B6.Cg-A^w-J Eda^Ta-6J Sxr^b Hya^-/J

Stock number: 001730
Research areas: Dermatology Research, Developmental Biology Research, Mouse/Human Gene Homologs, Reproductive Biology Research, Research Tools, Sensorineural Research

Allele

Symbol: Tp(Y)1Ct^Sxr-b
Name: Sex reversed, b variant
MGI accession ID: MGI:2136318
Generation method: Spontaneous
Marker symbol: Tp(Y)1Ct
Marker name: transposition, Chr Y, Cattanach 1
Chromosome: Y
Strain of origin: T16H stock
Molecular note: At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1Ct^Sxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lack one of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1Ct^Sxr-b from Tp(Y)1Ct^Sxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya.

Allele

Symbol: A^w-J
Name: white bellied agouti Jackson
MGI accession ID: MGI:1855946
Generation method: Spontaneous
Marker symbol: a
Marker name: nonagouti
Chromosome: 2
Strain of origin: C57BL/6J

Allele

Symbol: Eda^Ta-6J
Name: tabby 6 Jackson
MGI accession ID: MGI:1856202
Generation method: Spontaneous
Marker symbol: Eda
Marker name: ectodysplasin-A
Chromosome: X
Strain of origin: C57BL/6J-tp^3J/J
Molecular note: This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation.

Allele

MGI accession ID: MGI:96296
Marker symbol: Hya
Marker name: histocompatibility Y
Chromosome: Y