JAX
Mouse Strain Datasheet - 000692
WB/ReJ KitW/J
Also Known As: WB
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Kit mice generally have a well-defined belly spot with sharp edges and a very variable amount of white in the dorsal coat.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
|
F202
|
KitW
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Kit | KIT proto-oncogene receptor tyrosine kinase |
Pde6brd1
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Research Applications
- Sensorineural Research
- Cancer Research
- Dermatology Research
- Developmental Biology Research
- Endocrine Deficiency Research
- Immunology, Inflammation and Autoimmunity Research
- Neurobiology Research
- Reproductive Biology Research
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Detailed Description
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone.
Development
Mice carrying the KitW mutation were sent from Dr. S. J. Holman and Dr. Salome Waelsch to Elizabeth Russell at The Jackson Laboratory in the late 1940?s. Female #168 was bred with male #169 to begin the generation of inbred lines segregating for KitW and the resulting inbred lines were selected for frequency and longevity of homozygotes. The lines were maintained by full sibling inbreeding and line WB separated from WC at generation F8. Prior to F25 homozygotes on the WB background showed an average lifespan of 10.6 days. Additionally, the mean age of first litter at that time, 75 days, was earlier than that of WC, which was 92 days of age (Russell and McFarland, 1966). In 1960 WB/Re reached generation F36, in 1965 F56, in 1975 F97, in 1986 F126, in 1992 F138, and in 2010 F191. Embryos were cryopreserved in 1987.
Control Suggestions
Selected References
- Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. PubMed: 1559233MGI: J:468
- Cheers C; McKenzie IF. 1978. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19(3):755-62. PubMed: 305895MGI: J:5965
- Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. PubMed: 4337905MGI: J:5274
- Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. PubMed: 1693331MGI: J:10528
- Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. PubMed: 10857580MGI: J:109890
- Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type J Hered 50:19-25. MGI: J:2469
- Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. PubMed: 11578878MGI: J:71914
KitW
Allele Symbol: KitW
| Allele Name | dominant spotting |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | W |
| Gene Symbol and Name | Kit, KIT proto-oncogene receptor tyrosine kinase |
| Gene Synonym(s) | Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco1; Gsfsco5; Gsfsco5; Gsfsow3; Gsfsow3; MASTC; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; belly-spot; c-KIT; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male |
| Strain of Origin | old mutant of the mouse fancy |
| Chromosome | 5 |
| General Note | This is an old mutant of the mouse fancy. KitW mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286). |
| Molecular Note | A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing. |
Pde6brd1
Allele Symbol: Pde6brd1
| Allele Name | retinal degeneration 1 |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | Pdebrd1; rd; rd-1; rd1; rodless retina |
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
| Gene Synonym(s) | CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10 |
| Strain of Origin | various |
| Chromosome | 5 |
| General Note | The following inbred strains are known to be homozygous for Pde6b |
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Sensorineural Research
- Retinal Degeneration
- Pde6brd1
- Retinal Degeneration
Genotype: KitW related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Increased Tumor Incidence
- Gonadal Tumors
- Gonadal Tumors: ovarian
- Oncogenes
- Dermatology Research
- Color and White Spotting Defects
- Developmental Biology Research
- Neural Crest Defects
- Endocrine Deficiency Research
- Bone/Bone Marrow Defects
- Gonad Defects
- Skin Defects
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
- Mast Cell Deficiency
- Immunodeficiency
- Neurobiology Research
- Hearing Defects
- Receptor Defects
- Reproductive Biology Research
- Developmental Defects Affecting Gonads
- germ cell deficient
- Fertility Defects
- Gonadal Tumors
- ovarian
- Developmental Defects Affecting Gonads
- Research Tools
- Immunology, Inflammation and Autoimmunity Research
- Mast Cell Deficiency
- Immunology, Inflammation and Autoimmunity Research
- Sensorineural Research
- Hearing Defects
- Retinal Degeneration
Genotype: Pde6brd1 related
- Sensorineural Research
- Retinal Degeneration
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: KitW/Kit+
Not Specified
pigmentation phenotype
- abnormal coat/hair pigmentation
- (MGI Ref ID J:12955)
- irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance (MGI Ref ID J:12955)
- variable body spotting
- Background Sensitivity - variable amounts of white spotting (MGI Ref ID J:12955)
hematopoietic system phenotype
- hematopoietic system phenotype
- blood parameters are normal (MGI Ref ID J:14978)
reproductive system phenotype
- reproductive system phenotype
- system is normal (MGI Ref ID J:14978)
integument phenotype
- abnormal coat/hair pigmentation
- (MGI Ref ID J:12955)
- irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance (MGI Ref ID J:12955)
- variable body spotting
- Background Sensitivity - variable amounts of white spotting (MGI Ref ID J:12955)
Genotype: KitW/KitW
B6.Cg-KitW/J
growth/size/body region phenotype
- decreased body weight
- weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings (MGI Ref ID J:243758)
hematopoietic system phenotype
- macrocytic anemia
- identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is greatest in W/W homozygotes compared with homozygotes for the viable dominant spotting allele or compound heterozgyotes (MGI Ref ID J:243758)
mortality/aging
- abnormal survival
- heterozygous intercrosses produce only 14.5% homozygotes instead of the 25% expected, one sixth of which are born dead or die perinatally and nearly all the remainder die by 3 days of age, without postnatal growth (MGI Ref ID J:243758)
- perinatal lethality, incomplete penetrance
- (MGI Ref ID J:243758)
- prenatal lethality
- (MGI Ref ID J:243758)
Genotype: KitW/KitW
Not Specified
mortality/aging
- postnatal lethality, complete penetrance
- death is within the first week of birth (MGI Ref ID J:12955)
hematopoietic system phenotype
- macrocytic anemia
- macrocytic anemia begins at 12 days gestation leading to death within the first week of birth (MGI Ref ID J:14978)
pigmentation phenotype
- abnormal eye pigmentation
- pigment is restricted to retina (MGI Ref ID J:12955)
- absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color (MGI Ref ID J:12955)
vision/eye phenotype
- abnormal eye pigmentation
- pigment is restricted to retina (MGI Ref ID J:12955)
integument phenotype
- absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color (MGI Ref ID J:12955)
References
- Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. PubMed: 1559233MGI: J:468
- Cheers C; McKenzie IF. 1978. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19(3):755-62. PubMed: 305895MGI: J:5965
- Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. PubMed: 4337905MGI: J:5274
- Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. PubMed: 1693331MGI: J:10528
- Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. PubMed: 10857580MGI: J:109890
- Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type J Hered 50:19-25. MGI: J:2469
- Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. PubMed: 11578878MGI: J:71914
Additional References
- Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768MGI: J:75095
- Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. PubMed: 1764248MGI: J:619
- Lai YL; Li H; Chiang HS; Hsieh-Li HM. 2002. Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis. Mech Dev 113(2):185-7. PubMed: 11960710MGI: J:76545
- Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. PubMed: 11784036MGI: J:72582
Additional - KitW related
- Agosti V; Corbacioglu S; Ehlers I; Waskow C; Sommer G; Berrozpe G; Kissel H; Tucker CM; Manova K; Moore MA; Rodewald HR; Besmer P. 2004. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med 199(6):867-78. PubMed: 15024050MGI: J:90485
- Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10):4180-91. PubMed: 21926462MGI: J:178494
- Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res 98:97-103. PubMed: 22504036MGI: J:196831
- Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J Invest Dermatol 131(9):1906-15. PubMed: 21633369MGI: J:182201
- Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. PubMed: 19553284MGI: J:152856
- Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Moriishi K; Nakao A; Shimada S. 2016. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity. J Invest Dermatol 136(6):1290-2. PubMed: 26872602MGI: J:233457
- Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. PubMed: 23528820MGI: J:200049
- Arac A; Grimbaldeston MA; Nepomuceno AR; Olayiwola O; Pereira MP; Nishiyama Y; Tsykin A; Goodall GJ; Schlecht U; Vogel H; Tsai M; Galli SJ; Bliss TM; Steinberg GK. 2014. Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol 184(9):2493-504. PubMed: 25134760MGI: J:214825
- Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. PubMed: 16330751MGI: J:104357
- Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. PubMed: 21982232MGI: J:177655
- Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. PubMed: 16467148MGI: J:106065
- Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. PubMed: 10389693MGI: J:57206
- Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. PubMed: 11441111MGI: J:120524
- Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. PubMed: 16937373MGI: J:116633
- Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. PubMed: 19380799MGI: J:147712
- Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC. MGI: J:30699
- Bhetwal BP; Sanders KM; An C; Trappanese DM; Moreland RS; Perrino BA. 2013. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. J Physiol 591(Pt 12):2971-86. PubMed: 23613531MGI: J:210571
- Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. PubMed: 11085746MGI: J:65843
- Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol 184(3):1292-9. PubMed: 20038636MGI: J:159534
- Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101(12):1310-8. PubMed: 17932327MGI: J:142789
- Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol 179(5):3222-30. PubMed: 17709538MGI: J:151825
- Campagnolo L; Moscatelli I; Pellegrini M; Siracusa G; Stuhlmann H. 2008. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 8(6):389-96. PubMed: 18556249MGI: J:137617
- Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. PubMed: 15067077MGI: J:89115
- Carlos D; Yaochite JN; Rocha FA; Toso VD; Malmegrim KC; Ramos SG; Jamur MC; Oliver C; Camara NO; Andrade MV; Cunha FQ; Silva JS. 2015. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur J Immunol 45(10):2873-85. PubMed: 26234742MGI: J:233102
- Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28(7):1055-72. PubMed: 24825397MGI: J:210656
- Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol 185(6):3514-9. PubMed: 20709954MGI: J:163826
- Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. PubMed: 23077213MGI: J:191131
- Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. PubMed: 11602622MGI: J:72195
- Chen X; Feng BS; Zheng PY; Liao XQ; Chong J; Tang SG; Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. Am J Pathol 173(6):1647-56. PubMed: 18974296MGI: J:143927
- Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 107(9):1083-93. PubMed: 20847314MGI: J:178186
- Chikahisa S; Kodama T; Soya A; Sagawa Y; Ishimaru Y; Sei H; Nishino S. 2013. Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states. PLoS One 8(10):e78434. PubMed: 24205232MGI: J:209229
- Choi E; Han C; Park I; Lee B; Jin S; Choi H; Kim do H; Park ZY; Eddy EM; Cho C. 2008. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J Biol Chem 283(50):35283-94. PubMed: 18849567MGI: J:144592
- Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 188(9):1587-92. PubMed: 9802970MGI: J:50773
- Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction. Circulation 116(11 Suppl):I77-82. PubMed: 17846329MGI: J:139839
- Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. PubMed: 6971254MGI: J:6485
- Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. PubMed: 10229862MGI: J:119786
- Colucci F; Di Santo JP. 2000. The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells. Blood 95(3):984-91. PubMed: 10648413MGI: J:59898
- Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. PubMed: 12444173MGI: J:124384
- Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. PubMed: 11937563MGI: J:125656
- Cunin P; Penke LR; Thon JN; Monach PA; Jones T; Chang MH; Chen MM; Melki I; Lacroix S; Iwakura Y; Ware J; Gurish MF; Italiano JE; Boilard E; Nigrovic PA. 2017. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest 127(5):1714-1724. PubMed: 28375155MGI: J:244360
- D'Andrea MR; Saban MR; Gerard NP; Wershil BK; Saban R. 2005. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. Am J Physiol Regul Integr Comp Physiol 288(2):R491-500. PubMed: 15458971MGI: J:95761
- Dastych J; Taub D; Hardison MC; Metcalfe DD. 1998. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol 275(5 Pt 1):C1291-9. PubMed: 9814978MGI: J:50928
- Depinay N; Hacini F; Beghdadi W; Peronet R; Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176(7):4141-6. PubMed: 16547250MGI: J:129876
- Dietz JA; Li Y; Chung LM; Yandell BS; Schlamp CL; Nickells RW. 2008. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC Neurosci 9:74. PubMed: 18671875MGI: J:142950
- Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation. J Cell Sci 121(Pt 2):167-77. PubMed: 18089649MGI: J:130856
- Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 99(5):915-25. PubMed: 9062349MGI: J:78651
- Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 176(11):7062-70. PubMed: 16709868MGI: J:131785
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