These congenic mice are heterozygous for the Gpt alleles and the Gpd1 alleles from LT/SvEi (Gpta, Gpd1b) and the wild derived CAST/Ei strain (Gptb, Gpd1d).
Genetic Background | Generation |
---|---|
|
Marker Symbol | Marker Name | |
---|---|---|
Gpd1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | |
Gpt | glutamic pyruvic transaminase, soluble |
These congenic mice are heterozygous for the Gpt alleles and the Gpd1 alleles from LT/SvEi (Gpta, Gpd1b) and the wild derived CAST/Ei strain (Gptb, Gpd1d).
LT/SvEi was crossed once to CAST/Ei and the offspring were backcrossed to LT/SvEi to transfer the Mus castaneus derived Gptb and Gpd1d alleles onto LT/SvEi. At N10 mice carrying both Mus casteneus alleles were intercrossed to generate an LT/SvEi congenic strain homozygous for Gptb and Gpd1d. In 1982 N10F8 males from this strain were bred with LT/SvEi females to generate N11F1 embryos for cryopreservation as Stock No. 000793. The congenic interval may or may not have been shortened by this backcross. The strain continued to be maintained on the shelf and in 1988 homozygous N10F29 mice were bred together to generate embryos for cryopreservation as Stock No. 001440.
When using the LT.CAST-Gpta/Gptb Gpd1b/Gpd1d/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #000793 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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all offspring are Gpt<a>/Gpt<b> Gpd1<b>/Gpd1<d> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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