Hairless Rhino mice have spleen cells with a defective response to T-dependent antigens mice, and have increased numbers of Thy1 positive epidermal dendritic cells.Read More +
Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.
The rhino Jackson mutation (hrrh-J) was found at Carworth Farms (a New York commercial breeder) in a stock of undetermined genetic background and sent to The Jackson Laboratory in 1951. It was outcrossed to BALB/cHu for 6 generations and then sibling mated. At F15 in 1963 it was outcrossed to the albino hook (Hk) stock, which had C57BL/6J, AKR and A/Sn in its background, and was again sibling mated selecting away from hook. The stock was nonagouti (a/a), brown (Tyrp1b), albino (Tyrc) and carrying rhino Jackson (Hrrh-J). It was maintained by mating heterozygous (haired) females to rhino Jackson homozygous males and was cryopreserved as stock #000266 by mating heterozygous females to homozygous males at generation F76. The strain was maintained on the shelf in the production facility as JR#1591 and reached F148 in 2005.
When using the rhino Jackson mouse strain in a publication, please include JAX stock #001591 in your Materials and Methods section.