Mice homozygous for the Faslgld mutation display lymphadenopathy and systemic autoimmunity similar to that in Fasllpr homozygous mice. Homozygotes also have an enlarged spleen, greatly increased numbers of T, B, and null lymphocytes and develop immune complex glomerulonephrosis.
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fasl | Fas ligand (TNF superfamily, member 6) |
Mice homozygous for the Faslgld mutation display lymphadenopathy and systemic autoimmunity similar to that in Fasllpr homozygous mice. There is significant enlargement of all lymph nodes to 50 times the control weight by 20 weeks of age. Homozygotes also have an enlarged spleen, greatly increased numbers of T, B, and null lymphocytes and develop immune complex glomerulonephrosis. Onset of symptoms is dependent on genetic background with the C3H/HeJ strain having the earliest onset exhibiting glomerulonephritis by 22 weeks. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
The Cryaalop18 mutation was identified in the C57BL/6JSmn inbred strain in approximately 1991. This is at least 5 years from the date of the final (N10) backcross generation of B6Smn.C3-Faslgld/J. In 2003, four B6Smn.C3-Faslgld/J mice were assessed and the recessive lop18 phenotype was absent from all of them. This does not guarantee that the Cryaalop18 mutation is absent from this strain.
Allele Name | generalized lymphoproliferative disease |
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Allele Type | Spontaneous |
Allele Synonym(s) | CD95-; FasL-; gld; Tnfsf6gld |
Gene Symbol and Name | Fasl, Fas ligand (TNF superfamily, member 6) |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 1 |
Molecular Note | A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. |
When using the Fasl gld mouse strain in a publication, please cite the originating article(s) and include JAX stock #001021 in your Materials and Methods section.
Service/Product | Description | Price |
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Homozygous for Fasl<gld>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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