JAX Mouse Strain Datasheet - 001145

WSB/EiJ

Stock No:: 001145

Repository Live

Overview

Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Genetic overview

Genetic Background	Generation
	F61+F15 (01-JUL-16)

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Research Applications

Dermatology Research
Research Tools

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Base Price

Starting at:

$224.00 Domestic price for female

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Details

Detailed Description

Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. WSB is characterized by a distinct and consistent white head blaze, variable ventral spotting and a slight coat dilution on the agouti background. The variation in pigment is the result of the spontaneous mutation blaze (Kitl^blz).Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development

Founder mice for the wild-derived strain Watkins Star Line B (WSB) were trapped in Eastern Shore, Maryland by Michael Potter (NCI) in 1976. One of two lines, WSB was selected for dark agouti coat color with white head blaze. Mice were sent to EM Eicher at The Jackson Laboratory in 1986.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Selected References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.. In: . . MGI: J:89298

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Genetics

A

Allele Symbol: A

Allele Name	wild-type agouti
Allele Type	Spontaneous
Allele Synonym(s)	dark-bellied agouti
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)	AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor
Strain of Origin	various
Chromosome	2
General Note	The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.
Molecular Note	This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene.

Kitl^sl-blz

Allele Symbol: Kitl^sl-blz

Allele Name	blaze
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Kitl, kit ligand
Gene Synonym(s)	Clo; Con; DCUA; DFNA69; FPH2; FPHH; Gb; Gb; KL-1; Kitlg; MGF; Mgf; Mgf; SCF; SF; SHEP7; SLF; Sl; Sl; Steel; Steel factor; blaze; blz; blz; cloud gray; contrasted; grizzle-belly; grizzle-belly; mast cell growth factor; steel; stem cell factor
Strain of Origin	WSB/Pt
Chromosome	10
Molecular Note	Complementation tests with Kitl^Sl, Kitl^Sl-d, and Kitl^sl-24J showed blaze (blz) to be an allele of Kitl. The molecular lesion is undefined.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Dermatology Research
- Color and White Spotting Defects
Research Tools
- Genetics Research
  - Evolution and Systematics Research
  - Gene Mapping

Phenotype Information

References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.. In: . . MGI: J:89298

Additional References

Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation.. In: . . MGI: J:177037

Additional - A related

Blewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.. In: . . MGI: J:99816
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus.. In: . . MGI: J:3523
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)]. In: . . MGI: J:16568
Cota CD; Liu RR; Sumberac TM; Jung S; Vencato D; Millet YH; Gunn TM. 2008. Genetic and phenotypic studies of the dark-like mutant mouse.. In: . . MGI: J:143333
Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice.. In: . . MGI: J:131039
Dickie MM. 1969. Mutations at the agouti locus in the mouse.. In: . . MGI: J:30922
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus).. In: . . MGI: J:46318
Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression.. In: . . MGI: J:13122
Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice. In: . . MGI: J:156092
Green EL. 1968. . In: Handbook on Genetically Standardized Jax Mice. The Jackson Laboratory, Bar Harbor, ME. MGI: J:36414
Guido V; and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J. In: . . MGI: J:77218
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function.. In: . . MGI: J:129904
Kelly EM. 1957. Beige, bg. In: . . MGI: J:29744
Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice.. In: . . MGI: J:280
MouseBook^TM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK.. In: . . MGI: J:169366
Mutant Mouse Regional Resource Centers. 2004. Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). In: . . MGI: J:94077
Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations.. In: . . MGI: J:21244
Phillips RJS. 1966. A cis-trans position effect at the A locus of the house mouse.. In: . . MGI: J:5027
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice.. In: . . MGI: J:13094
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Siracusa LD; Washburn LL; Swing DA; Argeson AC; Jenkins NA; Copeland NG. 1995. Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles.. In: . . MGI: J:24247
Zheng B; Sage M; Cai WW; Thompson DM; Tavsanli BC; Cheah YC; Bradley A. 1999. Engineering a mouse balancer chromosome.. In: . . MGI: J:56548
von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). In: . . MGI: J:22593

Additional - Kitl^sl-blz related

Aylor DL; Valdar W; Foulds-Mathes W; Buus RJ; Verdugo RA; Baric RS; Ferris MT; Frelinger JA; Heise M; Frieman MB; Gralinski LE; Bell TA; Didion JD; Hua K; Nehrenberg DL; Powell CL; Steigerwalt J; Xie Y; Kelada SN; Collins FS; Yang IV; Schwartz DA; Branstetter LA; Chesler EJ; Miller DR; Spence J; Liu EY; McMillan L; Sarkar A; Wang J; Wang W; Zhang Q; Broman KW; Korstanje R; Durrant C; Mott R; Iraqi FA; Pomp D; Threadgill D; Pardo-Manuel de Villena F; Churchill GA. 2011. Genetic analysis of complex traits in the emerging collaborative cross.. In: . . MGI: J:169740
Washburn LL; Harris BS. 2010. The recessive mutation blaze (blz) that characterizes the WSB/EiJ strain is an allele of Kitl, Kitl<blz>. In: . . MGI: J:179958

Pricing & Availability

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Cryorecovery - Pricing

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We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Licensing Information

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JAX® Mice, Products & Services Conditions of Use

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Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

A

Allele Symbol: A

Kitlsl-blz

Allele Symbol: Kitlsl-blz

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Phenotype Information

References

Additional References

Additional - A related

Additional - Kitlsl-blz related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Kitl^sl-blz

Allele Symbol: Kitl^sl-blz

Additional - Kitl^sl-blz related