Overview

Also Known As:BXA8/PgnJ

Through high density SNP analysis, some AXB and BXA recombinant inbred strains were shown to be the same or nearly the same genetically. BXA17/Pgn was found to be a replica of BXA8/PgnJ (001697).

Genetic overview

Genetic Background	Generation

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Research Applications

Research Tools
Neurobiology Research

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Details

Detailed Description

Through high density SNP analysis, some AXB and BXA recombinant inbred strains were shown to be the same or nearly the same genetically. BXA17/Pgn was found to be a replica of BXA8/Pgn. BXA17/Pgn was lost in 1989 or 1990.

The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.

Development

The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.

Selected References

Sampson SB; Higgins DC; Elliot RW; Taylor BA; Lueders KK; Koza RA; Paigen B. 1998. An edited linkage map for the AXB and BXA recombinant inbred mouse strains. Mamm Genome 9(9):688-94PubMed: 9716653 MGI: J:45463

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Genetics

Currently there are no related genes or alleles for this strain.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
- Cardiovascular Research
- Diabetes and Obesity Research
- Genetics Research
  - Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
  - Gene Mapping
- Immunology, Inflammation and Autoimmunity Research
  - genes regulating susceptibility to infectious disease and endotoxin
Neurobiology Research
- Behavioral and Learning Defects
  - genes regulating preferences to alcohol and stress

Mammalian Phenotype Terms by Genotype

References

Sampson SB; Higgins DC; Elliot RW; Taylor BA; Lueders KK; Koza RA; Paigen B. 1998. An edited linkage map for the AXB and BXA recombinant inbred mouse strains. Mamm Genome 9(9):688-94PubMed: 9716653 MGI: J:45463

Additional References

Brodkin ES; Carlezon WA Jr; Haile CN; Kosten TA; Heninger GR ; Nestler EJ. 1998. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res 805(1-2):55-68PubMed: 9733917 MGI: J:50636
Gill K; Desaulniers N; Desjardins P; Lake K. 1998. Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9(12):929-35PubMed: 9880655 MGI: J:52467
Hamidi S; Aliesky HA; Williams RW; Rapoport B; McLachlan SM. 2013. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid 23(3):360-70PubMed: 22988948 MGI: J:204730
Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82PubMed: 17566079 MGI: J:127219
Marshall JD; Mu JL; Cheah YC; Nesbitt MN; Frankel WN; Paigen B. 1992. The AXB and BXA set of recombinant inbred mouse strains. Mamm Genome 3(12):669-80PubMed: 1477475 MGI: J:3516
Martin MV; Dong H; Vallera D; Lee D; Lu L; Williams RW; Rosen GD; Cheverud JM; Csernansky JG. 2006. Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes Brain Behav 5(8):614-23PubMed: 17081266 MGI: J:117408
McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9PubMed: 21209025 MGI: J:173883
Mu JL; Naggert JK; Nishina PM; Cheah YC; Paigen B. 1993. Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18. Mamm Genome 4(3):148-52PubMed: 8094988 MGI: J:4133

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Sibling x Sibling
Appearance
- black
  Related Genotype: a/a Tyrp1⁺/Tyrp1⁺ Tyr⁺/Tyr⁺

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Phone: 207-288-6470

Email: TechTran@jax.org

Overview

Also Known As:BXA8/PgnJ

Genetic overview

Research Applications

Details

Detailed Description

Development

Selected References

Genetics

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

References

Additional References

Technical Support

Genotyping Protocols

Mating System

Appearance

Terms Of Use

Terms Of Use

Licensing Information

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