SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age. SWR/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE). Germline deletion of about 50% of T-cell receptor V beta-chain gene segments and a T-cell receptor V alpha polymorphism are responsible for the resistance of SWR/J mice to collagen type II-induced arthritis. SWR/J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um² atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). SWR/J mice have been recommended for generation and propogation of transgenic mice because they are high responders to exogenous hormones, have large and prominent pronuclei with good resistance to lysis following microinjection, and are genetically well-defined. SWR/J mice may also be used as controls for comparison to the autoimmune diabetic NOD/ShiLtJ mice (Stock No. 001976), especially for experiments examining the aberrant immune functions of NOD/ShiLtJ mice. Both NOD and SWR/J mice are derived from Swiss mice. SWR/J are in some cases more suitable than random bred Swiss ICR mice because of their genetic uniformity. Unlike NOD/ShiLtJ mice they are not immunocompromised, and they are genetically very different from NOD. SWR/J mice appear to be the only inbred carrying the allele Soa^a (Taster) characterized by avoidance of sucrose octaacetate solutions at low concentrations (< 10-³M).

Development

The SWR inbred strain was developed by Clara J Lynch at The Rockefeller Institute who obtained swiss mice from A. de Coulon of Lausanne, Switzerland and began inbreeding around 1926. This strain was transferred to Raymond Parker at the University of Toronto who supplied them to The Jackson Laboratory in 1947 at F28+. In 1996 embryos were cryopreserved when this strain was at inbreeding generation F191.

Selected References

Deringer MK. 1970. Mammary tumors in strains BL-LyDe and SWR-LyDe mice. J Natl Cancer Inst 45(2):215-8. PubMed: 4324608 MGI: J:69927
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. PubMed: 9148789 MGI: J:41130
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. PubMed: 1971301 MGI: J:15484
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. PubMed: 7595076 MGI: J:28648
Kutscher CL; Miller DG. 1974. Age-dependent polydipsia in the SWR-J mouse. Physiol Behav 13(1):71-9. PubMed: 4850464 MGI: J:33646
Kutscher CL; Miller M; Schmalbach NL. 1975. Renal deficiency associated with diabetes insipidus in the SWR/J mouse. Physiol Behav 14(6):815-8. PubMed: 1187837 MGI: J:25303
Kutscher CL; Schmalbach NL. 1975. Effects of water deprivation, NaCl injection, and seven aversive taste stimuli on drinking in two normal mouse strains and one with diabetes insipidus. Physiol Behav 15(6):659-67. PubMed: 1226406 MGI: J:25302
Levine S; Sowinski R. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J Immunol 110(1):139-43. PubMed: 4631068 MGI: J:24660
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7. PubMed: 8753860 MGI: J:35147
Lynch CJ. 1969. The so-called Swiss mouse. Lab Anim Care 19(2):214-20. PubMed: 4240230 MGI: J:24849
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Ortman RA; Holderbaum D; Qu XM; Banerjee S; Haqqi TM. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 152(8):4175-82. PubMed: 8144978 MGI: J:17601
Osman GE; Hannibal MC; Anderson JP; Cheunsuk S; Lasky SR; Liggitt HD; Ladiges WC; Hood LE. 1999. T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49(9):764-72. PubMed: 10398803 MGI: J:109896
Osman GE; Jacobson DP; Li SW; Hood LE; Liggitt HD; Ladiges WC. 1997. SWR: an inbred strain suitable for generating transgenic mice. Lab Anim Sci 47(2):167-71. PubMed: 9150496 MGI: J:40533
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. PubMed: 7625360 MGI: J:28248
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Serreze DV; Leiter EH. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies. J Immunol 140(11):3801-7. PubMed: 2897395 MGI: J:27617
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. PubMed: 7106865 MGI: J:6828

View All References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Disc1^del

Allele Symbol: Disc1^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	Disc1^129S6; Disc1^delta6
Gene Symbol and Name	Disc1, disrupted in schizophrenia 1
Gene Synonym(s)	C1orf136; SCZD9
Strain of Origin	various
Chromosome	8
General Note	This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note	A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; Hc^Hfib2; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	C5; C5; C5D; C5a; C5b; CPAMD4; ECLZB; He; He; Hfib2; Hfib2; hepatic fibrogenesis 2
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Increased Tumor Incidence
  - Mammary Gland Tumors
  - Other Tissues/Organs
  - Other Tissues/Organs: lung
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Susceptible
Developmental Biology Research
- Lymphoid Tissue Defects
  - hematopoietic defects
Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
  - Related Inbred Strains
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)
- Immunodeficiency
  - specific complement deficiency
Research Tools
- General Purpose
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement
Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Phenotype Information

Festing Inbred Strain Characteristics: SWR

References

Deringer MK. 1970. Mammary tumors in strains BL-LyDe and SWR-LyDe mice. J Natl Cancer Inst 45(2):215-8. PubMed: 4324608 MGI: J:69927
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. PubMed: 9148789 MGI: J:41130
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. PubMed: 1971301 MGI: J:15484
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. PubMed: 7595076 MGI: J:28648
Kutscher CL; Miller DG. 1974. Age-dependent polydipsia in the SWR-J mouse. Physiol Behav 13(1):71-9. PubMed: 4850464 MGI: J:33646
Kutscher CL; Miller M; Schmalbach NL. 1975. Renal deficiency associated with diabetes insipidus in the SWR/J mouse. Physiol Behav 14(6):815-8. PubMed: 1187837 MGI: J:25303
Kutscher CL; Schmalbach NL. 1975. Effects of water deprivation, NaCl injection, and seven aversive taste stimuli on drinking in two normal mouse strains and one with diabetes insipidus. Physiol Behav 15(6):659-67. PubMed: 1226406 MGI: J:25302
Levine S; Sowinski R. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J Immunol 110(1):139-43. PubMed: 4631068 MGI: J:24660
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7. PubMed: 8753860 MGI: J:35147
Lynch CJ. 1969. The so-called Swiss mouse. Lab Anim Care 19(2):214-20. PubMed: 4240230 MGI: J:24849
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Ortman RA; Holderbaum D; Qu XM; Banerjee S; Haqqi TM. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 152(8):4175-82. PubMed: 8144978 MGI: J:17601
Osman GE; Hannibal MC; Anderson JP; Cheunsuk S; Lasky SR; Liggitt HD; Ladiges WC; Hood LE. 1999. T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49(9):764-72. PubMed: 10398803 MGI: J:109896
Osman GE; Jacobson DP; Li SW; Hood LE; Liggitt HD; Ladiges WC. 1997. SWR: an inbred strain suitable for generating transgenic mice. Lab Anim Sci 47(2):167-71. PubMed: 9150496 MGI: J:40533
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. PubMed: 7625360 MGI: J:28248
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Serreze DV; Leiter EH. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies. J Immunol 140(11):3801-7. PubMed: 2897395 MGI: J:27617
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. PubMed: 7106865 MGI: J:6828

Additional References

Beamer WG; Hoppe PC; Whitten WK. 1985. Spontaneous malignant granulosa cell tumors in ovaries of young SWR mice. Cancer Res 45(11 Pt 2):5575-81. PubMed: 4053032 MGI: J:34553
DiPetrillo K; Tsaih SW; Sheehan S; Johns C; Kelmenson P; Gavras H; Churchill GA; Paigen B. 2004. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics 17(2):215-20. PubMed: 14996992 MGI: J:89267
Eberhart GP; West DB; Boozer CN; Atkinson RL. 1994. Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity. Am J Physiol 266(5 Pt 2):R1423-8. PubMed: 8203615 MGI: J:18464
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607. PubMed: 26067236 MGI: J:223755
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. PubMed: 14945054 MGI: J:166288
Janke MR; Baty JD; Graubert TA. 2013. SWR/J mice are susceptible to alkylator-induced myeloid leukemia. Blood Cancer J 3(None):e161. PubMed: 24241401 MGI: J:250060
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. PubMed: 18440079 MGI: J:138681
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med 125(1):1-16. PubMed: 4959665 MGI: J:5016
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. Nature 282(5735):207-8. PubMed: 492335 MGI: J:6214
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. PubMed: 10749765 MGI: J:61602
Smith BK; West DB; York DA. 1997. Carbohydrate versus fat intake: differing patterns of macronutrient selection in two inbred mouse strains. Am J Physiol 272(1 Pt 2):R357-62. PubMed: 9039029 MGI: J:39025
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. PubMed: 1621856 MGI: J:1348
West DB; Goudey-Lefevre J; York B; Truett GE. 1994. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 94(4):1410-6. PubMed: 7929816 MGI: J:20700
West DB; Waguespack J; McCollister S. 1995. Dietary obesity in the mouse: interaction of strain with diet composition. Am J Physiol 268(3 Pt 2):R658-65. PubMed: 7900908 MGI: J:24480
West DB; Waguespack J; York B; Goudey-Lefevre J; Price RA. 1994. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome 5(9):546-52. PubMed: 8000138 MGI: J:20129
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 265(5):2435-40. PubMed: 2303408 MGI: J:23983
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. J Exp Med 165(5):1442-7. PubMed: 3572304 MGI: J:8690
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. PubMed: 15067087 MGI: J:122988

Additional - Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. PubMed: 4123113 MGI: J:84312
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. PubMed: 1030186 MGI: J:12156
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. PubMed: 18848954 MGI: J:143604
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. PubMed: 8148872 MGI: J:17460
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. Neurotoxicology 33(6):1436-42. PubMed: 22935098 MGI: J:225088
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. PubMed: 16291824 MGI: J:113285
Curran CP; Nebert DW; Genter MB; Patel KV; Schaefer TL; Skelton MR; Williams MT; Vorhees CV. 2011. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect 119(9):1286-93. PubMed: 21571617 MGI: J:260665
Curran CP; Vorhees CV; Williams MT; Genter MB; Miller ML; Nebert DW. 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicol Sci 119(1):189-208. PubMed: 20961953 MGI: J:260693
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. PubMed: 808546 MGI: J:5564
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. PubMed: 4110756 MGI: J:84250
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. PubMed: 4118365 MGI: J:84252
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. PubMed: 1658612 MGI: J:2134
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicol Sci 140(1):135-43. PubMed: 24718703 MGI: J:215349
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. PubMed: 22228805 MGI: J:183715
Klinefelter K; Hooven MK; Bates C; Colter BT; Dailey A; Infante SK; Kania-Korwel I; Lehmler HJ; Lopez-Juarez A; Ludwig CP; Curran CP. 2018. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 29(1-2):112-127. PubMed: 29197979 MGI: J:259801
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. PubMed: 679184 MGI: J:84318
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. PubMed: 22982977 MGI: J:192865
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. PubMed: 21270426 MGI: J:173706
Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A 100(10):5652-7. PubMed: 12730383 MGI: J:132380
Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York. MGI: J:30693
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. PubMed: 4716952 MGI: J:84313
Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134(1):76-89. PubMed: 4981257 MGI: J:84248
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. PubMed: 4114109 MGI: J:5282
Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. Mol Pharmacol 8(6):651-66. PubMed: 4118364 MGI: J:84251
Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol 236(65):107-10. PubMed: 4502804 MGI: J:84249
Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus. Biochem Pharmacol 28(1):149-51. PubMed: 758905 MGI: J:6074
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. PubMed: 7095422 MGI: J:6809
Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. J Biol Chem 248(1):169-78. PubMed: 4348203 MGI: J:84311
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. PubMed: 1091656 MGI: J:84317
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. PubMed: 1119809 MGI: J:84316
Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene. Mol Pharmacol 9(5):629-6. PubMed: 4788156 MGI: J:25852
Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol 35(6):823-30. PubMed: 2543914 MGI: J:27899
Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene Proc Am Assoc Cancer Res 2:335. MGI: J:84245
Poland A; Bradfield C. 1992. A brief review of the Ah locus. Tohoku J Exp Med 168(2):83-7. PubMed: 1339107 MGI: J:12546
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251(16):4936-46. PubMed: 956169 MGI: J:84247
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. PubMed: 2823093 MGI: J:8895
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. PubMed: 7969080 MGI: J:22144
Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor. Mol Pharmacol 36(1):121-7. PubMed: 2546046 MGI: J:126377
Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. J Biol Chem 249(17):5599-606. PubMed: 4370044 MGI: J:84314
Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453(7191):65-71. PubMed: 18362915 MGI: J:136052
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. PubMed: 4413562 MGI: J:84315
Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. Cancer Res 27(3):563-7. PubMed: 6021514 MGI: J:84246
Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. Cancer Res 29(8):1585-9. PubMed: 5807232 MGI: J:34134
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. PubMed: 6021513 MGI: J:26440
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. PubMed: 8408082 MGI: J:15153
Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. Biochem Biophys Res Commun 376(4):775-80. PubMed: 18814841 MGI: J:141523
Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. Toxicol Appl Pharmacol 267(3):209-17. PubMed: 23337360 MGI: J:193493
Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207(10):2239-53. PubMed: 20855496 MGI: J:165803
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. PubMed: 9443932 MGI: J:45850
Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125(2):345-58. PubMed: 22086975 MGI: J:183662
Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver. Toxicol Sci 129(2):372-9. PubMed: 22696238 MGI: J:188164
Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci I 10(19):1127-34. PubMed: 5132702 MGI: J:5244
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. PubMed: 4750810 MGI: J:5387
Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet 6(2):157-68. PubMed: 4666754 MGI: J:31977
Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res 25:149-93. PubMed: 405846 MGI: J:5822
Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 101(47):16677-82. PubMed: 15545609 MGI: J:94465
Williams EG; Mouchiroud L; Frochaux M; Pandey A; Andreux PA; Deplancke B; Auwerx J. 2014. An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genet 10(9):e1004673. PubMed: 25255223 MGI: J:232452
Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'. Toxicol Sci 111(2):238-46. PubMed: 19474220 MGI: J:154083
Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis 27(10):2116-23. PubMed: 16704990 MGI: J:113356
Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis. Blood 121(16):3195-204. PubMed: 23462117 MGI: J:197552

Additional - Disc1^del related

Clapcote SJ; Roder JC. 2006. Deletion polymorphism of disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Genetics 173(4):2407-10. PubMed: 16751659 MGI: J:111837
Clapcote SJ; Roder JC. 2007. Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 MGI Direct Data Submission :. MGI: J:118317
Dittrich L; Petese A; Jackson WS. 2017. The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. Sci Rep 7(1):5665. PubMed: 28720848 MGI: J:253695
Gomez-Sintes R; Kvajo M; Gogos JA; Lucas JJ. 2014. Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders. Front Behav Neurosci 8(None):253. PubMed: 25126062 MGI: J:250220
Ji B; Higa KK; Kim M; Zhou L; Young JW; Geyer MA; Zhou X. 2014. Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet 23(21):5683-705. PubMed: 24908665 MGI: J:214737
Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA. 2006. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A 103(10):3693-7. PubMed: 16484369 MGI: J:107244
Kuroda K; Yamada S; Tanaka M; Iizuka M; Yano H; Mori D; Tsuboi D; Nishioka T; Namba T; Iizuka Y; Kubota S; Nagai T; Ibi D; Wang R; Enomoto A; Isotani-Sakakibara M; Asai N; Kimura K; Kiyonari H; Abe T; Mizoguchi A; Sokabe M; Takahashi M; Yamada K; Kaibuchi K. 2011. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 20(23):4666-83. PubMed: 21903668 MGI: J:177560
Ritchie D; Clapcote S. 2013. Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim :. PubMed: 23563120 MGI: J:195189
Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. PubMed: 21595826 MGI: J:185685

Additional - Hc⁰ related

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Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol 175(3):1894-902. PubMed: 16034133 MGI: J:107269
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. PubMed: 16428769 MGI: J:104987
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties. Eur J Immunol 31(12):3595-601. PubMed: 11745379 MGI: J:151748
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A 111(4):1503-8. PubMed: 24474777 MGI: J:206648
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis. Arthritis Rheum 50(11):3721-8. PubMed: 15529344 MGI: J:94347
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. PubMed: 19805369 MGI: J:153217
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One 7(11):e50327. PubMed: 23189195 MGI: J:194784
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol 177(3):1872-8. PubMed: 16849499 MGI: J:138026
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Scand J Immunol 62(2):123-30. PubMed: 16101818 MGI: J:114316
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun 7:10346. PubMed: 26831747 MGI: J:236291
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. J Exp Med 120:897-924. PubMed: 14247728 MGI: J:13003
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice. J Appl Physiol 85(5):1676-83. PubMed: 9804569 MGI: J:51187
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol 81(11):5518-26. PubMed: 17360740 MGI: J:153322
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. PubMed: 16261419 MGI: J:102639
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. J Lab Clin Med 143(6):358-65. PubMed: 15192652 MGI: J:101948
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes. J Immunol 177(7):4688-98. PubMed: 16982908 MGI: J:139313
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. Int J Mol Med 16(4):605-8. PubMed: 16142393 MGI: J:107581
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. PLoS One 8(11):e81341. PubMed: 24260573 MGI: J:209669
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. J Immunol 176(6):3516-24. PubMed: 16517720 MGI: J:129509
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells. J Immunol 165(7):3689-94. PubMed: 11034373 MGI: J:151749
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis. FASEB J 22(10):3483-90. PubMed: 18587006 MGI: J:140250
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood 101(11):4472-8. PubMed: 12543861 MGI: J:151744
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. PubMed: 10449528 MGI: J:108724
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology 144(1):149-57. PubMed: 25039245 MGI: J:220131
Freeley SJ; Popat RJ; Parmar K; Kolev M; Hunt BJ; Stover CM; Schwaeble W; Kemper C; Robson MG. 2016. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. J Pathol 240(1):61-71. PubMed: 27235854 MGI: J:241547
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation. Immunity 11(2):163-71. PubMed: 10485651 MGI: J:151750
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644-54. PubMed: 14660741 MGI: J:86845
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37(8):835-43. PubMed: 15995705 MGI: J:100159
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis. J Exp Med 194(3):321-30. PubMed: 11489951 MGI: J:70882
Kalbitz M; Karbach M; Braumueller S; Kellermann P; Gebhard F; Huber-Lang M; Perl M. 2016. Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI). PLoS One 11(7):e0159417. PubMed: 27437704 MGI: J:248820
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 1(3):221-6. PubMed: 10973279 MGI: J:108211
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. PubMed: 11836529 MGI: J:151747
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells. J Exp Med 197(8):1007-16. PubMed: 12707300 MGI: J:151743
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. PubMed: 15379984 MGI: J:92933
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol 176(7):4315-22. PubMed: 16547268 MGI: J:129872
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. Leukemia 26(1):106-16. PubMed: 21769103 MGI: J:181063
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood 112(4):1109-19. PubMed: 18524992 MGI: J:138410
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4. J Immunol 175(11):7504-11. PubMed: 16301658 MGI: J:122156
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest 122(6):2234-8. PubMed: 22585573 MGI: J:190492
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration. J Appl Physiol 87(6):2357-61. PubMed: 10601189 MGI: J:103341
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. Leukemia 23(11):2052-62. PubMed: 19657368 MGI: J:154482
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. PubMed: 20033053 MGI: J:158026
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. PLoS One 8(12):e84802. PubMed: 24386419 MGI: J:209840
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. Shock 12(5):340-9. PubMed: 10565608 MGI: J:59655
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 166(4):2479-86. PubMed: 11160308 MGI: J:111000
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role. Mol Immunol 33(14):1135-7. PubMed: 9047380 MGI: J:38592
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis. Cell Immunol 162(2):326-32. PubMed: 7743560 MGI: J:25289
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113(12):2684-94. PubMed: 19136662 MGI: J:146538
Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res 99(2):209-17. PubMed: 16778128 MGI: J:123658
Mori L; de Libero G. 1998. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice. Arthritis Rheum 41(2):256-62. PubMed: 9485083 MGI: J:134111
Moulton RA; Mashruwala MA; Smith AK; Lindsey DR; Wetsel RA; Haviland DL; Hunter RL; Jagannath C. 2007. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice. J Leukoc Biol 82(4):956-67. PubMed: 17675563 MGI: J:125190
Mullick A; Elias M; Picard S; Bourget L; Jovcevski O; Gauthier S; Tuite A; Harakidas P; Bihun C; Massie B; Gros P. 2004. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun 72(10):5868-76. PubMed: 15385488 MGI: J:93132
Mullick A; Leon Z; Min-Oo G; Berghout J; Lo R; Daniels E; Gros P. 2006. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. Infect Immun 74(8):4439-51. PubMed: 16861630 MGI: J:112405
Niculescu T; Weerth S; Niculescu F; Cudrici C; Rus V; Raine CS; Shin ML; Rus H. 2004. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. J Immunol 172(9):5702-6. PubMed: 15100315 MGI: J:89686
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med 125(1):1-16. PubMed: 4959665 MGI: J:5016
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. Nature 282(5735):207-8. PubMed: 492335 MGI: J:6214
Patel SN; Berghout J; Lovegrove FE; Ayi K; Conroy A; Serghides L; Min-oo G; Gowda DC; Sarma JV; Rittirsch D; Ward PA; Liles WC; Gros P; Kain KC. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205(5):1133-43. PubMed: 18426986 MGI: J:136298
Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. 2006. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A 103(25):9649-54. PubMed: 16769899 MGI: J:111031
Pilione MR; Agosto LM; Kennett MJ; Harvill ET. 2006. CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection. Cell Microbiol 8(5):758-68. PubMed: 16611225 MGI: J:135740
Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132(3):1117-26. PubMed: 17383432 MGI: J:128218
Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 390(6656):172-5. PubMed: 9367154 MGI: J:44240
Ratajczak MZ; Lee H; Wysoczynski M; Wan W; Marlicz W; Laughlin MJ; Kucia M; Janowska-Wieczorek A; Ratajczak J. 2010. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due toactivation of complement cascade/membrane attack complex. Leukemia 24(5):976-85. PubMed: 20357827 MGI: J:160183
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. PubMed: 17536017 MGI: J:147022
Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. Am J Physiol Regul Integr Comp Physiol 280(4):R1037-44. PubMed: 11247825 MGI: J:114295
Rittirsch D; Flierl MA; Day DE; Nadeau BA; McGuire SR; Hoesel LM; Ipaktchi K; Zetoune FS; Sarma JV; Leng L; Huber-Lang MS; Neff TA; Bucala R; Ward PA. 2008. Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol 180(11):7664-72. PubMed: 18490769 MGI: J:136379
Rittirsch D; Flierl MA; Nadeau BA; Day DE; Huber-Lang M; Mackay CR; Zetoune FS; Gerard NP; Cianflone K; Kohl J; Gerard C; Sarma JV; Ward PA. 2008. Functional roles for C5a receptors in sepsis. Nat Med 14(5):551-7. PubMed: 18454156 MGI: J:136703
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76(1):97-102. PubMed: 17967861 MGI: J:130296
Schmitt J; Roderfeld M; Sabrane K; Zhang P; Tian Y; Mertens JC; Frei P; Stieger B; Weber A; Mullhaupt B; Roeb E; Geier A. 2012. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice. Biochem Biophys Res Commun 418(3):445-50. PubMed: 22277671 MGI: J:181268
Schultz G; Tedesco MM; Sho E; Nishimura T; Sharif S; Du X; Myles T; Morser J; Dalman RL; Leung LL. 2010. Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice. Arterioscler Thromb Vasc Biol 30(7):1363-70. PubMed: 20431069 MGI: J:180861
Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood 112(3):585-91. PubMed: 18490515 MGI: J:138440
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med 200(7):835-46. PubMed: 15466618 MGI: J:93949
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. PubMed: 18328742 MGI: J:132942
Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. Nat Immunol 14(2):162-71. PubMed: 23263555 MGI: J:192613
Strey CW; Markiewski M; Mastellos D; Tudoran R; Spruce LA; Greenbaum LE; Lambris JD. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 198(6):913-23. PubMed: 12975457 MGI: J:109380
Tanaka D; Kagari T; Doi H; Shimozato T. 2006. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis. Immunology 119(2):195-202. PubMed: 16836650 MGI: J:118551
Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol 175(10):6909-14. PubMed: 16272350 MGI: J:119691
Wang Y; Kristan J; Hao L; Lenkoski CS; Shen Y; Matis LA. 2000. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. J Immunol 164(8):4340-7. PubMed: 10754334 MGI: J:61587
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 265(5):2435-40. PubMed: 2303408 MGI: J:23983
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. J Exp Med 165(5):1442-7. PubMed: 3572304 MGI: J:8690
Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity. Infect Immun 73(10):6508-13. PubMed: 16177324 MGI: J:104212
Wright RJ; Bikoff EK; Stockinger B. 1998. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice. Immunology 95(3):309-13. PubMed: 9824491 MGI: J:50737
Xiao H; Schreiber A; Heeringa P; Falk RJ; Jennette JC. 2007. Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol 170(1):52-64. PubMed: 17200182 MGI: J:117048
Younger JG; Shankar-Sinha S; Mickiewicz M; Brinkman AS; Valencia GA; Sarma JV; Younkin EM; Standiford TJ; Zetoune FS; Ward PA. 2003. Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. Am J Respir Cell Mol Biol 29(4):432-8. PubMed: 14500254 MGI: J:94613
Zal T; Volkmann A; Stockinger B. 1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med 180(6):2089-99. PubMed: 7964486 MGI: J:111649
Zal T; Weiss S; Mellor A; Stockinger B. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc Natl Acad Sci U S A 93(17):9102-7. PubMed: 8799161 MGI: J:151753
Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 105(10):1363-71. PubMed: 10811844 MGI: J:120567
de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol 22(1):137-45. PubMed: 21148255 MGI: J:185883

Additional - Pde6b^rd1 related

Acosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. PubMed: 16163270 MGI: J:103970
Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. PubMed: 19524569 MGI: J:151412
Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. PubMed: 18326735 MGI: J:133024
Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. PubMed: 17471069 MGI: J:122802
Alavi MV; Bette S; Schimpf S; Schuettauf F; Schraermeyer U; Wehrl HF; Ruttiger L; Beck SC; Tonagel F; Pichler BJ; Knipper M; Peters T; Laufs J; Wissinger B. 2007. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain 130(Pt 4):1029-42. PubMed: 17314202 MGI: J:154966
Allen AE; Brown TM; Lucas RJ. 2011. A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus. J Neurosci 31(46):16833-43. PubMed: 22090509 MGI: J:177906
Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. PubMed: 21124780 MGI: J:167121
Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. PubMed: 15451375 MGI: J:92980
Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. PubMed: 16626665 MGI: J:109668
Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. PubMed: 15003290 MGI: J:121036
Arango-Gonzalez B; Trifunovic D; Sahaboglu A; Kranz K; Michalakis S; Farinelli P; Koch S; Koch F; Cottet S; Janssen-Bienhold U; Dedek K; Biel M; Zrenner E; Euler T; Ekstrom P; Ueffing M; Paquet-Durand F. 2014. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One 9(11):e112142. PubMed: 25392995 MGI: J:225151
Ardayfio P; Moon J; Leung KK; Youn-Hwang D; Kim KS. 2008. Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol Dis :. PubMed: 18573342 MGI: J:136304
Ash J; McLeod DS; Lutty GA. 2005. Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye. Mol Vis 11:298-308. PubMed: 15889014 MGI: J:98579
Ash JA; Velazquez R; Kelley CM; Powers BE; Ginsberg SD; Mufson EJ; Strupp BJ. 2014. Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiol Dis 70:32-42. PubMed: 24932939 MGI: J:218355
Atkinson CL; Feng J; Zhang DQ. 2013. Functional integrity and modification of retinal dopaminergic neurons in the rd1 mutant mouse: roles of melanopsin and GABA. J Neurophysiol 109(6):1589-99. PubMed: 23255724 MGI: J:238046
Audo I; Bujakowska K; Orhan E; Poloschek CM; Defoort-Dhellemmes S; Drumare I; Kohl S; Luu TD; Lecompte O; Zrenner E; Lancelot ME; Antonio A; Germain A; Michiels C; Audier C; Letexier M; Saraiva JP; Leroy BP; Munier FL; Mohand-Said S; Lorenz B; Friedburg C; Preising M; Kellner U; Renner AB; Moskova-Doumanova V; Berger W; Wissinger B; Hamel CP; Schorderet DF; De Baere E; Sharon D; Banin E; Jacobson SG; Bonneau D; Zanlonghi X; Le Meur G; Casteels I; Koenekoop R; Long VW; Meire F; Prescott K; de Ravel T; Simm. 2012. Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90(2):321-30. PubMed: 22325361 MGI: J:196741
Ayturk DG; Castrucci AM; Carr DE; Keller SR; Provencio I. 2015. Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge. PLoS One 10(5):e0127031. PubMed: 26011287 MGI: J:237743
Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. PubMed: 16503160 MGI: J:108601
BRUCKNER R. 1951. [Slit-lamp microscopy and ophthalmoscopy in rat and mouse.] Doc Ophthalmol 5-6:452-554. PubMed: 14896883 MGI: J:25576
Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. PubMed: 11980879 MGI: J:80080
Barabas P; Liu A; Xing W; Chen CK; Tong Z; Watt CB; Jones BW; Bernstein PS; Krizaj D. 2013. Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration. Proc Natl Acad Sci U S A 110(13):5181-6. PubMed: 23479632 MGI: J:194246
Barber AC; Hippert C; Duran Y; West EL; Bainbridge JW; Warre-Cornish K; Luhmann UF; Lakowski J; Sowden JC; Ali RR; Pearson RA. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A 110(1):354-9. PubMed: 23248312 MGI: J:192521
Belichenko PV; Madani R; Rey-Bellet L; Pihlgren M; Becker A; Plassard A; Vuillermot S; Giriens V; Nosheny RL; Kleschevnikov AM; Valletta JS; Bengtsson SK; Linke GR; Maloney MT; Hickman DT; Reis P; Granet A; Mlaki D; Lopez-Deber MP; Do L; Singhal N; Masliah E; Pearn ML; Pfeifer A; Muhs A; Mobley WC. 2016. An Anti-beta-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One 11(3):e0152471. PubMed: 27023444 MGI: J:253508
Bhatti F; Ball G; Hobbs R; Linens A; Munzar S; Akram R; Barber AJ; Anderson M; Elliott M; Edwards M. 2015. Pulmonary surfactant protein a is expressed in mouse retina by Muller cells and impacts neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 56(1):232-42. PubMed: 25406276 MGI: J:230990
Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. PubMed: 16600853 MGI: J:122947
Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. PubMed: 864040 MGI: J:5812
Borowska J; Trenholm S; Awatramani GB. 2011. An intrinsic neural oscillator in the degenerating mouse retina. J Neurosci 31(13):5000-12. PubMed: 21451038 MGI: J:171202
Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. PubMed: 2481314 MGI: J:10184
Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. PubMed: 1977087 MGI: J:10777
Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. PubMed: 8385352 MGI: J:4366
Bramall AN; Szego MJ; Pacione LR; Chang I; Diez E; D'Orleans-Juste P; Stewart DJ; Hauswirth WW; Yanagisawa M; McInnes RR. 2013. Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. PLoS One 8(2):e58023. PubMed: 23469133 MGI: J:198395
Brown TM; Gias C; Hatori M; Keding SR; Semo M; Coffey PJ; Gigg J; Piggins HD; Panda S; Lucas RJ. 2010. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol 8(12):e1000558. PubMed: 21151887 MGI: J:170401
Brown TM; Tsujimura S; Allen AE; Wynne J; Bedford R; Vickery G; Vugler A; Lucas RJ. 2012. Melanopsin-based brightness discrimination in mice and humans. Curr Biol 22(12):1134-41. PubMed: 22633808 MGI: J:199509
Buhr ED; Van Gelder RN. 2014. Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A 111(23):8625-30. PubMed: 24843129 MGI: J:211359
Buhr ED; Yue WW; Ren X; Jiang Z; Liao HW; Mei X; Vemaraju S; Nguyen MT; Reed RR; Lang RA; Yau KW; Van Gelder RN. 2015. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc Natl Acad Sci U S A 112(42):13093-8. PubMed: 26392540 MGI: J:227078
Bumsted KM; Rizzolo LJ; Barnstable CJ. 2001. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res 73(3):383-92. PubMed: 11520113 MGI: J:115620
Busskamp V; Duebel J; Balya D; Fradot M; Viney TJ; Siegert S; Groner AC; Cabuy E; Forster V; Seeliger M; Biel M; Humphries P; Paques M; Mohand-Said S; Trono D; Deisseroth K; Sahel JA; Picaud S; Roska B. 2010. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329(5990):413-7. PubMed: 20576849 MGI: J:162017
Cai R; Xue W; Liu S; Petersen RB; Huang K; Zheng L. 2015. Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury. FASEB J 29(7):2749-58. PubMed: 25805836 MGI: J:225470
Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. Am J Anat 133(2):179-212. PubMed: 5009246 MGI: J:5250
Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci 29(4):761-7. PubMed: 19200071 MGI: J:146469
Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98. PubMed: 659071 MGI: J:5988
Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. PubMed: 9054517 MGI: J:39262
Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. PubMed: 10600408 MGI: J:59343
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768 MGI: J:75095
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. PubMed: 16332269 MGI: J:156373
Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. PubMed: 23800770 MGI: J:198916
Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. Invest Ophthalmol Vis Sci 53(2):1066-75. PubMed: 22169101 MGI: J:191520
Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. PubMed: 19131628 MGI: J:143166
Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A :. PubMed: 19966223 MGI: J:155817
Chen Q; Qiu F; Zhou K; Matlock HG; Takahashi Y; Rajala RVS; Yang Y; Moran E; Ma JX. 2017. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARalpha. Diabetes 66(6):1671-1682. PubMed: 28270521 MGI: J:246071
Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani GB; Kalloniatis M. 2013. Early remodeling of Muller cells in the rd/rd mouse model of retinal dystrophy. J Comp Neurol 521(11):2439-53. PubMed: 23348616 MGI: J:200732
Cohen AI; Blazynski C. 1990. Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors. Vis Neurosci 4(1):43-52. PubMed: 1702315 MGI: J:78184
Comitato A; Sanges D; Rossi A; Humphries MM; Marigo V. 2014. Activation of Bax in three models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 55(6):3555-62. PubMed: 24825107 MGI: J:230024
Cornett A; Sucic JF; Hillsburg D; Cyr L; Johnson C; Polanco A; Figuereo J; Cabine K; Russo N; Sturtevant A; Jarvinen MK. 2011. Altered glial gene expression, density, and architecture in the visual cortex upon retinal degeneration. Brain Res 1422:46-56. PubMed: 21983206 MGI: J:179028
Danciger M; Bowes C; Kozak CA; LaVail MM; Farber DB. 1990. Fine mapping of a putative rd cDNA and its co-segregation with rd expression. Invest Ophthalmol Vis Sci 31(8):1427-32. PubMed: 1974892 MGI: J:10689
Daniels DM; Stoddart CW; Martin-Iverson MT; Lai CM; Redmond TM; Rakoczy PE. 2003. Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65(-/-) mice. Physiol Behav 79(4-5):701-11. PubMed: 12954412 MGI: J:96439
Davies VJ; Powell KA; White KE; Yip W; Hogan V; Hollins AJ; Davies JR; Piechota M; Brownstein DG; Moat SJ; Nichols PP; Wride MA; Boulton ME; Votruba M. 2008. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Brain 131(Pt 2):368-80. PubMed: 18222992 MGI: J:181670
Davis KE; Eleftheriou CG; Allen AE; Procyk CA; Lucas RJ. 2015. Melanopsin-derived visual responses under light adapted conditions in the mouse dLGN. PLoS One 10(3):e0123424. PubMed: 25822371 MGI: J:233435
Davis RJ; Tosi J; Janisch KM; Kasanuki JM; Wang NK; Kong J; Tsui I; Cilluffo M; Woodruff ML; Fain GL; Lin CS; Tsang SH. 2008. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci 49(11):5067-76. PubMed: 18658088 MGI: J:141984
Del Rio P; Irmler M; Arango-Gonzalez B; Favor J; Bobe C; Bartsch U; Vecino E; Beckers J; Hauck SM; Ueffing M. 2011. GDNF-induced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration. Glia 59(5):821-32. PubMed: 21360756 MGI: J:169746
Delyfer MN; Forster V; Neveux N; Picaud S; Leveillard T; Sahel JA. 2005. Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina. Mol Vis 11:688-96. PubMed: 16163266 MGI: J:103968
Demos C; Bandyopadhyay M; Rohrer B. 2008. Identification of candidate genes for human retinal degeneration loci using differentially expressed genes from mouse photoreceptor dystrophy models. Mol Vis 14:1639-49. PubMed: 18776951 MGI: J:140115
Doonan F; Donovan M; Cotter TG. 2003. Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J Neurosci 23(13):5723-31. PubMed: 12843276 MGI: J:84389
Drager UC; Hubel DH. 1978. Studies of visual function and its decay in mice with hereditary retinal degeneration. J Comp Neurol 180(1):85-114. PubMed: 649791 MGI: J:5980
Du Y; Davisson MT; Kafadar K; Gardiner K. 2006. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 382:39-46. PubMed: 16904273 MGI: J:115050
Ekstrom P; Sanyal S; Narfstrom K; Chader GJ; van Veen T. 1988. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29(9):1363-71. PubMed: 3417421 MGI: J:27850
El Shamieh S; Neuille M; Terray A; Orhan E; Condroyer C; Demontant V; Michiels C; Antonio A; Boyard F; Lancelot ME; Letexier M; Saraiva JP; Leveillard T; Mohand-Said S; Goureau O; Sahel JA; Zeitz C; Audo I. 2014. Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy. Am J Hum Genet 94(4):625-33. PubMed: 24680887 MGI: J:227870
Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. PubMed: 17600127 MGI: J:123928
Flanigan TJ; Xue Y; Kishan Rao S; Dhanushkodi A; McDonald MP. 2014. Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics. Genes Brain Behav 13(5):488-500. PubMed: 24655396 MGI: J:223699
Fletcher RT; Sanyal S; Krishna G; Aguirre G; Chader GJ. 1986. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. J Neurochem 46(4):1240-5. PubMed: 3005510 MGI: J:12044
Foster RG; Argamaso S; Coleman S; Colwell CS; Lederman A; Provencio I. 1993. Photoreceptors regulating circadian behavior: a mouse model. J Biol Rhythms 8 Suppl:S17-23. PubMed: 8274758 MGI: J:17940
Foster RG; Provencio I; Hudson D; Fiske S; De Grip W; Menaker M. 1991. Circadian photoreception in the retinally degenerate mouse (rd/rd). J Comp Physiol [A] 169(1):39-50. PubMed: 1941717 MGI: J:83743
Frasson M; Picaud S; Leveillard T; Simonutti M; Mohand-Said S; Dreyfus H; Hicks D; Sabel J. 1999. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Invest Ophthalmol Vis Sci 40(11):2724-34. PubMed: 10509671 MGI: J:57866
Frasson M; Sahel JA; Fabre M; Simonutti M; Dreyfus H; Picaud S. 1999. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 5(10):1183-7. PubMed: 10502823 MGI: J:57986
Gao H; Hollyfield JG. 1995. Basic fibroblast growth factor in retinal development: differential levels of bFGF expression and content in normal and retinal degeneration (rd) mutant mice. Dev Biol 169(1):168-184. PubMed: 7750636 MGI: J:25273
Garcia-Fernandez JM; Jimenez AJ; Foster RG. 1995. The persistence of cone photoreceptors within the dorsal retina of aged retinally degenerate mice (rd/rd): implications for circadian organization. Neurosci Lett 187(1):33-6. PubMed: 7617296 MGI: J:25157
Gaub BM; Berry MH; Holt AE; Reiner A; Kienzler MA; Dolgova N; Nikonov S; Aguirre GD; Beltran WA; Flannery JG; Isacoff EY. 2014. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proc Natl Acad Sci U S A 111(51):E5574-83. PubMed: 25489083 MGI: J:216941
Gimenez E; Montoliu L. 2001. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 35(2):153-6. PubMed: 11315164 MGI: J:69558
Goel M; Dhingra NK. 2012. Muller glia express rhodopsin in a mouse model of inherited retinal degeneration. Neuroscience 225:152-61. PubMed: 22967839 MGI: J:192477
Golub MS; Germann SL; Mercer M; Gordon MN; Morgan DG; Mayer LP; Hoyer PB. 2008. Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse. Neurobiol Aging 29(10):1512-23. PubMed: 17451844 MGI: J:140912
Gouras P; Du J; Kjeldbye H; Kwun R; Lopez R; Zack DJ. 1991. Transplanted photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest Ophthalmol Vis Sci 32(13):3167-74. PubMed: 1748547 MGI: J:607
Gouras P; Du J; Kjeldbye H; Yamamoto S; Zack DJ. 1994. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci 35(8):3145-53. PubMed: 8045709 MGI: J:20769
Grafstein B; Murray M; Ingoglia NA. 1972. Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors. Brain Res 44(1):37-48. PubMed: 4115728 MGI: J:5292
Graham DR; Overbeek PA; Ash JD. 2005. Leukemia inhibitory factor blocks expression of crx and nrl transcription factors to inhibit photoreceptor differentiation. Invest Ophthalmol Vis Sci 46(7):2601-10. PubMed: 15980254 MGI: J:99409
Greferath U; Goh HC; Chua PY; Astrand E; O'Brien EE; Fletcher EL; Murphy M. 2009. Mapping retinal degeneration and loss-of-function in Rd-FTL mice. Invest Ophthalmol Vis Sci 50(12):5955-64. PubMed: 19661224 MGI: J:158255
Grimm C; Wenzel A; Stanescu D; Samardzija M; Hotop S; Groszer M; Naash M; Gassmann M; Reme C. 2004. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci 24(25):5651-8. PubMed: 15215287 MGI: J:133235
Hackam AS; Strom R; Liu D; Qian J; Wang C; Otteson D; Gunatilaka T; Farkas RH; Chowers I; Kageyama M; Leveillard T; Sahel JA; Campochiaro PA; Parmigiani G; Zack DJ. 2004. Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Invest Ophthalmol Vis Sci 45(9):2929-42. PubMed: 15326104 MGI: J:92921
Hafezi F; Abegg M; Grimm C; Wenzel A; Munz K; Sturmer J; Farber DB; Reme CE. 1998. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci 39(12):2239-44. PubMed: 9804131 MGI: J:112088
Hanno Y; Nakahira M; Jishage K; Noda T; Yoshihara Y. 2003. Tracking mouse visual pathways with WGA transgene. Eur J Neurosci 18(10):2910-4. PubMed: 14656342 MGI: J:128266
Hart AW; McKie L; Morgan JE; Gautier P; West K; Jackson IJ; Cross SH. 2005. Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci 46(9):3443-50. PubMed: 16123450 MGI: J:101336
Hatori M; Gill S; Mure LS; Goulding M; O'Leary DD; Panda S. 2014. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3:e03357. PubMed: 25035422 MGI: J:228603
Hatori M; Le H; Vollmers C; Keding SR; Tanaka N; Schmedt C; Jegla T; Panda S. 2008. Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS One 3(6):e2451. PubMed: 18545654 MGI: J:137151
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. PubMed: 10493779 MGI: J:59481
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. PubMed: 7479945 MGI: J:121993
Heynen SR; Tanimoto N; Joly S; Seeliger MW; Samardzija M; Grimm C. 2011. Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Mol Vis 17:2934-46. PubMed: 22128240 MGI: J:179662
Hippert C; Graca AB; Barber AC; West EL; Smith AJ; Ali RR; Pearson RA. 2015. Muller glia activation in response to inherited retinal degeneration is highly varied and disease-specific. PLoS One 10(3):e0120415. PubMed: 25793273 MGI: J:233438
Holt R; Brown L; Broadgate S; Butler R; Jagannath A; Downes S; Peirson S; Halford S. 2015. Identification of rod- and cone-specific expression signatures to identify candidate genes for retinal disease. Exp Eye Res 132:161-73. PubMed: 25579607 MGI: J:230269
Hopp RM; Ransom N; Hilsenbeck SG; Papermaster DS; Windle JJ. 1998. Apoptosis in the murine rd1 retinal degeneration is predominantly p53-independent. Mol Vis 4:5. PubMed: 9485488 MGI: J:47520
Horev G; Benjamini Y; Sakov A; Golani I. 2007. Estimating wall guidance and attraction in mouse free locomotor behavior. Genes Brain Behav 6(1):30-41. PubMed: 17233639 MGI: J:132656
Hsiao FC; Liao YH; Tsai LL. 2013. Differential effects of retinal degeneration on sleep and wakefulness responses to short light-dark cycles in albino mice. Neuroscience 248C:459-468. PubMed: 23811394 MGI: J:207054
Huang Z; Zhou T; Sun X; Zheng Y; Cheng B; Li M; Liu X; He C. 2018. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. Cell Death Differ 25(1):180-189. PubMed: 28885615 MGI: J:259669
Huber G; Beck SC; Grimm C; Sahaboglu-Tekgoz A; Paquet-Durand F; Wenzel A; Humphries P; Redmond TM; Seeliger MW; Fischer MD. 2009. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci 50(12):5888-95. PubMed: 19661229 MGI: J:158254
Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1997. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett 232(3):143-6. PubMed: 9310300 MGI: J:43873
Huerta JJ; Llamosas MM; Cernuda-Cernuda R; Garcia-Fernandez JM. 1999. Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. Brain Res 834(1-2):122-7. PubMed: 10407100 MGI: J:56973
Hughes S; Jagannath A; Hickey D; Gatti S; Wood M; Peirson SN; Foster RG; Hankins MW. 2015. Using siRNA to define functional interactions between melanopsin and multiple G Protein partners. Cell Mol Life Sci 72(1):165-79. PubMed: 24958088 MGI: J:232057
Hughes S; Pothecary CA; Jagannath A; Foster RG; Hankins MW; Peirson SN. 2012. Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. Eur J Neurosci 35(1):34-43. PubMed: 22211741 MGI: J:184336
Hussain AA; Willmott NJ; Voaden MJ. 1992. Cyclic GMP, calcium and photoreceptor sensitivity in mice heterozygous for the rod dysplasia gene designated rd. Vision Res 32(1):29-36. PubMed: 1323896 MGI: J:611
Hwang DY; Fleming SM; Ardayfio P; Moran-Gates T; Kim H; Tarazi FI; Chesselet MF; Kim KS. 2005. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J Neurosci 25(8):2132-7. PubMed: 15728853 MGI: J:98209
Ionita MA; Pittler SJ. 2007. Focus on molecules: rod cGMP phosphodiesterase type 6. Exp Eye Res 84(1):1-2. PubMed: 16563379 MGI: J:123170
Ivanova E; Yee CW; Sagdullaev BT. 2016. Disruption in dopaminergic innervation during photoreceptor degeneration. J Comp Neurol 524(6):1208-21. PubMed: 26356010 MGI: J:231114
Ivanova E; Yee CW; Sagdullaev BT. 2015. Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina. Front Cell Neurosci 9:390. PubMed: 26483638 MGI: J:239860
Jagannath A; Hughes S; Abdelgany A; Pothecary CA; Di Pretoro S; Pires SS; Vachtsevanos A; Pilorz V; Brown LA; Hossbach M; MacLaren RE; Halford S; Gatti S; Hankins MW; Wood MJ; Foster RG; Peirson SN. 2015. Isoforms of Melanopsin Mediate Different Behavioral Responses to Light. Curr Biol 25(18):2430-4. PubMed: 26320947 MGI: J:252142
Jain V; Srivastava I; Palchaudhuri S; Goel M; Sinha-Mahapatra SK; Dhingra NK. 2016. Classical Photoreceptors Are Primarily Responsible for the Pupillary Light Reflex in Mouse. PLoS One 11(6):e0157226. PubMed: 27295136 MGI: J:252391
Janus C; Flores AY; Xu G; Borchelt DR. 2015. Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains. Neurobiol Aging 36(9):2519-32. PubMed: 26089165 MGI: J:226285
Ji X; Liu Y; Hurd R; Wang J; Fitzmaurice B; Nishina PM; Chang B. 2016. Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, theta. Invest Ophthalmol Vis Sci 57(3):877-88. PubMed: 26978024 MGI: J:237977
Jia L; Oh EC; Ng L; Srinivas M; Brooks M; Swaroop A; Forrest D. 2009. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A 106(41):17534-9. PubMed: 19805139 MGI: J:153683
Johnson LE; van Veen T; Ekstrom PA. 2005. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell Tissue Res 320(2):213-22. PubMed: 15789220 MGI: J:105103
Jomary C; Cullen J; Jones SE. 2006. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Invest Ophthalmol Vis Sci 47(4):1620-9. PubMed: 16565401 MGI: J:108445
Jomary C; Thomas M; Grist J; Milbrandt J; Neal MJ; Jones SE. 1999. Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina. Invest Ophthalmol Vis Sci 40(3):568-74. PubMed: 10067959 MGI: J:53298
Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. PubMed: 12866125 MGI: J:84675
Jones SE; Jomary C; Grist J; Stewart HJ; Neal MJ. 2000. Identification by array screening of altered nm23-M2/PuF mRNA expression in mouse retinal degeneration. Mol Cell Biol Res Commun 4(1):20-5. PubMed: 11152623 MGI: J:66982
Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of Pax-6 mRNA in the retinal degeneration (rd) mouse. Biochem Biophys Res Commun 252(1):236-40. PubMed: 9813176 MGI: J:50978
Jones SE; Jomary C; Grist J; Thomas MR; Neal MJ. 1998. Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration. Neuroreport 9(18):4161-5. PubMed: 9926867 MGI: J:52955
Joseph RM; Li T. 1996. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. Invest Ophthalmol Vis Sci 37(12):2434-46. PubMed: 8933760 MGI: J:37285
Kahle M; Horsch M; Fridrich B; Seelig A; Schultheiss J; Leonhardt J; Irmler M; Beckers J; Rathkolb B; Wolf E; Franke N; Gailus-Durner V; Fuchs H; de Angelis MH; Neschen S. 2013. Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab 2(4):435-46. PubMed: 24327959 MGI: J:220415
Kanan Y; Hoffhines A; Rauhauser A; Murray A; Al-Ubaidi MR. 2009. Protein tyrosine-O-sulfation in the retina. Exp Eye Res 89(4):559-67. PubMed: 19523945 MGI: J:154498
Kaneko H; Nishiguchi KM; Nakamura M; Kachi S; Terasaki H. 2008. Retardation of photoreceptor degeneration in the detached retina of rd1 mouse. Invest Ophthalmol Vis Sci 49(2):781-7. PubMed: 18235028 MGI: J:132586
Karasawa K; Tanaka A; Jung K; Matsuda A; Okamoto N; Oida K; Ebihara N; Ohmori K; Matsuda H. 2011. Retinal degeneration and rd1 mutation in NC/Tnd mice-a human atopic dermatitis model. Curr Eye Res 36(4):350-7. PubMed: 21275519 MGI: J:179794
Katti C; Butler R; Sekaran S. 2013. Diurnal and circadian regulation of connexin 36 transcript and protein in the mammalian retina. Invest Ophthalmol Vis Sci 54(1):821-9. PubMed: 23307963 MGI: J:214563
Keady BT; Le YZ; Pazour GJ. 2011. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell 22(7):921-30. PubMed: 21307337 MGI: J:183002
Keeler C. 1966. Retinal degeneration in the mouse is rodless retina. J Hered 57(2):47-50. PubMed: 5916892 MGI: J:5007
Keeler CE. 1924. The inheritance of a retinal abnormality in white mice Proc Natl Acad Sci U S A 10(7):329-33. PubMed: 16576828 MGI: J:24999
Keeler CE. 1926. On the Occurrence in the House Mouse of Mendelizing Structural Defect of the Retina Producing Blindness. Proc Natl Acad Sci U S A 12(4):255-8. PubMed: 16576989 MGI: J:153354
Keeler CE; Sutcliffe E; Chaffee EL. 1928. Normal and 'Rodless' Retinae of the House Mouse with Respect to the Electromotive Force Generated through Stimulation by Light. Proc Natl Acad Sci U S A 14(6):477-84. PubMed: 16577134 MGI: J:153353
Kida E; Rabe A; Walus M; Albertini G; Golabek AA. 2013. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. Exp Neurol 240:178-89. PubMed: 23201095 MGI: J:196979
Kirschman LT; Kolandaivelu S; Frederick JM; Dang L; Goldberg AF; Baehr W; Ramamurthy V. 2010. The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells. Hum Mol Genet 19(6):1076-87. PubMed: 20042464 MGI: J:157652
Klein SL; Kriegsfeld LJ; Hairston JE; Rau V; Nelson RJ; Yarowsky PJ. 1996. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav 60(4):1159-64. PubMed: 8884947 MGI: J:174274
Kokkinopoulos I; Pearson RA; Macneil A; Dhomen NS; Maclaren RE; Ali RR; Sowden JC. 2008. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Mol Cell Neurosci 38(3):359-73. PubMed: 18514541 MGI: J:137047
Kolandaivelu S; Chang B; Ramamurthy V. 2011. Rod Phosphodiesterase-6 (PDE6) Catalytic Subunits Restore Cone Function in a Mouse Model Lacking Cone PDE6 Catalytic Subunit. J Biol Chem 286(38):33252-9. PubMed: 21799013 MGI: J:176734
Kolandaivelu S; Huang J; Hurley JB; Ramamurthy V. 2009. AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. J Biol Chem 284(45):30853-61. PubMed: 19758987 MGI: J:156330
Kolesnikov AV; Orban T; Jin H; Brooks C; Hofmann L; Dong Z; Sokolov M; Palczewski K; Kefalov VJ. 2017. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A 114(45):E9675-E9684. PubMed: 29078372 MGI: J:254310
Komeima K; Rogers BS; Lu L; Campochiaro PA. 2006. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci U S A 103(30):11300-5. PubMed: 16849425 MGI: J:111826
Komeima K; Usui S; Shen J; Rogers BS; Campochiaro PA. 2008. Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Free Radic Biol Med 45(6):905-12. PubMed: 18634866 MGI: J:142007
Kooragayala K; Gotoh N; Cogliati T; Nellissery J; Kaden TR; French S; Balaban R; Li W; Covian R; Swaroop A. 2015. Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria. Invest Ophthalmol Vis Sci 56(13):8428-36. PubMed: 26747773 MGI: J:231018
Koso H; Tsuhako A; Lai CY; Baba Y; Otsu M; Ueno K; Nagasaki M; Suzuki Y; Watanabe S. 2016. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. Glia 64(11):2005-24. PubMed: 27459098 MGI: J:235625
Kranz K; Paquet-Durand F; Weiler R; Janssen-Bienhold U; Dedek K. 2013. Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones. PLoS One 8(2):e57163. PubMed: 23468924 MGI: J:199394
Kucharska J; Del Rio P; Arango-Gonzalez B; Gorza M; Feuchtinger A; Hauck SM; Ueffing M. 2014. Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa. J Neurochem 130(2):227-40. PubMed: 24593181 MGI: J:213667
Kuenzi F; Rosahl TW; Morton RA; Fitzjohn SM; Collingridge GL; Seabrook GR. 2003. Hippocampal synaptic plasticity in mice carrying the rd mutation in the gene encoding cGMP phosphodiesterase type 6 (PDE6). Brain Res 967(1-2):144-51. PubMed: 12650975 MGI: J:82830
Kulkarni M; Trifunovic D; Schubert T; Euler T; Paquet-Durand F. 2016. Calcium dynamics change in degenerating cone photoreceptors. Hum Mol Genet 25(17):3729-3740. PubMed: 27402880 MGI: J:237860
LaVail MM; Matthes MT; Yasumura D; Steinberg RH. 1997. Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse. Exp Eye Res 65(1):45-50. PubMed: 9237863 MGI: J:42223
LaVail MM; Mullen RJ. 1976. Role of the pigment epithelium in inherited retinal degeneration analyzed with experimental mouse chimeras. Exp Eye Res 23(2):227-45. PubMed: 976367 MGI: J:5708
LaVail MW; Yasumura D; Matthes MT; Lau-Villacorta C; Unoki K; Sung CH; Steinberg RH. 1998. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39(3):592-602. PubMed: 9501871 MGI: J:46230
Lahdenranta J; Pasqualini R; Schlingemann RO; Hagedorn M; Stallcup WB; Bucana CD; Sidman RL; Arap W. 2001. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration. Proc Natl Acad Sci U S A 98(18):10368-73. PubMed: 11526242 MGI: J:126744
Langmann T; Di Gioia SA; Rau I; Stohr H; Maksimovic NS; Corbo JC; Renner AB; Zrenner E; Kumaramanickavel G; Karlstetter M; Arsenijevic Y; Weber BH; Gal A; Rivolta C. 2010. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet 87(3):376-81. PubMed: 20705278 MGI: J:169189
Lavail MM; Nishikawa S; Duncan JL; Yang H; Matthes MT; Yasumura D; Vollrath D; Overbeek PA; Ash JD; Robinson ML. 2008. Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations. J Comp Neurol 511(6):724-35. PubMed: 18925574 MGI: J:176641
Lin B; Koizumi A; Tanaka N; Panda S; Masland RH. 2008. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A 105(41):16009-14. PubMed: 18836071 MGI: J:141434
Lin B; Masland RH; Strettoi E. 2009. Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res 88(3):589-99. PubMed: 19087876 MGI: J:146569
Lin B; Peng EB. 2013. Retinal ganglion cells are resistant to photoreceptor loss in retinal degeneration. PLoS One 8(6):e68084. PubMed: 23840814 MGI: J:204325
Liu SH; Gottsch JD; Vinores SA; Derevjanik NL; McLeod DS; Lutty GA. 2001. EMAP cytokine expression in developing retinas of normal and retinal degeneration (rd) mutant mice. J Neuroimmunol 114(1-2):28-34. PubMed: 11240012 MGI: J:102963
Lohr HR; Kuntchithapautham K; Sharma AK; Rohrer B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res 83(2):380-9. PubMed: 16626700 MGI: J:116326
Lopez-Luppo M; Catita J; Ramos D; Navarro M; Carretero A; Mendes-Jorge L; Munoz-Canoves P; Rodriguez-Baeza A; Nacher V; Ruberte J. 2017. Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging. Invest Ophthalmol Vis Sci 58(7):2832-2842. PubMed: 28570738 MGI: J:257592
Louros SR; Hooks BM; Litvina L; Carvalho AL; Chen C. 2014. A role for stargazin in experience-dependent plasticity. Cell Rep 7(5):1614-25. PubMed: 24882000 MGI: J:211786
Lu B; Coffey P; Lund R. 2004. Increased c-fos-like immunoreactivity in the superior colliculus and lateral geniculate nucleus of the rd mouse. Brain Res 1025(1-2):220-5. PubMed: 15464763 MGI: J:107774
Lucas RJ; Freedman MS; Munoz M; Garcia-Fernandez JM; Foster RG. 1999. Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors. Science 284(5413):505-7. PubMed: 10205062 MGI: J:128478
Lupi D; Oster H; Thompson S; Foster RG. 2008. The acute light-induction of sleep is mediated by OPN4-based photoreception. Nat Neurosci :. PubMed: 18711396 MGI: J:141041
Lupi D; Semo M; Foster RG. 2012. Impact of age and retinal degeneration on the light input to circadian brain structures. Neurobiol Aging 33(2):383-92. PubMed: 20409612 MGI: J:188243
Majumder A; Pahlberg J; Muradov H; Boyd KK; Sampath AP; Artemyev NO. 2015. Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation. J Neurosci 35(24):9225-35. PubMed: 26085644 MGI: J:222549
Marc RE; Jones BW; Anderson JR; Kinard K; Marshak DW; Wilson JH; Wensel T; Lucas RJ. 2007. Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48(7):3364-71. PubMed: 17591910 MGI: J:123271
Margolis DJ; Gartland AJ; Singer JH; Detwiler PB. 2014. Network oscillations drive correlated spiking of ON and OFF ganglion cells in the rd1 mouse model of retinal degeneration. PLoS One 9(1):e86253. PubMed: 24489706 MGI: J:212697
Masana MI; Sumaya IC; Becker-Andre M; Dubocovich ML. 2007. Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol 292(6):R2357-67. PubMed: 17303680 MGI: J:121989
Matynia A; Parikh S; Chen B; Kim P; McNeill DS; Nusinowitz S; Evans C; Gorin MB. 2012. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res 105:60-9. PubMed: 23078956 MGI: J:203664
May A; Nimtschke U; May CA. 2009. The architecture of the mouse ciliary processes and their changes during retinal degeneration. Exp Eye Res 88(3):561-5. PubMed: 19059237 MGI: J:146578
May CA. 2009. Fibrae medullares in the retina of the RD mouse: a case report. Curr Eye Res 34(5):411-3. PubMed: 19401885 MGI: J:149565
McFadyen MP; Kusek G; Bolivar VJ; Flaherty L. 2003. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav 2(4):214-9. PubMed: 12953787 MGI: J:104873
McKenzie JA; Fruttiger M; Abraham S; Lange CA; Stone J; Gandhi P; Wang X; Bainbridge J; Moss SE; Greenwood J. 2012. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol 180(1):399-409. PubMed: 22067912 MGI: J:180164
Meng R; Wu J; Harper DC; Wang Y; Kowalska MA; Abrams CS; Brass LF; Poncz M; Stalker TJ; Marks MS. 2015. Defective release of alpha granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125(10):1623-32. PubMed: 25477496 MGI: J:221384
Menu dit Huart L; Lorentz O; Goureau O; Leveillard T; Sahel JA. 2004. DNA repair in the degenerating mouse retina. Mol Cell Neurosci 26(3):441-9. PubMed: 15234348 MGI: J:109747
Menzler J; Channappa L; Zeck G. 2014. Rhythmic ganglion cell activity in bleached and blind adult mouse retinas. PLoS One 9(8):e106047. PubMed: 25153888 MGI: J:219242
Menzler J; Zeck G. 2011. Network oscillations in rod-degenerated mouse retinas. J Neurosci 31(6):2280-91. PubMed: 21307264 MGI: J:169452
Mitton KP; Guzman AE; Deshpande M; Byrd D; DeLooff C; Mkoyan K; Zlojutro P; Wallace A; Metcalf B; Laux K; Sotzen J; Tran T. 2014. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Mol Vis 20(None):1527-44. PubMed: 25489226 MGI: J:220255
Mohand-Said S; Deudon-Combe A; Hicks D; Simonutti M; Forster V ; Fintz AC ; Leveillard T ; Dreyfus H ; Sahel JA. 1998. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci U S A 95(14):8357-62. PubMed: 9653191 MGI: J:48731
Molnar T; Barabas P; Birnbaumer L; Punzo C; Kefalov V; Krizaj D. 2012. Store-operated channels regulate intracellular calcium in mammalian rods. J Physiol 590(Pt 15):3465-81. PubMed: 22674725 MGI: J:200207
Montana CL; Kolesnikov AV; Shen SQ; Myers CA; Kefalov VJ; Corbo JC. 2013. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proc Natl Acad Sci U S A 110(5):1732-7. PubMed: 23319618 MGI: J:193697
Morin LP; Studholme KM. 2011. Separation of function for classical and ganglion cell photoreceptors with respect to circadian rhythm entrainment and induction of photosomnolence. Neuroscience 199:213-24. PubMed: 21985934 MGI: J:184037
Mrosovsky N; Foster RG; Salmon PA. 1999. Thresholds for masking responses to light in three strains of retinally degenerate mice. J Comp Physiol [A] 184(4):423-8. PubMed: 10377976 MGI: J:56471
Mrosovsky N; Hampton RR. 1997. Spatial responses to light in mice with severe retinal degeneration. Neurosci Lett 222(3):204-6. PubMed: 9148250 MGI: J:40689
Mure LS; Hatori M; Zhu Q; Demas J; Kim IM; Nayak SK; Panda S. 2016. Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells. Neuron 90(5):1016-27. PubMed: 27181062 MGI: J:239646
Nakamura K; Harada C; Okumura A; Namekata K; Mitamura Y; Yoshida K; Ohno S; Yoshida H; Harada T. 2005. Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol Vis 11:1229-35. PubMed: 16402023 MGI: J:136765
Nakamura PA; Tang S; Shimchuk AA; Ding S; Reh TA. 2016. Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa. Invest Ophthalmol Vis Sci 57(14):6407-6415. PubMed: 27893103 MGI: J:254678
Namekata K; Okumura A; Harada C; Nakamura K; Yoshida H; Harada T. 2006. Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors. Mol Vis 12:1586-93. PubMed: 17200657 MGI: J:117332
Nishiguchi KM; Carvalho LS; Rizzi M; Powell K; Holthaus SM; Azam SA; Duran Y; Ribeiro J; Luhmann UF; Bainbridge JW; Smith AJ; Ali RR. 2015. Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun 6:6006. PubMed: 25613321 MGI: J:219703
Nishiguchi KM; Nakamura M; Kaneko H; Kachi S; Terasaki H. 2007. The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration. Invest Ophthalmol Vis Sci 48(9):4315-20. PubMed: 17724222 MGI: J:126933
Nishikawa S; LaVail MM. 1998. Neovascularization of the RPE: temporal differences in mice with rod photoreceptor gene defects. Exp Eye Res 67(5):509-15. PubMed: 9878212 MGI: J:52112
Nivison-Smith L; Zhu Y; Whatham A; Bui BV; Fletcher EL; Acosta ML; Kalloniatis M. 2014. Sildenafil alters retinal function in mouse carriers of retinitis pigmentosa. Exp Eye Res 128:43-56. PubMed: 25239397 MGI: J:230189
Nuhn JS; Fuerst PG. 2014. Developmental localization of adhesion and scaffolding proteins at the cone synapse. Gene Expr Patterns 16(1):36-50. PubMed: 25176525 MGI: J:216508
O'Leary TP; Brown RE. 2009. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res 201(1):120-7. PubMed: 19428625 MGI: J:148386
Ogilvie JM; Hakenewerth AM; Gardner RR; Martak JG; Maggio VM. 2009. Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo. Mol Vis 15:2868-78. PubMed: 20038975 MGI: J:157088
Otani A; Kojima H; Guo C; Oishi A; Yoshimura N. 2012. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol 180(1):328-36. PubMed: 22074737 MGI: J:180155
Owens L; Buhr E; Tu DC; Lamprecht TL; Lee J; Van Gelder RN. 2012. Effect of circadian clock gene mutations on nonvisual photoreception in the mouse. Invest Ophthalmol Vis Sci 53(1):454-60. PubMed: 22159024 MGI: J:191526
Panda S; Provencio I; Tu DC; Pires SS; Rollag MD; Castrucci AM; Pletcher MT; Sato TK; Wiltshire T; Andahazy M; Kay SA; Van Gelder RN; Hogenesch JB. 2003. Melanopsin is required for non-image-forming photic responses in blind mice. Science 301(5632):525-7. PubMed: 12829787 MGI: J:165769
Panda S; Sato TK; Castrucci AM; Rollag MD; DeGrip WJ; Hogenesch JB; Provencio I; Kay SA. 2002. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 298(5601):2213-6. PubMed: 12481141 MGI: J:81501
Pang J; Cheng M; Haire SE; Barker E; Planelles V; Blanks JC. 2006. Efficiency of lentiviral transduction during development in normal and rd mice. Mol Vis 12:756-67. PubMed: 16862069 MGI: J:111621
Paper W; Kroeber M; Heersink S; Stephan DA; Fuchshofer R; Russell P; Tamm ER. 2008. Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res 87(3):257-67. PubMed: 18602390 MGI: J:141881
Paquet-Durand F ; Hauck SM ; van Veen T ; Ueffing M ; Ekstrom P. 2009. PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem 108(3):796-810. PubMed: 19187097 MGI: J:146653
Paquet-Durand F; Azadi S; Hauck SM; Ueffing M; van Veen T; Ekstrom P. 2006. Calpain is activated in degenerating photoreceptors in the rd1 mouse. J Neurochem 96(3):802-14. PubMed: 16405498 MGI: J:106017
Paquet-Durand F; Beck S; Michalakis S; Goldmann T; Huber G; Muhlfriedel R; Trifunovic D; Fischer MD; Fahl E; Duetsch G; Becirovic E; Wolfrum U; van Veen T; Biel M; Tanimoto N; Seeliger MW. 2011. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet 20(5):941-7. PubMed: 21149284 MGI: J:169039
Park H; Tan CC; Faulkner A; Jabbar SB; Schmid G; Abey J; Iuvone PM; Pardue MT. 2013. Retinal degeneration increases susceptibility to myopia in mice. Mol Vis 19:2068-79. PubMed: 24146540 MGI: J:205341
Park SJ; Lee DS; Lim EJ; Choi SH; Kang WS; Kim IB; Chun MH. 2008. The absence of the clathrin-dependent endocytosis in rod bipolar cells of the FVB/N mouse retina. Neurosci Lett 439(2):165-9. PubMed: 18514403 MGI: J:137049
Peirson SN; Oster H; Jones SL; Leitges M; Hankins MW; Foster RG. 2007. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Curr Biol 17(16):1363-72. PubMed: 17702581 MGI: J:128396
Peng GH; Chen S. 2007. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet 16(20):3433-52. PubMed: 17656371 MGI: J:129889
Pennesi ME; Michaels KV; Magee SS; Maricle A; Davin SP; Garg AK; Gale MJ; Tu DC; Wen Y; Erker LR; Francis PJ. 2012. Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 53(8):4644-56. PubMed: 22562504 MGI: J:213983
Petrasch-Parwez E; Habbes HW; Weickert S; Lobbecke-Schumacher M; Striedinger K; Wieczorek S; Dermietzel R; Epplen JT. 2004. Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease. J Comp Neurol 479(2):181-97. PubMed: 15452853 MGI: J:135880
Phelan JK; Bok D. 2000. Analysis and quantitation of mRNAs encoding the alpha- and beta-subunits of rod photoreceptor cGMP phosphodiesterase in neonatal retinal degeneration (rd) mouse retinas. Exp Eye Res 71(2):119-28. PubMed: 10930317 MGI: J:63861
Pickard GE; Baver SB; Ogilvie MD; Sollars PJ. 2009. Light-induced fos expression in intrinsically photosensitive retinal ganglion cells in melanopsin knockout (opn4) mice. PLoS One 4(3):e4984. PubMed: 19319185 MGI: J:147460
Pittler SJ; Baehr W. 1991. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A 88(19):8322-6. PubMed: 1656438 MGI: J:11513
Pittler SJ; Keeler CE; Sidman RL; Baehr W. 1993. PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc Natl Acad Sci U S A 90(20):9616-9. PubMed: 8415750 MGI: J:15231
Popper P; Farber DB; Micevych PE; Minoofar K; Bronstein JM. 1997. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp Neurol 143(2):246-54. PubMed: 9056387 MGI: J:38831
Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A 91(3):974-8. PubMed: 8302876 MGI: J:16708
Prigge CL; Yeh PT; Liou NF; Lee CC; You SF; Liu LL; McNeill DS; Chew KS; Hattar S; Chen SK; Zhang DQ. 2016. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci 36(27):7184-97. PubMed: 27383593 MGI: J:234637
Provencio I; Cooper HM; Foster RG. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. J Comp Neurol 395(4):417-39. PubMed: 9619497 MGI: J:47756
Provencio I; Foster RG. 1995. Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics. Brain Res 694(1-2):183-90. PubMed: 8974643 MGI: J:29236
Provencio I; Wong S; Lederman AB; Argamaso SM; Foster RG. 1994. Visual and circadian responses to light in aged retinally degenerate mice. Vision Res 34(14):1799-806. PubMed: 7941382 MGI: J:19843
Punzo C; Cepko C. 2007. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 48(2):849-57. PubMed: 17251487 MGI: J:123282
Punzo C; Kornacker K; Cepko CL. 2009. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44-52. PubMed: 19060896 MGI: J:144720
Qiao X; Pennesi M; Seong E; Gao H; Burmeister M; Wu SM. 2003. Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain. Vision Res 43(8):859-65. PubMed: 12668055 MGI: J:88031
RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/) :. MGI: J:133634
Rao A; Dallman R; Henderson S; Chen CK. 2007. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. J Neurosci 27(51):14199-204. PubMed: 18094259 MGI: J:129267
Rattner A; Wang Y; Zhou Y; Williams J; Nathans J. 2014. The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling. Invest Ophthalmol Vis Sci 55(12):8614-25. PubMed: 25414188 MGI: J:230295
Read DS; McCall MA; Gregg RG. 2002. Absence of voltage-dependent calcium channels delays photoreceptor degeneration in rd mice. Exp Eye Res 75(4):415-20. PubMed: 12387789 MGI: J:79923
Rich KA; Zhan Y; Blanks JC. 1997. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol 388(1):47-63. PubMed: 9364238 MGI: J:44100
Roesch K; Stadler MB; Cepko CL. 2012. Gene expression changes within Muller glial cells in retinitis pigmentosa. Mol Vis 18:1197-214. PubMed: 22665967 MGI: J:191614
Rohrer B; Demos C; Frigg R; Grimm C. 2007. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res 84(1):82-91. PubMed: 17069800 MGI: J:123183
Rossi C; Strettoi E; Galli-Resta L. 2003. The spatial order of horizontal cells is not affected by massive alterations in the organization of other retinal cells. J Neurosci 23(30):9924-8. PubMed: 14586022 MGI: J:120041
Ruan GX; Allen GC; Yamazaki S; McMahon DG. 2008. An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol 6(10):e249. PubMed: 18959477 MGI: J:141081
Ruggiero L; Allen CN; Lane Brown R; Robinson DW. 2009. The development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration. Eur J Neurosci 29(2):359-67. PubMed: 19200239 MGI: J:146465
Ryu SB; Ye JH; Goo YS; Kim CH; Kim KH. 2010. Temporal response properties of retinal ganglion cells in rd1 mice evoked by amplitude-modulated electrical pulse trains. Invest Ophthalmol Vis Sci 51(12):6762-9. PubMed: 20671284 MGI: J:171389
SIDMAN RL; GREEN MC. 1965. RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII. J Hered 56:23-9. PubMed: 14276177 MGI: J:114
Sahaboglu A; Tanimoto N; Kaur J; Sancho-Pelluz J; Huber G; Fahl E; Arango-Gonzalez B; Zrenner E; Ekstrom P; Lowenheim H; Seeliger M; Paquet-Durand F. 2010. PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One 5(11):e15495. PubMed: 21124852 MGI: J:167317
Samardzija M; Wenzel A; Aufenberg S; Thiersch M; Reme C; Grimm C. 2006. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J 20(13):2411-3. PubMed: 16966486 MGI: J:114638
Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. PubMed: 17122101 MGI: J:123100
Sancho-Pelluz J; Wunderlich KA; Rauch U; Romero FJ; van Veen T; Limb GA; Crocker PR; Perez MT. 2008. Sialoadhesin expression in intact degenerating retinas and following transplantation. Invest Ophthalmol Vis Sci 49(12):5602-10. PubMed: 18641281 MGI: J:142000
Sanz MM; Johnson LE; Ahuja S; Ekstrom PA; Romero J; van Veen T. 2007. Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration. Neuroscience 145(3):1120-9. PubMed: 17293057 MGI: J:121644
Sasahara M; Otani A; Oishi A; Kojima H; Yodoi Y; Kameda T; Nakamura H; Yoshimura N. 2008. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol 172(6):1693-703. PubMed: 18483210 MGI: J:136339
Schmidt SY; Lolley RN. 1973. Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice. J Cell Biol 57(1):117-23. PubMed: 4347974 MGI: J:5332
Scott A; Powner MB; Fruttiger M. 2014. Quantification of vascular tortuosity as an early outcome measure in oxygen induced retinopathy (OIR). Exp Eye Res 120:55-60. PubMed: 24418725 MGI: J:210367
Selby CP; Thompson C; Schmitz TM; Van Gelder RN; Sancar A. 2000. Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice Proc Natl Acad Sci U S A 97(26):14697-702. PubMed: 11114194 MGI: J:66580
Semo M; Gias C; Ahmado A; Sugano E; Allen AE; Lawrence JM; Tomita H; Coffey PJ; Vugler AA. 2010. Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. PLoS One 5(11):e15009. PubMed: 21124784 MGI: J:167120
Semo M; Lupi D; Peirson SN; Butler JN; Foster RG. 2003. Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 18(11):3007-17. PubMed: 14656296 MGI: J:89691
Semo M; Peirson S; Lupi D; Lucas RJ; Jeffery G; Foster RG. 2003. Melanopsin retinal ganglion cells and the maintenance of circadian and pupillary responses to light in aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci 17(9):1793-801. PubMed: 12752778 MGI: J:128149
Sharma AK; Rohrer B. 2007. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res 32(3):259-69. PubMed: 17453946 MGI: J:121112
Sheedlo HJ; Jaynes D; Bolan AL; Turner JE. 1995. Mullerian glia in dystrophic rodent retinas: an immunocytochemical analysis. Brain Res Dev Brain Res 85(2):171-80. PubMed: 7600664 MGI: J:24543
Sooy K; Noble J; McBride A; Binnie M; Yau JL; Seckl JR; Walker BR; Webster SP. 2015. Cognitive and Disease-Modifying Effects of 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. Endocrinology 156(12):4592-603. PubMed: 26305888 MGI: J:232753
Srinivasan Y; Lovicu FJ; Overbeek PA. 1998. Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts. J Clin Invest 101(3):625-34. PubMed: 9449696 MGI: J:135895
Srivastava P; Sinha-Mahapatra SK; Ghosh A; Srivastava I; Dhingra NK. 2015. Differential alterations in the expression of neurotransmitter receptors in inner retina following loss of photoreceptors in rd1 mouse. PLoS One 10(4):e0123896. PubMed: 25835503 MGI: J:233420
Stone C; Pinto LH. 1993. Response properties of ganglion cells in the isolated mouse retina. Vis Neurosci 10(1):31-9. PubMed: 8424927 MGI: J:116795
Strettoi E; Pignatelli V. 2000. Modifications of retinal neurons in a mouse model of retinitis pigmentosa Proc Natl Acad Sci U S A 97(20):11020-5. PubMed: 10995468 MGI: J:64742
Strettoi E; Pignatelli V; Rossi C; Porciatti V; Falsini B. 2003. Remodeling of second-order neurons in the retina of rd/rd mutant mice. Vision Res 43(8):867-77. PubMed: 12668056 MGI: J:92316
Strettoi E; Porciatti V; Falsini B; Pignatelli V; Rossi C. 2002. Morphological and functional abnormalities in the inner retina of the rd/rd mouse. J Neurosci 22(13):5492-504. PubMed: 12097501 MGI: J:109225
Sumaya IC; Masana MI; Dubocovich ML. 2005. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res 39(2):170-7. PubMed: 16098095 MGI: J:114318
Sun J; Mandai M; Kamao H; Hashiguchi T; Shikamura M; Kawamata S; Sugita S; Takahashi M. 2015. Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice. Stem Cells 33(5):1543-53. PubMed: 25728228 MGI: J:224164
Syeda S; Patel AK; Lee T; Hackam AS. 2015. Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88. Exp Neurol 267(None):1-12. PubMed: 25725353 MGI: J:221046
Takahashi M; Miyoshi H; Verma IM; Gage FH. 1999. Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 73(9):7812-6. PubMed: 10438872 MGI: J:56759
Tansley K. 1954. An inherited retinal degeneration in the mouse J Hered 45:123-27. MGI: J:15333
Thaung C; Arnold K; Jackson IJ; Coffey PJ. 2002. Presence of visual head tracking differentiates normal sighted from retinal degenerate mice. Neurosci Lett 325(1):21-4. PubMed: 12023058 MGI: J:107978
Thompson CL; Selby CP; Partch CL; Plante DT; Thresher RJ; Araujo F; Sancar A. 2004. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res 122(2):158-66. PubMed: 15010208 MGI: J:88468
Thompson S; Blodi FR; Lee S; Welder CR; Mullins RF; Tucker BA; Stasheff SF; Stone EM. 2014. Photoreceptor cells with profound structural deficits can support useful vision in mice. Invest Ophthalmol Vis Sci 55(3):1859-66. PubMed: 24569582 MGI: J:229505
Thompson S; Foster RG; Stone EM; Sheffield VC; Mrosovsky N. 2008. Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light. Eur J Neurosci 27(8):1973-9. PubMed: 18412618 MGI: J:136825
Thompson S; Lupi D; Hankins MW; Peirson SN; Foster RG. 2008. The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate. Eur J Neurosci 28(4):724-9. PubMed: 18702692 MGI: J:140577
Thompson S; Mullins RF; Philp AR; Stone EM; Mrosovsky N. 2008. Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd). Invest Ophthalmol Vis Sci 49(6):2737-42. PubMed: 18515598 MGI: J:137044
Thompson S; Stasheff SF; Hernandez J; Nylen E; East JS; Kardon RH; Pinto LH; Mullins RF; Stone EM. 2011. Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice. Invest Ophthalmol Vis Sci 52(1):618-23. PubMed: 20847113 MGI: J:171559
Thyagarajan S; van Wyk M; Lehmann K; Lowel S; Feng G; Wassle H. 2010. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30(26):8745-58. PubMed: 20592196 MGI: J:161847
Tochitsky I; Polosukhina A; Degtyar VE; Gallerani N; Smith CM; Friedman A; Van Gelder RN; Trauner D; Kaufer D; Kramer RH. 2014. Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron 81(4):800-13. PubMed: 24559673 MGI: J:220643
Tsang SH; Gouras P; Yamashita CK; Kjeldbye H; Fisher J; Farber DB; Goff SP. 1996. Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science 272(5264):1026-9. PubMed: 8638127 MGI: J:33048
Tsuchiya S; Buhr ED; Higashide T; Sugiyama K; Van Gelder RN. 2017. Light entrainment of the murine intraocular pressure circadian rhythm utilizes non-local mechanisms. PLoS One 12(9):e0184790. PubMed: 28934261 MGI: J:249791
Tu DC; Owens LA; Anderson L; Golczak M; Doyle SE; McCall M; Menaker M; Palczewski K; Van Gelder RN. 2006. Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A 103(27):10426-31. PubMed: 16788071 MGI: J:111700
Tu DC; Zhang D; Demas J; Slutsky EB; Provencio I; Holy TE; Van Gelder RN. 2005. Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells. Neuron 48(6):987-99. PubMed: 16364902 MGI: J:107606
Tucker B; Klassen H; Yang L; Chen DF; Young MJ. 2008. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Invest Ophthalmol Vis Sci 49(4):1686-95. PubMed: 18385092 MGI: J:136153
Usui S; Oveson BC; Lee SY; Jo YJ; Yoshida T; Miki A; Miki K; Iwase T; Lu L; Campochiaro PA. 2009. NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa. J Neurochem 110(3):1028-37. PubMed: 19493169 MGI: J:152819
Van Gelder RN; Wee R; Lee JA; Tu DC. 2003. Reduced pupillary light responses in mice lacking cryptochromes. Science 299(5604):222. PubMed: 12522242 MGI: J:81500
Vazquez-Chona FR; Clark AM; Levine EM. 2009. Rlbp1 promoter drives robust Muller glial GFP expression in transgenic mice. Invest Ophthalmol Vis Sci 50(8):3996-4003. PubMed: 19324864 MGI: J:154561
Venkatesh A; Ma S; Le YZ; Hall MN; Ruegg MA; Punzo C. 2015. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest 125(4):1446-58. PubMed: 25798619 MGI: J:222273
Viczian A; Sanyal S; Toffenetti J; Chader GJ; Farber DB. 1992. Photoreceptor-specific mRNAs in mice carrying different allelic combinations at the rd and rds loci. Exp Eye Res 54(6):853-60. PubMed: 1381682 MGI: J:2579
Vlachantoni D; Bramall AN; Murphy MP; Taylor RW; Shu X; Tulloch B; Van Veen T; Turnbull DM; McInnes RR; Wright AF. 2011. Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. Hum Mol Genet 20(2):322-35. PubMed: 21051333 MGI: J:166898
Wahlin KJ; Adler R; Zack DJ; Campochiaro PA. 2001. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res 73(5):693-701. PubMed: 11747369 MGI: J:73377
Wang Y; Wang ZY; Zhou MN; Cai J; Sun LY; Liu XY; Daugherty BL; Pestka S. 1997. Sequencing and bacterial expression of a novel murine alpha interferon gene. Sci China C Life Sci 40(3):277-283. MGI: J:41297
Warthen DM; Wiltgen BJ; Provencio I. 2011. Light enhances learned fear. Proc Natl Acad Sci U S A 108(33):13788-93. PubMed: 21808002 MGI: J:175610
Welge-Lussen U; Wilsch C; Neuhardt T; Wayne Streilein J; Lutjen-Drecoll E. 1999. Loss of anterior chamber-associated immune deviation (ACAID) in aged retinal degeneration (rd) mice. Invest Ophthalmol Vis Sci 40(13):3209-14. PubMed: 10586944 MGI: J:58745
Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. PubMed: 21052544 MGI: J:166679
Wong P; Borst DE; Farber D; Danciger JS; Tenniswood M; Chader GJ; van Veen T. 1994. Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa. Biochem Cell Biol 72(9-10):439-46. PubMed: 7605616 MGI: J:24128
Worthington KS; Wiley LA; Bartlett AM; Stone EM; Mullins RF; Salem AK; Guymon CA; Tucker BA. 2014. Mechanical properties of murine and porcine ocular tissues in compression. Exp Eye Res 121:194-9. PubMed: 24613781 MGI: J:229490
Wu J; Trogadis J; Bremner R. 2001. Rod and cone degeneration in the rd mouse is p53 independent. Mol Vis 7:101-6. PubMed: 11344337 MGI: J:126023
Wunderlich KA; Leveillard T; Penkowa M; Zrenner E; Perez MT. 2010. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Invest Ophthalmol Vis Sci 51(9):4809-20. PubMed: 20357188 MGI: J:164094
Xiang L; Chen XJ; Wu KC; Zhang CJ; Zhou GH; Lv JN; Sun LF; Cheng FF; Cai XB; Jin ZB. 2017. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A 114(24):6376-6381. PubMed: 28559309 MGI: J:244554
Xiong W; MacColl Garfinkel AE; Li Y; Benowitz LI; Cepko CL. 2015. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest 125(4):1433-45. PubMed: 25798616 MGI: J:222275
Yamada H; Yamada E; Hackett SF; Ozaki H; Okamoto N; Campochiaro PA. 1999. Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina. J Cell Physiol 179(2):149-56. PubMed: 10199554 MGI: J:54326
Yan W; Lewin A; Hauswirth W. 1998. Selective degradation of nonsense beta-phosphodiesterase mRNA in the heterozygous rd mouse. Invest Ophthalmol Vis Sci 39(13):2529-36. PubMed: 9856762 MGI: J:51361
Yang LP; Wu LM; Guo XJ; Tso MO. 2007. Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse. Invest Ophthalmol Vis Sci 48(11):5191-8. PubMed: 17962473 MGI: J:127157
Yazulla S; Studholme KM; Pinto LH. 1997. Differences in the retinal GABA system among control, spastic mutant and retinal degeneration mutant mice. Vision Res 37(24):3471-82. PubMed: 9425524 MGI: J:45280
Yee CW; Toychiev AH; Ivanova E; Sagdullaev BT. 2014. Aberrant synaptic input to retinal ganglion cells varies with morphology in a mouse model of retinal degeneration. J Comp Neurol 522(18):4085-99. PubMed: 25099614 MGI: J:238192
Yi H; Nakamura RE; Mohamed O; Dufort D; Hackam AS. 2007. Characterization of Wnt signaling during photoreceptor degeneration. Invest Ophthalmol Vis Sci 48(12):5733-41. PubMed: 18055826 MGI: J:132500
Yoshimura T; Ebihara S. 1998. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. Brain Res 779(1-2):188-93. PubMed: 9473668 MGI: J:45462
Yoshimura T; Ebihara S. 1996. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. J Comp Physiol [A] 178(6):797-802. PubMed: 8667293 MGI: J:33685
Yoshimura T; Nishio M; Goto M; Ebihara S. 1994. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). J Biol Rhythms 9(1):51-60. PubMed: 7949306 MGI: J:19351
Yoshimura T; Yokota Y; Ishikawa A; Yasuo S; Hayashi N; Suzuki T; Okabayashi N; Namikawa T; Ebihara S. 2002. Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice. J Biol Rhythms 17(6):512-9. PubMed: 12465884 MGI: J:80788
Zeiss CJ; Johnson EA. 2004. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Invest Ophthalmol Vis Sci 45(3):971-6. PubMed: 14985319 MGI: J:109731
Zeiss CJ; Neal J; Johnson EA. 2004. Caspase-3 in postnatal retinal development and degeneration. Invest Ophthalmol Vis Sci 45(3):964-70. PubMed: 14985318 MGI: J:88367
Zencak D; Crippa SV; Tekaya M; Tanger E; Schorderet DE; Munier FL; van Lohuizen M; Arsenijevic Y. 2006. BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 572:209-15. PubMed: 17249577 MGI: J:154016
Zencak D; Schouwey K; Chen D; Ekstrom P; Tanger E; Bremner R; van Lohuizen M; Arsenijevic Y. 2013. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 110(7):E593-601. PubMed: 23359713 MGI: J:194322
Zeng H; Ding M; Chen XX; Lu Q. 2014. Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice. Neuroscience 275:54-61. PubMed: 24929065 MGI: J:215397
Zeng HY; Lu QJ; Liu Q; Liu KG; Wang NL. 2011. The role of CCR1 expression in the retinal degeneration in rd mice. Curr Eye Res 36(3):264-9. PubMed: 21275605 MGI: J:179793
Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. PubMed: 23221340 MGI: J:194158
Zhao L; Zabel MK; Wang X; Ma W; Shah P; Fariss RN; Qian H; Parkhurst CN; Gan WB; Wong WT. 2015. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7(9):1179-97. PubMed: 26139610 MGI: J:233541
Zhu Y; Tu DC; Denner D; Shane T; Fitzgerald CM; Van Gelder RN. 2007. Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses. Invest Ophthalmol Vis Sci 48(3):1268-75. PubMed: 17325172 MGI: J:123259
van Oosterhout F; Fisher SP; van Diepen HC; Watson TS; Houben T; VanderLeest HT; Thompson S; Peirson SN; Foster RG; Meijer JH. 2012. Ultraviolet light provides a major input to non-image-forming light detection in mice. Curr Biol 22(15):1397-402. PubMed: 22771039 MGI: J:199506
van Wyk M; Pielecka-Fortuna J; Lowel S; Kleinlogel S. 2015. Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool. PLoS Biol 13(5):e1002143. PubMed: 25950461 MGI: J:222959

Also Known As: SW, swiss

Genetic overview

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Development

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Ahrd

Allele Symbol: Ahrd

Disc1del

Allele Symbol: Disc1del

Hc0

Allele Symbol: Hc0

Pde6brd1

Allele Symbol: Pde6brd1

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This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Hc0 related

Genotype: Pde6brd1 related

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Additional - Ahrd related

Additional - Disc1del related

Additional - Hc0 related

Additional - Pde6brd1 related

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