CBA/CaGnLeJ

Stock number: 001143
Strain synonyms: CBA Carter Lane, CBACa
Research areas: Cancer Research, Research Tools, Sensorineural Research

Description

CBA was developed from a cross of a Bagg albino female and a DBA male. The substrain CBA/Ca is a general purpose strain, and is commonly used for immunology research.

Detailed description

CBA was developed from a cross of an unpedigreed Bagg albino female and an early DBA progenitor male. C3H mice are descended from the same cross. The strain was initially bred for longevity and a low incidence of spontaneous mammary tumors (as compared to C3H). The substrain CBA/Ca is a general purpose strain, and is commonly used for immunology research. CBA/Ca mice do not carry the retinal degeneration 1 allele (Pde6b^rd1) and are not histocompatible with the CBA/J substrain. This strain also lacks the nob8 mutation in Grm6.

Development

Beginning in 1920, Strong developed the CBA inbred strain from a cross of an unpedigreed Bagg albino-derived female and an early DBA progenitor male. C3H mice are descended from the same cross. Progeny were selected for low mammary tumor incidence. Strong sent the CBA mice to Little at The Jackson Laboratory, then to Haldane and Gruneberg (university College, London) in 1932, to Carr and Carter (Institute of Animal Genetics, Edinburgh, Scotland) in 1947, to Green at The Jackson Laboratory in 1950. This substrain was held by Green and then Lane at The Jackson Laboratory.

Allele

Symbol: Grm6⁺
Name: wild type
MGI accession ID: MGI:2176771
Generation method: Not Specified
Marker symbol: Grm6
Marker name: glutamate receptor, metabotropic 6
Marker synonyms: CSNB1B; GPRC1F; mGlu6; mGluR6; nerg1; nob3
Chromosome: 11
Strain of origin: Not Applicable