These mice carry the spontaneous ocd mutation and are characterized by reduced body size with abnormal development of the head, legs, forefront feet and tail.Read More +
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Osteochondrodystrophy (ocd) is an autosomal recessive mouse mutation characterized by a short, slightly domed head, reduced body size, disproportionately shortened long bones of the legs, supination of the forefeet, and short thickened tail. Histologically, the epiphyses are thinner than normal. The columnar organization of the proliferative zone of cartilage is disorderly, with pleomorphic and occasionally necrotic chondrocytes.
Osteochondrodystrophy (ocd) arose spontaneously in strain C3H/HeSn at the Jackson Laboratory in 1980. It was maintained by inbreeding ever since and reached generation F74+4 in 2006. In 2006 embryos were cryopreserved from C3H/HeSnJ females bred to homozygous males at generation F81.
|Gene Symbol and Name||ocd, osteochondrodystrophy|
|Strain of Origin||C3H/HeSnJ|
|General Note||This mutation is not an allele of Papss2 or Tcirg1, other mutations on Chr 19 that produce similar phenotypes (J:11111).|