Mice of this BALB/cWt subline do not develop clinical or histopathological symptoms of experimental allergic encephalitis as do mice of other sublines. Mice of this subline show a high frequency of true hermaphroditism and a skewed sex ratio.Read More +
Experimental allergic encephalitis (EAE) is an autoimmune disease of the nervous system induced by sensitization of experimental animals with homogenates of whole brain and/or spinal cord tissue, myelin, or myelin components. Many of the clinical and histologic aspects of EAE are similar to those of multiple sclerosis (MS), making EAE a useful MS model (Alvord et al., 1984). Mice of different sublines of the BALB/c inbred strain exhibit marked differences in the incidence and severity of EAE induced by immunization with spinal cord homogenate (Hickey et al., 1986) or with myelin proteolipid protein (PLP) (Tuohy et al., 1988). The most severe response to PLP was development in nine of ten BALB/cPt mice of rapid onset, severe clinical disease with limb paralysis accompanied histologically by meningeal and perivascular infiltration by mononuclear and polymorphonuclear lymphocytes, particularly of the spinal cord. At the opposite end of the spectrum, none of ten BALB/cORNL or of nine BALB/cWt mice developed clinical or histopathological symptoms. As all sublines of BALB/c share the H2d haplotype, it is proposed that PLP-induced EAE in these strains is influenced by the effects of genetic loci outside the major histocompatibility complex.
BALB/cWt mice have a high frequency of true hermaphroditism and skewed sex ratio due in part to nondisjunction of the Y Chromosome resulting in XO/XY and XO/XY/XYY mosaicism.
Currently there are no related genes or alleles for this strain.
When using the BALB/cWtEiJ mouse strain in a publication, please include JAX stock #001311 in your Materials and Methods section.