The Eicher (Ei) C57BL/6 subline was separated from the parental C57BL/6J in 1976 and has been maintained as a separate subline since. C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. C57BL/6J mice are used in a variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research.
Read More +The Eicher (Ei) C57BL/6 subline was separated from the parental C57BL/6J in 1976 and has been maintained as a separate subline since. C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors.
This subline differs from C57BL/6J at one known locus, although there may be others that have not been identifed. C57BL/6JEiJ does not have a spontaneous deletion in nicotinamide nucleotide transhydrogenase (Nnt), but does have the n-Tr20m1J mutation.
The Eicher subline separated from the parental C57BL/6J in 1976 when that inbred was at generation F129. It has been maintained as a separately inbreeding subline ever since.
Allele Name | mutation 1, Jackson |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | n-Tr20C57BL/6J; n-TRtct5rs4644711-T; rs46447118 |
Gene Symbol and Name | n-TRtct5, nuclear encoded tRNA arginine 5 (anticodon TCT) |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 1 |
Molecular Note | This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. |
When using the Black 6 Eicher mouse strain in a publication, please include JAX stock #000924 in your Materials and Methods section.
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Inbred, 1 pair minimum will be supplied |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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