: 94939
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. (2): 234-45. PubMed: 15379984 MGI: 93922
Younger JG; Shankar-Sinha S; Mickiewicz M; Brinkman AS; Valencia GA; Sarma JV; Younkin EM; Standiford TJ; Zetoune FS; Ward PA. 2003. Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. (4): 432-8. PubMed: 14500254 MGI: 95604
Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. (3): 585-91. PubMed: 18490515 MGI: 139533
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. (8): 835-43. PubMed: 15995705 MGI: 101186
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. (6): 358-65. PubMed: 15192652 MGI: 103015
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. (6): 2357-61. PubMed: 10601189 MGI: 104410
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. (10): 775-83. PubMed: 16261419 MGI: 103708
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. (4): 1109-19. PubMed: 18524992 MGI: 139503
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. (2): 1196-203. PubMed: 16428769 MGI: 106059
Actor JK; Breij E; Wetsel RA; Hoffmann H; Hunter RL Jr; Jagannath C. 2001. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis. (5): 464-74. PubMed: 11309154 MGI: 105051
Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. (10): 6508-13. PubMed: 16177324 MGI: 105283
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. (5): 340-9. PubMed: 10565608 MGI: 60596
Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. (3): 1894-902. PubMed: 16034133 MGI: 108343
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. (4): 605-8. PubMed: 16142393 MGI: 108655
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. (3): 221-6. PubMed: 10973279 MGI: 109285
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. (4): 577-83. PubMed: 10449528 MGI: 109802
Strey CW; Markiewski M; Mastellos D; Tudoran R; Spruce LA; Greenbaum LE; Lambris JD. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration. (6): 913-23. PubMed: 12975457 MGI: 110459
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. (4): 2479-86. PubMed: 11160308 MGI: 112083
Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. 2006. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. (25): 9649-54. PubMed: 16769899 MGI: 112114
Zal T; Volkmann A; Stockinger B. 1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. (6): 2089-99. PubMed: 7964486 MGI: 112733
Mullick A; Leon Z; Min-Oo G; Berghout J; Lo R; Daniels E; Gros P. 2006. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. (8): 4439-51. PubMed: 16861630 MGI: 113491
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. (2): 123-30. PubMed: 16101818 MGI: 115403
Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. (4): R1037-44. PubMed: 11247825 MGI: 115382
Xiao H; Schreiber A; Heeringa P; Falk RJ; Jennette JC. 2007. Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. (1): 52-64. PubMed: 17200182 MGI: 118137
Tanaka D; Kagari T; Doi H; Shimozato T. 2006. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. (2): 195-202. PubMed: 16836650 MGI: 119640
Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. (10): 6909-14. PubMed: 16272350 MGI: 120782
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. (7): 4688-98. PubMed: 16982908 MGI: 140406
Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury. (10): 1363-71. PubMed: 10811844 MGI: 121658
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. (11): 7504-11. PubMed: 16301658 MGI: 123248
Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. (2): 209-17. PubMed: 16778128 MGI: 124750
Moulton RA; Mashruwala MA; Smith AK; Lindsey DR; Wetsel RA; Haviland DL; Hunter RL; Jagannath C. 2007. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. (4): 956-67. PubMed: 17675563 MGI: 126282
Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. (3): 1117-26. PubMed: 17383432 MGI: 129310
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. (7): 4315-22. PubMed: 16547268 MGI: 130964
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice. (5): 1676-83. PubMed: 9804569 MGI: 51631
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. (1): 97-102. PubMed: 17967861 MGI: 131389
Pilione MR; Agosto LM; Kennett MJ; Harvill ET. 2006. CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection. (5): 758-68. PubMed: 16611225 MGI: 136833
Mori L; de Libero G. 1998. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. (2): 256-62. PubMed: 9485083 MGI: 135204
Rittirsch D; Flierl MA; Nadeau BA; Day DE; Huber-Lang M; Mackay CR; Zetoune FS; Gerard NP; Cianflone K; Kohl J; Gerard C; Sarma JV; Ward PA. 2008. Functional roles for C5a receptors in sepsis. (5): 551-7. PubMed: 18454156 MGI: 137796
Patel SN; Berghout J; Lovegrove FE; Ayi K; Conroy A; Serghides L; Min-oo G; Gowda DC; Sarma JV; Rittirsch D; Ward PA; Liles WC; Gros P; Kain KC. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. (5): 1133-43. PubMed: 18426986 MGI: 137391
Rittirsch D; Flierl MA; Day DE; Nadeau BA; McGuire SR; Hoesel LM; Ipaktchi K; Zetoune FS; Sarma JV; Leng L; Huber-Lang MS; Neff TA; Bucala R; Ward PA. 2008. Acute lung injury induced by lipopolysaccharide is independent of complement activation. (11): 7664-72. PubMed: 18490769 MGI: 137472
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. (6): 3516-24. PubMed: 16517720 MGI: 130601
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. (3): 1872-8. PubMed: 16849499 MGI: 139119
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis. (10): 3483-90. PubMed: 18587006 MGI: 141343
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. (12): 2684-94. PubMed: 19136662 MGI: 147631
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. (7): 2423-31. PubMed: 17536017 MGI: 148115
Wright RJ; Bikoff EK; Stockinger B. 1998. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice. (3): 309-13. PubMed: 9824491 MGI: 51167
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. (8): 1007-16. PubMed: 12707300 MGI: 152836
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. (11): 4472-8. PubMed: 12543861 MGI: 152837
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. (3): 244-50. PubMed: 11836529 MGI: 152840
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties. (12): 3595-601. PubMed: 11745379 MGI: 152841
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells. (7): 3689-94. PubMed: 11034373 MGI: 152842
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. (11): 5518-26. PubMed: 17360740 MGI: 154415
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. (39): 16758-63. PubMed: 19805369 MGI: 154310
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. (11): 2052-62. PubMed: 19657368 MGI: 155575
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. (3): 573-82. PubMed: 20033053 MGI: 159119
Ratajczak MZ; Lee H; Wysoczynski M; Wan W; Marlicz W; Laughlin MJ; Kucia M; Janowska-Wieczorek A; Ratajczak J. 2010. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due toactivation of complement cascade/membrane attack complex. (5): 976-85. PubMed: 20357827 MGI: 161279
Schultz G; Tedesco MM; Sho E; Nishimura T; Sharif S; Du X; Myles T; Morser J; Dalman RL; Leung LL. 2010. Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. (7): 1363-70. PubMed: 20431069 MGI: 181957
Schmitt J; Roderfeld M; Sabrane K; Zhang P; Tian Y; Mertens JC; Frei P; Stieger B; Weber A; Mullhaupt B; Roeb E; Geier A. 2012. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice. (3): 445-50. PubMed: 22277671 MGI: 182364
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. (1): 106-16. PubMed: 21769103 MGI: 182159
de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5. (1): 137-45. PubMed: 21148255 MGI: 186979
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. (6): 2234-8. PubMed: 22585573 MGI: 191588
Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. (2): 162-71. PubMed: 23263555 MGI: 193709
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. (8): e43602. PubMed: 22952717 MGI: 192759
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. (11): e50327. PubMed: 23189195 MGI: 195880
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. (4): 1503-8. PubMed: 24474777 MGI: 207745
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. (12): e84802. PubMed: 24386419 MGI: 210937
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. (11): e81341. PubMed: 24260573 MGI: 210766
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. (1): 149-57. PubMed: 25039245 MGI: 221228
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. 10346. PubMed: 26831747 MGI: 237383
Freeley SJ; Popat RJ; Parmar K; Kolev M; Hunt BJ; Stover CM; Schwaeble W; Kemper C; Robson MG. 2016. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. (1): 61-71. PubMed: 27235854 MGI: 242639
Kalbitz M; Karbach M; Braumueller S; Kellermann P; Gebhard F; Huber-Lang M; Perl M. 2016. Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI). (7): e0159417. PubMed: 27437704 MGI: 261473
Syed SN; Rau E; Ziegelmann M; Sogkas G; Brune B; Schmidt RE. 2018. C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. (4): 696-704. PubMed: 29277896 MGI: 283060

Additional - mt-Atp8^m1

Yu X; Gimsa U; Wester-Rosenlof L; Kanitz E; Otten W; Kunz M; Ibrahim SM. 2009. Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains. (1): 159-65. PubMed: 19037013 MGI: 144994
Weiss H; Wester-Rosenloef L; Koch C; Koch F; Baltrusch S; Tiedge M; Ibrahim S. 2012. The mitochondrial Atp8 mutation induces mitochondrial ROS generation, secretory dysfunction, and beta-cell mass adaptation in conplastic B6-mtFVB mice. (10): 4666-76. PubMed: 22919063 MGI: 194040
Hirose M; Kunstner A; Schilf P; Sunderhauf A; Rupp J; Johren O; Schwaninger M; Sina C; Baines JF; Ibrahim SM. 2017. Mitochondrial gene polymorphism is associated with gut microbial communities in mice. (1): 15293. PubMed: 29127319 MGI: 272235

Additional - Pde6b^rd1

SIDMAN RL; GREEN MC. 1965. RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII. 23-9. PubMed: 14276177 MGI: 114
Gouras P; Du J; Kjeldbye H; Kwun R; Lopez R; Zack DJ. 1991. Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. (13): 3167-74. PubMed: 1748547 MGI: 607
Hussain AA; Willmott NJ; Voaden MJ. 1992. Cyclic GMP, calcium and photoreceptor sensitivity in mice heterozygous for the rod dysplasia gene designated rd. (1): 29-36. PubMed: 1323896 MGI: 611
Viczian A; Sanyal S; Toffenetti J; Chader GJ; Farber DB. 1992. Photoreceptor-specific mRNAs in mice carrying different allelic combinations at the rd and rds loci. (6): 853-60. PubMed: 1381682 MGI: 2579
Keeler C. 1966. Retinal degeneration in the mouse is rodless retina. (2): 47-50. PubMed: 5916892 MGI: 4996
Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. (7): 2955-9. PubMed: 8385352 MGI: 4361
Grafstein B; Murray M; Ingoglia NA. 1972. Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors. (1): 37-48. PubMed: 4115728 MGI: 5281
Schmidt SY; Lolley RN. 1973. Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice. (1): 117-23. PubMed: 4347974 MGI: 5321
Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. (2): 179-212. PubMed: 5009246 MGI: 5239
Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. (2): 317-27. PubMed: 864040 MGI: 5801
Drager UC; Hubel DH. 1978. Studies of visual function and its decay in mice with hereditary retinal degeneration. (1): 85-114. PubMed: 649791 MGI: 5969
Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. (6): 489-98. PubMed: 659071 MGI: 5977
LaVail MM; Mullen RJ. 1976. Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. (2): 227-45. PubMed: 976367 MGI: 5697
Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] (24): 9722-6. PubMed: 2481314 MGI: 10172
Pittler SJ; Baehr W. 1991. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. (19): 8322-6. PubMed: 1656438 MGI: 11500
Danciger M; Bowes C; Kozak CA; LaVail MM; Farber DB. 1990. Fine mapping of a putative rd cDNA and its co-segregation with rd expression. (8): 1427-32. PubMed: 1974892 MGI: 10677
Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. (4): 1240-5. PubMed: 3005510 MGI: 12018
Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] (6294): 677-80. PubMed: 1977087 MGI: 10765
Pittler SJ; Keeler CE; Sidman RL; Baehr W. 1993. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. (20): 9616-9. PubMed: 8415750 MGI: 15141
Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. (3): 974-8. PubMed: 8302876 MGI: 16586
Tansley K. 1954. An inherited retinal degeneration in the mouse 123-27. MGI: 15242
Foster RG; Argamaso S; Coleman S; Colwell CS; Lederman A; Provencio I. 1993. Photoreceptors regulating circadian behavior: a mouse model. S17-23. PubMed: 8274758 MGI: 17792
Yoshimura T; Nishio M; Goto M; Ebihara S. 1994. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). (1): 51-60. PubMed: 7949306 MGI: 19504
Provencio I; Wong S; Lederman AB; Argamaso SM; Foster RG. 1994. Visual and circadian responses to light in aged retinally degenerate mice. (14): 1799-806. PubMed: 7941382 MGI: 20012
Gouras P; Du J; Kjeldbye H; Yamamoto S; Zack DJ. 1994. Long-term photoreceptor transplants in dystrophic and normal mouse retina. (8): 3145-53. PubMed: 8045709 MGI: 20940
Keeler CE. 1924. The inheritance of a retinal abnormality in white mice (7): 329-33. PubMed: 16576828 MGI: 25090
BRUCKNER R. 1951. [Slit-lamp microscopy and ophthalmoscopy in rat and mouse.] 452-554. PubMed: 14896883 MGI: 25691
Garcia-Fernandez JM; Jimenez AJ; Foster RG. 1995. The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization. (1): 33-6. PubMed: 7617296 MGI: 25265
Gao H; Hollyfield JG. 1995. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. (1): 168-184. PubMed: 7750636 MGI: 25381
Sheedlo HJ; Jaynes D; Bolan AL; Turner JE. 1995. Mullerian glia in dystrophic rodent retinas: an immunocytochemical analysis. (2): 171-80. PubMed: 7600664 MGI: 24635
Provencio I; Foster RG. 1995. Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics. (1-2): 183-90. PubMed: 8974643 MGI: 29285
Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. (9): 1363-71. PubMed: 3417421 MGI: 27946
Yoshimura T; Ebihara S. 1996. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. (6): 797-802. PubMed: 8667293 MGI: 33816
Kahle M; Horsch M; Fridrich B; Seelig A; Schultheiss J; Leonhardt J; Irmler M; Beckers J; Rathkolb B; Wolf E; Franke N; Gailus-Durner V; Fuchs H; de Angelis MH; Neschen S. 2013. Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. (4): 435-46. PubMed: 24327959 MGI: 221512
Mrosovsky N; Hampton RR. 1997. Spatial responses to light in mice with severe retinal degeneration. (3): 204-6. PubMed: 9148250 MGI: 40880
Joseph RM; Li T. 1996. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. (12): 2434-46. PubMed: 8933760 MGI: 37443
Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. (4): 423-30. PubMed: 9054517 MGI: 39469
Popper P; Farber DB; Micevych PE; Minoofar K; Bronstein JM. 1997. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. (2): 246-54. PubMed: 9056387 MGI: 39018
Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1997. Fos expression in the retina of rd/rd mice during the light/dark cycle. (3): 143-6. PubMed: 9310300 MGI: 44128
LaVail MM; Matthes MT; Yasumura D; Steinberg RH. 1997. Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. (1): 45-50. PubMed: 9237863 MGI: 42452
Rich KA; Zhan Y; Blanks JC. 1997. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. (1): 47-63. PubMed: 9364238 MGI: 44359
Yazulla S; Studholme KM; Pinto LH. 1997. Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice. (24): 3471-82. PubMed: 9425524 MGI: 45563
Provencio I; Cooper HM; Foster RG. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. (4): 417-39. PubMed: 9619497 MGI: 48077
Mohand-Said S; Deudon-Combe A; Hicks D; Simonutti M; Forster V ; Fintz AC ; Leveillard T ; Dreyfus H ; Sahel JA. 1998. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. (14): 8357-62. PubMed: 9653191 MGI: 49081
Yoshimura T; Ebihara S. 1998. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. (1-2): 188-93. PubMed: 9473668 MGI: 45746
LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. (3): 592-602. PubMed: 9501871 MGI: 46523
Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. 5. PubMed: 9485488 MGI: 47837
Jomary C; Thomas M; Grist J; Milbrandt J; Neal MJ; Jones SE. 1999. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. (3): 568-74. PubMed: 10067959 MGI: 53807
Yan W; Lewin A; Hauswirth W. 1998. Selective degradation of nonsense beta-phosphodiesterase mRNA in the heterozygous rd mouse. (13): 2529-36. PubMed: 9856762 MGI: 51808
Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration. (18): 4161-5. PubMed: 9926867 MGI: 53457
Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of Pax-6 mRNA in the retinal degeneration (rd) mouse. (1): 236-40. PubMed: 9813176 MGI: 51416
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Hatori M; Gill S; Mure LS; Goulding M; O'Leary DD; Panda S. 2014. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. e03357. PubMed: 25035422 MGI: 229698
Hughes S; Jagannath A; Hickey D; Gatti S; Wood M; Peirson SN; Foster RG; Hankins MW. 2015. Using siRNA to define functional interactions between melanopsin and multiple G Protein partners. (1): 165-79. PubMed: 24958088 MGI: 233151
Holt R; Brown L; Broadgate S; Butler R; Jagannath A; Downes S; Peirson S; Halford S. 2015. Identification of rod- and cone-specific expression signatures to identify candidate genes for retinal disease. 161-73. PubMed: 25579607 MGI: 231363
Kooragayala K; Gotoh N; Cogliati T; Nellissery J; Kaden TR; French S; Balaban R; Li W; Covian R; Swaroop A. 2015. Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria. (13): 8428-36. PubMed: 26747773 MGI: 232112
Thompson S; Blodi FR; Lee S; Welder CR; Mullins RF; Tucker BA; Stasheff SF; Stone EM. 2014. Photoreceptor cells with profound structural deficits can support useful vision in mice. (3): 1859-66. PubMed: 24569582 MGI: 230600
Worthington KS; Wiley LA; Bartlett AM; Stone EM; Mullins RF; Salem AK; Guymon CA; Tucker BA. 2014. Mechanical properties of murine and porcine ocular tissues in compression. 194-9. PubMed: 24613781 MGI: 230585
Rattner A; Wang Y; Zhou Y; Williams J; Nathans J. 2014. The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling. (12): 8614-25. PubMed: 25414188 MGI: 231389
Comitato A; Sanges D; Rossi A; Humphries MM; Marigo V. 2014. Activation of Bax in three models of retinitis pigmentosa. (6): 3555-62. PubMed: 24825107 MGI: 231119
Bhatti F; Ball G; Hobbs R; Linens A; Munzar S; Akram R; Barber AJ; Anderson M; Elliott M; Edwards M. 2015. Pulmonary surfactant protein a is expressed in mouse retina by Muller cells and impacts neovascularization in oxygen-induced retinopathy. (1): 232-42. PubMed: 25406276 MGI: 232084
Sooy K; Noble J; McBride A; Binnie M; Yau JL; Seckl JR; Walker BR; Webster SP. 2015. Cognitive and Disease-Modifying Effects of 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. (12): 4592-603. PubMed: 26305888 MGI: 233846
Ivanova E; Yee CW; Sagdullaev BT. 2016. Disruption in dopaminergic innervation during photoreceptor degeneration. (6): 1208-21. PubMed: 26356010 MGI: 232208
Nishiguchi KM; Carvalho LS; Rizzi M; Powell K; Holthaus SM; Azam SA; Duran Y; Ribeiro J; Luhmann UF; Bainbridge JW; Smith AJ; Ali RR. 2015. Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. 6006. PubMed: 25613321 MGI: 220800
Koso H; Tsuhako A; Lai CY; Baba Y; Otsu M; Ueno K; Nagasaki M; Suzuki Y; Watanabe S. 2016. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. (11): 2005-24. PubMed: 27459098 MGI: 236717
Ji X; Liu Y; Hurd R; Wang J; Fitzmaurice B; Nishina PM; Chang B. 2016. Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, theta. (3): 877-88. PubMed: 26978024 MGI: 239069
Yee CW; Toychiev AH; Ivanova E; Sagdullaev BT. 2014. Aberrant synaptic input to retinal ganglion cells varies with morphology in a mouse model of retinal degeneration. (18): 4085-99. PubMed: 25099614 MGI: 239284
Atkinson CL; Feng J; Zhang DQ. 2013. Functional integrity and modification of retinal dopaminergic neurons in the rd1 mutant mouse: roles of melanopsin and GABA. (6): 1589-99. PubMed: 23255724 MGI: 239138
Prigge CL; Yeh PT; Liou NF; Lee CC; You SF; Liu LL; McNeill DS; Chew KS; Hattar S; Chen SK; Zhang DQ. 2016. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. (27): 7184-97. PubMed: 27383593 MGI: 235729
Ayturk DG; Castrucci AM; Carr DE; Keller SR; Provencio I. 2015. Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge. (5): e0127031. PubMed: 26011287 MGI: 238835
Kulkarni M; Trifunovic D; Schubert T; Euler T; Paquet-Durand F. 2016. Calcium dynamics change in degenerating cone photoreceptors. (17): 3729-3740. PubMed: 27402880 MGI: 238952
Ivanova E; Yee CW; Sagdullaev BT. 2015. Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina. 390. PubMed: 26483638 MGI: 240952
Mure LS; Hatori M; Zhu Q; Demas J; Kim IM; Nayak SK; Panda S. 2016. Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells. (5): 1016-27. PubMed: 27181062 MGI: 240738
Chen Q; Qiu F; Zhou K; Matlock HG; Takahashi Y; Rajala RVS; Yang Y; Moran E; Ma JX. 2017. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARalpha. (6): 1671-1682. PubMed: 28270521 MGI: 254637
Schon C; Paquet-Durand F; Michalakis S. 2016. Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice. (6): e0156974. PubMed: 27270916 MGI: 261426
Tsuchiya S; Buhr ED; Higashide T; Sugiyama K; Van Gelder RN. 2017. Light entrainment of the murine intraocular pressure circadian rhythm utilizes non-local mechanisms. (9): e0184790. PubMed: 28934261 MGI: 252849
Nakamura PA; Tang S; Shimchuk AA; Ding S; Reh TA. 2016. Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa. (14): 6407-6415. PubMed: 27893103 MGI: 273219
Jagannath A; Hughes S; Abdelgany A; Pothecary CA; Di Pretoro S; Pires SS; Vachtsevanos A; Pilorz V; Brown LA; Hossbach M; MacLaren RE; Halford S; Gatti S; Hankins MW; Wood MJ; Foster RG; Peirson SN. 2015. Isoforms of Melanopsin Mediate Different Behavioral Responses to Light. (18): 2430-4. PubMed: 26320947 MGI: 257740
Kolesnikov AV; Orban T; Jin H; Brooks C; Hofmann L; Dong Z; Sokolov M; Palczewski K; Kefalov VJ. 2017. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. (45): E9675-E9684. PubMed: 29078372 MGI: 264358
Jain V; Srivastava I; Palchaudhuri S; Goel M; Sinha-Mahapatra SK; Dhingra NK. 2016. Classical Photoreceptors Are Primarily Responsible for the Pupillary Light Reflex in Mouse. (6): e0157226. PubMed: 27295136 MGI: 261128
Lopez-Luppo M; Catita J; Ramos D; Navarro M; Carretero A; Mendes-Jorge L; Munoz-Canoves P; Rodriguez-Baeza A; Nacher V; Ruberte J. 2017. Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging. (7): 2832-2842. PubMed: 28570738 MGI: 273701
Xiang L; Chen XJ; Wu KC; Zhang CJ; Zhou GH; Lv JN; Sun LF; Cheng FF; Cai XB; Jin ZB. 2017. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. (24): 6376-6381. PubMed: 28559309 MGI: 245644
Belichenko PV; Madani R; Rey-Bellet L; Pihlgren M; Becker A; Plassard A; Vuillermot S; Giriens V; Nosheny RL; Kleschevnikov AM; Valletta JS; Bengtsson SK; Linke GR; Maloney MT; Hickman DT; Reis P; Granet A; Mlaki D; Lopez-Deber MP; Do L; Singhal N; Masliah E; Pearn ML; Pfeifer A; Muhs A; Mobley WC. 2016. An Anti-beta-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. (3): e0152471. PubMed: 27023444 MGI: 259461
Huang Z; Zhou T; Sun X; Zheng Y; Cheng B; Li M; Liu X; He C. 2018. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. (1): 180-189. PubMed: 28885615 MGI: 280660
Laprell L; Tochitsky I; Kaur K; Manookin MB; Stein M; Barber DM; Schon C; Michalakis S; Biel M; Kramer RH; Sumser MP; Trauner D; Van Gelder RN. 2017. Photopharmacological control of bipolar cells restores visual function in blind mice. (7): 2598-2611. PubMed: 28581442 MGI: 246055
Lucas RJ; Douglas RH; Foster RG. 2001. Characterization of an ocular photopigment capable of driving pupillary constriction in mice. (6): 621-6. PubMed: 11369943 MGI: 110477
Bhatti F; Kung JW; Vieira F. 2018. Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice. (7): e0199824. PubMed: 29969487 MGI: 290244
Popova EY; Salzberg AC; Yang C; Zhang SS; Barnstable CJ. 2017. Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes. (6): e0179230. PubMed: 28640837 MGI: 251132

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is an exceptional breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: A/A Tyr^c/Tyr^c

Animal Health Reports

Facility Barrier Level Descriptions

Pricing & Availability

Readily Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Volume Pricing Details

QUANTITY	VOLUME PRICING

Volume Pricing Program
Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached
Sexes: Sexes of the same strain may be combined to reach minimum quantity levels to receive the volume pricing
Shipment: All shipping destinations qualify

Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: FVB, Friend Virus B NIH Jackson

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Important Note

Detailed Description

Development

Selected References

Pde6brd1

Allele Symbol: Pde6brd1

Hc0

Allele Symbol: Hc0

Disc1del

Allele Symbol: Disc1del

mt-Atp8m1

Allele Symbol: mt-Atp8m1

Gpr84del

Allele Symbol: Gpr84del

Bfsp2Dundee

Allele Symbol: Bfsp2Dundee

Fv1

Marker Symbol: Fv1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Hc0 related

Genotype: Pde6brd1 related

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Additional - Bfsp2Dundee

Additional - Disc1del

Additional - Gpr84del

Additional - Hc0

Additional - mt-Atp8m1

Additional - Pde6brd1

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Animal Health Reports

Live Mouse

Volume Pricing Details

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Hc⁰

Allele Symbol: Hc⁰

Disc1^del

Allele Symbol: Disc1^del

mt-Atp8^m1

Allele Symbol: mt-Atp8^m1

Gpr84^del

Allele Symbol: Gpr84^del

Bfsp2^Dundee

Allele Symbol: Bfsp2^Dundee

Genotype: Hc⁰ related

Genotype: Pde6b^rd1 related

Additional - Bfsp2^Dundee

Additional - Disc1^del

Additional - Gpr84^del

Additional - Hc⁰

Additional - mt-Atp8^m1

Additional - Pde6b^rd1