B10.D2-H2^bm23/EgJ

Stock number: 001163
Research areas: Immunology, Inflammation and Autoimmunity Research, Sensorineural Research

Description

These mice carry the spontaneous H2^bm23 mutation, a major histocompatibility variant.

Detailed description

The bm23 spontaneous variant in the H2-K^b sequence consists of two nucleotide substitutions resulting in two amino acid changes, which are predicted to impact the TCR interaction and peptide binding domain, R75H and D77S. The H2^bm23 mutant allele causes an increase in the percentage of the CD8 T cells bearing Valpha3.2 both in peripheral T cells and CD8 single positive thymocytes. (sim et al, 1997.)

Development

H2K^bm23 is a spontaneous mutation initially identified in one male and two female progeny of a C57BL/10SnEg female bred to B10.D2/nSnEg male. Although the male had been treated with ethylnitrosourea, the H2^b haplotype was passed from the female and thus bm23 was a spontaneous mutation. (Egorov and Egorov, 1984). Embryos were cryopreserved in 1996.

Allele

MGI accession ID: MGI:95894
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17