These mice carry a cesium irradiation -induced mutation characterized by chronic polyuria, increased serum BUN and creatinine levels, and hydronephrosis.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Radiation induced | Uox | urate oxidase |
Marker Symbol | Marker Name | |
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In(3)55Rk-d | inversion, Chr 3, Roderick 55, distal | |
In(3)55Rk-p | inversion, Chr 3, Roderick 55, proximal |
The Uoxin homozygous phenotype has incomplete penetrance. While 63% of Uoxin homozygotes die by 12-14 days of age, those that live to adulthood generally live a normal breeding life span. Homozygous adults display chronic polyuria, increased serum BUN and creatinine levels, and hydronephrosis with a concomitant inflammatory response that is followed by glomerular and tubular dilation. (Cook et al., 2001.)
Allele Name | urate oxidase In(3)55Rk-induced |
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Allele Type | Radiation induced |
Allele Synonym(s) | |
Gene Symbol and Name | Uox, urate oxidase |
Gene Synonym(s) | |
Strain of Origin | DBA/2J |
Chromosome | 3 |
General Note | See also In(3)55Rk-d and In(3)55Rk-p. |
Molecular Note | PCR analysis on genomic DNA derived from mice carrying the In(3)55K inversion suggests that a disruption 3' to base 844 of exon 7 results in the mutation. Northern blot analysis on mRNA derived from liver RNA of homozygous mice confirmed that negligible amounts of encoded transcript was produced from this allele. |
Marker Synonym(s) | |
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Chromosome(s) | 3 |
Marker Synonym(s) | |
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Chromosome(s) | 3 |
When using the B6;D2-In(3)55Rk Uoxin/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001378 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for In(3)55Rk |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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