These mice carry the spontaneous H2bm23 mutation, a major histocompatibility variant.
Read More +Genetic Background | Generation |
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Marker Symbol | Marker Name | |
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H2 | histocompatibility-2, MHC |
The bm23 spontaneous variant in the H2-Kb sequence consists of two nucleotide substitutions resulting in two amino acid changes, which are predicted to impact the TCR interaction and peptide binding domain, R75H and D77S. The H2bm23 mutant allele causes an increase in the percentage of the CD8 T cells bearing Valpha3.2 both in peripheral T cells and CD8 single positive thymocytes. (sim et al, 1997.)
H2Kbm23 is a spontaneous mutation initially identified in one male and two female progeny of a C57BL/10SnEg female bred to B10.D2/nSnEg male. Although the male had been treated with ethylnitrosourea, the H2b haplotype was passed from the female and thus bm23 was a spontaneous mutation. (Egorov and Egorov, 1984). Embryos were cryopreserved in 1996.
When using the B10.D2-H2bm23/EgJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001163 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for H2<bm23>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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