Overview

This inbred strain has been described (Mouse Genome Database; Inbred Strains of Mice and Rats, Michael Festing) as exhibiting at least 50% amyloid with obesity in crosses with other strains, low tumor incidence, and lacks microsomal glucuronidases.

Genetic overview

Genetic Background	Generation

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Research Applications

Metabolism Research
Mouse/Human Gene Homologs
Neurobiology Research
Sensorineural Research
Research Tools
Dermatology Research

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Base Price

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Details

Detailed Description

This inbred strain has been described (Mouse Genome Database; Inbred Strains of Mice and Rats, Michael Festing) as exhibiting at least 50% amyloid with obesity in crosses with other strains, low tumor incidence, and lacks microsomal glucuronidases. The extant strain has no yellow or dilute alleles. MacDearmid et al (2006) found that YBR/EiJ mice can be infected by mouse mammary tumor virus and transmit infectious MMTV, but virus production is attenuated relative to that seen in other inbred mice and YBR/EiJ mice clear the infection in successive generations. This dominant trait is not the result of antiviral antibody production, as is the case with I/LnJ mice, but rather is mediated by YBR/EiJ T cells. Nair et al (2016) mapped 2 alleles in YBR/EiJ that cause mice of this strain to develop a progressive depigmenting iris disease, elevated intraocular pressure, and glaucoma. The progressive pigment-dispersing iris stromal atrophy maps to the Tyrp1^b allele on Chromosome 4, but is less severe than that found in DBA/2J, which has an additional mutation in Gpnmb. Only the iris stroma is prone to degeneration, not the iris pigment epithelium, which degenerates in DBA/2J. Independent of Tyrp1^b, there is also a locus on YBR/EiJ Chromosome 17 between 73,461,956 bp and 86,112, 456 bp that causes high intraocular pressure to develop and when combined with Tyrp1^b the consequence is compounded. Independent of Tyrp1^b on a mixed B6;YBR background this Chromosome 17 locus may provide a model for open-angle glaucoma with no iris disease. Piletz et al. (1981) found that YBR carries an electrophoretic variant of whey acidic protein that is not found in 58 other inbred strains and may be caused by a cysteine to arginine substitution. Zheng et al (1999) found late onset hearing loss in YBR/EiJ, and slightly larger than average external ear canal volume (2007).

Development

The stock from which this strain eventually derived was described by C.C. Little in 1934 (J Exp Med, v59 p229) as A^y/a B/b^r D/d^b, the black-eyed yellow offspring of a cross between an early DBA and Dunn’s derivative of Brooke’s English Stock, which was A^y/a B/b^r D/D (heterozygous for yellow, brown, and wildtype for dilute). This stock was shared by C. C. Little, at The Jackson Laboratory, with H. B. Andervont, at NCI, Bethesda in 1936, who sent it to W. E. Heston, NCI in 1946, when inbreeding had reach generation F30. Heston sent it to J. W. Wilson, Brown University in 1948, who sent it to T. S. Hauschka, Roswell Park Memorial Institute, Buffalo, NY in 1951, who gave it to V. M. Chapman, also at Roswell Park Memorial Institute, in1973, and he sent it to EM Eicher, at The Jackson Laboratory in 1979. The strain that arrived in the laboratory of Eva Eicher was nonagouti brown, with no yellow or dilute alleles (a/a b/b D/D). In 1980, with 25 generations of additional sibling inbreeding after arrival, this inbred strain was transferred to The Jackson Laboratory Mouse Mutant Resource and in 1989 embryos were cryopreserved at generation ?+F25+13.

Selected References

MacDearmid CC; Case LK; Starling CL; Golovkina TV. 2006. Gradual elimination of retroviruses in YBR/Ei mice. J Virol 80(5):2206-15PubMed: 16474128 MGI: J:263130
Nair KS; Cosma M; Raghupathy N; Sellarole MA; Tolman NG; de Vries W; Smith RS; John SW. 2016. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech 9(8):863-71PubMed: 27483353 MGI: J:234169

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Genetics

Tyrp1^b

Allele Symbol: Tyrp1^b

Allele Name	brown
Allele Type	Spontaneous
Allele Synonym(s)	b
Gene Symbol and Name	Tyrp1, tyrosinase-related protein 1
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	4
Molecular Note	A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype.

Ces1e^h

Allele Symbol: Ces1e^h

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	Eg⁰
Gene Symbol and Name	Ces1e, carboxylesterase 1E
Gene Synonym(s)
Strain of Origin	Not Specified
Chromosome	8

Mx1^s1

Allele Symbol: Mx1^s1

Allele Name	myxovirus susceptibility 1
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Mx1, MX dynamin-like GTPase 1
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	16
General Note	The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Resistance is specific for the orthomyxoviruses (J:6265). It is dependent on the presence of interferon-alpha and -beta but not -gamma (J:7365). The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Susceptibility alleles do not produce the protein (J:8273). The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). The MX-1 protein is a GTPase containing a GTP binding domain (J:1417) and this binding core is also necessary (J:21243). Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1^r. The Mx1^r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1^s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1^r allele. This large deletion apparently renders the protein incapable of providing resistance to influenza. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1^s2 allele in which there is a nonsense mutation (J:9452). Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892).
Molecular Note	Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi.

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	ah; Ah^d; Ah^k; Ahhⁿ; AhRd; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Metabolism Research
Neurobiology Research
- Hearing Defects
  - Age related hearing loss, control
Sensorineural Research
- Hearing Defects
  - Age related hearing loss, control
- Eye Defects
  - hereditary glaucoma

Genotype: Tyrp1^b related

Mouse/Human Gene Homologs
- oculocutaneous albinism type III
Dermatology Research
- Color and White Spotting Defects

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Mammalian Phenotype Terms by Genotype

Phenotype Information

Festing Inbred Strain Characteristics: YBR

References

MacDearmid CC; Case LK; Starling CL; Golovkina TV. 2006. Gradual elimination of retroviruses in YBR/Ei mice. J Virol 80(5):2206-15PubMed: 16474128 MGI: J:263130
Nair KS; Cosma M; Raghupathy N; Sellarole MA; Tolman NG; de Vries W; Smith RS; John SW. 2016. YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17. Dis Model Mech 9(8):863-71PubMed: 27483353 MGI: J:234169

Additional References

Andervont HB. 1938. The incidence of induced subcutaneous and pulmonary tumors and spontaneous mammary tumors in hybrid mice Public Health Rep 53(37):1665-71MGI: J:26374
Chapman VM; Noell WK; Adler D. 1975. Alb-1 Mouse News Lett 53:61MGI: J:13686
Meisler MH; Antonucci TK; Treisman LO; Gumucio DL; Samuelson LC. 1986. Interstrain variation in amylase gene copy number and mRNA abundance in three mouse tissues. Genetics 113(3):713-22PubMed: 3488242 MGI: J:8356
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298
Piletz JE; Ganschow RE. 1981. Genetic variation of milk proteins in mice. Biochem Genet 19(9-10):1023-30PubMed: 7332524 MGI: J:6693
Piletz JE; Heinlen M; Ganschow RE. 1981. Biochemical characterization of a novel whey protein from murine milk. J Biol Chem 256(22):11509-16PubMed: 6975276 MGI: J:6634
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12PubMed: 2169579 MGI: J:34840
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107PubMed: 10320101 MGI: J:54812
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543

Additional - Ahr^d related

Additional - Ces1e^h related

Additional - Mx1^s1 related

Additional - Tyrp1^b related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Appearance
- brown, nonagouti
  Related Genotype: a/a Tyrp1^b/Tyrp1^b
Citation
When using the YBR/EiJ mouse strain in a publication, please include JAX stock #000933 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

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