Shiverer is an autosomal recessive mutation in the mouse characterized by early generalized tremors that become prominent in the hindquarters with age. Seizure behavior begins after weaning and increases in frequency during the animal's shortened lifespan. The most prominent pathological feature is a deficiency of myelin and myelin basic protein in the central nervous system. These mice may be useful in studies relating to myelin related diseases.
Read More +Genetic Background | Generation |
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000658 C3HeB/FeJ |
N40+N6F5
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mbp | myelin basic protein |
Starting at:
$278.00 Domestic price for female 4-week |
556.00 Domestic price for breeder pair |
Mice homozygous for the shiverer spontaneous mutation (Mpbshi) show a generalized tremor during locomotion from 12 days of age. This shivering increases in severity with age, and there is incoordination of the hindlimbs. Post-weaning mice undergo seizure-like attacks during which they may lie rigid and motionless for many seconds. Homozygotes are noticeably smaller than their littermates by 4 weeks of age and their life span is shortened. They usually die between 50 and 100 days of age, often while undergoing an attack. They are fertile but do not breed well. There is a severe myelin deficiency throughout the CNS, and a moderate hypomyelination in the PNS. Occasional regions of normal appearing myelin are found throughout the CNS. Heterozygous mice behave normally and have structurally normal myelin but produce only half the normal amount of MBP in both CNS and PNS. Myelin deficient (Mbpshi-mld) homozygotes closely resemble shiverer mice in behavior, neuropathology, and MBP deficiency.
The shiverer spontaneous mutation involves a large deletion from intron 1 to exon 6. The portion of the gene remaining includes exon 1 and 12.4-14.4 kb of intron 1 sequences.
Allele Name | shiverer |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | shi |
Gene Symbol and Name | Mbp, myelin basic protein |
Gene Synonym(s) | |
Strain of Origin | SWV |
Chromosome | 18 |
Molecular Note | The shiverer mutation involves a large deletion from intron 1 to exon 6. The portion of the gene remaining includes exon 1 and 12.4-14.4 kb of intron 1 sequences. |
When using the C3HeB/FeJ-shiverer mouse strain in a publication, please cite the originating article(s) and include JAX stock #001428 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Please inquire |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J WT PRX-#1 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Het PRX-#16 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Hom PRX-#1003 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J WT PRX-#1 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Het PRX-#16 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Hom PRX-#1003 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J WT PRX-#1 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Het PRX-#16 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Hom PRX-#1003 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J WT PRX-#1 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Het PRX-#16 mES cells | $1200.00 |
Mouse ES Cells | C3Fe.SWV-Mbp<shi>/J Hom PRX-#1003 mES cells | $1200.00 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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