The Eicher (Ei) C57BL/6 subline was separated from the parental C57BL/6J in 1976 and has been maintained as a separate subline since. C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. C57BL/6J mice are used in a variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research.Read More +
The Eicher (Ei) C57BL/6 subline was separated from the parental C57BL/6J in 1976 and has been maintained as a separate subline since. C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors.
This subline differs from C57BL/6J at one known locus, although there may be others that have not been identifed. C57BL/6JEiJ does not have a spontaneous deletion in nicotinamide nucleotide transhydrogenase (Nnt), but does have the n-Tr20m1J mutation.
The Eicher subline separated from the parental C57BL/6J in 1976 when that inbred was at generation F129. It has been maintained as a separately inbreeding subline ever since.
|Allele Name||mutation 1, Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Allele Synonym(s)||n-Tr20C57BL/6J; n-TRtct5rs4644711-T; rs46447118|
|Gene Symbol and Name||n-TRtct5, nuclear encoded tRNA arginine 5 (anticodon TCT)|
|Strain of Origin||C57BL/6J|
|Molecular Note||This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder.|
When using the Black 6 Eicher mouse strain in a publication, please include JAX stock #000924 in your Materials and Methods section.
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