These mice carry the spontaneous Paf mutation and are characterized by a patchy or striped coat in females and a dark, shiny coat in males with eventual hair loss.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Paf | patchy fur |
Stock No. 001529 mice have the spontaneous Paf mutation on the X Chromosome, and may be genotyped based on the coat phenotype described below.
Heterozygous females (XPaf/X) have patchy or striped coats.
Hemizygous males (XPaf/Y) have a dark, shiny coat until hair loss begins between 12 and 30 days of age when the underfur is lost and the coat becomes sparse and bristly.
Homozygous females (XPaf/XPaf) initially have a dark shiny coat which looks like that of XPaf/Y males although less bristly and sparse and appears more striped or patched than heterozygous females.
Due to X-Y nondisjunction, approximately 1% of offspring from Paf/Y males are XXY phenotypic males and 19% are XO phenotypic females.
Paf arose at TJL in the bouncy-3J subline of C3H/HeSnJ and was first recognized as patches of fur missing in the coat of a female. This female was bred with a wildtype brother and 7 females and 5 males out of 37 phenotyped offspring had abnormal coats with the male phenotype being more severe. This was maintained by closed colony breeding, primarily using sibling pairs and in 1991 heterozygous females were bred with C3H/HeSnJ males to generate embryos for cryopreservation.
Allele Name | patchy fur |
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Allele Type | Spontaneous |
Allele Synonym(s) | In(XPAR)Paf; XPaf |
Gene Symbol and Name | Paf, patchy fur |
Gene Synonym(s) | |
Strain of Origin | C3H/HeSn-bc3J |
Chromosome | X |
Molecular Note | This mutation comprises an inversion of an X chromosome segment with breakpoints distal to Amel and proximal to the PAR marker DXYHgu1. The mutation in this allele is within a ~0.2 cM interval that includes the boundary of the pseudoautosomal region (PAR), a sequence common to the X and Y chromosomes. As a consequence X-Y nondisjunction occurs in hemizygous males, resulting in XO and XXY progeny. |
When using the patchy fur mouse strain in a publication, please cite the originating article(s) and include JAX stock #001529 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
X linked - Heterozygous or Wild-type females and males for Paf , 1 pair minimum |
Frozen Mouse Embryo | C3H/HeSn-Paf/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H/HeSn-Paf/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H/HeSn-Paf/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C3H/HeSn-Paf/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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