This strain carries the hypogonadal mutation (Gnrh1hpg) and mice are characterized by an overall underdevelopment of the reproductive tract.
Read More +This strain is segregating for Gnrh1hpg.
Mice homozygous for the hypogonadal mutation (Gnrh1hpg) are characterized by an overall underdevelopment of the reproductive tract. Male mice have a small penis and scrotum and a short ano-genital distance. All male reproductive organs are present but are immature. The testes are small and undescended. Spermatogenesis is arrested, usually by the diplotene stage. The vagina of female mice does not open fully, the uterus is thread-like, and the ovaries are very small. Homozygous mutant mice are deficient in LH, FSH, and gonadal steroids. They also exhibit aberrant PRL secretion patterns. Both sexes are sterile although fertility can be restored with hormone replacement.
Origin: WG Beamer, 1988 following hysterectomy and fostering on B6D2 of a stock carrying hpg (hypogonadal) mutation obtained from Bruce Cattanach.
Male and female mice heterozygous for Gnrh1hpg were mated to produce embryos for cryopreservation in 2008.
Allele Name | retinal degeneration 1 |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | Pdebrd1; rd; rd1; rd-1; rodless retina |
Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 5 |
General Note | The following inbred strains are known to be homozygous for Pde6b |
Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C-to-A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain, has been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. |
Allele Name | hypogonadal |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | Gnrh-; gnrhhpg; hpg |
Gene Symbol and Name | Gnrh1, gonadotropin releasing hormone 1 |
Gene Synonym(s) | |
Strain of Origin | C3H101H-Rb(1.3)1Bnr |
Chromosome | 14 |
Molecular Note | The mutation in the hypogonadal mouse is an approximately 33.5 kb deletion that removes two exons that encode most of the protein. |
Homozygotes are infertile.
When using the HPG/BmJ mouse strain in a publication, please include JAX stock #000804 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Homozygous or Wild-type for Gnrh1<hpg>, 1 pair minimum |
Frozen Mouse Embryo | HPG/BmJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | HPG/BmJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | HPG/BmJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | HPG/BmJ Frozen Embryos | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.