Overview

Also Known As:small

SM/J mice carry a number of rare polymorphic alleles and are often matched to other strains for quantitative trait locus analysis. These mice are susceptible to diet-induced obesity and diet-induced atherosclerosis. SM/J mice exhibit a hyperresponsiveness to B cell mitogens. Small in size at birth and through weaning, SM/J mice attain a normal body weight as they age.

Genetic overview

Genetic Background	Generation
	F229 (2019-06-13 00:00:00)

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Research Applications

Developmental Biology Research
Cardiovascular Research
Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research

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Base Price

Starting at:

$236.78 Domestic price for female 4-week

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Details

Detailed Description

SM/J mice carry a number of rare polymorphic alleles and are often matched to LG/J (Stock No. 000675), A/J (Stock No. 000646) or NZB/BINJ (Stock No. 000684) for quantitative trait locus analysis. These mice are susceptible to diet-induced obesity and diet-induced atherosclerosis. SM/J mice exhibit a hyperresponsiveness to B cell mitogens (Clark et al. 1981, Engel et al. 1981). A point mutation in Neu1 is responsible for a partial deficiency of lysosomal neuraminadase and may explain the altered immune response (Rottier et al. 1998). Small in size at birth and through weaning, SM/J mice attain a normal body weight as they age.

Development

SM/J, created by MacArthur in 1939 from crosses involving 7 inbred strains - among them DBA - followed by inbreeding with selection for small body size, is segregating white-bellied agouti (A^w) vs. nonagouti (a) at the agouti locus.

Selected References

Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23PubMed: 2317166 MGI: J:22615
Macarthur JW. 1949. Selection for Small and Large Body Size in the House Mouse. Genetics 34(2):194-209PubMed: 17247310 MGI: J:2452
Macarthur JW. 1944. Genetics of body size and related characters. Am Naturalist 78:142-57MGI: J:25351
Anunciado RV; Nishimura M; Mori M; Ishikawa A; Tanaka S; Horio F; Ohno T; Namikawa T. 2001. Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim 50(4):319-24PubMed: 11515095 MGI: J:71465
Pitman WA; Korstanje R; Churchill GA; Nicodeme E; Albers JJ; Cheung MC; Staton MA; Sampson SS; Harris S; Paigen B. 2002. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics 9(2):93-102PubMed: 12006675 MGI: J:76707
Korstanje R; Albers JJ; Wolfbauer G; Li R; Tu AY; Churchill GA; Paigen BJ. 2004. Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice. Arterioscler Thromb Vasc Biol 24(1):155-60PubMed: 14592843 MGI: J:86340
Ehrich TH; Kenney JP; Vaughn TT; Pletscher LS; Cheverud JM. 2003. Diet, obesity, and hyperglycemia in LG/J and SM/J mice. Obes Res 11(11):1400-10PubMed: 14627762 MGI: J:86873
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298
Korstanje R; Li R; Howard T; Kelmenson P; Marshall J; Paigen B; Churchill G. 2004. Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population. J Lipid Res 45(5):881-8PubMed: 14993241 MGI: J:89309

View All References

Genetics

Il3ra^m1

Allele Symbol: Il3ra^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	Il3ra^m1; mutation 1
Gene Symbol and Name	Il3ra, interleukin 3 receptor, alpha chain
Gene Synonym(s)	Cyrl; SUT-1; hIL-3Ra; IL-3 receptor alpha chain; IL3R; IL3RAY; IL3RX; IL3RY; CD123
Strain of Origin	multiple strains
Chromosome	14
General Note	This allele has been identified in A/J, A/WySnJ, A/HeJ, C58/J, RF/J, AKR/J, SM/J, BUB/BnJ, CE/J, and NZB/B1NJ. see J:24918.
Molecular Note	Sequence analysis revealed A/J mice lack the sequence corresponding to exon 8, which encodes 10 amino acid residues in the extracellular domain. Aberrant splicing was due to a 5 base pair deletion at the branch point in intron 7.

Neu1^a

Allele Symbol: Neu1^a

Allele Name	a variant
Allele Type	Not Applicable
Allele Synonym(s)	a variant; Neu1^a
Gene Symbol and Name	Neu1, neuraminidase 1
Gene Synonym(s)	acid phosphatase, liver; expressed sequence AA407316; alpha glucosidase processing; Neu-1; SIAL1; sialidase 1; expressed sequence AA407268; G9; Bat-7; Bat7; Apl; NANH; NEU; Aglp; Bat-7; Bat7; lysosomal sialidase; Map-2; Map-2; Neu-1; HLA-B-associated transcript 7; mannosidase processing 2; Aglp; Apl; AA407268; AA407316
Strain of Origin	SM/J
Chromosome	17
General Note	Low activity determined by the Neu1^a allele occurs in the SM/J inbred strain and in wild mice in the area of Ann Arbor, Michigan; all other inbred strains have high activity determined by the Neu1^b allele. Heterozygotes have intermediate activity. Neuraminidase removes extra sialic acid residues from these enzymes. The defective neuraminidase of Neu1^a> mice, by failing to remove the extra sialic acid, changes their electrophoretic mobility (J:6480). Level of activity of neuraminidase in activated T lymphocytes is also depressed in Neu1^a/Neu1^a mice (J:7976).
Molecular Note	Sequencing of the a allele revealed 5 nucleotide differences compared to the b allele. These changes alter the amino acid residues 11, 15, 17, 19 and 209 of the encoded protein from Gly, Tyr, Ala, Arg and Leu to Arg, Cys, Val, Cys and Ile, respectively. This encoded protein has 85-95% less activity than the protein encoded by the b allele as demonstrated in an in vitro assay. Further studies attributed most of the activity loss to the variation at position 209. Later studies detected 4 silent mutations in the signal peptide sequence and 2 mutations (c.-240C>T and c.-519G>A) in the promoter region. The mutation c.-519G>A creates a novel binding site for Nkx3-1 and Nkx3-2. In vitro assays demonstrated that binding of Nkx3-2 specifically represses promoter driven expression.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)	deletion; Gpr84^del
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	GPCR4; EX33
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Ogg1^m1

Allele Symbol: Ogg1^m1

Allele Name	mutation 1
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	Ogg1^m1; mutation 1
Gene Symbol and Name	Ogg1, 8-oxoguanine DNA-glycosylase 1
Gene Synonym(s)	MUTM; Mmh; HMMH; HOGG1; OGH1
Strain of Origin	various
Chromosome	6
Molecular Note	A guanine to adenine change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of the 336th amino acid, arginine, by histidine (R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal.

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

glycoproteinosis

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Developmental Biology Research
- Growth Defects
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Susceptible
Diabetes and Obesity Research
- Obesity Without Diabetes
  - diet-induced
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - defects in humoral immune responses

Genotype: Il3ra^m1 related

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Neu1^a/Neu1^a
SM/J

cardiovascular system phenotype

abnormal Kupffer cell morphology
- cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

growth/size/body region phenotype

decreased body weight
- compared to C57BL/6 controls

hematopoietic system phenotype

abnormal Kupffer cell morphology
- cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

homeostasis/metabolism phenotype

abnormal enzyme/coenzyme activity
- deficient enzymatic activity of neuraminidase was reported
- tissue specific decrease in sialidase activity

immune system phenotype

abnormal Kupffer cell morphology
- cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

liver/biliary system phenotype

abnormal Kupffer cell morphology
- cells contain large membrane bound bodies containing lipid droplets and membrane like structures that are not present in C57BL/6 controls

renal/urinary system phenotype

abnormal proximal convoluted tubule morphology
- cells with high levels of membranous accumulations degenerate releasing cellular debris into the intercellular space and the lumen of the tubules
- some epithelial cells accumulate large membrane-bound structures containing membranous whorls

Genotype: Il3ra^m1/Il3ra^m1
SM/J

hematopoietic system phenotype

abnormal common myeloid progenitor cell morphology
- CFU-GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3

Phenotype Information

Festing Inbred Strain Characteristics: SM

References

Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23PubMed: 2317166 MGI: J:22615
Macarthur JW. 1949. Selection for Small and Large Body Size in the House Mouse. Genetics 34(2):194-209PubMed: 17247310 MGI: J:2452
Macarthur JW. 1944. Genetics of body size and related characters. Am Naturalist 78:142-57MGI: J:25351
Anunciado RV; Nishimura M; Mori M; Ishikawa A; Tanaka S; Horio F; Ohno T; Namikawa T. 2001. Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim 50(4):319-24PubMed: 11515095 MGI: J:71465
Pitman WA; Korstanje R; Churchill GA; Nicodeme E; Albers JJ; Cheung MC; Staton MA; Sampson SS; Harris S; Paigen B. 2002. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics 9(2):93-102PubMed: 12006675 MGI: J:76707
Korstanje R; Albers JJ; Wolfbauer G; Li R; Tu AY; Churchill GA; Paigen BJ. 2004. Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice. Arterioscler Thromb Vasc Biol 24(1):155-60PubMed: 14592843 MGI: J:86340
Ehrich TH; Kenney JP; Vaughn TT; Pletscher LS; Cheverud JM. 2003. Diet, obesity, and hyperglycemia in LG/J and SM/J mice. Obes Res 11(11):1400-10PubMed: 14627762 MGI: J:86873
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298
Korstanje R; Li R; Howard T; Kelmenson P; Marshall J; Paigen B; Churchill G. 2004. Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population. J Lipid Res 45(5):881-8PubMed: 14993241 MGI: J:89309

Additional References

Wahlsten D; Bachmanov A; Finn DA; Crabbe JC. 2006. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103(44):16364-9PubMed: 17053075 MGI: J:115640
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
Cheverud JM; Fawcett GL; Jarvis JP; Norgard EA; Pavlicev M; Pletscher LS; Polonsky KS; Ye H; Bell GI; Semenkovich CF. 2010. Calpain-10 is a component of the obesity-related quantitative trait locus Adip1. J Lipid Res 51(5):907-13PubMed: 20388922 MGI: J:153477
Bedelbaeva K; Snyder A; Gourevitch D; Clark L; Zhang XM; Leferovich J; Cheverud JM; Lieberman P; Heber-Katz E. 2010. Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci U S A 107(13):5845-50PubMed: 20231440 MGI: J:158653
Sinke AP; Caputo C; Tsaih SW; Yuan R; Ren D; Deen PM; Korstanje R. 2011. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics 43(5):265-70PubMed: 21177381 MGI: J:171768
Crowley JJ; Kim Y; Szatkiewicz JP; Pratt AL; Quackenbush CR; Adkins DE; van den Oord E; Bogue MA; Yang H; Wang W; Threadgill DW; de Villena FP; McLeod HL; Sullivan PF. 2012. Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice. Mamm Genome 23(5-6):322-35PubMed: 22207321 MGI: J:179972
Clark PJ; Kohman RA; Miller DS; Bhattacharya TK; Brzezinska WJ; Rhodes JS. 2011. Genetic influences on exercise-induced adult hippocampal neurogenesis across 12 divergent mouse strains. Genes Brain Behav 10(3):345-53PubMed: 21223504 MGI: J:183496
Yuan R; Meng Q; Nautiyal J; Flurkey K; Tsaih SW; Krier R; Parker MG; Harrison DE; Paigen B. 2012. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A 109(21):8224-9PubMed: 22566614 MGI: J:184775
Lightfoot JT; Leamy L; Pomp D; Turner MJ; Fodor AA; Knab A; Bowen RS; Ferguson D; Moore-Harrison T; Hamilton A. 2010. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol 109(3):623-34PubMed: 20538847 MGI: J:185928
Frankel WN; Lee BK; Stoye JP; Coffin JM; Eicher EM. 1992. Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains. Mamm Genome 2(2):110-22PubMed: 1311971 MGI: J:1883
Harrill AH; Desmet KD; Wolf KK; Bridges AS; Eaddy JS; Kurtz CL; Hall JE; Paine MF; Tidwell RR; Watkins PB. 2012. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci 130(2):416-26PubMed: 22940726 MGI: J:192655
Goes CP; Sauce B; Peripato AC. 2012. Milk ejection in mice LG/J x SM/J. Mamm Genome 23(11-12):770-9PubMed: 23052823 MGI: J:193933
Leduc MS; Hageman RS; Meng Q; Verdugo RA; Tsaih SW; Churchill GA; Paigen B; Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9(5):823-36PubMed: 20735370 MGI: J:201869
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Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
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Chella Krishnan K; Kurt Z; Barrere-Cain R; Sabir S; Das A; Floyd R; Vergnes L; Zhao Y; Che N; Charugundla S; Qi H; Zhou Z; Meng Y; Pan C; Seldin MM; Norheim F; Hui S; Reue K; Lusis AJ; Yang X. 2018. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6(1):103-115.e7PubMed: 29361464 MGI: J:272734
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Radovanovic I; Leung V; Iliescu A; Bongfen SE; Mullick A; Langlais D; Gros P. 2014. Genetic control of susceptibility to Candida albicans in SM/J mice. J Immunol 193(3):1290-300PubMed: 24973457 MGI: J:276529
Chen YG; Tsaih SW; Serreze DV. 2012. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun 13(2):164-74PubMed: 21938016 MGI: J:276531
Berndt A; Leme AS; Williams LK; Von Smith R; Savage HS; Stearns TM; Tsaih SW; Shapiro SD; Peters LL; Paigen B; Svenson KL. 2011. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics 43(1):1-11PubMed: 20823217 MGI: J:276536
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Leme AS; Berndt A; Williams LK; Tsaih SW; Szatkiewicz JP; Verdugo R; Paigen B; Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics 283(4):317-26PubMed: 20143096 MGI: J:276589
Hager R; Cheverud JM; Wolf JB. 2009. Relative contribution of additive, dominance, and imprinting effects to phenotypic variation in body size and growth between divergent selection lines of mice. Evolution 63(5):1118-28PubMed: 19187253 MGI: J:276792
Cheng R; Lim JE; Samocha KE; Sokoloff G; Abney M; Skol AD; Palmer AA. 2010. Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations. Genetics 185(3):1033-44PubMed: 20439773 MGI: J:281451
Beamer WG; Donahue LR; Rosen CJ; Baylink DJ. 1996. Genetic variability in adult bone density among inbred strains of mice. Bone 18(5):397-403PubMed: 8739896 MGI: J:33789
Mogil JS; Wilson SG; Bon K; Lee SE; Chung K; Raber P; Pieper JO; Hain HS; Belknap JK; Hubert L; Elmer GI; Chung JM; Devor M. 1999. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80(1-2):67-82PubMed: 10204719 MGI: J:54425
Rottier RJ; Bonten E; d'Azzo A. 1998. A point mutation in the neu-1 locus causes the neuraminidase defect in the SM/J mouse. Hum Mol Genet 7(2):313-21PubMed: 9425240 MGI: J:77236
Bachmanov AA; Beauchamp GK; Tordoff MG. 2002. Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet 32(6):445-57PubMed: 12467342 MGI: J:80489
Bachmanov AA; Reed DR; Beauchamp GK; Tordoff MG. 2002. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32(6):435-43PubMed: 12467341 MGI: J:80495
Anunciado RV; Nishimura M; Mori M; Ishikawa A; Tanaka S; Horio F; Ohno T; Namikawa T. 2003. Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice. Exp Anim 52(1):37-42PubMed: 12638235 MGI: J:82274
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159
Klingenberg CP; Leamy LJ; Cheverud JM. 2004. Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandible. Genetics 166(4):1909-21PubMed: 15126408 MGI: J:89613
Lush IE. 1989. The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet Res 53(2):95-9PubMed: 2744455 MGI: J:9874

Additional - Gpr84^del related

Additional - Il3ra^m1 related

Additional - Neu1^a related

Additional - Ogg1^m1 related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a challenging breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- white-bellied agouti
  Related Genotype: A^w/a
  
  black
  Related Genotype: a/a
Citation
When using the SM/J mouse strain in a publication, please include JAX stock #000687 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

AX11 (Maximum)

Pricing & Availability

Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Please inquire

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As:small

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Selected References

Il3ram1

Allele Symbol: Il3ram1

Neu1a

Allele Symbol: Neu1a

Gpr84del

Allele Symbol: Gpr84del

Ogg1m1

Allele Symbol: Ogg1m1

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Il3ram1 related

Mammalian Phenotype Terms by Genotype

Genotype: Neu1a/Neu1aSM/J

cardiovascular system phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

liver/biliary system phenotype

renal/urinary system phenotype

Genotype: Il3ram1/Il3ram1SM/J

hematopoietic system phenotype

Phenotype Information

References

Additional References

Additional - Gpr84del related

Additional - Il3ram1 related

Additional - Neu1a related

Additional - Ogg1m1 related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Il3ra^m1

Allele Symbol: Il3ra^m1

Neu1^a

Allele Symbol: Neu1^a

Gpr84^del

Allele Symbol: Gpr84^del

Ogg1^m1

Allele Symbol: Ogg1^m1

Genotype: Il3ra^m1 related

Genotype: Neu1^a/Neu1^a
SM/J

Genotype: Il3ra^m1/Il3ra^m1
SM/J

Additional - Gpr84^del related

Additional - Il3ra^m1 related

Additional - Neu1^a related

Additional - Ogg1^m1 related