C3H/HeSn-ocd/J

Stock number: 001431
Product name: osteochondrodystrophy
Research areas: Developmental Biology Research

Description

These mice carry the spontaneous ocd mutation and are characterized by reduced body size with abnormal development of the head, legs, forefront feet and tail.

Detailed description

Osteochondrodystrophy (ocd) is an autosomal recessive mouse mutation characterized by a short, slightly domed head, reduced body size, disproportionately shortened long bones of the legs, supination of the forefeet, and short thickened tail. Histologically, the epiphyses are thinner than normal. The columnar organization of the proliferative zone of cartilage is disorderly, with pleomorphic and occasionally necrotic chondrocytes.

Development

Osteochondrodystrophy (ocd) arose spontaneously in strain C3H/HeSn at the Jackson Laboratory in 1980. It was maintained by inbreeding ever since and reached generation F74+4 in 2006. In 2006 embryos were cryopreserved from C3H/HeSnJ females bred to homozygous males at generation F81.

Allele

Symbol: ocd
Name: osteochondrodystrophy
MGI accession ID: MGI:1856974
Generation method: Spontaneous
Marker symbol: ocd
Marker name: osteochondrodystrophy
Chromosome: 19
Strain of origin: C3H/HeSnJ
General note: This mutation is not an allele of Papss2 or Tcirg1, other mutations on Chr 19 that produce similar phenotypes (J:11111).