These mice carry the pink-eyed dilution allele and a spontaneous mutation at the Prop1 locus that is characterized by growth retardation.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Oca2 | oculocutaneous albinism II |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Prop1 | paired like homeodomain factor 1 |
Mice homozygous for the Ames dwarf spontaneous mutation (Prop1df) resemble mice homozygous for the Snell's dwarf mutation (Pit1dw). Homozygous Ames dwarf mutant mice show growth retardation after the first postnatal week, and weight at 2 months is only about one-half normal. Females and most males are sterile. There is no detectable growth hormone or prolactin. Ames dwarf mice have a secondary immune deficiency presumably resulting from the lack of growth hormone.
Allele Name | pink-eyed dilution |
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Allele Type | Spontaneous |
Allele Synonym(s) | p; R262X |
Gene Symbol and Name | Oca2, oculocutaneous albinism II |
Gene Synonym(s) | |
Strain of Origin | Asiatic fancy mice |
Chromosome | 7 |
General Note | Oca2p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782). |
Molecular Note | A nonsense substitution was identified to account for the phenotype. It is a C-to-T substitution in exon 7 in the codon for the 262nd amino acid of the OCA2 protein (p.R262*). |
Allele Name | Ames dwarf |
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Allele Type | Spontaneous |
Allele Synonym(s) | Amesdf; df; DW; Prop1- |
Gene Symbol and Name | Prop1, paired like homeodomain factor 1 |
Gene Synonym(s) | |
Strain of Origin | Goodale large mice x pink-eyed stock |
Chromosome | 11 |
General Note | The Ames dwarf mutation arose spontaneously in descendants of a cross of the Goodale large mouse stock to a pink-eyed stock. |
Molecular Note | A T-to-C mutation results in a serine to proline substitution at position 83 (p.S83P) within the alpha1 helix in the homeodomain of the encoded peptide. |
When using the Ames dwarf mouse strain in a publication, please cite the originating article(s) and include JAX stock #001618 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Oca2<p>, Homozygous or Heterozygous or wild-type for Prop1<df> |
Frozen Mouse Embryo | STOCK Oca2<p> Prop1<df>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | STOCK Oca2<p> Prop1<df>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | STOCK Oca2<p> Prop1<df>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | STOCK Oca2<p> Prop1<df>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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