CALB/RkJ

Stock number: 001489
Research areas: Developmental Biology Research, Research Tools, Sensorineural Research

Description

This strain is extinct. Please search the JAX^® Mice Database for other wild-derived strains.

Detailed description

CALB/Rk was derived from wild mice caught in California. CALB is a natural hybrid strain combining the M. domesticus genome with at least five regions of M. castaneus located in three different chromosomes. In addition, CALB mice exhibit colobomas of the optic nerve and retina. The coloboma phenotype that have some features in common with human morning glory syndrome. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development

Progenitors of the CALB/Rk strain were originally trapped in California by Dr Richard Sage. Descendants of these mice were imported to The Jackson Laboratory from Dr Verne Chapman's colony in 1984 (TH Roderick, personal communication; Akeson and Davisson 1991). Sequence data has determined that in addition to Mus musculus domesticus, CALB/RkJ has haplotypes related to Mus musculus castaneus on at least five regions located in three different chromosomes. CALB/RkJ is believed to be a hybrid of the two species (Ideraabdullah FY, et al. 2004).