This strain is homozygous for a reciprocal translocation between Chromosome 7 and Chromosome 15.
Read More +Genetic Background | Generation |
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Marker Symbol | Marker Name | |
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T(7;15)9H | reciprocal translocation, Chr 7 and 15, Harwell 9 | |
T(7;15)9H | reciprocal translocation, Chr 7 and 15, Harwell 9 |
This strain is homozygous for a reciprocal translocation between Chromosome 7 and Chromosome 15, which is of value in characterizing the relationship of the breakpoint in Chromosome 7 to the imprinted region on Chromosome 7. For more information on this imprinted region see MRC Harwell imprinting.
This translocation was generated by A. G. Searle in the early 1960?s through X-irradiation of a (C3H/HeH x 101/H)F1 male which was then bred to a CBA/H female and their female offspring were bred to C57BL/H males. Many years later this translocation was imported into The Jackson Laboratory by Dr. Eva Eicher. This line was bred to B6CBACaF1/J-Aw-J/A for 7 generations and then sibling inbred to homozygosity and maintained that way. The translocation was tested for homozygosity by cytogenetic analysis for reciprocal products, break points (7B5-C;15C). Embryos were cryopreserved from homozygous crosses at generation F36.
Before cryopreservation matings of homozygous mice were very good breeders, documented as having four or more litters of 8 or more pups. There was a recessive tail mutation recovered from the strain before cryopreservation; it is unknown if the mutation is still segregating in the cryopreserved mice. From the time of the strain?s importation, all mice eventually developed a crusty discharge or exudate on one or both eyes. The Jackson Laboratory veterinary staff at the time determined the condition to be benign. It is unknown if the eye condition is a characteristic of the homozygous T(7;15)9H genotype or if it will develop in mice that are recovered from cryopreservation.
When using the STOCK T(7;15)9H/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001752 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for T(7;15)9H, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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