JAX Mouse Strain Datasheet - 001145

WSB/EiJ

Stock No:: 001145

Repository Live

Overview

Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Genetic overview

Genetic Background	Generation
	F61+F15 (01-JUL-16)

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Research Applications

Dermatology Research
Research Tools

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Base Price

Starting at:

$212.00 Domestic price for female

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Details

Detailed Description

Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. WSB is characterized by a distinct and consistent white head blaze, variable ventral spotting and a slight coat dilution on the agouti background. The variation in pigment is the result of the spontaneous mutation blaze (Kitl^blz).Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development

Founder mice for the wild-derived strain Watkins Star Line B (WSB) were trapped in Centerville, Maryland by Michael Potter (NCI) in 1976. WSB and WSA were separated from the founder line, CLA, at generation 3. The WSB, comprised mice selected for dark agouti coat color and white head blaze, Mice were sent to EM Eicher at The Jackson Laboratory in 1986. The blaze pigmentation was found to be a Kit allele, Kitl^sl-blz.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Selected References
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
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Genetics

A

Allele Symbol: A

Allele Name wild-type agouti

Allele Type Spontaneous

Allele Synonym(s) dark-bellied agouti

Gene Symbol and Name a, nonagouti

Gene Synonym(s) AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor

Strain of Origin various

Chromosome 2

General Note The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.

Molecular Note This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene.

Kitl^sl-blz

Allele Symbol: Kitl^sl-blz

Allele Name blaze

Allele Type Spontaneous

Allele Synonym(s)

Gene Symbol and Name Kitl, kit ligand

Gene Synonym(s) Clo; Con; DCUA; DFNA69; FPH2; FPHH; Gb; Gb; KL-1; Kitlg; MGF; Mgf; Mgf; SCF; SF; SHEP7; SLF; Sl; Sl; Steel; Steel factor; blaze; blz; blz; cloud gray; contrasted; grizzle-belly; grizzle-belly; mast cell growth factor; steel; stem cell factor

Strain of Origin WSB/Pt

Chromosome 10

Molecular Note Complementation tests with Kitl^Sl, Kitl^Sl-d, and Kitl^sl-24J showed blaze (blz) to be an allele of Kitl. The molecular lesion is undefined.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects
Research Tools
Genetics Research
Evolution and Systematics Research
Gene Mapping

Phenotype Information

References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298

Additional References
Aylor DL; Valdar W; Foulds-Mathes W; Buus RJ; Verdugo RA; Baric RS; Ferris MT; Frelinger JA; Heise M; Frieman MB; Gralinski LE; Bell TA; Didion JD; Hua K; Nehrenberg DL; Powell CL; Steigerwalt J; Xie Y; Kelada SN; Collins FS; Yang IV; Schwartz DA; Branstetter LA; Chesler EJ; Miller DR; Spence J; Liu EY; McMillan L; Sarkar A; Wang J; Wang W; Zhang Q; Broman KW; Korstanje R; Durrant C; Mott R; Iraqi FA; Pomp D; Threadgill D; de Villena FP; Churchill GA. 2011. Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res 21(8):1213-22. PubMed: 21406540 MGI: J:169740
Bell TA; de la Casa-Esperon E; Doherty HE; Ideraabdullah F; Kim K; Wang Y; Lange LA; Wilhemsen K; Lange EM; Sapienza C; de Villena FP. 2006. The Paternal Gene of the DDK Syndrome Maps to the Schlafen Gene Cluster on Mouse Chromosome 11. Genetics 172(1):411-23. PubMed: 16172501 MGI: J:105162
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. PubMed: 21921910 MGI: J:177037

Additional - A related
Blewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. PubMed: 15890782 MGI: J:99816
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. PubMed: 1473152 MGI: J:3523
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. PubMed: 3227730 MGI: J:16568
Cota CD; Liu RR; Sumberac TM; Jung S; Vencato D; Millet YH; Gunn TM. 2008. Genetic and phenotypic studies of the dark-like mutant mouse. Genesis 46(10):562-73. PubMed: 18821597 MGI: J:143333
Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. PubMed: 18172198 MGI: J:131039
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. PubMed: 5798139 MGI: J:30922
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144. MGI: J:46318
Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. PubMed: 16578176 MGI: J:13122
Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179. MGI: J:156092
Green EL. 1968. . In: Handbook on Genetically Standardized Jax Mice. The Jackson Laboratory, Bar Harbor, ME. MGI: J:36414
Guido V; and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :. MGI: J:77218
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. PubMed: 17652101 MGI: J:129904
Kelly EM. 1957. Beige, bg Mouse News Lett 16:36. MGI: J:29744
Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice. J Genet 40:229-41. MGI: J:280
MouseBook^TM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :. MGI: J:169366
Mutant Mouse Regional Resource Centers. 2004. Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) Unpublished :. MGI: J:94077
Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. PubMed: 7980472 MGI: J:21244
Phillips RJS. 1966. A cis-trans position effect at the A locus of the house mouse. Genetics 54(2):485-95. PubMed: 5968639 MGI: J:5027
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. MGI: J:13094
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Siracusa LD; Washburn LL; Swing DA; Argeson AC; Jenkins NA; Copeland NG. 1995. Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J Hered 86(2):121-8. PubMed: 7751596 MGI: J:24247
Zheng B; Sage M; Cai WW; Thompson DM; Tavsanli BC; Cheah YC; Bradley A. 1999. Engineering a mouse balancer chromosome. Nat Genet 22(4):375-8. PubMed: 10431243 MGI: J:56548
von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23. MGI: J:22593
Additional - Kitl^sl-blz related
Aylor DL; Valdar W; Foulds-Mathes W; Buus RJ; Verdugo RA; Baric RS; Ferris MT; Frelinger JA; Heise M; Frieman MB; Gralinski LE; Bell TA; Didion JD; Hua K; Nehrenberg DL; Powell CL; Steigerwalt J; Xie Y; Kelada SN; Collins FS; Yang IV; Schwartz DA; Branstetter LA; Chesler EJ; Miller DR; Spence J; Liu EY; McMillan L; Sarkar A; Wang J; Wang W; Zhang Q; Broman KW; Korstanje R; Durrant C; Mott R; Iraqi FA; Pomp D; Threadgill D; de Villena FP; Churchill GA. 2011. Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res 21(8):1213-22. PubMed: 21406540 MGI: J:169740
Washburn LL; Harris BS. 2010. The recessive mutation blaze (blz) that characterizes the WSB/EiJ strain is an allele of Kitl, Kitl<blz> Personal Communication :. MGI: J:179958

Allele Name	wild-type agouti
Allele Type	Spontaneous
Allele Synonym(s)	dark-bellied agouti
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)	AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor
Strain of Origin	various
Chromosome	2
General Note	The A allele is usually regarded as a wild-type allele. For example,the C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.
Molecular Note	This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene.

Allele Name	blaze
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Kitl, kit ligand
Gene Synonym(s)	Clo; Con; DCUA; DFNA69; FPH2; FPHH; Gb; Gb; KL-1; Kitlg; MGF; Mgf; Mgf; SCF; SF; SHEP7; SLF; Sl; Sl; Steel; Steel factor; blaze; blz; blz; cloud gray; contrasted; grizzle-belly; grizzle-belly; mast cell growth factor; steel; stem cell factor
Strain of Origin	WSB/Pt
Chromosome	10
Molecular Note	Complementation tests with Kitl^Sl, Kitl^Sl-d, and Kitl^sl-24J showed blaze (blz) to be an allele of Kitl. The molecular lesion is undefined.

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

A

Allele Symbol: A

Kitlsl-blz

Allele Symbol: Kitlsl-blz

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Phenotype Information

References

Additional References

Additional - A related

Additional - Kitlsl-blz related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

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Kitl^sl-blz

Allele Symbol: Kitl^sl-blz

Additional - Kitl^sl-blz related