This inbred strain is derived from a mixture of strains and carries the Rb2Lub, Rb3Bnr, Rb4Bnr, and Rb7Bnr Robertsonian Chromosomes.
This strain is homozygous for retinal degeneration 3, rd3.
This inbred strain is derived from a mixture of strains and carries the Rb2Lub, Rb3Bnr, Rb4Bnr, and Rb7Bnr Robertsonian Chromosomes.
Origin: Muriel Davisson 1984 from crosses between 1) a stock derived from an "Orobie" male captured near Bergamo, N. Italy x a 129/- female (note that the Orobie stock was developed with crosses involving C57BL/6J, DBA/2J and AEJ/Gn) and 2) the inbred strain RBD. Homozygous for Rb(2.8)2Lub, Rb(5.15)3Bnr, Rb(11.13)4Bnr, Rb(16.17)7Bnr and has a Y chromosome from the Orobie wild population. Embryos of the strain were cryopreserved in 1993 at F32.
Allele Name | tobacco darkening |
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Allele Type | Spontaneous |
Allele Synonym(s) | Etob |
Gene Symbol and Name | Mc1r, melanocortin 1 receptor |
Gene Synonym(s) | |
Strain of Origin | M. m. domesticus poschiavinus |
Chromosome | 8 |
Molecular Note | Two independent PCR assays found a C-to-T mutation at coding nucleotide 206 resulting in a serine to leucine alteration in codon 69 (p.S69L). A second nucleotide C-to-T change results in a silent mutation at position 166. The result is a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele. |
Allele Name | retinal degeneration 3 |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Rd3, retinal degeneration 3 |
Gene Synonym(s) | |
Strain of Origin | RBF/DnJ |
Chromosome | 1 |
General Note | This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367). |
Molecular Note | A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded. |
Allele Name | targeted mutation 7, Peter J Detloff |
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Allele Type | Targeted (Not Applicable) |
Allele Synonym(s) | hprtNosignalQ38 |
Gene Symbol and Name | Hprt, hypoxanthine guanine phosphoribosyl transferase |
Gene Synonym(s) | |
Promoter | Hprt, hypoxanthine guanine phosphoribosyl transferase, mouse, laboratory |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | X |
Molecular Note | Exon 3 was disrupted by the insertion of a cassette containing a myc tag, and 38 CAG repeats encoding 38 glutamine residues. Neither a nuclear localization signal (NLS) nor a nuclear export signal (NES) was included in the targeting construct. |
Marker Synonym(s) | |
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Chromosome(s) | 15 |
Marker Synonym(s) | |
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Chromosome(s) | 2 |
Marker Synonym(s) | |
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Chromosome(s) | 16 |
When using the RBJ/DnJ mouse strain in a publication, please include JAX stock #000807 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Inbred, 1 pair minimum will be supplied |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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