LT.CAST-Gpt^a/Gpt^b Gpd1^b/Gpd1^d/J

Stock number: 000793

Detailed description

These congenic mice are heterozygous for the Gpt alleles and the Gpd1 alleles from LT/SvEi (Gpt^a, Gpd1^b) and the wild derived CAST/Ei strain (Gpt^b, Gpd1^d).

Development

LT/SvEi was crossed once to CAST/Ei and the offspring were backcrossed to LT/SvEi to transfer the Mus castaneus derived Gpt^b and Gpd1^d alleles onto LT/SvEi. At N10 mice carrying both Mus casteneus alleles were intercrossed to generate an LT/SvEi congenic strain homozygous for Gpt^b and Gpd1^d. In 1982 N10F8 males from this strain were bred with LT/SvEi females to generate N11F1 embryos for cryopreservation as Stock No. 000793. The congenic interval may or may not have been shortened by this backcross. The strain continued to be maintained on the shelf and in 1988 homozygous N10F29 mice were bred together to generate embryos for cryopreservation as Stock No. 001440.

Allele

MGI accession ID: MGI:95679
Marker symbol: Gpd1
Marker name: glycerol-3-phosphate dehydrogenase 1 (soluble)
Marker synonyms: Gdc1; Gdc-1; Gpd3; GPD-C; GPDH; GPDH-C; HTGTI
Chromosome: 15

Allele

MGI accession ID: MGI:95802
Marker symbol: Gpt
Marker name: glutamic pyruvic transaminase, soluble
Marker synonyms: 1300007J06Rik; 2310022B03Rik; AAT1; ALAT; ALT; ALT1; Gpt1; Gpt-1; SGPT
Chromosome: 15