Overview

Also Known As: PL

PL/J mice are widely used in studies of retinal degeneration and other areas of research. PL/J mice show a moderate susceptibility to experimental allergic encephalitis with late onset and high mortality. Reports of leukemia incidence vary from 50% in females and 19% in males to 80-90%. In addition to a low threshold to electroconvulsive seizures, PL/J mice are susceptible to handling and rhythmic tossing-induced seizures and very highly responsive to phytohemagglutinin.

Genetic overview

Genetic Background	Generation
	F222pF227pF13 (2019-08-27 00:00:00)

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Research Applications

Neurobiology Research
Cancer Research
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research
Mouse/Human Gene Homologs

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Base Price

Starting at:

$205.90 Domestic price for female 4-week

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Details

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Detailed Description

PL/J mice show a moderate susceptibility to experimental allergic encephalitis (EAE) with late onset and high mortality. Reports of leukemia incidence vary from 50% in females and 19% in males to 80-90%. In addition to a low threshold to electroconvulsive seizures, PL/J mice are susceptible to handling and rhythmic tossing-induced seizures (Kitami et al. 2004) and very highly responsive to phytohemagglutinin (Heiniger et al. 1975).

Development

The PL inbred strain was developed by Clara J Lynch at The Rockefeller Institute as a high-leukemia strain. PL mice were transferred to The Jackson Laboratory in 1951 at F22.

Selected References

Heiniger HJ; Taylor BA; Hards EJ; Meier H. 1975. Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res 35(3):825-31PubMed: 163691 MGI: J:22608
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

View All References

Genetics

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)	deletion; Gpr84^del
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	GPCR4; EX33
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	age related hearing loss 1; Cdh23^ahl
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Mx1^s1

Allele Symbol: Mx1^s1

Allele Name	myxovirus susceptibility 1
Allele Type	Spontaneous
Allele Synonym(s)	Mx1^s1; myxovirus susceptibility 1
Gene Symbol and Name	Mx1, MX dynamin-like GTPase 1
Gene Synonym(s)	Mx; Mx-1; Mx; Mx-1; AI893580; myxovirus (influenza) resistance 1 polypeptide; expressed sequence AI893580; IFI-78K; MxA; MX; IFI78; MXB; lncMX1-215
Strain of Origin	multiple strains
Chromosome	16
General Note	The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Resistance is specific for the orthomyxoviruses (J:6265). It is dependent on the presence of interferon-alpha and -beta but not -gamma (J:7365). The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Susceptibility alleles do not produce the protein (J:8273). The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). The MX-1 protein is a GTPase containing a GTP binding domain (J:1417) and this binding core is also necessary (J:21243). Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1^r. The Mx1^r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1^s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1^r allele. This large deletion apparently renders the protein incapable of providing resistance to influenza. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1^s2 allele in which there is a nonsense mutation (J:9452). Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892).
Molecular Note	Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi.

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Allele Name	retinal degeneration 1
Allele Type	Spontaneous
Allele Synonym(s)	retinal degeneration 1; Pde6b^rd1
Gene Symbol and Name	Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Gene Synonym(s)	rd; rd1; Pdeb; r; rd; rd10; nmf137; r; retinal degeneration; retinal degeneration 1; retinal degeneration 10; CSNB3; CSNBAD2; rd1; rd-1; rd10; PDEB; RP40; phosphodiesterase, cGMP, rod receptor, beta polypeptide; Pdeb; GMP-PDEbeta
Strain of Origin	various
Chromosome	5
General Note	The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note	Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Epilepsy
- Hearing Defects
  - Age related hearing loss
Cancer Research
- Increased Tumor Incidence
  - Leukemia
Sensorineural Research
- Retinal Degeneration
  - Homozygous for Pde6b^rd1
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Pde6b^rd1 related

Sensorineural Research
- Retinal Degeneration
Mouse/Human Gene Homologs
- retinitis pigmentosa, autosomal recessive

Mammalian Phenotype Terms by Genotype

Phenotype Information

Festing Inbred Strain Characteristics: PL

References

Heiniger HJ; Taylor BA; Hards EJ; Meier H. 1975. Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res 35(3):825-31PubMed: 163691 MGI: J:22608
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

Biddle FG; Eales BA; Nishioka Y. 1991. A DNA polymorphism from five inbred strains of the mouse identifies a functional class of domesticus-type Y chromosome that produces the same phenotypic distribution of gonadal hermaphrodites. Genome 34(1):96-104PubMed: 2026324 MGI: J:11152
Wahlsten D; Bachmanov A; Finn DA; Crabbe JC. 2006. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103(44):16364-9PubMed: 17053075 MGI: J:115640
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29PubMed: 18440079 MGI: J:138681
Milner LC; Crabbe JC. 2008. Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav 7(4):496-505PubMed: 18182070 MGI: J:149042
Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
Sinke AP; Caputo C; Tsaih SW; Yuan R; Ren D; Deen PM; Korstanje R. 2011. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics 43(5):265-70PubMed: 21177381 MGI: J:171768
Yuan R; Meng Q; Nautiyal J; Flurkey K; Tsaih SW; Krier R; Parker MG; Harrison DE; Paigen B. 2012. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A 109(21):8224-9PubMed: 22566614 MGI: J:184775
Lightfoot JT; Leamy L; Pomp D; Turner MJ; Fodor AA; Knab A; Bowen RS; Ferguson D; Moore-Harrison T; Hamilton A. 2010. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol 109(3):623-34PubMed: 20538847 MGI: J:185928
Harrill AH; Desmet KD; Wolf KK; Bridges AS; Eaddy JS; Kurtz CL; Hall JE; Paine MF; Tidwell RR; Watkins PB. 2012. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci 130(2):416-26PubMed: 22940726 MGI: J:192655
Leduc MS; Hageman RS; Meng Q; Verdugo RA; Tsaih SW; Churchill GA; Paigen B; Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9(5):823-36PubMed: 20735370 MGI: J:201869
Jonczyk MS; Simon M; Kumar S; Fernandes VE; Sylvius N; Mallon AM; Denny P; Andrew PW. 2014. Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection. PLoS One 9(3):e89831PubMed: 24594938 MGI: J:214701
Yuan R; Tsaih SW; Petkova SB; Marin de Evsikova C; Xing S; Marion MA; Bogue MA; Mills KD; Peters LL; Bult CJ; Rosen CJ; Sundberg JP; Harrison DE; Churchill GA; Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8(3):277-87PubMed: 19627267 MGI: J:216124
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607PubMed: 26067236 MGI: J:223755
Storer JB. 1966. Longevity and gross pathology at death in 22 inbred mouse strains. J Gerontol 21(3):404-9PubMed: 5944803 MGI: J:22621
Wiltshire T; Ervin RB; Duan H; Bogue MA; Zamboni WC; Cook S; Chung W; Zou F; Tarantino LM. 2015. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains. Genes Brain Behav 14(3):271-80PubMed: 25727211 MGI: J:235925
Sundberg JP; Berndt A; Sundberg BA; Silva KA; Kennedy V; Bronson R; Yuan R; Paigen B; Harrison D; Schofield PN. 2011. The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice. Pathobiol Aging Age Relat Dis 1PubMed: 22953031 MGI: J:236844
Liu JL; Wang TS; Zhao M. 2016. Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda) 6(9):2929-35PubMed: 27449513 MGI: J:244239
Gubner NR; Wilhelm CJ; Phillips TJ; Mitchell SH. 2010. Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcohol Clin Exp Res 34(8):1353-62PubMed: 20491731 MGI: J:266371
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Chella Krishnan K; Kurt Z; Barrere-Cain R; Sabir S; Das A; Floyd R; Vergnes L; Zhao Y; Che N; Charugundla S; Qi H; Zhou Z; Meng Y; Pan C; Seldin MM; Norheim F; Hui S; Reue K; Lusis AJ; Yang X. 2018. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6(1):103-115.e7PubMed: 29361464 MGI: J:272734
Zimmerman H; Yin Z; Zou F; Everett ET. 2019. Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping. Front Genet 10:291PubMed: 31001328 MGI: J:275176
Geuther BQ; Deats SP; Fox KJ; Murray SA; Braun RE; White JK; Chesler EJ; Lutz CM; Kumar V. 2019. Robust mouse tracking in complex environments using neural networks. Commun Biol 2:124PubMed: 30937403 MGI: J:275426
Frick A; Fedoriw Y; Richards K; Damania B; Parks B; Suzuki O; Benton CS; Chan E; Thomas RS; Wiltshire T. 2015. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med 8:81-98PubMed: 25897258 MGI: J:275938
Benton CS; Miller BH; Skwerer S; Suzuki O; Schultz LE; Cameron MD; Marron JS; Pletcher MT; Wiltshire T. 2012. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl) 221(2):297-315PubMed: 22113448 MGI: J:275939
Vinyard CJ; Payseur BA. 2008. Of mice and mammals: utilizing classical inbred mice to study the genetic architecture of function and performance in mammals. Integr Comp Biol 48(3):324-37PubMed: 21669795 MGI: J:275940
Tomasini-Johansson B; Mosher DF. 2009. Plasma fibronectin concentration in inbred mouse strains. Thromb Haemost 102(6):1278-80PubMed: 19967162 MGI: J:275941
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Wooley CM; Xing S; Burgess RW; Cox GA; Seburn KL. 2009. Age, experience and genetic background influence treadmill walking in mice. Physiol Behav 96(2):350-61PubMed: 19027767 MGI: J:275950
Lin X; Yue P; Chen Z; Schonfeld G. 2005. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol 288(6):G1179-89PubMed: 15591160 MGI: J:275968
Metten P; Crabbe JC. 2005. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci 119(4):911-25PubMed: 16187819 MGI: J:276057
Avila JJ; Kim SK; Massett MP. 2017. Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains. Front Physiol 8:974PubMed: 29249981 MGI: J:276478
Chen YG; Tsaih SW; Serreze DV. 2012. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun 13(2):164-74PubMed: 21938016 MGI: J:276531
Berndt A; Leme AS; Williams LK; Von Smith R; Savage HS; Stearns TM; Tsaih SW; Shapiro SD; Peters LL; Paigen B; Svenson KL. 2011. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics 43(1):1-11PubMed: 20823217 MGI: J:276536
Leme AS; Berndt A; Williams LK; Tsaih SW; Szatkiewicz JP; Verdugo R; Paigen B; Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics 283(4):317-26PubMed: 20143096 MGI: J:276589
Garcia CO; Kanbour-Shakir A; Tang H; Molina JF; Espinoza LR; Gharavi AE. 1997. Induction of experimental antiphospholipid antibody syndrome in PL/J mice following immunization with beta 2 GPI. Am J Reprod Immunol 37(1):118-24PubMed: 9138445 MGI: J:280852
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7PubMed: 8753860 MGI: J:35147
Belknap JK; Riggan J; Cross S; Young ER; Gallaher EJ; Crabbe JC. 1998. Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains Pharmacol Biochem Behav 59(2):353-60PubMed: 9476981 MGI: J:46034
Crabbe JC; Gallaher EJ; Cross SJ; Belknap JK. 1998. Genetic determinants of sensitivity to diazepam in inbred mice. Behav Neurosci 112(3):668-77PubMed: 9676982 MGI: J:48988
Staats J. 1976. Standardized nomenclature for inbred strains of mice: sixth listing. Cancer Res 36(12):4333-77PubMed: 1000487 MGI: J:5731
Daniel WL; Harrison BW; Nelson K. 1982. Genetic regulation of murine hepatic arylsulfatase B activity during development. J Hered 73(1):24-8PubMed: 7069188 MGI: J:6740
Crabbe JC; Metten P; Gallaher EJ; Belknap JK. 2002. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology (Berl) 161(4):408-16PubMed: 12073169 MGI: J:77863
Bachmanov AA; Beauchamp GK; Tordoff MG. 2002. Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet 32(6):445-57PubMed: 12467342 MGI: J:80489
Bachmanov AA; Reed DR; Beauchamp GK; Tordoff MG. 2002. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32(6):435-43PubMed: 12467341 MGI: J:80495
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159

Additional - Cdh23^ahl related

Additional - Gpr84^del related

Additional - Mx1^s1 related

Additional - Pde6b^rd1 related

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a good breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- albino
  Related Genotype: Tyr^c/Tyr^c
Citation
When using the PL/J mouse strain in a publication, please include JAX stock #000680 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

AX10 (Standard)

Pricing & Availability

Available

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International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

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Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: PL

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Selected References

Gpr84del

Allele Symbol: Gpr84del

Cdh23ahl

Allele Symbol: Cdh23ahl

Mx1s1

Allele Symbol: Mx1s1

Pde6brd1

Allele Symbol: Pde6brd1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Genotype: Pde6brd1 related

Mammalian Phenotype Terms by Genotype

Phenotype Information

References

Additional References

Additional - Cdh23ahl related

Additional - Gpr84del related

Additional - Mx1s1 related

Additional - Pde6brd1 related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Gpr84^del

Allele Symbol: Gpr84^del

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Mx1^s1

Allele Symbol: Mx1^s1

Pde6b^rd1

Allele Symbol: Pde6b^rd1

Genotype: Cdh23^ahl related

Genotype: Pde6b^rd1 related

Additional - Cdh23^ahl related

Additional - Gpr84^del related

Additional - Mx1^s1 related

Additional - Pde6b^rd1 related