JAX Mouse Strain Datasheet - 000933

YBR/EiJ

Stock No:: 000933

Inbred Strain

Available for Registering Interest

Overview

This strain is currently unavailable due to replenishing of cryopreserved stocks. We are unable to determine when it will be available in the future.

Genetic overview

Genetic Background	Generation

View Genetics

Research Applications

Metabolism Research
Neurobiology Research
Sensorineural Research
Research Tools
Dermatology Research

View All Research Applications

Details

Development

The stock from which this strain eventually derived was described by C.C. Little in 1934 (J Exp Med, v59 p229) as A^y/a B/b^r D/d^b, the black-eyed yellow offspring of a cross between an early DBA and Dunn's derivative of Brooke's English Stock, which was A^y/a B/b^r D/D (heterozygous for yellow, brown, and wildtype for dilute). This stock was shared by C. C. Little, at The Jackson Laboratory, with H. B. Andervont, at NCI, Bethesda in 1936, who sent it to W. E. Heston, NCI in 1946, when inbreeding had reach generation F30. Heston sent it to J. W. Wilson, Brown University in 1948, who sent it to T. S. Hauschka, Roswell Park Memorial Institute, Buffalo, NY in 1951, who gave it to V. M. Chapman, also at Roswell Park Memorial Institute, in1973, and he sent it to EM Eicher, at The Jackson Laboratory in 1979. The strain that arrived in the laboratory of Eva Eicher was nonagouti brown, with no yellow or dilute alleles (a/a b/b D/D). In 1980, with 25 generations of additional sibling inbreeding after arrival, this inbred strain was transferred to The Jackson Laboratory Mouse Mutant Resource and in 1989 embryos were cryopreserved at generation ?+F25+13.

Selected References

Nair KS; Cosma M; Raghupathy N; Sellarole MA; Tolman NG; de Vries W; Smith RS; John SW. 2016. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech 9(8):863-71. PubMed: 27483353 MGI: J:234169
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31. PubMed: 17611057 MGI: J:123543

View All References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Tyrp1^b

Allele Symbol: Tyrp1^b

Allele Name	brown
Allele Type	Spontaneous
Allele Synonym(s)	b
Gene Symbol and Name	Tyrp1, tyrosinase-related protein 1
Gene Synonym(s)	B; CAS2; CATB; GP75; OCA3; Oca3; TRP; TRP-1; TRP1; TYRP; Tyrp; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; isa; tyrosinase-related protein
Strain of Origin	old mutant of the mouse fancy
Chromosome	4
Molecular Note	A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Metabolism Research
Neurobiology Research
- Hearing Defects
  - Age related hearing loss, control
Sensorineural Research
- Eye Defects
  - hereditary glaucoma
- Hearing Defects
  - Age related hearing loss, control

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Tyrp1^b related

Dermatology Research
- Color and White Spotting Defects

Mammalian Phenotype Terms by Genotype

pigmentation phenotype

abnormal iris stromal pigmentation

nervous system phenotype

abnormal optic nerve morphology
- older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration

optic nerve degeneration
- by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage

retinal ganglion cell degeneration
- in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found

cardiovascular system phenotype

corneal vascularization
- some YBR/EiJ mice develop vascularization of the cornea at 1 year of age

hearing/vestibular/ear phenotype

abnormal hearing electrophysiology
- abnormal tympanogram relative to CBA/CaJ and a panel of 61 inbred strains

increased or absent threshold for auditory brainstem response

vision/eye phenotype

abnormal aqueous humor
- as these mice age the deteriorating iris stroma causes released pigment and debris to accumulate at the iridocorneal angle, focal tissue adhesions form, angle closure occurs and there is a block of aqueous humor drainage

abnormal iris stroma morphology
- YBR/EiJ develop age-related iris stromal atrophy with increasing iris depigmentation and iris stromal cell loss but no iris pigment epithelial cell loss

abnormal iris stromal pigmentation

abnormal optic nerve morphology
- older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration

corneal vascularization
- some YBR/EiJ mice develop vascularization of the cornea at 1 year of age

iris stroma hypoplasia
- by 9 months of age itis stromal atrophy causes thinning of the iris stroma and peripupillary atrophy with increasing transillumination defects

ocular hypertension
- beginning at approximately 6 to 7 months of age and increasing with age, apparently as a result of pigment debris released from deteriorating iris stroma accumulating at the iridocorneal angle

optic nerve degeneration
- by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage

retinal ganglion cell degeneration
- in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found

Phenotype Information

Festing Inbred Strain Characteristics: YBR

References

Nair KS; Cosma M; Raghupathy N; Sellarole MA; Tolman NG; de Vries W; Smith RS; John SW. 2016. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech 9(8):863-71. PubMed: 27483353 MGI: J:234169
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31. PubMed: 17611057 MGI: J:123543

Additional References

Chapman VM; Noell WK; Adler D. 1975. Alb-1 Mouse News Lett 53:61. MGI: J:13686
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107. PubMed: 10320101 MGI: J:54812

Additional - Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. PubMed: 4123113 MGI: J:84312
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. PubMed: 1030186 MGI: J:12156
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. PubMed: 18848954 MGI: J:143604
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. PubMed: 8148872 MGI: J:17460
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. Neurotoxicology 33(6):1436-42. PubMed: 22935098 MGI: J:225088
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. PubMed: 16291824 MGI: J:113285
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. PubMed: 808546 MGI: J:5564
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. PubMed: 4110756 MGI: J:84250
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. PubMed: 4118365 MGI: J:84252
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. PubMed: 1658612 MGI: J:2134
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicol Sci 140(1):135-43. PubMed: 24718703 MGI: J:215349
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. PubMed: 22228805 MGI: J:183715
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. PubMed: 679184 MGI: J:84318
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. PubMed: 22982977 MGI: J:192865
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. PubMed: 21270426 MGI: J:173706
Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A 100(10):5652-7. PubMed: 12730383 MGI: J:132380
Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York. MGI: J:30693
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. PubMed: 4716952 MGI: J:84313
Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134(1):76-89. PubMed: 4981257 MGI: J:84248
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. PubMed: 4114109 MGI: J:5282
Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. Mol Pharmacol 8(6):651-66. PubMed: 4118364 MGI: J:84251
Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol 236(65):107-10. PubMed: 4502804 MGI: J:84249
Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus. Biochem Pharmacol 28(1):149-51. PubMed: 758905 MGI: J:6074
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. PubMed: 7095422 MGI: J:6809
Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. J Biol Chem 248(1):169-78. PubMed: 4348203 MGI: J:84311
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. PubMed: 1091656 MGI: J:84317
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. PubMed: 1119809 MGI: J:84316
Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. Mol Pharmacol 9(5):629-6. PubMed: 4788156 MGI: J:25852
Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol 35(6):823-30. PubMed: 2543914 MGI: J:27899
Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene Proc Am Assoc Cancer Res 2:335. MGI: J:84245
Poland A; Bradfield C. 1992. A brief review of the Ah locus. Tohoku J Exp Med 168(2):83-7. PubMed: 1339107 MGI: J:12546
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251(16):4936-46. PubMed: 956169 MGI: J:84247
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. PubMed: 2823093 MGI: J:8895
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. PubMed: 7969080 MGI: J:22144
Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor. Mol Pharmacol 36(1):121-7. PubMed: 2546046 MGI: J:126377
Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. J Biol Chem 249(17):5599-606. PubMed: 4370044 MGI: J:84314
Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453(7191):65-71. PubMed: 18362915 MGI: J:136052
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. PubMed: 4413562 MGI: J:84315
Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. Cancer Res 27(3):563-7. PubMed: 6021514 MGI: J:84246
Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. Cancer Res 29(8):1585-9. PubMed: 5807232 MGI: J:34134
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. PubMed: 6021513 MGI: J:26440
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. PubMed: 8408082 MGI: J:15153
Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochem Biophys Res Commun 376(4):775-80. PubMed: 18814841 MGI: J:141523
Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol 267(3):209-17. PubMed: 23337360 MGI: J:193493
Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207(10):2239-53. PubMed: 20855496 MGI: J:165803
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. PubMed: 9443932 MGI: J:45850
Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125(2):345-58. PubMed: 22086975 MGI: J:183662
Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver. Toxicol Sci 129(2):372-9. PubMed: 22696238 MGI: J:188164
Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci I 10(19):1127-34. PubMed: 5132702 MGI: J:5244
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. PubMed: 4750810 MGI: J:5387
Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet 6(2):157-68. PubMed: 4666754 MGI: J:31977
Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25:149-93. PubMed: 405846 MGI: J:5822
Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 101(47):16677-82. PubMed: 15545609 MGI: J:94465
Williams EG; Mouchiroud L; Frochaux M; Pandey A; Andreux PA; Deplancke B; Auwerx J. 2014. An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genet 10(9):e1004673. PubMed: 25255223 MGI: J:232452
Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'. Toxicol Sci 111(2):238-46. PubMed: 19474220 MGI: J:154083
Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis 27(10):2116-23. PubMed: 16704990 MGI: J:113356
Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 121(16):3195-204. PubMed: 23462117 MGI: J:197552

Additional - Tyrp1^b related

Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. PubMed: 16827931 MGI: J:128215
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. PubMed: 18402690 MGI: J:134670
Barabas P; Huang W; Chen H; Koehler CL; Howell G; John SW; Tian N; Renteria RC; Krizaj D. 2011. Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 52(9):6766-73. PubMed: 21757588 MGI: J:181395
Brooks BP; Larson DM; Chan CC; Kjellstrom S; Smith RS; Crawford MA; Lamoreux L; Huizing M; Hess R; Jiao X; Hejtmancik JF; Maminishkis A; John SW; Bush R; Pavan WJ. 2007. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48(9):3905-13. PubMed: 17724166 MGI: J:124886
Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. PubMed: 13877379 MGI: J:160128
Center EM; Hunter RL; Dodge AH. 1967. Effects of the luxoid gene (lu) on liver esterase isozymes of the mouse. Genetics 55(2):349-58. PubMed: 6067640 MGI: J:109970
Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. PubMed: 13880466 MGI: J:12173
Gajewska M; Krysiak E; Wirth-Dziecialowska E. 2010. New coat color mutation mapped in distal part MMU10 MGI Direct Data Submission :. MGI: J:162146
Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague. MGI: J:30758
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. PubMed: 4634048 MGI: J:5346
Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. PubMed: 18158332 MGI: J:131073
Hunsicker PR. 1969. White-based brown, B<W> Mouse News Lett 40:41. MGI: J:13492
Kelly EM. 1957. Beige, bg Mouse News Lett 16:36. MGI: J:29744
Kobayashi T; Imokawa G; Bennett DC; Hearing VJ. 1998. Tyrosinase stabilization by Tyrp1 (the brown locus protein). J Biol Chem 273(48):31801-5. PubMed: 9822646 MGI: J:51301
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. PubMed: 11277491 MGI: J:103803
Little CC. 1916. The occurrence of three recognized coat mutations in mice Am Naturalist 1:335-349. MGI: J:150254
Manor U; Disanza A; Grati M; Andrade L; Lin H; Di Fiore PP; Scita G; Kachar B. 2011. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol 21(2):167-72. PubMed: 21236676 MGI: J:171832
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. PubMed: 17247639 MGI: J:12970
Matheu A; Pantoja C; Efeyan A; Criado LM; Martin-Caballero J; Flores JM; Klatt P; Serrano M. 2004. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev 18(22):2736-46. PubMed: 15520276 MGI: J:93879
Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/03/01 MGI Direct Data Submission :. MGI: J:180879
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. PubMed: 5902512 MGI: J:5001
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Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :. MGI: J:100221
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Overview

Genetic overview

Research Applications

Details

Development

Selected References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Tyrp1^b

Allele Symbol: Tyrp1^b

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahr^d related

Genotype: Tyrp1^b related

Mammalian Phenotype Terms by Genotype

pigmentation phenotype

nervous system phenotype

cardiovascular system phenotype

hearing/vestibular/ear phenotype

vision/eye phenotype

Phenotype Information

References

Additional References

Additional - Ahr^d related

Additional - Tyrp1^b related

Technical Support

Genotyping Protocols

Appearance

Citation

Terms Of Use

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Overview

Genetic overview

Research Applications

Details

Development

Selected References

Genetics

Ahrd

Allele Symbol: Ahrd

Tyrp1b

Allele Symbol: Tyrp1b

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Tyrp1b related

Mammalian Phenotype Terms by Genotype

pigmentation phenotype

nervous system phenotype

cardiovascular system phenotype

hearing/vestibular/ear phenotype

vision/eye phenotype

Phenotype Information

References

Additional References

Additional - Ahrd related

Additional - Tyrp1b related

Technical Support

Genotyping Protocols

Appearance

Citation

Terms Of Use

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Related Strains

Ahr^d

Allele Symbol: Ahr^d

Tyrp1^b

Allele Symbol: Tyrp1^b

Genotype: Ahr^d related

Genotype: Tyrp1^b related

Additional - Ahr^d related

Additional - Tyrp1^b related