The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases. As with many other wild-derived strains, this strain is extremely sensitive to noise, vibration and any change in environment. Breeding slumps are frequent and the use of foster mothers is often necessary to sustain a litter. In an effort to expand this strain from a recent severe breeding depression the diet was changed to a 10% fat grain. Subsequent to the use of the high fat diet some mice of this strain are found to develop large fat deposits on their neck and some develop long toenails as they age. In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (<a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48351102-48351202;v=rs108080490;vdb=variation;vf=14473644">rs108080490</a> and <a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48350652-48351652;v=rs107649577;vdb=variation;vf=14110567">rs107649577</a>; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).

The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders.

Live mice available in varying quantities. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for specifics.