Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.Read More +
Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. WSB is characterized by a distinct and consistent white head blaze, variable ventral spotting and a slight coat dilution on the agouti background. The variation in pigment is the result of the spontaneous mutation blaze (Kitlblz).
Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.
Founder mice for the wild-derived strain Watkins Star Line B (WSB) were trapped in Centerville, Maryland by Michael Potter (NCI) in 1976. WSB and WSA were separated from the founder line, CLA, at generation 3. The WSB, comprised mice selected for dark agouti coat color and white head blaze, Mice were sent to EM Eicher at The Jackson Laboratory in 1986. The blaze pigmentation was found to be a Kit allele, Kitlsl-blz.
|Allele Name||wild-type agouti|
|Allele Synonym(s)||A; wild-type agouti|
|Gene Symbol and Name||a, nonagouti|
|Gene Synonym(s)||agouti signal protein; As; ASP; As; agouti; agouti suppressor; AGTI; SHEP9; AGSW; AGTIL|
|Strain of Origin||various|
|General Note||The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.|
|Molecular Note||This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene.|
|Allele Type||Not Applicable (Not Specified)|
|Allele Synonym(s)||Cox7a2ll; long|
|Gene Symbol and Name||Cox7a2l, cytochrome c oxidase subunit 7A2 like|
|Gene Synonym(s)||COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1|
|Strain of Origin||multiple strains|
|General Note||Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T+ Itpr3tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.|
|Molecular Note||This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.|
|Allele Synonym(s)||blaze; Kitlsl-blz|
|Gene Symbol and Name||Kitl, kit ligand|
|Gene Synonym(s)||SF; grizzle-belly; contrasted; blz; blaze; Clo; SHEP7; Mgf; cloud gray; KL-1; MGF; Sl; mast cell growth factor; Gb; grizzle-belly; SCF; SLF; Gb; FPH2; Sl; Steel; Steel factor; stem cell factor; steel; blz; Con; FPHH; Mgf; DCUA; DFNA69; Kitlg|
|Strain of Origin||WSB/Pt|
|Molecular Note||Complementation tests with KitlSl, KitlSl-d, and Kitlsl-24J showed blaze (blz) to be an allele of Kitl. The molecular lesion is undefined.|
These mice are very difficult to handle.
When using the WSB/EiJ mouse strain in a publication, please include JAX stock #001145 in your Materials and Methods section.
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