STOCK Krt27^Re-wc/J

Stock number: 001610
Product name: wavy coat
Research areas: Dermatology Research

Description

These mice carry a spontaneous mutation at the Krt27 locus characterized by a waviness of the coat.

Detailed description

Wavy coat (Krt27^Re-wc) resembles rex (Krt27^Re) except that its effects are more severe. Waviness of the juvenile coat is visible a little earlier, and the adult coat appears rougher. Morphology of individual hairs and hair development are also affected in the same order of severity.

Development

The mutation wavy coat, a dominant allele at the rex (Krt27^Re) location, arose in 1968 in a chronic neutron irradiation experiment using an unspecified genetic background. It was imported to the Jackson Laboratory from Dr. Mary Lyon at Harwell in 1989. It was outcrossed once to a C57BL/6J female and then sibling mated. Embryos were cryopreserved in 1990 from matings of wavy coated homozygous males at N1F2 to C57BL/6J females.

Allele

Symbol: Krt27^Re-wc
Name: wavy coat
MGI accession ID: MGI:1856138
Generation method: Radiation induced
Marker symbol: Krt27
Marker name: keratin 27
Chromosome: 11
Strain of origin: (C3H/HeH x 101/H)F1
Molecular note: This alleles contains a 1004 bp deletion that contains exon 6.