These congenic mice carry a mobility variant of lactate dehydrogenase A. Homozygous mice are fertile and show no apparent deleterious effects of the mutation.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Chemically induced (other) | Ldha | lactate dehydrogenase A |
These congenic mice carry a mobility variant of lactate dehydrogenase A. Homozygous mice are fertile and show no apparent deleterious effects of the mutation.
C57BL/6J females were bred with triethylenemelamine treated DBA/2J males and an Ldh1 mobility variant was identified in their progeny and named Ldh1b. This mutation was imported into The Jackson Laboratory and maintained by Dr. Thomas Roderick then transferred to Dr. Beverly Paigen. This allele was backcrossed to C57BL/6J for 10 generations then intercrossed to generate a homozygous strain that was sibling mated for 21 generations before homozygous males were crossed to C57BL/6J females to generate embryos for cryopreservation in 1993. (Soares, 1977 and 1978.)
Allele Name | mobility variant b |
---|---|
Allele Type | Chemically induced (other) |
Allele Synonym(s) | Ldh-1b |
Gene Symbol and Name | Ldha, lactate dehydrogenase A |
Gene Synonym(s) | |
Strain of Origin | (C57BL/6J x DBA/2J)F1 |
Chromosome | 7 |
General Note | Induced by triethylenemelamine (TEM). |
Molecular Note | This mutation results in reduced activity of the enzyme; the zymogram pattern of homozygotes for this allele shows considerably less staining intensity than that of wild-type mice. |
When using the B6.Cg-Ldhab/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001373 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Ldh1<b> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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