This wild-derived inbred strain is being rebuilt from a severe breeding slump so orders are not being accepted at this time and likely will not be for much of this year.
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders.
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.
SPRET was derived from wild mice trapped by RD Sage in 1978 in Puerto Real, Cadiz Province, Spain. Mice were sent to Dr Mike Potter at The National Cancer Institute who subsequently transferred mice to Dr Eva Eicher at The Jackson Laboratory in 1983.
|Allele Name||b-3 variant|
|Allele Type||Not Applicable|
|Gene Symbol and Name||Ahr, aryl-hydrocarbon receptor|
|Gene Synonym(s)||Ah; Ah; Ahh; Ahh; Ahre; Ahre; In; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity|
|Strain of Origin||M. spretus|
|General Note|| |
Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains
|Molecular Note||This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele.|
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