These mice carry a spontaneous mutation at the Krt27 locus characterized by a waviness of the coat.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Radiation induced | Krt27 | keratin 27 |
Wavy coat (Krt27Re-wc) resembles rex (Krt27Re) except that its effects are more severe. Waviness of the juvenile coat is visible a little earlier, and the adult coat appears rougher. Morphology of individual hairs and hair development are also affected in the same order of severity.
The mutation wavy coat, a dominant allele at the rex (Krt27Re) location, arose in 1968 in a chronic neutron irradiation experiment using an unspecified genetic background. It was imported to the Jackson Laboratory from Dr. Mary Lyon at Harwell in 1989. It was outcrossed once to a C57BL/6J female and then sibling mated. Embryos were cryopreserved in 1990 from matings of wavy coated homozygous males at N1F2 to C57BL/6J females.
Allele Name | wavy coat |
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Allele Type | Radiation induced |
Allele Synonym(s) | Rewc; wavy coat |
Gene Symbol and Name | Krt27, keratin 27 |
Gene Synonym(s) | |
Strain of Origin | (C3H/HeH x 101/H)F1 |
Chromosome | 11 |
Molecular Note | This alleles contains a 1004 bp deletion that contains exon 6. |
When using the wavy coat mouse strain in a publication, please cite the originating article(s) and include JAX stock #001610 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Krt27<Re-wc> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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