RHJ/LeJ

Stock number: 001591
Product name: rhino Jackson
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.

Hairless Rhino mice have spleen cells with a defective response to T-dependent antigens mice, and have increased numbers of Thy1 positive epidermal dendritic cells.

Detailed description

Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.

Development

The rhino Jackson mutation (hr^rh-J) was found at Carworth Farms (a New York commercial breeder) in a stock of undetermined genetic background and sent to The Jackson Laboratory in 1951. It was outcrossed to BALB/cHu for 6 generations and then sibling mated. At F15 in 1963 it was outcrossed to the albino hook (Hk) stock, which had C57BL/6J, AKR and A/Sn in its background, and was again sibling mated selecting away from hook. The stock was nonagouti (a/a), brown (Tyrp1^b), albino (Tyr^c) and carrying rhino Jackson (Hr^rh-J). It was maintained by mating heterozygous (haired) females to rhino Jackson homozygous males and was cryopreserved as stock #000266 by mating heterozygous females to homozygous males at generation F76. The strain was maintained on the shelf in the production facility as JR#1591 and reached F148 in 2005.

Allele

Symbol: Hr^rh-J
Name: rhino Jackson
MGI accession ID: MGI:1856061
Generation method: Spontaneous
Marker symbol: Hr
Marker name: lysine demethylase and nuclear receptor corepressor
Chromosome: 14
Strain of origin: Carworth Farms stock