These mice carry the spontaneous ocd mutation and are characterized by reduced body size with abnormal development of the head, legs, forefront feet and tail.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | ocd | osteochondrodystrophy |
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Osteochondrodystrophy (ocd) is an autosomal recessive mouse mutation characterized by a short, slightly domed head, reduced body size, disproportionately shortened long bones of the legs, supination of the forefeet, and short thickened tail. Histologically, the epiphyses are thinner than normal. The columnar organization of the proliferative zone of cartilage is disorderly, with pleomorphic and occasionally necrotic chondrocytes.
Osteochondrodystrophy (ocd) arose spontaneously in strain C3H/HeSn at the Jackson Laboratory in 1980. It was maintained by inbreeding ever since and reached generation F74+4 in 2006. In 2006 embryos were cryopreserved from C3H/HeSnJ females bred to homozygous males at generation F81.
Allele Name | osteochondrodystrophy |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | ocd, osteochondrodystrophy |
Gene Synonym(s) | |
Strain of Origin | C3H/HeSnJ |
Chromosome | 19 |
General Note | This mutation is not an allele of Papss2 or Tcirg1, other mutations on Chr 19 that produce similar phenotypes (J:11111). |
When using the osteochondrodystrophy mouse strain in a publication, please cite the originating article(s) and include JAX stock #001431 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for ocd |
Frozen Mouse Embryo | C3H/HeSn-ocd/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H/HeSn-ocd/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C3H/HeSn-ocd/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C3H/HeSn-ocd/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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