Homozygous variable spotting mice (Ets1vs) exhibit sporadic white spotting. Ets1 is an active critical enhancer for Sox10 expression in neural crest -derived structures, and this enhancer activation is significantly inhibited by the variable spotting mutation.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | Ets1 | E26 avian leukemia oncogene 1, 5' domain |
Homozygous variable spotting mice (Ets1vs) exhibit sporadic white spotting. Ets1 is an active critical enhancer for Sox10 expression in neural crest -derived structures, and this enhancer activation is significantly inhibited by the variable spotting mutation.
The variable spotting (vs) mutation arose spontaneously in 1981 in the Animal Resources colony of C3HeB/FeJ at The Jackson Laboratory when that inbred was at F111. The mutation was maintained by breeding heterozygotes with homozygotes of either gender and in 1988 heterozygous females and homozygous males at F30 and F31 were bred together to generate embryos for cryopreservation.
Allele Name | variable spotting |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Ets1, E26 avian leukemia oncogene 1, 5' domain |
Gene Synonym(s) | |
Strain of Origin | C3HeB/FeJ |
Chromosome | 9 |
Molecular Note | The molecular lesion is a nucleotide G-to-A transition in exon 3 at nucleotide position 647 (or coding nucleotide 305) (RefSeq NM_011808.2), which results in a glycine to glutamate substitution at residue 102 (p.G102E) within the Pointed (PNT) domain of the encoded protein. Multiple sequence alignment showed that this glycine residue is highly conserved among different species. |
When using the variable spotting mouse strain in a publication, please cite the originating article(s) and include JAX stock #001292 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for vs |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.