STOCK T(7;15)9H/J

Stock number: 001752
Product name: T9H
Research areas: Research Tools

Description

This strain is homozygous for a reciprocal translocation between Chromosome 7 and Chromosome 15.

Detailed description

This strain is homozygous for a reciprocal translocation between Chromosome 7 and Chromosome 15, which is of value in characterizing the relationship of the breakpoint in Chromosome 7 to the imprinted region on Chromosome 7. For more information on this imprinted region see MRC Harwell imprinting.

Development

This translocation was generated by A. G. Searle in the early 1960?s through X-irradiation of a (C3H/HeH x 101/H)F1 male which was then bred to a CBA/H female and their female offspring were bred to C57BL/H males. Many years later this translocation was imported into The Jackson Laboratory by Dr. Eva Eicher. This line was bred to B6CBACaF1/J-A^w-J/A for 7 generations and then sibling inbred to homozygosity and maintained that way. The translocation was tested for homozygosity by cytogenetic analysis for reciprocal products, break points (7B5-C;15C). Embryos were cryopreserved from homozygous crosses at generation F36.

Allele

MGI accession ID: MGI:103967
Marker symbol: T(7;15)9H
Marker name: reciprocal translocation, Chr 7 and 15, Harwell 9
Chromosome: 7

Allele

MGI accession ID: MGI:103968
Marker symbol: T(7;15)9H
Marker name: reciprocal translocation, Chr 7 and 15, Harwell 9
Chromosome: 15