JAX Mouse Strain Datasheet - 000686

SJL/J

Stock No:: 000686 |; SJL

Inbred Strain

Readily Available

Overview

Also Known As: SJL, Swiss Jim Lambert

SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease by approximately one year of age. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene resulting in decreased levels of dysferlin protein in SJL/J mice and making this strain a good model for limb girdle muscular dystrophy 2B. SJL mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice. SJL are immunocompetent but have elevated levels of circulating T cells.

Genetic overview

Genetic Background	Generation
	F208 (05-AUG-14)

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Research Applications

Cancer Research
Cardiovascular Research
Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Research Tools
Sensorineural Research
Virology Research

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Base Price

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$30.20 Domestic price for male 3-week

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease by approximately one year of age. Sarcomas first appear in the Peyer's patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes. Most of the tumors are mixed-cell types classified as type B reticulum cell neoplasms, but a few are type A histiocytomas. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene. This Dysf^im allele has been shown to result in decreased levels of dysferlin protein in SJL/J mice and makes this strain a good model for limb girdle muscular dystrophy 2B. This spontaneous myopathy is characterized by a progressive loss of muscle mass and strength corresponding with an increase in muscle pathology including muscle fibers with central nuclei, size variation, splitting, inflammatory infiltrate, necrosis, and eventual replacement of muscle fiber with fat. While muscle weakness can be detected as early as three weeks of age the greatest pathology occurs after six months of age. SJL/J mice have also been shown to have an increased rate of muscle regeneration after injury when compared to BALB/c mice. Due to a mutation in Ceacam1 SJL/J mice are resistant to infection by certain strains of mouse hepatitis virus MHV-4.

SJL mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687). SJL/J are also useful as a control strain for studying immune defects in NOD/ShiLtJ mice (Stock No. 001976), a model for type 1 diabetes (IDDM). Both NOD and SJL/J are derived from Swiss mice; SJL are immunocompetent but have elevated levels of circulating T cells.

Development

SJL mice were developed by James Lambert at The Jackson Laboratory in 1955 from three different sources of Swiss Webster mice.

Selected References

Bittner RE; Anderson LV; Burkhardt E; Bashir R; Vafiadaki E; Ivanova S; Raffelsberger T; Maerk I; Hoger H; Jung M; Karbasiyan M; Storch M; Lassmann H; Moss JA; Davison K; Harrison R; Bushby KM; Reis A. 1999. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B [letter] Nat Genet 23(2):141-2. PubMed: 10508505 MGI: J:57764
Crispens CG. 1973. Some characteristics of strain SJL-JDg mice. Lab Anim Sci 23(3):408-13. PubMed: 4351481 MGI: J:25445
Dal Canto MC; Melvold RW; Kim BS; Miller SD. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc Res Tech 32(3):215-29. PubMed: 8527856 MGI: J:109910
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. PubMed: 9148789 MGI: J:41130
Fujinaga S; Poel WE; Williams WC; Dmochowski L. 1970. Biological and morphological studies of SJL-J strain reticulum cell neoplasms induced and transmitted serially in low-leukemia-strain mice. Cancer Res 30(3):729-42. PubMed: 4316600 MGI: J:25329
McGeachie JK; Grounds MD. 1995. Retarded myogenic cell replication in regenerating skeletal muscles of old mice: an autoradiographic study in young and old BALBc and SJL/J mice. Cell Tissue Res 280(2):277-82. PubMed: 7781025 MGI: J:25692
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Vafiadaki E; Reis A; Keers S; Harrison R; Anderson LV; Raffelsberger T; Ivanova S; Hoger H; Bittner RE; Bushby K; Bashir R. 2001. Cloning of the mouse dysferlin gene and genomic characterization of the SJL-Dysf mutation. Neuroreport 12(3):625-9. PubMed: 11234777 MGI: J:67994
Weller AH; Magliato SA; Bell KP; Rosenberg NL. 1997. Spontaneous myopathy in the SJL/J mouse: pathology and strength loss. Muscle Nerve 20(1):72-82. PubMed: 8995586 MGI: J:38007

View All References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Ceacam1^Hv2-r

Allele Symbol: Ceacam1^Hv2-r

Allele Name	hepatitis virus (MHV-4) resistance
Allele Type	Spontaneous
Allele Synonym(s)	Ceacam1b
Gene Symbol and Name	Ceacam1, carcinoembryonic antigen-related cell adhesion molecule 1
Gene Synonym(s)	BGP; BGP1; BGPI; BGPR; Bgp; Bgp; Bgp1; Bgp1; C-CAM; CD66a; Cc1; Ccam1; Cea-1; Cea-1; Cea-7; Cea-7; Cea1; Cea1; Cea7; Cea7; Hv-2; Hv-2; Hv2; Hv2; MHVR1; Mhv-1; Mhv-1; biliary glycoprotein; biliary glycoprotein 1; carcinoembryonic antigen 1; carcinoembryonic antigen 7; hepatitis virus (MHV-4) susceptibility; mCEA1; mmCGM1; mmCGM2; resistance to MHV (A59) replication in macrophages
Strain of Origin	SJL/J
Chromosome	7
General Note	Previously called Mhv-1, Hv2. This locus controls resistance of neurons and macrophages to infection by the JHM and A59 strains of mouse hepatitis virus MHV-4. The allele Ceacam1^Hv2-r determines resistance and has been found only in the SJL/J strain; the strains A/J, C57BL/10, BALB/c, NZB, DBA/2, AKR/J, CBA/J, C3H/He, and SWR are all susceptible to infection (Ceacam1^Hv2-s. Heterozygotes are fully susceptible (J:6451, J:14870, J:7456).
Molecular Note	This allele determines resistance to infection by the A59 strains of mouse hepatitis virus MHV-4, and is found only in the SJL/J strain. The protein encoded by this allele differs in the first 27 of the 108 amino acids of the first Ig domain compared to the susceptible allele. This region is thought to be important for virus binding.

Disc1^del

Allele Symbol: Disc1^del

Allele Name	deletion
Allele Type	Spontaneous
Allele Synonym(s)	Disc1^129S6; Disc1^delta6
Gene Symbol and Name	Disc1, disrupted in schizophrenia 1
Gene Synonym(s)	C1orf136; SCZD9
Strain of Origin	various
Chromosome	8
General Note	This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T⁺ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).
Molecular Note	A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7.

Dysf^im

Allele Symbol: Dysf^im

Allele Name	inflammatory myopathy
Allele Type	Spontaneous
Allele Synonym(s)	SJL-Dysf
Gene Symbol and Name	Dysf, dysferlin
Gene Synonym(s)	2310004N10Rik; 2310004N10Rik; AI604795; D6Pas3; DNA segment, Chr 6, Pasteur Institute 3; FER1L1; LGMD2B; MMD1; RIKEN cDNA 2310004N10 gene; expressed sequence AI604795
Strain of Origin	SJL
Chromosome	6
Molecular Note	The molecular basis for the mutation is due to a splicing mutation in the gene, resulting from a 141 bp deletion of a small tandem repeat in an intron. This splicing mutation results in the deletion of an exon from the encoded mRNA. This results in a 171 bp in-frame deletion in the encoded mRNA, and is predicted to remove 57 amino acids from the corresponding protein. This region corresponds to most of the fourth C2 domain of the protein, and the deletion likely results in instability of the protein.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	EX33; GPCR4
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Il2^m1

Allele Symbol: Il2^m1

Allele Name	mutation 1
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Il2, interleukin 2
Gene Synonym(s)	IL-2; Il-2; TCGF; lymphokine
Strain of Origin	multiple strains
Chromosome	3
Molecular Note	This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	Pdeb^rd1; rd; rd-1; rd1; rodless retina
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; Pdeb; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; r; rd; rd; rd-1; rd1; rd1; rd10; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Rmcf^s

Allele Symbol: Rmcf^s

Allele Name	MCF sensitive
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Increased Tumor Incidence
  - Other Tissues/Organs
  - Other Tissues/Organs: reticulum cell sarcomas, Hodgkin's disease
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Relatively Resistant
Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
  - Related Inbred Strains
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)
Neurobiology Research
- Angelman syndrome
- Muscular Dystrophy
  - Limb-Girdle type
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - NK Cell Deficiency
Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1
Virology Research
- Hepatitis B Virus

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration

Mammalian Phenotype Terms by Genotype

Genotype: Ceacam1^Hv2-r/Ceacam1^Hv2-r
SJL/J

immune system phenotype

decreased susceptibility to viral infection
- Background Sensitivity - resistance to infection by the A59 strains of mouse hepatitis virus MHV-4, and is found only in the SJL/J strain

Genotype: Dysf^im/Dysf^im
SJL

muscle phenotype

dystrophic muscle
- changes apparent from 3 weeks of age

progressive muscle weakness
- detectable by 3 weeks of age

Phenotype Information

Body Weight Information - JAX^® Mice Strain SJL/J (000686)

References

Bittner RE; Anderson LV; Burkhardt E; Bashir R; Vafiadaki E; Ivanova S; Raffelsberger T; Maerk I; Hoger H; Jung M; Karbasiyan M; Storch M; Lassmann H; Moss JA; Davison K; Harrison R; Bushby KM; Reis A. 1999. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B [letter] Nat Genet 23(2):141-2. PubMed: 10508505 MGI: J:57764
Crispens CG. 1973. Some characteristics of strain SJL-JDg mice. Lab Anim Sci 23(3):408-13. PubMed: 4351481 MGI: J:25445
Dal Canto MC; Melvold RW; Kim BS; Miller SD. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc Res Tech 32(3):215-29. PubMed: 8527856 MGI: J:109910
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. PubMed: 9148789 MGI: J:41130
Fujinaga S; Poel WE; Williams WC; Dmochowski L. 1970. Biological and morphological studies of SJL-J strain reticulum cell neoplasms induced and transmitted serially in low-leukemia-strain mice. Cancer Res 30(3):729-42. PubMed: 4316600 MGI: J:25329
McGeachie JK; Grounds MD. 1995. Retarded myogenic cell replication in regenerating skeletal muscles of old mice: an autoradiographic study in young and old BALBc and SJL/J mice. Cell Tissue Res 280(2):277-82. PubMed: 7781025 MGI: J:25692
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. PubMed: 8355588 MGI: J:13267
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. PubMed: 2317166 MGI: J:22615
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Vafiadaki E; Reis A; Keers S; Harrison R; Anderson LV; Raffelsberger T; Ivanova S; Hoger H; Bittner RE; Bushby K; Bashir R. 2001. Cloning of the mouse dysferlin gene and genomic characterization of the SJL-Dysf mutation. Neuroreport 12(3):625-9. PubMed: 11234777 MGI: J:67994
Weller AH; Magliato SA; Bell KP; Rosenberg NL. 1997. Spontaneous myopathy in the SJL/J mouse: pathology and strength loss. Muscle Nerve 20(1):72-82. PubMed: 8995586 MGI: J:38007

Additional References

Dveksler GS; Dieffenbach CW; Cardellichio CB; McCuaig K; Pensiero MN; Jiang GS; Beauchemin N; Holmes KV. 1993. Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J Virol 67(1):1-8. PubMed: 8380065 MGI: J:92495
Kumar RK. 1983. Hodgkin's disease. SJL/J murine lymphoma. Am J Pathol 110(3):393-6. PubMed: 6829714 MGI: J:35739
Mitchell CA; McGeachie JK; Grounds MD. 1992. Cellular differences in the regeneration of murine skeletal muscle: a quantitative histological study in SJL/J and BALB/c mice. Cell Tissue Res 269(1):159-66. PubMed: 1423478 MGI: J:2981
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. PubMed: 18440079 MGI: J:138681
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579 MGI: J:34840
Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. PubMed: 10783140 MGI: J:61808
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. PubMed: 7106865 MGI: J:6828
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. PubMed: 10749765 MGI: J:61602
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. PubMed: 10885659 MGI: J:137818
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. PubMed: 16314476 MGI: J:137817
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. PubMed: 1621856 MGI: J:1348
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. PubMed: 15067087 MGI: J:122988
Yokomori K; Lai MM. 1992. The receptor for mouse hepatitis virus in the resistant mouse strain SJL is functional: implications for the requirement of a second factor for viral infection. J Virol 66(12):6931-8. PubMed: 1279194 MGI: J:3241

Additional - Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. PubMed: 4123113 MGI: J:84312
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. PubMed: 1030186 MGI: J:12156
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. PubMed: 18848954 MGI: J:143604
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. PubMed: 8148872 MGI: J:17460
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. Neurotoxicology 33(6):1436-42. PubMed: 22935098 MGI: J:225088
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. PubMed: 16291824 MGI: J:113285
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. PubMed: 808546 MGI: J:5564
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. PubMed: 4110756 MGI: J:84250
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. PubMed: 4118365 MGI: J:84252
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. PubMed: 1658612 MGI: J:2134
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. Toxicol Sci 140(1):135-43. PubMed: 24718703 MGI: J:215349
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. PubMed: 22228805 MGI: J:183715
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. PubMed: 679184 MGI: J:84318
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. PubMed: 22982977 MGI: J:192865
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. PubMed: 21270426 MGI: J:173706
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Additional - Ceacam1^Hv2-r related

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Additional - Disc1^del related

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Additional - Dysf^im related

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Additional - Gpr84^del related

Perez CJ; Dumas A; Vallieres L; Guenet JL; Benavides F. 2013. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. J Hered 104(4):565-71. PubMed: 23616478 MGI: J:237405

Additional - Il2^m1 related

Choi Y; Simon-Stoos K; Puck J. 2002. Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol 32(3):677-85. PubMed: 11857342 MGI: J:75331

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Additional - Rmcf^s related

Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med 167(5):1535-46. PubMed: 2835418 MGI: J:27618
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Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. PubMed: 12134027 MGI: J:78083

Also Known As: SJL, Swiss Jim Lambert

Genetic overview

Research Applications

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Important Note

Detailed Description

Development

Selected References

Ahrd

Allele Symbol: Ahrd

Ceacam1Hv2-r

Allele Symbol: Ceacam1Hv2-r

Disc1del

Allele Symbol: Disc1del

Dysfim

Allele Symbol: Dysfim

Gpr84del

Allele Symbol: Gpr84del

Il2m1

Allele Symbol: Il2m1

Pde6brd1

Allele Symbol: Pde6brd1

Rmcfs

Allele Symbol: Rmcfs

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Pde6brd1 related

Mammalian Phenotype Terms by Genotype

Genotype: Ceacam1Hv2-r/Ceacam1Hv2-rSJL/J

immune system phenotype

Genotype: Dysfim/DysfimSJL

muscle phenotype

Phenotype Information

References

Additional References

Additional - Ahrd related

Additional - Ceacam1Hv2-r related

Additional - Disc1del related

Additional - Dysfim related

Additional - Gpr84del related

Additional - Il2m1 related

Additional - Pde6brd1 related

Additional - Rmcfs related

Genotyping Protocols

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Ahr^d

Allele Symbol: Ahr^d

Ceacam1^Hv2-r

Allele Symbol: Ceacam1^Hv2-r

Disc1^del

Allele Symbol: Disc1^del

Dysf^im

Allele Symbol: Dysf^im

Gpr84^del

Allele Symbol: Gpr84^del

Il2^m1

Allele Symbol: Il2^m1

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Rmcf^s

Allele Symbol: Rmcf^s

Genotype: Ahr^d related

Genotype: Pde6b^rd1 related

Genotype: Ceacam1^Hv2-r/Ceacam1^Hv2-r
SJL/J

Genotype: Dysf^im/Dysf^im
SJL

Additional - Ahr^d related

Additional - Ceacam1^Hv2-r related

Additional - Disc1^del related

Additional - Dysf^im related

Additional - Gpr84^del related

Additional - Il2^m1 related

Additional - Pde6b^rd1 related

Additional - Rmcf^s related