These mice carry a spontaneous mutation at the A (nonagouti) locus characterized by a range of coat colors from mostly yellow to almost completely black and the color is usually patchy or striped.Read More +
The dominant Ahvy allele has the broadest array of expressivity of any of the agouti alleles. Carriers' coat colors range from mostly yellow to almost completely black and the color is usually patchy or striped. Mice with coats on the yellow end of the spectrum tend to develop obesity while those with more black coats do not. Homozygotes are viable and fertile, and are more likely to have yellow or mostly yellow coats than are heterozygotes. Ahvy is recessive to Ay, dominant to a and ae, and results in an increase in the yellow pigment in the belly coat of Ahvy/at and Ahvy/Aw mice.
|Allele Name||hypervariable yellow|
|Gene Symbol and Name||a, nonagouti|
|Strain of Origin||C3H/HeJ|
|Molecular Note||Sequencing of 5' RACE and genomic PCR products revealed that this allele resulted from the integration of an intracisternal A particle (IAP) in an antisense orientation within the 5'untranslated region of exon 1C. Methylation assay results indciate that the agouti and yellow mosaic phenotype characteristic of this allele is due to differential epigenetic methylation of the IAP.|