This colony is currently unavailable and we are unable to determine when it will be distributed in the future. As we have more information, we will provide updates here.The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders. Read More +
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.
This inbred strain has a nonsense mutation in Trem2 affecting codon 148 (dbSNP ID: rs107649577 [Ensembl GRCm38.p6]).
SPRET was derived from wild mice trapped by RD Sage in 1978 in Puerto Real, Cadiz Province, Spain. Mice were sent to Dr Mike Potter at The National Cancer Institute who subsequently transferred mice to Dr Eva Eicher at The Jackson Laboratory in 1983.
|Allele Name||b-3 variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||Ahrb-3; b-3 variant|
|Gene Symbol and Name||Ahr, aryl-hydrocarbon receptor|
|Gene Synonym(s)||bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity; RP85|
|Strain of Origin||M. spretus|
|General Note|| |
Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains
|Molecular Note||This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele.|
|Allele Type||Not Applicable (Not Specified)|
|Allele Synonym(s)||Cox7a2ll; long|
|Gene Symbol and Name||Cox7a2l, cytochrome c oxidase subunit 7A2 like|
|Gene Synonym(s)||COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1|
|Strain of Origin||multiple strains|
|General Note||Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T+ Itpr3tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.|
|Molecular Note||This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.|
Subsequent to a severe breeding slump in 2015 this strain was moved onto grain with 10% fat and has performed much better.
When using the SPRET/EiJ mouse strain in a publication, please include JAX stock #001146 in your Materials and Methods section.
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