Overview

Genetic overview

Genetic Background	Generation
000664 C57BL/6J

Tp(Y)1Ct^Sxr-b

Allele Type	Gene Symbol	Gene Name
Spontaneous	Tp(Y)1Ct	transposition, Chr Y, Cattanach 1

A^w-J

Allele Type	Gene Symbol	Gene Name
Spontaneous	a	nonagouti

Eda^Ta-6J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Eda	ectodysplasin-A

Marker(s)

	Marker Symbol	Marker Name
	Hya	histocompatibility Y

View Genetics

Research Applications

Reproductive Biology Research
Research Tools
Dermatology Research
Developmental Biology Research
Sensorineural Research
Mouse/Human Gene Homologs

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Genetics

Tp(Y)1Ct^Sxr-b

Allele Symbol: Tp(Y)1Ct^Sxr-b

Allele Name	Sex reversed, b variant
Allele Type	Spontaneous
Allele Synonym(s)	HY^-; Sxr'
Gene Symbol and Name	Tp(Y)1Ct, transposition, Chr Y, Cattanach 1
Gene Synonym(s)
Strain of Origin	T16H stock
Chromosome	Y
Molecular Note	At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1Ct^Sxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lack one of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1Ct^Sxr-b from Tp(Y)1Ct^Sxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya.

A^w-J

Allele Symbol: A^w-J

Allele Name	white bellied agouti Jackson
Allele Type	Spontaneous
Allele Synonym(s)	A^WJ
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)
Strain of Origin	C57BL/6J
Chromosome	2

Eda^Ta-6J

Allele Symbol: Eda^Ta-6J

Allele Name	tabby 6 Jackson
Allele Type	Spontaneous
Allele Synonym(s)	Ta^6J; Ta2; Tabby
Gene Symbol and Name	Eda, ectodysplasin-A
Gene Synonym(s)
Strain of Origin	C57BL/6J-tp^3J/J
Chromosome	X
Molecular Note	This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation.

Hya

Marker Symbol: Hya

Marker Synonym(s)
Chromosome(s)	Y

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Reproductive Biology Research
- Developmental Defects Affecting Gonads
- Fertility Defects
Research Tools
- Genetics Research

Genotype: Eda^Ta-6J related

Dermatology Research
- Color and White Spotting Defects
- Skin and Hair Texture Defects
Developmental Biology Research
- Eye Defects
Sensorineural Research
- Eye Defects
Mouse/Human Gene Homologs
- hypohidrotic ectodermal dysplasia

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Tp(Y)1Ct^Sxr-b/+
Not Specified

reproductive system phenotype

abnormal primary sex determination
- chromosomally XX mice inheriting this genotype develop as males

primary sex reversal
- chromosomally XX mice inheriting this genotype develop as males

References

Additional - A^w-J related

Additional - Eda^Ta-6J related

Additional - Hya related

Additional - Tp(Y)1Ct^Sxr-b related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- QPCR:Hya<->
- QPCR:Sry
- Separated PCR:A A A Alternate2
- Genotyping resources and troubleshooting
Breeding Considerations

Comments: This strain is maintained using Eda^Ta-6J as a phenotypic marker to expedite progeny testing at each of the two alternate generations. In the first generation a X^Eda-Ta-6JY^? male is bred to a C57BL/6J-A^w-J female (Stock No. 000051); striped male offspring (genotype XX^{Eda-Ta-6J sxrb}) prove that the male parent is X^Eda-Ta-6JY^sxrb. Four genotypically distinct offspring result from the breeding scheme C57BL/6J-A^w-J x X^Eda-Ta-6JY^sxrb: XX^Eda-Ta-6J transversely striped females; XY normal males; XY^sxrb phenotypically normal males; and XX^{Eda-Ta-6J sxrb} which are transversely striped, sterile males due to sex-reversion and which prove the paternal genotype. The phenotypically normal males are then bred with heterozygous C57BL/6J-A^w-J-Eda^Ta-6J females (Stock No. 000338) in the second generation of breeding. Again, transversely striped male offspring (genotype XX^{Ta-6J sxrb}) of these breeding pairs prove that the male parent is a carrier of Y^sxrb. Eight genotypically distinct offspring result from the breeding scheme heterozygous C57BL/6J-A^w-J-Eda^Ta-6J x XY^sxrb: XY normal males; XY^sxrb phenotypically normal males; X^Eda-Ta-6JY tabby males; X^Eda-Ta-6JY^sxrb tabby males; XX normal females; X^Eda-Ta-6JX transversely striped females; XX^sxrb sterile males; and X^Eda-Ta-6JX^sxrb transversely striped sterile males that prove the paternal genotype to be XY^sxrb. The Tabby male progeny (X^Eda-Ta-6JY^?) are then bred with C57BL/6J-A^w-J females for the first generation progeny test (C57BL/6J-A^w-J x X^Eda-Ta-6JY^sxrb). XX^sxrb sex-reversed males can be distinguished from XY and XY^sxrb males by their small testes which are detectable by palpation at 6-8 weeks of age. C57BL/6J-A^w-J is used in breeding because the agouti coat color is necessary for viewing the Eda^Ta-6J phenotypes. It is important to note that only the X^sxrb carrying progeny of these breeding schemes will be sex reversed; XY^sxrb mice a re male, not sex reversed. XX^sxrb and X^Eda-Ta-6JX^sxrb sex-reversed males are sterile.
- Additional Breeding and Husbandry Support
Citation
When using the B6.Cg-A^w-J Eda^Ta-6J Sxr^b Hya^-/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001730 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

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Animal Care and Use for SERVICES

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No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

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Genetic overview

Marker(s)

Research Applications

Base Price

Tp(Y)1CtSxr-b

Allele Symbol: Tp(Y)1CtSxr-b

Aw-J

Allele Symbol: Aw-J

EdaTa-6J

Allele Symbol: EdaTa-6J

Hya

Marker Symbol: Hya

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: EdaTa-6J related

Mammalian Phenotype Terms by Genotype

Genotype: Tp(Y)1CtSxr-b/+Not Specified

reproductive system phenotype

References

Additional - Aw-J related

Additional - EdaTa-6J related

Additional - Hya related

Additional - Tp(Y)1CtSxr-b related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Tp(Y)1Ct^Sxr-b

Allele Symbol: Tp(Y)1Ct^Sxr-b

A^w-J

Allele Symbol: A^w-J

Eda^Ta-6J

Allele Symbol: Eda^Ta-6J

Genotype: Eda^Ta-6J related

Genotype: Tp(Y)1Ct^Sxr-b/+
Not Specified

Additional - A^w-J related

Additional - Eda^Ta-6J related

Additional - Tp(Y)1Ct^Sxr-b related