JAX Mouse Strain Datasheet - 000692

WB/ReJ Kit^W/J

Stock No:: 000692 |; WB

Available Now

Overview

Also Known As: WB

Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Kit mice generally have a well-defined belly spot with sharp edges and a very variable amount of white in the dorsal coat.

Genetic overview

Genetic Background	Generation
	F202 (05-AUG-14)

Kit^W

Allele Type	Gene Symbol	Gene Name
Spontaneous	Kit	KIT proto-oncogene receptor tyrosine kinase

Pde6b^rd1

Allele Type	Gene Symbol	Gene Name
Spontaneous	Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide

View Genetics

Research Applications

Sensorineural Research
Cancer Research
Dermatology Research
Developmental Biology Research
Endocrine Deficiency Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Reproductive Biology Research

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Base Price

Starting at:

$331.46 Domestic price for female 3-week

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

Development

Mice carrying the Kit^W mutation were sent from Dr. S. J. Holman and Dr. Salome Waelsch to Elizabeth Russell at The Jackson Laboratory in the late 1940?s. Female #168 was bred with male #169 to begin the generation of inbred lines segregating for Kit^W and the resulting inbred lines were selected for frequency and longevity of homozygotes. The lines were maintained by full sibling inbreeding and line WB separated from WC at generation F8. Prior to F25 homozygotes on the WB background showed an average lifespan of 10.6 days. Additionally, the mean age of first litter at that time, 75 days, was earlier than that of WC, which was 92 days of age (Russell and McFarland, 1966). In 1960 WB/Re reached generation F36, in 1965 F56, in 1975 F97, in 1986 F126, in 1992 F138, and in 2010 F191. Embryos were cryopreserved in 1987.

Control Suggestions

Wild-type from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. PubMed: 1559233 MGI: J:468
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. PubMed: 4337905 MGI: J:5274
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. PubMed: 1693331 MGI: J:10528
Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. PubMed: 10857580 MGI: J:109890
Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type J Hered 50:19-25. MGI: J:2469
Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. PubMed: 11578878 MGI: J:71914

View All References

Genetics

Kit^W

Allele Symbol: Kit^W

Allele Name	dominant spotting
Allele Type	Spontaneous
Allele Synonym(s)	W
Gene Symbol and Name	Kit, KIT proto-oncogene receptor tyrosine kinase
Gene Synonym(s)	Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco1; Gsfsco5; Gsfsco5; Gsfsow3; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; belly-spot; c-KIT; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male
Strain of Origin	old mutant of the mouse fancy
Chromosome	5
General Note	This is an old mutant of the mouse fancy. Kit^W mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286).
Molecular Note	A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Sensorineural Research
- Retinal Degeneration
  - Pde6b^rd1

Genotype: Kit^W related

Cancer Research
- Growth Factors/Receptors/Cytokines
- Increased Tumor Incidence
  - Gonadal Tumors
  - Gonadal Tumors: ovarian
- Oncogenes
Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Neural Crest Defects
Endocrine Deficiency Research
- Bone/Bone Marrow Defects
- Gonad Defects
- Skin Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - Mast Cell Deficiency
Neurobiology Research
- Hearing Defects
- Receptor Defects
Reproductive Biology Research
- Developmental Defects Affecting Gonads
  - germ cell deficient
- Fertility Defects
- Gonadal Tumors
  - ovarian
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - Mast Cell Deficiency
Sensorineural Research
- Hearing Defects
- Retinal Degeneration

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Kit^W/Kit⁺
Not Specified

pigmentation phenotype

abnormal coat/hair pigmentation

irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting
- Background Sensitivity - variable amounts of white spotting

hematopoietic system phenotype

hematopoietic system phenotype
- blood parameters are normal

reproductive system phenotype

reproductive system phenotype
- system is normal

integument phenotype

abnormal coat/hair pigmentation

irregular coat pigmentation
- pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting
- Background Sensitivity - variable amounts of white spotting

Genotype: Kit^W/Kit^W
Not Specified

mortality/aging

postnatal lethality, complete penetrance
- death is within the first week of birth

hematopoietic system phenotype

macrocytic anemia
- macrocytic anemia begins at 12 days gestation leading to death within the first week of birth

pigmentation phenotype

abnormal eye pigmentation
- pigment is restricted to retina

absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color

vision/eye phenotype

abnormal eye pigmentation
- pigment is restricted to retina

integument phenotype

absent coat pigmentation
- white coat color, vividly contrasts with normal black eye color

References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. PubMed: 1559233 MGI: J:468
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. PubMed: 4337905 MGI: J:5274
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. PubMed: 1693331 MGI: J:10528
Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. PubMed: 10857580 MGI: J:109890
Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type J Hered 50:19-25. MGI: J:2469
Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. PubMed: 11578878 MGI: J:71914

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768 MGI: J:75095
Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. PubMed: 1764248 MGI: J:619
Lai YL; Li H; Chiang HS; Hsieh-Li HM. 2002. Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis. Mech Dev 113(2):185-7. PubMed: 11960710 MGI: J:76545
Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. PubMed: 11784036 MGI: J:72582

Additional - Kit^W related

Agosti V; Corbacioglu S; Ehlers I; Waskow C; Sommer G; Berrozpe G; Kissel H; Tucker CM; Manova K; Moore MA; Rodewald HR; Besmer P. 2004. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med 199(6):867-78. PubMed: 15024050 MGI: J:90485
Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10):4180-91. PubMed: 21926462 MGI: J:178494
Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res 98:97-103. PubMed: 22504036 MGI: J:196831
Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J Invest Dermatol 131(9):1906-15. PubMed: 21633369 MGI: J:182201
Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. PubMed: 19553284 MGI: J:152856
Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Moriishi K; Nakao A; Shimada S. 2016. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity. J Invest Dermatol 136(6):1290-2. PubMed: 26872602 MGI: J:233457
Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. PubMed: 23528820 MGI: J:200049
Arac A; Grimbaldeston MA; Nepomuceno AR; Olayiwola O; Pereira MP; Nishiyama Y; Tsykin A; Goodall GJ; Schlecht U; Vogel H; Tsai M; Galli SJ; Bliss TM; Steinberg GK. 2014. Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol 184(9):2493-504. PubMed: 25134760 MGI: J:214825
Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. PubMed: 16330751 MGI: J:104357
Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. PubMed: 21982232 MGI: J:177655
Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. PubMed: 16467148 MGI: J:106065
Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. PubMed: 10389693 MGI: J:57206
Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. PubMed: 11441111 MGI: J:120524
Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. PubMed: 16937373 MGI: J:116633
Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. PubMed: 19380799 MGI: J:147712
Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC. MGI: J:30699
Bhetwal BP; Sanders KM; An C; Trappanese DM; Moreland RS; Perrino BA. 2013. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. J Physiol 591(Pt 12):2971-86. PubMed: 23613531 MGI: J:210571
Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. PubMed: 11085746 MGI: J:65843
Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol 184(3):1292-9. PubMed: 20038636 MGI: J:159534
Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101(12):1310-8. PubMed: 17932327 MGI: J:142789
Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol 179(5):3222-30. PubMed: 17709538 MGI: J:151825
Campagnolo L; Moscatelli I; Pellegrini M; Siracusa G; Stuhlmann H. 2008. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 8(6):389-96. PubMed: 18556249 MGI: J:137617
Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. PubMed: 15067077 MGI: J:89115
Carlos D; Yaochite JN; Rocha FA; Toso VD; Malmegrim KC; Ramos SG; Jamur MC; Oliver C; Camara NO; Andrade MV; Cunha FQ; Silva JS. 2015. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur J Immunol 45(10):2873-85. PubMed: 26234742 MGI: J:233102
Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28(7):1055-72. PubMed: 24825397 MGI: J:210656
Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol 185(6):3514-9. PubMed: 20709954 MGI: J:163826
Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. PubMed: 23077213 MGI: J:191131
Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. PubMed: 11602622 MGI: J:72195
Chen X; Feng BS; Zheng PY; Liao XQ; Chong J; Tang SG; Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. Am J Pathol 173(6):1647-56. PubMed: 18974296 MGI: J:143927
Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 107(9):1083-93. PubMed: 20847314 MGI: J:178186
Chikahisa S; Kodama T; Soya A; Sagawa Y; Ishimaru Y; Sei H; Nishino S. 2013. Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states. PLoS One 8(10):e78434. PubMed: 24205232 MGI: J:209229
Choi E; Han C; Park I; Lee B; Jin S; Choi H; Kim do H; Park ZY; Eddy EM; Cho C. 2008. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J Biol Chem 283(50):35283-94. PubMed: 18849567 MGI: J:144592
Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 188(9):1587-92. PubMed: 9802970 MGI: J:50773
Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction. Circulation 116(11 Suppl):I77-82. PubMed: 17846329 MGI: J:139839
Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. PubMed: 6971254 MGI: J:6485
Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. PubMed: 10229862 MGI: J:119786
Colucci F; Di Santo JP. 2000. The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells. Blood 95(3):984-91. PubMed: 10648413 MGI: J:59898
Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. PubMed: 12444173 MGI: J:124384
Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. PubMed: 11937563 MGI: J:125656
D'Andrea MR; Saban MR; Gerard NP; Wershil BK; Saban R. 2005. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. Am J Physiol Regul Integr Comp Physiol 288(2):R491-500. PubMed: 15458971 MGI: J:95761
Dastych J; Taub D; Hardison MC; Metcalfe DD. 1998. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol 275(5 Pt 1):C1291-9. PubMed: 9814978 MGI: J:50928
Depinay N; Hacini F; Beghdadi W; Peronet R; Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176(7):4141-6. PubMed: 16547250 MGI: J:129876
Dietz JA; Li Y; Chung LM; Yandell BS; Schlamp CL; Nickells RW. 2008. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC Neurosci 9:74. PubMed: 18671875 MGI: J:142950
Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation. J Cell Sci 121(Pt 2):167-77. PubMed: 18089649 MGI: J:130856
Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 99(5):915-25. PubMed: 9062349 MGI: J:78651
Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 176(11):7062-70. PubMed: 16709868 MGI: J:131785
Dunford PJ; Williams KN; Desai PJ; Karlsson L; McQueen D; Thurmond RL. 2007. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol 119(1):176-83. PubMed: 17208599 MGI: J:169999
Dunn LC. 1937. Studies on Spotting Patterns II. Genetic Analysis of Variegated Spotting in the House Mouse. Genetics 22(1):43-64. PubMed: 17246829 MGI: J:12955
Ebihara C; Ebihara K; Aizawa-Abe M; Mashimo T; Tomita T; Zhao M; Gumbilai V; Kusakabe T; Yamamoto Y; Aotani D; Yamamoto-Kataoka S; Sakai T; Hosoda K; Serikawa T; Nakao K. 2015. Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis. Hum Mol Genet 24(15):4238-49. PubMed: 25934999 MGI: J:226956
Edelson BT; Li Z; Pappan LK; Zutter MM. 2004. Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin. Blood 103(6):2214-20. PubMed: 14645004 MGI: J:88567
Eller K; Wolf D; Huber JM; Metz M; Mayer G; McKenzie AN; Maurer M; Rosenkranz AR; Wolf AM. 2011. IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression. J Immunol 186(1):83-91. PubMed: 21115728 MGI: J:168723
Everett ET; Pablos JL; Harley RA; LeRoy EC; Norris JS. 1995. The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. Comp Biochem Physiol A Physiol 110(2):159-65. PubMed: 7704626 MGI: J:24076
Fazel S; Cimini M; Chen L; Li S; Angoulvant D; Fedak P; Verma S; Weisel RD; Keating A; Li RK. 2006. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116(7):1865-77. PubMed: 16823487 MGI: J:111717
Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. PubMed: 17600127 MGI: J:123928
Feng ZC; Donnelly L; Li J; Krishnamurthy M; Riopel M; Wang R. 2012. Inhibition of Gsk3beta activity improves beta-cell function in c-Kit(Wv/+) male mice. Lab Invest 92(4):543-55. PubMed: 22249311 MGI: J:181933
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KitW

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Pde6brd1

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