Overview

This strain is extinct. Please search the JAX^® Mice Database for other wild-derived strains.

Genetic overview

Genetic Background	Generation

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Research Applications

Research Tools
Sensorineural Research
Developmental Biology Research

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Details

Detailed Description

CALB/Rk was derived from wild mice caught in California. CALB is a natural hybrid strain combining the M. domesticus genome with at least five regions of M. castaneus located in three different chromosomes. In addition, CALB mice exhibit colobomas of the optic nerve and retina. The coloboma phenotype that have some features in common with human morning glory syndrome. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development

Progenitors of the CALB/Rk strain were originally trapped in California by Dr Richard Sage. Descendants of these mice were imported to The Jackson Laboratory from Dr Verne Chapman's colony in 1984 (TH Roderick, personal communication; Akeson and Davisson 1991). Sequence data has determined that in addition to Mus musculus domesticus, CALB/RkJ has haplotypes related to Mus musculus castaneus on at least five regions located in three different chromosomes. CALB/RkJ is believed to be a hybrid of the two species (Ideraabdullah FY, et al. 2004).

Selected References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

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Genetics

Currently there are no related genes or alleles for this strain.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research
  - Gene Mapping: Polymorphisms
  - Gene Mapping
  - Evolution and Systematics Research
Sensorineural Research
- Eye Defects
  - Optic Nerve Coloboma
Developmental Biology Research
- Eye Defects

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22PubMed: 10493779 MGI: J:59481
Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7PubMed: 15466288 MGI: J:193384

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Sibling x Sibling
Appearance
- light-bellied agouti
  Related Genotype: A^w ?/A^w ?

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Overview

Genetic overview

Research Applications

Details

Detailed Description

Development

Selected References

Genetics

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Technical Support

Genotyping Protocols

Mating System

Appearance

Terms Of Use

Terms Of Use

Licensing Information

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