Overview

Both PERA and PERC (Stock No. 001307) were derived from wild mice trapped in Peru. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Genetic overview

Genetic Background	Generation

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Research Applications

Research Tools

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Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

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Details

Detailed Description

Both PERA and PERC (Stock No. 001307) were derived from wild mice trapped in Peru. PERA mice exhibit a moderate susceptibility to induced experimental autoimmune encephalitis (EAE). In comparison to other strains, disease onset is late, disease severity is high, and the mortality rate is 60% with a 50% spontaneous relapse. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development

In 1961, founders were trapped for ME Wallace, University of Cambridge, by O Atteck in a Peruvian Yard that was used to dry maize cobs in Nana Village, Rimac Valley, Peru. These mice were held in a small, closed colony by Wallace. In 1971, at approximately F25, members of this colony were sent to EM Eicher and TH Roderick at The Jackson Laboratory where inbreeding continued. In 2003 this inbred strain reached F88.

Selected References

Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77PubMed: 8878692 MGI: J:35710
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298
Seidelmann SB; De Luca C; Leibel RL; Breslow JL; Tall AR; Welch CL. 2005. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol 25(1):204-10PubMed: 15514201 MGI: J:94548
Velupillai P; Carroll JP; Benjamin TL. 2002. Susceptibility to polyomavirus-induced tumors in inbred mice: role of innate immune responses. J Virol 76(19):9657-63PubMed: 12208944 MGI: J:78911
Velupillai P; Yoshizawa I; Dey DC; Nahill SR; Carroll JP; Bronson RT; Benjamin TL. 1999. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol 73(12):10079-85PubMed: 10559322 MGI: J:58441
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104

View All References

Genetics

Lith9^PERA/EiJ

Allele Symbol: Lith9^PERA/EiJ

Allele Name	PERA/EiJ
Allele Type	QTL
Allele Synonym(s)
Gene Symbol and Name	Lith9, lithogenic gene 9
Gene Synonym(s)
Strain of Origin	PERA/EiJ
Chromosome	17
General Note	Lith9 exhibits additive inheritance.
Molecular Note	This allele confers increased gallstone score compared to I/LnJ. This allele confers susceptibility to gallstone formation compared to DBA/2J.

Mx1^s2

Allele Symbol: Mx1^s2

Allele Name	myxovirus susceptibility 2
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Mx1, MX dynamin-like GTPase 1
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	16
General Note	The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Resistance is specific for the orthomyxoviruses (J:6265). It is dependent on the presence of interferon-alpha and -beta but not -gamma (J:7365). The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Susceptibility alleles do not produce the protein (J:8273). The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). The MX-1 protein is a GTPase containing a GTP binding domain (J:1417) and this binding core is also necessary (J:21243). Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1^r. The Mx1^r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1^s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1^r allele. This large deletion apparently renders the protein incapable of providing resistance to influenza. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1^s2 allele in which there is a nonsense mutation (J:9452). Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892).
Molecular Note	CBA/J, CE/J, I/LnJ and PERA/Ei strains have a nonsense mutation that results in a null allele and susceptibility to myxoviruses.

Ahr^b-2

Allele Symbol: Ahr^b-2

Allele Name	b-2 variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^b-2; Ah^h
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)
Strain of Origin	BALB/cBy
Chromosome	12
General Note	C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains
Molecular Note	This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cBy allele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele).

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Research Tools
- Genetics Research
  - Evolution and Systematics Research
  - Gene Mapping: Polymorphisms
  - Gene Mapping

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Lith9^I/LnJ/Lith9^PERA/EiJ
involves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

gallstones
- increased gallstone score

Genotype: Lith9^PERA/EiJ/Lith9^PERA/EiJ
involves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

gallstones
- increased gallstone score

Genotype: Lith9^PERA/EiJ/?
involves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

gallstones
- susceptibility to gallstone formation

Phenotype Information

References

Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77PubMed: 8878692 MGI: J:35710
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298
Seidelmann SB; De Luca C; Leibel RL; Breslow JL; Tall AR; Welch CL. 2005. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol 25(1):204-10PubMed: 15514201 MGI: J:94548
Velupillai P; Carroll JP; Benjamin TL. 2002. Susceptibility to polyomavirus-induced tumors in inbred mice: role of innate immune responses. J Virol 76(19):9657-63PubMed: 12208944 MGI: J:78911
Velupillai P; Yoshizawa I; Dey DC; Nahill SR; Carroll JP; Bronson RT; Benjamin TL. 1999. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol 73(12):10079-85PubMed: 10559322 MGI: J:58441
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104

Additional References

Bell TA; de la Casa-Esperon E; Doherty HE; Ideraabdullah F; Kim K; Wang Y; Lange LA; Wilhemsen K; Lange EM; Sapienza C; de Villena FP. 2006. The Paternal Gene of the DDK Syndrome Maps to the Schlafen Gene Cluster on Mouse Chromosome 11. Genetics 172(1):411-23PubMed: 16172501 MGI: J:105162
Cheah YC; Nadeau JH; Pugh S; Paigen B. 1994. New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains. Mamm Genome 5(12):762-7PubMed: 7894156 MGI: J:22175
Frick A; Fedoriw Y; Richards K; Damania B; Parks B; Suzuki O; Benton CS; Chan E; Thomas RS; Wiltshire T. 2015. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med 8:81-98PubMed: 25897258 MGI: J:275938
Harr B. 2006. Genomic islands of differentiation between house mouse subspecies. Genome Res 16(6):730-7PubMed: 16687734 MGI: J:281702
Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7PubMed: 15466288 MGI: J:193384
Ideraabdullah FY; Kim K; Pomp D; Moran JL; Beier D; Villena FP. 2007. Rescue of the Mouse DDK Syndrome by Parent-of-Origin-Dependent Modifiers. Biol Reprod 76(2):286-293PubMed: 17050856 MGI: J:121171
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7PubMed: 8753860 MGI: J:35147
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29PubMed: 18440079 MGI: J:138681
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12PubMed: 2169579 MGI: J:34840
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Wahlsten D; Bachmanov A; Finn DA; Crabbe JC. 2006. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103(44):16364-9PubMed: 17053075 MGI: J:115640
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159
Wiltshire T; Ervin RB; Duan H; Bogue MA; Zamboni WC; Cook S; Chung W; Zou F; Tarantino LM. 2015. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains. Genes Brain Behav 14(3):271-80PubMed: 25727211 MGI: J:235925
Wittenburg H; Lyons MA; Li R; Churchill GA; Carey MC; Paigen B. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125(3):868-81PubMed: 12949731 MGI: J:84582
Yang JN; Dudley J. 1992. Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream V kappa 9 gene. J Immunol 149(4):1242-51PubMed: 1323611 MGI: J:1819
Yoneyama N; Crabbe JC; Ford MM; Murillo A; Finn DA. 2008. Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 42(3):149-60PubMed: 18358676 MGI: J:268914
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Zimmerman H; Yin Z; Zou F; Everett ET. 2019. Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping. Front Genet 10:291PubMed: 31001328 MGI: J:275176

Additional - Ahr^b-2 related

Additional - Lith9^PERA/EiJ related

Additional - Mx1^s2 related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Appearance
- agouti
  Related Genotype: A/A
Citation
When using the PERA/EiJ mouse strain in a publication, please include JAX stock #000930 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Inbred, 1 pair minimum will be supplied

Related Products and Services

Frozen Mouse Embryo	PERA/EiJ Frozen Embryos	$2595.00
Frozen Mouse Embryo	PERA/EiJ Frozen Embryos	$2595.00
Frozen Mouse Embryo	PERA/EiJ Frozen Embryos	$3373.50
Frozen Mouse Embryo	PERA/EiJ Frozen Embryos	$3373.50

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

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General Terms and Conditions

Questions about Terms of Use

Licensing Information

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Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

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Genetic overview

Research Applications

Base Price

Detailed Description

Development

Selected References

Lith9PERA/EiJ

Allele Symbol: Lith9PERA/EiJ

Mx1s2

Allele Symbol: Mx1s2

Ahrb-2

Allele Symbol: Ahrb-2

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

Genotype: Lith9I/LnJ/Lith9PERA/EiJinvolves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

Genotype: Lith9PERA/EiJ/Lith9PERA/EiJinvolves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

Genotype: Lith9PERA/EiJ/?involves: I/LnJ * PERA/EiJ

liver/biliary system phenotype

Phenotype Information

References

Additional References

Additional - Ahrb-2 related

Additional - Lith9PERA/EiJ related

Additional - Mx1s2 related

Genotyping Protocols

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Lith9^PERA/EiJ

Allele Symbol: Lith9^PERA/EiJ

Mx1^s2

Allele Symbol: Mx1^s2

Ahr^b-2

Allele Symbol: Ahr^b-2

Genotype: Lith9^I/LnJ/Lith9^PERA/EiJ
involves: I/LnJ * PERA/EiJ

Genotype: Lith9^PERA/EiJ/Lith9^PERA/EiJ
involves: I/LnJ * PERA/EiJ

Genotype: Lith9^PERA/EiJ/?
involves: I/LnJ * PERA/EiJ

Additional - Ahr^b-2 related

Additional - Lith9^PERA/EiJ related

Additional - Mx1^s2 related