JAX Mouse Strain Datasheet - 000692

WB/ReJ Kit^W/J

Stock No:: 000692 |; WB

Available Now

Overview

Also Known As: WB

Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Kit mice generally have a well-defined belly spot with sharp edges and a very variable amount of white in the dorsal coat.

Genetic overview

Genetic Background	Generation
	F202 (05-AUG-14)

Kit^W

Allele Type	Gene Symbol	Gene Name
Spontaneous	Kit	KIT proto-oncogene receptor tyrosine kinase

Pde6b^rd1

Allele Type	Gene Symbol	Gene Name
Spontaneous	Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide

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Research Applications

Sensorineural Research
Cancer Research
Dermatology Research
Developmental Biology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Reproductive Biology Research

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Base Price

Starting at:

$331.46 Domestic price for female 3-week

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

Development

Mice carrying the Kit^W mutation were sent from Dr. S. J. Holman and Dr. Salome Waelsch to Elizabeth Russell at The Jackson Laboratory in the late 1940?s. Female #168 was bred with male #169 to begin the generation of inbred lines segregating for Kit^W and the resulting inbred lines were selected for frequency and longevity of homozygotes. The lines were maintained by full sibling inbreeding and line WB separated from WC at generation F8. Prior to F25 homozygotes on the WB background showed an average lifespan of 10.6 days. Additionally, the mean age of first litter at that time, 75 days, was earlier than that of WC, which was 92 days of age (Russell and McFarland, 1966). In 1960 WB/Re reached generation F36, in 1965 F56, in 1975 F97, in 1986 F126, in 1992 F138, and in 2010 F191. Embryos were cryopreserved in 1987.

Control Suggestions

Wild-type from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).. In: . . MGI: J:468
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells.. In: . . MGI: J:5274
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.. In: . . MGI: J:10528
Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia.. In: . . MGI: J:109890
Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type. In: . . MGI: J:2469
Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis.. In: . . MGI: J:71914

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Genetics

Kit^W

Allele Symbol: Kit^W

Allele Name	dominant spotting
Allele Type	Spontaneous
Allele Synonym(s)	W
Gene Symbol and Name	Kit, KIT proto-oncogene receptor tyrosine kinase
Gene Synonym(s)	Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco1; Gsfsco5; Gsfsco5; Gsfsow3; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; belly-spot; c-KIT; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male
Strain of Origin	old mutant of the mouse fancy
Chromosome	5
General Note	This is an old mutant of the mouse fancy. Kit^W mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286).
Molecular Note	A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Sensorineural Research
- Retinal Degeneration
  - Pde6b^rd1

Genotype: Kit^W related

Cancer Research
- Growth Factors/Receptors/Cytokines
- Increased Tumor Incidence
  - Gonadal Tumors
  - Gonadal Tumors: ovarian
- Oncogenes
Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Neural Crest Defects
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
- Gonad Defects
- Skin Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - Mast Cell Deficiency
Neurobiology Research
- Hearing Defects
- Receptor Defects
Reproductive Biology Research
- Developmental Defects Affecting Gonads
  - germ cell deficient
- Fertility Defects
- Gonadal Tumors
  - ovarian
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - Mast Cell Deficiency
Sensorineural Research
- Hearing Defects
- Retinal Degeneration

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Kit^W/Kit⁺
Not Specified

pigmentation phenotype

abnormal coat/hair pigmentation

irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting
- Background Sensitivity - variable amounts of white spotting

hematopoietic system phenotype

hematopoietic system phenotype
- blood parameters are normal

reproductive system phenotype

reproductive system phenotype
- system is normal

integument phenotype

abnormal coat/hair pigmentation

irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting
- Background Sensitivity - variable amounts of white spotting

Genotype: Kit^W/Kit^W
Not Specified

mortality/aging

postnatal lethality, complete penetrance
- death is within the first week of birth

hematopoietic system phenotype

macrocytic anemia
- macrocytic anemia begins at 12 days gestation leading to death within the first week of birth

pigmentation phenotype

abnormal eye pigmentation
- pigment is restricted to retina

absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color

vision/eye phenotype

abnormal eye pigmentation
- pigment is restricted to retina

integument phenotype

absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color

References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).. In: . . MGI: J:468
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells.. In: . . MGI: J:5274
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.. In: . . MGI: J:10528
Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia.. In: . . MGI: J:109890
Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type. In: . . MGI: J:2469
Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis.. In: . . MGI: J:71914

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse.. In: . . MGI: J:75095
Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells.. In: . . MGI: J:619
Lai YL; Li H; Chiang HS; Hsieh-Li HM. 2002. Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.. In: . . MGI: J:76545
Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity.. In: . . MGI: J:72582

Additional - Kit^W related

Agosti V; Corbacioglu S; Ehlers I; Waskow C; Sommer G; Berrozpe G; Kissel H; Tucker CM; Manova K; Moore MA; Rodewald HR; Besmer P. 2004. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development.. In: . . MGI: J:90485
Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.. In: . . MGI: J:178494
Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.. In: . . MGI: J:196831
Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress.. In: . . MGI: J:182201
Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes.. In: . . MGI: J:152856
Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Moriishi K; Nakao A; Shimada S. 2016. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity.. In: . . MGI: J:233457
Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production.. In: . . MGI: J:200049
Arac A; Grimbaldeston MA; Nepomuceno AR; Olayiwola O; Pereira MP; Nishiyama Y; Tsykin A; Goodall GJ; Schlecht U; Vogel H; Tsai M; Galli SJ; Bliss TM; Steinberg GK. 2014. Evidence that meningeal mast cells can worsen stroke pathology in mice.. In: . . MGI: J:214825
Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.. In: . . MGI: J:104357
Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.. In: . . MGI: J:177655
Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.. In: . . MGI: J:106065
Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice.. In: . . MGI: J:57206
Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung.. In: . . MGI: J:120524
Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract.. In: . . MGI: J:116633
Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.. In: . . MGI: J:147712
Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC. MGI: J:30699
Bhetwal BP; Sanders KM; An C; Trappanese DM; Moreland RS; Perrino BA. 2013. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus.. In: . . MGI: J:210571
Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. In: . . MGI: J:65843
Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.. In: . . MGI: J:159534
Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia.. In: . . MGI: J:142789
Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines?. In: . . MGI: J:151825
Campagnolo L; Moscatelli I; Pellegrini M; Siracusa G; Stuhlmann H. 2008. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes.. In: . . MGI: J:137617
Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets.. In: . . MGI: J:89115
Carlos D; Yaochite JN; Rocha FA; Toso VD; Malmegrim KC; Ramos SG; Jamur MC; Oliver C; Camara NO; Andrade MV; Cunha FQ; Silva JS. 2015. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice.. In: . . MGI: J:233102
Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.. In: . . MGI: J:210656
Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.. In: . . MGI: J:163826
Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.. In: . . MGI: J:191131
Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid.. In: . . MGI: J:72195
Chen X; Feng BS; Zheng PY; Liao XQ; Chong J; Tang SG; Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine.. In: . . MGI: J:143927
Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity.. In: . . MGI: J:178186
Chikahisa S; Kodama T; Soya A; Sagawa Y; Ishimaru Y; Sei H; Nishino S. 2013. Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states.. In: . . MGI: J:209229
Choi E; Han C; Park I; Lee B; Jin S; Choi H; Kim do H; Park ZY; Eddy EM; Cho C. 2008. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis.. In: . . MGI: J:144592
Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.. In: . . MGI: J:50773
Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction.. In: . . MGI: J:139839
Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity.. In: . . MGI: J:6485
Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.. In: . . MGI: J:119786
Colucci F; Di Santo JP. 2000. The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells.. In: . . MGI: J:59898
Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis.. In: . . MGI: J:124384
Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG.. In: . . MGI: J:125656
D'Andrea MR; Saban MR; Gerard NP; Wershil BK; Saban R. 2005. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves.. In: . . MGI: J:95761
Dastych J; Taub D; Hardison MC; Metcalfe DD. 1998. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis.. In: . . MGI: J:50928
Depinay N; Hacini F; Beghdadi W; Peronet R; Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites.. In: . . MGI: J:129876
Dietz JA; Li Y; Chung LM; Yandell BS; Schlamp CL; Nickells RW. 2008. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.. In: . . MGI: J:142950
Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation.. In: . . MGI: J:130856
Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.. In: . . MGI: J:78651
Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.. In: . . MGI: J:131785
Dunford PJ; Williams KN; Desai PJ; Karlsson L; McQueen D; Thurmond RL. 2007. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.. In: . . MGI: J:169999
Dunn LC. 1937. Studies on Spotting Patterns II. Genetic Analysis of Variegated Spotting in the House Mouse.. In: . . MGI: J:12955
Ebihara C; Ebihara K; Aizawa-Abe M; Mashimo T; Tomita T; Zhao M; Gumbilai V; Kusakabe T; Yamamoto Y; Aotani D; Yamamoto-Kataoka S; Sakai T; Hosoda K; Serikawa T; Nakao K. 2015. Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.. In: . . MGI: J:226956
Edelson BT; Li Z; Pappan LK; Zutter MM. 2004. Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin.. In: . . MGI: J:88567
Eller K; Wolf D; Huber JM; Metz M; Mayer G; McKenzie AN; Maurer M; Rosenkranz AR; Wolf AM. 2011. IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.. In: . . MGI: J:168723
Everett ET; Pablos JL; Harley RA; LeRoy EC; Norris JS. 1995. The role of mast cells in the development of skin fibrosis in tight-skin mutant mice.. In: . . MGI: J:24076
Fazel S; Cimini M; Chen L; Li S; Angoulvant D; Fedak P; Verma S; Weisel RD; Keating A; Li RK. 2006. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines.. In: . . MGI: J:111717
Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea.. In: . . MGI: J:123928
Feng ZC; Donnelly L; Li J; Krishnamurthy M; Riopel M; Wang R. 2012. Inhibition of Gsk3beta activity improves beta-cell function in c-Kit(Wv/+) male mice.. In: . . MGI: J:181933
Fewkes NM; Krauss AC; Guimond M; Meadors JL; Dobre S; Mackall CL. 2010. Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation.. In: . . MGI: J:160231
Feyerabend TB; Weiser A; Tietz A; Stassen M; Harris N; Kopf M; Radermacher P; Moller P; Benoist C; Mathis D; Fehling HJ; Rodewald HR. 2011. Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity.. In: . . MGI: J:178942
Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses.. In: . . MGI: J:112038
Forrest AS; Hennig GW; Jokela-Willis S; Park CD; Sanders KM. 2009. Prostaglandin regulation of gastric slow waves and peristalsis.. In: . . MGI: J:149682
Fujimura T; Furukawa H; Doi Y; Makishima K; Fujimoto S. 1999. Immunoreactivity of endothelins and endothelin receptor in the stria vascularis of the mouse cochlea.. In: . . MGI: J:108904
Fujimura T; Suzuki H; Shimizu T; Tokui N; Kitamura T; Udaka T; Doi Y. 2005. Pathological alterations of strial capillaries in dominant white spotting W/Wv mice.. In: . . MGI: J:102420
Furusawa J; Moro K; Motomura Y; Okamoto K; Zhu J; Takayanagi H; Kubo M; Koyasu S. 2013. Critical role of p38 and GATA3 in natural helper cell function.. In: . . MGI: J:205695
Furuta T; Kikuchi T; Iwakura Y; Watanabe N. 2006. Protective roles of mast cells and mast cell-derived TNF in murine malaria.. In: . . MGI: J:139538
Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles.. In: . . MGI: J:6571
Goldman DC; Berg LK; Heinrich MC; Christian JL. 2006. Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus.. In: . . MGI: J:131233
Gore BB; Wong KG; Tessier-Lavigne M. 2008. Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target.. In: . . MGI: J:132880
Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.. In: . . MGI: J:125267
Gruneberg H. 1942. Inherited macrocytic anaemias in the house mouse. II. Dominance relationships. In: . . MGI: J:14978
Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing.. In: . . MGI: J:119138
Gutierrez DA; Muralidhar S; Feyerabend TB; Herzig S; Rodewald HR. 2015. Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance.. In: . . MGI: J:225848
Hasegawa H; Noguchi J; Yamashita M; Okada R; Sugimoto R; Furuya M; Unoki T; Funakoshi Y; Baba T; Kanaho Y. 2012. Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.. In: . . MGI: J:185835
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Additional - Pde6b^rd1 related

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Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases.. In: . . MGI: J:122802
Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.. In: . . MGI: J:154966
Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.. In: . . MGI: J:177906
Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades.. In: . . MGI: J:167121
Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration.. In: . . MGI: J:92980
Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration.. In: . . MGI: J:109668
Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina.. In: . . MGI: J:121036
Arango-Gonzalez B; Trifunovic D; Sahaboglu A; Kranz K; Michalakis S; Farinelli P; Koch S; Koch F; Cottet S; Janssen-Bienhold U; Dedek K; Biel M; Zrenner E; Euler T; Ekstrom P; Ueffing M; Paquet-Durand F. 2014. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.. In: . . MGI: J:225151
Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease.. In: . . MGI: J:136304
Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye.. In: . . MGI: J:98579
Ash JA; Velazquez R; Kelley CM; Powers BE; Ginsberg SD; Mufson EJ; Strupp BJ. 2014. Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.. In: . . MGI: J:218355
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Audo I; Bujakowska K; Orhan E; Poloschek CM; Defoort-Dhellemmes S; Drumare I; Kohl S; Luu TD; Lecompte O; Zrenner E; Lancelot ME; Antonio A; Germain A; Michiels C; Audier C; Letexier M; Saraiva JP; Leroy BP; Munier FL; Mohand-Said S; Lorenz B; Friedburg C; Preising M; Kellner U; Renner AB; Moskova-Doumanova V; Berger W; Wissinger B; Hamel CP; Schorderet DF; De Baere E; Sharon D; Banin E; Jacobson SG; Bonneau D; Zanlonghi X; Le Meur G; Casteels I; Koenekoop R; Long VW; Meire F; Prescott K; de Ravel T; Simm. 2012. Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness.. In: . . MGI: J:196741
Ayturk DG; Castrucci AM; Carr DE; Keller SR; Provencio I. 2015. Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge.. In: . . MGI: J:237743
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Bhatti F; Ball G; Hobbs R; Linens A; Munzar S; Akram R; Barber AJ; Anderson M; Elliott M; Edwards M. 2015. Pulmonary surfactant protein a is expressed in mouse retina by Muller cells and impacts neovascularization in oxygen-induced retinopathy.. In: . . MGI: J:230990
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Buhr ED; Yue WW; Ren X; Jiang Z; Liao HW; Mei X; Vemaraju S; Nguyen MT; Reed RR; Lang RA; Yau KW; Van Gelder RN. 2015. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.. In: . . MGI: J:227078
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Busskamp V; Duebel J; Balya D; Fradot M; Viney TJ; Siegert S; Groner AC; Cabuy E; Forster V; Seeliger M; Biel M; Humphries P; Paques M; Mohand-Said S; Trono D; Deisseroth K; Sahel JA; Picaud S; Roska B. 2010. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa.. In: . . MGI: J:162017
Cai R; Xue W; Liu S; Petersen RB; Huang K; Zheng L. 2015. Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury.. In: . . MGI: J:225470
Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study.. In: . . MGI: J:5250
Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction.. In: . . MGI: J:146469
Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina.. In: . . MGI: J:5988
Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse.. In: . . MGI: J:39262
Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations.. In: . . MGI: J:59343
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse.. In: . . MGI: J:75095
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases.. In: . . MGI: J:156373
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Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration.. In: . . MGI: J:191520
Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas.. In: . . MGI: J:143166
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Nuhn JS; Fuerst PG. 2014. Developmental localization of adhesion and scaffolding proteins at the cone synapse.. In: . . MGI: J:216508
O'Leary TP; Brown RE. 2009. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.. In: . . MGI: J:148386
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Owens L; Buhr E; Tu DC; Lamprecht TL; Lee J; Van Gelder RN. 2012. Effect of circadian clock gene mutations on nonvisual photoreception in the mouse.. In: . . MGI: J:191526
Panda S; Provencio I; Tu DC; Pires SS; Rollag MD; Castrucci AM; Pletcher MT; Sato TK; Wiltshire T; Andahazy M; Kay SA; Van Gelder RN; Hogenesch JB. 2003. Melanopsin is required for non-image-forming photic responses in blind mice.. In: . . MGI: J:165769
Panda S; Sato TK; Castrucci AM; Rollag MD; DeGrip WJ; Hogenesch JB; Provencio I; Kay SA. 2002. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting.. In: . . MGI: J:81501
Pang J; Cheng M; Haire SE; Barker E; Planelles V; Blanks JC. 2006. Efficiency of lentiviral transduction during development in normal and rd mice.. In: . . MGI: J:111621
Paper W; Kroeber M; Heersink S; Stephan DA; Fuchshofer R; Russell P; Tamm ER. 2008. Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression.. In: . . MGI: J:141881
Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models.. In: . . MGI: J:146653
Paquet-Durand F; Azadi S; Hauck SM; Ueffing M; van Veen T; Ekstrom P. 2006. Calpain is activated in degenerating photoreceptors in the rd1 mouse.. In: . . MGI: J:106017
Paquet-Durand F; Beck S; Michalakis S; Goldmann T; Huber G; Muhlfriedel R; Trifunovic D; Fischer MD; Fahl E; Duetsch G; Becirovic E; Wolfrum U; van Veen T; Biel M; Tanimoto N; Seeliger MW. 2011. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.. In: . . MGI: J:169039
Park H; Tan CC; Faulkner A; Jabbar SB; Schmid G; Abey J; Iuvone PM; Pardue MT. 2013. Retinal degeneration increases susceptibility to myopia in mice.. In: . . MGI: J:205341
Park SJ; Lee DS; Lim EJ; Choi SH; Kang WS; Kim IB; Chun MH. 2008. The absence of the clathrin-dependent endocytosis in rod bipolar cells of the FVB/N mouse retina.. In: . . MGI: J:137049
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Also Known As: WB

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KitW

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Pde6brd1

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Kit^W

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