Homozygotes and heterozygotes for this revertant allele are phenotypically indistinguishable from wild-type.
The C57BL/6J-Oca2p-un+3J strain was created by mating Oca2p-un individuals having at least 50% wild-type pigmentation to nonmosaic Oca2p-un/Oca2p-un sibs. Pigmented offspring of this mating were intercrossed to obtain mice homozygous for the revertant allele.
|Allele Name||pink-eyed dilution unstable wild-type revertant 3 Jackson|
|Gene Symbol and Name||Oca2, oculocutaneous albinism II|
|Strain of Origin||C57BL/6J-Oca2p-un|
|Molecular Note||Removal, presumably by unequal homologous recombination, of an ~70 kb DNA duplication derived from retroviral-like intracisternal A particles that characterizes pun, restores wild-type coat pigmentation.|
Mice homozygous or heterozygous for Oca2p-un+3J exhibit normal hair and eye pigmentation. While maintaining a live colony, these mice are bred as homozygotes.
When using the revertant 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #001506 in your Materials and Methods section.