CBACa.C3-Kit^W-x/J

Stock number: 000965
Product name: dominant spotting x
Research areas: Cancer Research, Dermatology Research, Developmental Biology Research, Endocrine Deficiency Research, Immunology, Inflammation and Autoimmunity Research, Mouse/Human Gene Homologs, Neurobiology Research, Reproductive Biology Research, Research Tools, Sensorineural Research

Detailed description

Kit^W mutations in the mouse have pleiotropic effects on embryonic development and hematopoiesis. The characteristic phenotype of mutants at this locus, which includes white coat color, sterility, and anemia, can be attributed to the failure of stem cell populations to migrate and/or proliferate effectively during development. The region encoding amino acids 342 to 791 is disrupted in the Kit^W-x mutation.

Development

The Kit^W-x mutation arose in the C3H/HeJ strain. The mutation has been backrossed for 21 generations onto the CBA/CaJ strain and embryos were cryopreserved in 1983.

Allele

Symbol: Kit^W-x
Name: dominant spotting x
MGI accession ID: MGI:1856267
Generation method: Spontaneous
Marker symbol: Kit
Marker name: KIT proto-oncogene receptor tyrosine kinase
Marker synonyms: belly-spot; CD117; c-KIT; Dominant white spotting; Gsfsco1; Gsfsco5; Gsfsow3; MASTC; PBT; SCFR; SCO1; SCO5; SOW3; Steel Factor Receptor; Tr-kit
Chromosome: 5
Strain of origin: C3H/HeJ
Molecular note: This allele involves a rearrangement in the Kit gene.