JAX Mouse Strain Datasheet - 000674

I/LnJ

Stock No:: 000674 |; I Lyon

Inbred Strain

Repository Live

Overview

Also Known As: I Lyon, I/FnLn, I/Lyn

I inbred mice are a piebald strain that lacks a corpus callosum and exhibits behaviors consistent with attention deficit hyperactivity disorder (ADHD). They are resistant to mouse mammary tumor virus (MMTV) and generate neutralizing antibodies to MMTV and Murine Leukemia Virus (MuLv).

Genetic overview

Genetic Background	Generation
	F158+pF3 (05-JUN-17)

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Research Applications

Neurobiology Research
Reproductive Biology Research
Sensorineural Research
Metabolism Research
Research Tools
Dermatology Research
Developmental Biology Research
Immunology, Inflammation and Autoimmunity Research

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Base Price

Starting at:

$224.00 Domestic price for female

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Details

Detailed Description

I/LnJ mice were originally derived by Dr. LC Strong in 1926 from an unpedigreed stock of mice. A high proportion of mice from this strain lack a corpus callosum. This absence is associated with slow growth of the medial septum subadjacent to the cavum septi. I/LnJ mice are resistant to mmtv induced mammary tumor development and generate neutralizing antibodies to mmtv and MuLv virions that effectively block viral transmission. Due to a frameshift mutation in alpha 1 phosphorylase kinase these mice have increased glycogen content in resting skeletal muscle. The reproductive performance of I/LnJ mice is very poor. Further analysis indicates that oocytes from I/LnJ mice display retarded kinetics of meiotic maturation and a high frequency of metaphase I arrest. Some oocytes fail to resume meiosis. Oocytes have many very small centrosomes with an absence of microtubules. I/LnJ mice, in addition to carrying several other coat color alleles, are homozygous for the piebald mutation (Ednrb^s). Thus, these mice show irregular white spotting, the amount of which is greatly influenced by minor modifying genes. They also have dark eyes. The white areas of the coat are completely lacking in neural crest-derived melanocytes, and there is a reduction in the number of melanocytes in the choroid layer of the eye. Although kinked tail is not a phenotype noted at birth, approximately 10% of pups at wean age and 20% of breeders have a single kink in the tail. This phenotype was recorded in 2006, and whether this strain characteristic was part of the original phenotype of this inbred strain or arose subsequent to inbreeding is not known.

Selected References

Albertini DF; Eppig JJ. 1995. Unusual cytoskeletal and chromatin configurations in mouse oocytes that are atypical in meiotic progression.. In: . . MGI: J:109918
Bender PK; Lalley PA. 1989. I/Lyn mouse phosphorylase kinase deficiency: mutation disrupts expression of the alpha/alpha'-subunit mRNAs.. In: . . MGI: J:10186
Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism.. In: . . MGI: J:163153
Case LK; Purdy A; Golovkina TV. 2005. Molecular and cellular basis of the retrovirus resistance in I/LnJ mice.. In: . . MGI: J:122155
Hosoda K; Hammer RE; Richardson JA; Baynash AG; Cheung JC; Giaid A; Yanagisawa M. 1994. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.. In: . . MGI: J:22206
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.. In: . . MGI: J:89298
Wahlsten D; Bulman-Fleming B. 1994. Retarded growth of the medial septum: a major gene effect in acallosal mice.. In: . . MGI: J:16942
Wahlsten D; Schalomon PM. 1994. A new hybrid mouse model for agenesis of the corpus callosum.. In: . . MGI: J:21337

View All References

Genetics

Ahr^d

Allele Symbol: Ahr^d

Allele Name	d variant
Allele Type	Not Applicable
Allele Synonym(s)	Ah^d; Ah^k; AhRd; Ahhⁿ; ah; in
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity
Strain of Origin	Not Applicable
Chromosome	12
General Note	Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note	This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Ednrb^s

Allele Symbol: Ednrb^s

Allele Name	piebald
Allele Type	Spontaneous
Allele Synonym(s)	pied spotting; s
Gene Symbol and Name	Ednrb, endothelin receptor type B
Gene Synonym(s)	ABCDS; AU022549; ET-B; ET-BR; ETB; ETB1; ETBR; ETR-b; ETRB; ETb; Ednra; Etb; HSCR; HSCR2; Sox10m1; WS4A; expressed sequence AU022549; piebald; s
Strain of Origin	old mutant of the mouse fancy
Chromosome	14
General Note	Also called piebald spotting. This is a very old mutation of the mouse fancy, and was described in the scientific literature as early as 1920 (J23183). Some piebalds in existing stocks may be of independent origin.
Molecular Note	This mutation is allelic to a targeted mutation for this gene. Homozygous mice produce approximately 25% of the normal levels of transcript from this allele. RT-PCR analysis demonstrated that no alterations in the coding sequence would result in any alteration of the amino acid sequence. A 5.5 kb retrotransposon-like element is found in intron 1. About 75% of the mRNA produced is an aberrant 6.5 kb form lacking exons 2-6 but containing exon 1. The remaining 25% of the mRNA formed is of normal, 4.4 kb, size.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	EX33; GPCR4
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Hc⁰

Allele Symbol: Hc⁰

Allele Name	deficient
Allele Type	Spontaneous
Allele Synonym(s)	C5-; C5-d; C5-def; C5-deficient; hc^o
Gene Symbol and Name	Hc, hemolytic complement
Gene Synonym(s)	C5; C5; C5D; C5a; C5b; CPAMD4; ECLZB; He; He
Strain of Origin	multiple strains
Chromosome	2
General Note	This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note	A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5.

Myo5a^d

Allele Symbol: Myo5a^d

Allele Name	dilute
Allele Type	Spontaneous
Allele Synonym(s)	Maltese dilution; blue dilution; d; d^v
Gene Symbol and Name	Myo5a, myosin VA
Gene Synonym(s)	9630007J19Rik; 9630007J19Rik; AI413174; AI661011; D; Dbv; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myh12; Myo5; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flail; flailer; flr; myosin V; nmf244
Strain of Origin	old mutant of the mouse fancy
Chromosome	9
Molecular Note	This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.

Phka1^I/FnLn

Allele Symbol: Phka1^I/FnLn

Allele Name	I/FnLn
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Phka1, phosphorylase kinase alpha 1
Gene Synonym(s)	9830108K24Rik; 9830108K24Rik; PHKA; Pcyt1b; Phka; Phka; RIKEN cDNA 9830108K24 gene; phosphorylase kinase alpha
Strain of Origin	I/FnLn
Chromosome	X
Molecular Note	An insertion of a T residue after codon 429 results in a frameshift and premature termination 17 codons downstream which is only approximately one third of the normal protein length. Northern blot analysis reveals a great reduction of this transcript in muscle extracts.

vic1

Allele Symbol: vic1

Allele Name	virus infectivity controller 1
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	vic1, virus infectivity controller 1
Gene Synonym(s)
Strain of Origin	I/St
Chromosome	17

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Angelman syndrome
- Hearing Defects
  - Age related hearing loss, control
- Neurodevelopmental Defects
  - acallosal
Reproductive Biology Research
- Developmental Defects Affecting Gonads
- Fertility Defects
Sensorineural Research
- Hearing Defects
  - Age related hearing loss, control

Genotype: Ahr^d related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Ednrb^s related

Dermatology Research
- Color and White Spotting Defects
Developmental Biology Research
- Neural Crest Defects
- Neurodevelopmental Defects
Neurobiology Research
- Hearing Defects
- Neurodevelopmental Defects
- Receptor Defects
Sensorineural Research
- Hearing Defects

Genotype: Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - specific complement deficiency
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - specific complement deficiency, C5 complement

Genotype: Myo5a^d related

Dermatology Research
- Color and White Spotting Defects

Genotype: vic1 related

Cancer Research
Immunology, Inflammation and Autoimmunity Research
Virology Research

Mammalian Phenotype Terms by Genotype

Genotype: Phka1^I/FnLn/Phka1^I/FnLn
I/FnLn

homeostasis/metabolism phenotype

increased skeletal muscle glycogen level
- the glycogen content of resting skeletal muscle is two to three fold higher than that in C57BL/FnLn controls, with a mean of 11.5mg/g tissue versus 4.4mg/g, and epinephrine does not induce phosphorylase kinase activity

muscle phenotype

increased skeletal muscle glycogen level
- the glycogen content of resting skeletal muscle is two to three fold higher than that in C57BL/FnLn controls, with a mean of 11.5mg/g tissue versus 4.4mg/g, and epinephrine does not induce phosphorylase kinase activity

Genotype: Phka1^I/FnLn/Y
I/FnLn

homeostasis/metabolism phenotype

increased skeletal muscle glycogen level
- the glycogen content of resting skeletal muscle in hemizygous males is three fold higher than that in C57BL/FnLn controls, with a mean of 13.1mg/g tissue versus 4mg/g

muscle phenotype

increased skeletal muscle glycogen level
- the glycogen content of resting skeletal muscle in hemizygous males is three fold higher than that in C57BL/FnLn controls, with a mean of 13.1mg/g tissue versus 4mg/g

Genotype: vic1/vic1
I/LnJ

immune system phenotype

decreased susceptibility to viral infection
- although MMTV and MuLV infection can occur, MMTV transmission and mammary tumor induction are blocked and MuLV transmission and virally induced disease are blocked, and these responses are mediated by anti-virion antibodies, require gamma interferon, cytotoxic immune responses, but not interleukin 12toxic immune responses, but not interleukin 12

neoplasm

decreased incidence of induced tumors
- mammary glands become infected with MMTV but at 1.5 years zero of 24 infected females develop tumors

Phenotype Information

Festing Inbred Strain Characteristics: I

References

Albertini DF; Eppig JJ. 1995. Unusual cytoskeletal and chromatin configurations in mouse oocytes that are atypical in meiotic progression.. In: . . MGI: J:109918
Bender PK; Lalley PA. 1989. I/Lyn mouse phosphorylase kinase deficiency: mutation disrupts expression of the alpha/alpha'-subunit mRNAs.. In: . . MGI: J:10186
Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism.. In: . . MGI: J:163153
Case LK; Purdy A; Golovkina TV. 2005. Molecular and cellular basis of the retrovirus resistance in I/LnJ mice.. In: . . MGI: J:122155
Hosoda K; Hammer RE; Richardson JA; Baynash AG; Cheung JC; Giaid A; Yanagisawa M. 1994. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.. In: . . MGI: J:22206
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.. In: . . MGI: J:89298
Wahlsten D; Bulman-Fleming B. 1994. Retarded growth of the medial septum: a major gene effect in acallosal mice.. In: . . MGI: J:16942
Wahlsten D; Schalomon PM. 1994. A new hybrid mouse model for agenesis of the corpus callosum.. In: . . MGI: J:21337

Additional References

Baynash AG; Hosoda K; Giaid A; Richardson JA; Emoto N; Hammer RE; Yanagisawa M. 1994. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.. In: . . MGI: J:22207
Golovkina TV. 2000. A novel mechanism of resistance to mouse mammary tumor virus infection.. In: . . MGI: J:60602
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice. In: . . MGI: J:166288
Lyon JB Jr. 1970. The X-chromosome and the enzymes controlling muscle glycogen: phosphorylase kinase.. In: . . MGI: J:5156
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles.. In: . . MGI: J:34840
Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies.. In: . . MGI: J:81554
Schneider A; Davidson JJ; Wullrich A; Kilimann MW. 1993. Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform.. In: . . MGI: J:15833
Wahlsten D; Ozaki HS; Livy D. 1992. Deficient corpus callosum in hybrids between ddN and three other abnormal mouse strains.. In: . . MGI: J:2581

Additional - Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.. In: . . MGI: J:84312
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA.. In: . . MGI: J:12156
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure.. In: . . MGI: J:143604
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.. In: . . MGI: J:17460
Curran CP; Altenhofen E; Ashworth A; Brown A; Kamau-Cheggeh C; Curran M; Evans A; Floyd R; Fowler J; Garber H; Hays B; Kraemer S; Lang A; Mynhier A; Samuels A; Strohmaier C. 2012. Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.. In: . . MGI: J:225088
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.. In: . . MGI: J:113285
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.. In: . . MGI: J:5564
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.. In: . . MGI: J:84250
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.. In: . . MGI: J:84252
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells.. In: . . MGI: J:2134
Kennedy GD; Nukaya M; Moran SM; Glover E; Weinberg S; Balbo S; Hecht SS; Pitot HC; Drinkwater NR; Bradfield CA. 2014. Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.. In: . . MGI: J:215349
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice.. In: . . MGI: J:183715
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus.. In: . . MGI: J:84318
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.. In: . . MGI: J:192865
Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues.. In: . . MGI: J:173706
Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.. In: . . MGI: J:132380
Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York. MGI: J:30693
Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus.. In: . . MGI: J:84313
Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.. In: . . MGI: J:84248
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse.. In: . . MGI: J:5282
Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450.. In: . . MGI: J:84251
Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse.. In: . . MGI: J:84249
Nebert DW; Jensen NM. 1979. Benzo[a]pyrene-initiated leukemia in mice. Association with allelic differences at the Ah locus.. In: . . MGI: J:6074
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains.. In: . . MGI: J:6809
Nebert DW; Kon H. 1973. Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals.. In: . . MGI: J:84311
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse.. In: . . MGI: J:84317
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus.. In: . . MGI: J:84316
Oesch F; Morris N; Daly JW. 1973. Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene.. In: . . MGI: J:25852
Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene.. In: . . MGI: J:27899
Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. In: . . MGI: J:84245
Poland A; Bradfield C. 1992. A brief review of the Ah locus.. In: . . MGI: J:12546
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles.. In: . . MGI: J:34840
Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.. In: . . MGI: J:84247
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12.. In: . . MGI: J:8895
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor.. In: . . MGI: J:22144
Poland A; Teitelbaum P; Glover E; Kende A. 1989. Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor.. In: . . MGI: J:126377
Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons.. In: . . MGI: J:84314
Quintana FJ; Basso AS; Iglesias AH; Korn T; Farez MF; Bettelli E; Caccamo M; Oukka M; Weiner HL. 2008. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.. In: . . MGI: J:136052
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci.. In: . . MGI: J:84315
Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice.. In: . . MGI: J:84246
Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene.. In: . . MGI: J:34134
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice.. In: . . MGI: J:26440
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment.. In: . . MGI: J:15153
Shi Z; Chen Y; Dong H; Amos-Kroohs RM; Nebert DW. 2008. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor.. In: . . MGI: J:141523
Shivanna B; Zhang W; Jiang W; Welty SE; Couroucli XI; Wang L; Moorthy B. 2013. Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice.. In: . . MGI: J:193493
Simonian PL; Wehrmann F; Roark CL; Born WK; O'Brien RL; Fontenot AP. 2010. gammadelta T cells protect against lung fibrosis via IL-22.. In: . . MGI: J:165803
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.. In: . . MGI: J:45850
Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.. In: . . MGI: J:183662
Tanos R; Murray IA; Smith PB; Patterson A; Perdew GH. 2012. Role of the ah receptor in homeostatic control of Fatty Acid synthesis in the liver.. In: . . MGI: J:188164
Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice.. In: . . MGI: J:5244
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.. In: . . MGI: J:5387
Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J.. In: . . MGI: J:31977
Thorgeirsson SS; Nebert DW. 1977. The Ah locus and the metabolism of chemical carcinogens and other foreign compounds.. In: . . MGI: J:5822
Walisser JA; Bunger MK; Glover E; Bradfield CA. 2004. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development.. In: . . MGI: J:94465
Williams EG; Mouchiroud L; Frochaux M; Pandey A; Andreux PA; Deplancke B; Auwerx J. 2014. An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.. In: . . MGI: J:232452
Yeager RL; Reisman SA; Aleksunes LM; Klaassen CD. 2009. Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'.. In: . . MGI: J:154083
Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene.. In: . . MGI: J:113356
Zhou Y; Tung HY; Tsai YM; Hsu SC; Chang HW; Kawasaki H; Tseng HC; Plunkett B; Gao P; Hung CH; Vonakis BM; Huang SK. 2013. Aryl hydrocarbon receptor controls murine mast cell homeostasis.. In: . . MGI: J:197552

Additional - Ednrb^s related

Asher JH Jr; Friedman TB. 1990. Mouse and hamster mutants as models for Waardenburg syndromes in humans.. In: . . MGI: J:200892
BIELSCHOWSKY M; SCHOFIELD GC. 1962. Studies on megacolon in piebald mice.. In: . . MGI: J:12312
BILLINGHAM RE; SILVERS WK. 1960. The melanocytes of mammals.. In: . . MGI: J:15014
Bondurand N; Southard-Smith EM. 2016. Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.. In: . . MGI: J:235629
Cantrell VA; Owens SE; Chandler RL; Airey DC; Bradley KM; Smith JR; Southard-Smith EM. 2004. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease.. In: . . MGI: J:93622
Carrasquillo MM; McCallion AS; Puffenberger EG; Kashuk CS; Nouri N; Chakravarti A. 2002. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease.. In: . . MGI: J:112429
Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse.. In: . . MGI: J:160128
Dang R; Sasaki N; Torigoe D; Agui T. 2012. Anatomic modifications in the enteric nervous system of JF1 mice with the classic piebald mutation.. In: . . MGI: J:193523
Deol MS. 1971. Spotting genes and internal pigmentation patterns in the mouse.. In: . . MGI: J:5220
Dunn LC. 1920. Types of white spotting in mice. In: . . MGI: J:23183
Dunn LC; Charles DR. 1937. Studies on Spotting Patterns I. Analysis of Quantitative Variations in the Pied Spotting of the House Mouse.. In: . . MGI: J:12952
Dunn LC; Macdowell EC; Lebedeff GA. 1937. Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse.. In: . . MGI: J:12954
Dunn LC; Mohr J. 1952. An Association of Hereditary Eye Defects with White Spotting.. In: . . MGI: J:13123
Eicher EM; Green MC. 1972. The T6 translocation in the mouse: its use in trisomy mapping, centromere localization, and cytological identification of linkage group 3.. In: . . MGI: J:5291
Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague. MGI: J:30758
Hauschka TS; Jacobs BB; Holdridge BA. 1968. Recessive yellow and its interaction with belted in the mouse.. In: . . MGI: J:5110
Keeler CE. 1931. The Independence of Dominant Spotting and Recessive Spotting ('Piebald') in the House Mouse.. In: . . MGI: J:153352
Koide T; Moriwaki K; Uchida K; Mita A; Sagai T; Yonekawa H; Katoh H; Miyashita N; Tsuchiya K; Nielsen TJ; Shiroishi T. 1998. A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele [published erratum appears in Mamm Genome 1998 Apr;9(4):344]. In: . . MGI: J:42684
Kumagai T; Wada A; Tsudzuki M; Nishimura M; Kunieda T. 1998. Nucleotide sequence of endothelin-B receptor gene reveals origin of piebald mutation in laboratory mouse.. In: . . MGI: J:56133
Kuwaki T; Ling GY; Onodera M; Ishii T; Nakamura A; Ju KH; Cao WH; Kumada M; Kurihara H; Kurihara Y; Yazaki Y; Ohuchi T; Yanagisawa M; Fukuda Y. 1999. Endothelin in the central control of cardiovascular and respiratory functions.. In: . . MGI: J:60070
Lamoreux ML. 1999. Strain-specific white-spotting patterns in laboratory mice. In: . . MGI: J:106083
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.. In: . . MGI: J:12970
Matsushima Y; Shinkai Y; Kobayashi Y; Sakamoto M; Kunieda T; Tachibana M. 2002. A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene.. In: . . MGI: J:76584
Mayer TC. 1967. Temporal skin factors influencing the development of melanoblasts in piebald mice.. In: . . MGI: J:5060
Mayer TC. 1965. The development of piebald spotting in mice.. In: . . MGI: J:12725
Mayer TC. 1977. Enhancement of melanocyte development from piebald neural crest by a favorable tissue environment.. In: . . MGI: J:5782
Mayer TC. 1967. Pigment cell migration in piebald mice.. In: . . MGI: J:5036
McCallion AS; Stames E; Conlon RA; Chakravarti A. 2003. Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb.. In: . . MGI: J:81970
Metallinos DL; Oppenheimer AJ; Rinchik EM; Russell LB; Dietrich W; Tilghman SM. 1994. Fine structure mapping and deletion analysis of the murine piebald locus.. In: . . MGI: J:16291
Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285]. In: . . MGI: J:29467
Nadler EP; Boyle P; Murdock AD; Dilorenzo C; Barksdale EM; Ford HR. 2003. Newborn endothelin receptor type B mutant (piebald) mice have a higher resting anal sphincter pressure than newborn C57BL/6 mice.. In: . . MGI: J:86743
Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN. In: . . MGI: J:100221
Ohuchi T; Kuwaki T; Ling GY; Dewit D; Ju KH; Onodera M; Cao WH; Yanagisawa M; Kumada M. 1999. Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice.. In: . . MGI: J:54703
PIERRO LJ; CHASE HB. 1963. Slate--a new coat color mutant in the mouse.. In: . . MGI: J:25388
Pavan WJ; Mac S; Cheng M; Tilghman SM. 1995. Quantitative trait loci that modify the severity of spotting in piebald mice.. In: . . MGI: J:28905
Ro S; Hwang SJ; Muto M; Jewett WK; Spencer NJ. 2006. Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity.. In: . . MGI: J:109114
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Sviderskaya EV; Easty DJ; Bennett DC. 1998. Impaired growth and differentiation of diploid but not immortal melanoblasts from endothelin receptor B mutant (piebald) mice.. In: . . MGI: J:51286
Watanabe Y; Stanchina L; Lecerf L; Gacem N; Conidi A; Baral V; Pingault V; Huylebroeck D; Bondurand N. 2017. Differentiation of Mouse Enteric Nervous System Progenitor Cells Is Controlled by Endothelin 3 and Requires Regulation of Ednrb by SOX10 and ZEB2.. In: . . MGI: J:242712
Yamada T; Ohtani S; Sakurai T; Tsuji T; Kunieda T; Yanagisawa M. 2006. Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1.. In: . . MGI: J:110573

Additional - Gpr84^del related

Perez CJ; Dumas A; Vallieres L; Guenet JL; Benavides F. 2013. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84.. In: . . MGI: J:237405

Additional - Hc⁰ related

Actor JK; Breij E; Wetsel RA; Hoffmann H; Hunter RL Jr; Jagannath C. 2001. A role for complement C5 in organism containment and granulomatous response during murine tuberculosis.. In: . . MGI: J:103981
Addis-Lieser E; Kohl J; Chiaramonte MG. 2005. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis.. In: . . MGI: J:107269
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation.. In: . . MGI: J:104987
Barthlott T; Stockinger B. 2001. Lineage fate alteration of thymocytes developing in an MHC environment containing MHC/peptide ligands with antagonist properties.. In: . . MGI: J:151748
Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.. In: . . MGI: J:206648
Bauer K; Yu X; Wernhoff P; Koczan D; Thiesen HJ; Ibrahim SM. 2004. Identification of new quantitative trait loci in mice with collagen-induced arthritis.. In: . . MGI: J:94347
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.. In: . . MGI: J:153217
Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.. In: . . MGI: J:194784
Bora NS; Kaliappan S; Jha P; Xu Q; Sohn JH; Dhaulakhandi DB; Kaplan HJ; Bora PS. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.. In: . . MGI: J:138026
Borders CW; Courtney A; Ronen K; Pilar Laborde-Lahoz M; Guidry TV; Hwang SA; Olsen M; Hunter RL Jr; Hollmann TJ; Wetsel RA; Actor JK. 2005. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate.. In: . . MGI: J:114316
Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma.. In: . . MGI: J:191663
Bulla R; Tripodo C; Rami D; Ling GS; Agostinis C; Guarnotta C; Zorzet S; Durigutto P; Botto M; Tedesco F. 2016. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.. In: . . MGI: J:236291
CINADER B; DUBISKI S; WARDLAW AC. 1964. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT.. In: . . MGI: J:13003
Carter WO; Bull C; Bortolon E; Yang L; Jesmok GJ; Gundel RH. 1998. A murine skeletal muscle ischemia-reperfusion injury model: differential pathology in BALB/c and DBA/2N mice.. In: . . MGI: J:51187
Chen HC; Hofman FM; Kung JT; Lin YD; Wu-Hsieh BA. 2007. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage.. In: . . MGI: J:153322
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.. In: . . MGI: J:102639
Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia.. In: . . MGI: J:101948
Daniel DS; Dai G; Singh CR; Lindsey DR; Smith AK; Dhandayuthapani S; Hunter RL Jr; Jagannath C. 2006. The reduced bactericidal function of complement C5-deficient murine macrophages is associated with defects in the synthesis and delivery of reactive oxygen radicals to mycobacterial phagosomes.. In: . . MGI: J:139313
Deguchi Y; Andoh A; Inatomi O; Araki Y; Hata K; Tsujikawa T; Kitoh K; Fujiyama Y. 2005. Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5.. In: . . MGI: J:107581
Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing.. In: . . MGI: J:209669
Fairweather D; Frisancho-Kiss S; Njoku DB; Nyland JF; Kaya Z; Yusung SA; Davis SE; Frisancho JA; Barrett MA; Rose NR. 2006. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.. In: . . MGI: J:129509
Ferreira C; Barthlott T; Garcia S; Zamoyska R; Stockinger B. 2000. Differential survival of naive CD4 and CD8 T cells.. In: . . MGI: J:151749
Flierl MA; Rittirsch D; Nadeau BA; Day DE; Zetoune FS; Sarma JV; Huber-Lang MS; Ward PA. 2008. Functions of the complement components C3 and C5 during sepsis.. In: . . MGI: J:140250
Flynn S; Stockinger B. 2003. Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation.. In: . . MGI: J:151744
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes.. In: . . MGI: J:108724
Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.. In: . . MGI: J:220131
Freeley SJ; Popat RJ; Parmar K; Kolev M; Hunt BJ; Stover CM; Schwaeble W; Kemper C; Robson MG. 2016. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5.. In: . . MGI: J:241547
Garcia S; DiSanto J; Stockinger B. 1999. Following the development of a CD4 T cell response in vivo: from activation to memory formation.. In: . . MGI: J:151750
Girardi G; Berman J; Redecha P; Spruce L; Thurman JM; Kraus D; Hollmann TJ; Casali P; Caroll MC; Wetsel RA; Lambris JD; Holers VM; Salmon JE. 2003. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.. In: . . MGI: J:86845
Hillebrandt S; Wasmuth HE; Weiskirchen R; Hellerbrand C; Keppeler H; Werth A; Schirin-Sokhan R; Wilkens G; Geier A; Lorenzen J; Kohl J; Gressner AM; Matern S; Lammert F. 2005. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.. In: . . MGI: J:100159
Ji H; Gauguier D; Ohmura K; Gonzalez A; Duchatelle V; Danoy P; Garchon HJ; Degott C; Lathrop M; Benoist C; Mathis D. 2001. Genetic influences on the end-stage effector phase of arthritis.. In: . . MGI: J:70882
Karp CL; Grupe A; Schadt E; Ewart SL; Keane-Moore M; Cuomo PJ; Kohl J; Wahl L; Kuperman D; Germer S; Aud D; Peltz G; Wills-Karp M. 2000. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.. In: . . MGI: J:108211
Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells.. In: . . MGI: J:151747
Kassiotis G; Zamoyska R; Stockinger B. 2003. Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells.. In: . . MGI: J:151743
Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.. In: . . MGI: J:92933
Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice.. In: . . MGI: J:129872
Kim CH; Wu W; Wysoczynski M; Abdel-Latif A; Sunkara M; Morris A; Kucia M; Ratajczak J; Ratajczak MZ. 2012. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors.. In: . . MGI: J:181063
Kim DD; Miwa T; Kimura Y; Schwendener RA; van Lookeren Campagne M; Song WC. 2008. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.. In: . . MGI: J:138410
Kirimanjeswara GS; Mann PB; Pilione M; Kennett MJ; Harvill ET. 2005. The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4.. In: . . MGI: J:122156
Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease.. In: . . MGI: J:190492
Kyriakides C; Austen W Jr; Wang Y; Favuzza J; Kobzik L; Moore FD Jr; Hechtman HB. 1999. Membrane attack complex of complement and neutrophils mediate the injury of acid aspiration.. In: . . MGI: J:103341
Lee HM; Wu W; Wysoczynski M; Liu R; Zuba-Surma EK; Kucia M; Ratajczak J; Ratajczak MZ. 2009. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes.. In: . . MGI: J:154482
Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.. In: . . MGI: J:158026
Liu Q; He S; Groysman L; Shaked D; Russin J; Cen S; Mack WJ. 2013. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition.. In: . . MGI: J:209840
Mahesh J; Daly J; Cheadle WG; Kotwal GJ. 1999. Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice.. In: . . MGI: J:59655
Mastellos D; Papadimitriou JC; Franchini S; Tsonis PA; Lambris JD. 2001. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.. In: . . MGI: J:111000
Miller CG; Cook DN; Kotwal GJ. 1996. Two chemotactic factors, C5a and MIP-1alpha, dramatically alter the mortality from zymosan-induced multiple organ dysfunction syndrome (MODS): C5a contributes to MODS while MIP-1alpha has a protective role.. In: . . MGI: J:38592
Miller CG; Justus DE; Jayaraman S; Kotwal GJ. 1995. Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.. In: . . MGI: J:25289
Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry.. In: . . MGI: J:146538
Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia.. In: . . MGI: J:123658
Mori L; de Libero G. 1998. Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice.. In: . . MGI: J:134111
Moulton RA; Mashruwala MA; Smith AK; Lindsey DR; Wetsel RA; Haviland DL; Hunter RL; Jagannath C. 2007. Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice.. In: . . MGI: J:125190
Mullick A; Elias M; Picard S; Bourget L; Jovcevski O; Gauthier S; Tuite A; Harakidas P; Bihun C; Massie B; Gros P. 2004. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain.. In: . . MGI: J:93132
Mullick A; Leon Z; Min-Oo G; Berghout J; Lo R; Daniels E; Gros P. 2006. Cardiac failure in C5-deficient A/J mice after Candida albicans infection.. In: . . MGI: J:112405
Niculescu T; Weerth S; Niculescu F; Cudrici C; Rus V; Raine CS; Shin ML; Rus H. 2004. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis.. In: . . MGI: J:89686
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect.. In: . . MGI: J:5016
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice.. In: . . MGI: J:6214
Patel SN; Berghout J; Lovegrove FE; Ayi K; Conroy A; Serghides L; Min-oo G; Gowda DC; Sarma JV; Rittirsch D; Ward PA; Liles WC; Gros P; Kain KC. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria.. In: . . MGI: J:136298
Pickering MC; Warren J; Rose KL; Carlucci F; Wang Y; Walport MJ; Cook HT; Botto M. 2006. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.. In: . . MGI: J:111031
Pilione MR; Agosto LM; Kennett MJ; Harvill ET. 2006. CD11b is required for the resolution of inflammation induced by Bordetella bronchiseptica respiratory infection.. In: . . MGI: J:135740
Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice.. In: . . MGI: J:128218
Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice.. In: . . MGI: J:44240
Ratajczak MZ; Lee H; Wysoczynski M; Wan W; Marlicz W; Laughlin MJ; Kucia M; Janowska-Wieczorek A; Ratajczak J. 2010. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due toactivation of complement cascade/membrane attack complex.. In: . . MGI: J:160183
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury.. In: . . MGI: J:147022
Refici ML; Metzger DW; Arulanandam BP; Lennartz MR; Loegering DJ. 2001. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels.. In: . . MGI: J:114295
Rittirsch D; Flierl MA; Day DE; Nadeau BA; McGuire SR; Hoesel LM; Ipaktchi K; Zetoune FS; Sarma JV; Leng L; Huber-Lang MS; Neff TA; Bucala R; Ward PA. 2008. Acute lung injury induced by lipopolysaccharide is independent of complement activation.. In: . . MGI: J:136379
Rittirsch D; Flierl MA; Nadeau BA; Day DE; Huber-Lang M; Mackay CR; Zetoune FS; Gerard NP; Cianflone K; Kohl J; Gerard C; Sarma JV; Ward PA. 2008. Functional roles for C5a receptors in sepsis.. In: . . MGI: J:136703
Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.. In: . . MGI: J:130296
Schmitt J; Roderfeld M; Sabrane K; Zhang P; Tian Y; Mertens JC; Frei P; Stieger B; Weber A; Mullhaupt B; Roeb E; Geier A. 2012. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice.. In: . . MGI: J:181268
Schultz G; Tedesco MM; Sho E; Nishimura T; Sharif S; Du X; Myles T; Morser J; Dalman RL; Leung LL. 2010. Enhanced abdominal aortic aneurysm formation in thrombin-activatable procarboxypeptidase B-deficient mice.. In: . . MGI: J:180861
Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.. In: . . MGI: J:138440
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment.. In: . . MGI: J:93949
Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.. In: . . MGI: J:132942
Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells.. In: . . MGI: J:192613
Strey CW; Markiewski M; Mastellos D; Tudoran R; Spruce LA; Greenbaum LE; Lambris JD. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration.. In: . . MGI: J:109380
Tanaka D; Kagari T; Doi H; Shimozato T. 2006. Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis.. In: . . MGI: J:118551
Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis.. In: . . MGI: J:119691
Wang Y; Kristan J; Hao L; Lenkoski CS; Shen Y; Matis LA. 2000. A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis.. In: . . MGI: J:61587
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon.. In: . . MGI: J:23983
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency.. In: . . MGI: J:8690
Wolfe DN; Kirimanjeswara GS; Harvill ET. 2005. Clearance of Bordetella parapertussis from the lower respiratory tract requires humoral and cellular immunity.. In: . . MGI: J:104212
Wright RJ; Bikoff EK; Stockinger B. 1998. The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.. In: . . MGI: J:50737
Xiao H; Schreiber A; Heeringa P; Falk RJ; Jennette JC. 2007. Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies.. In: . . MGI: J:117048
Younger JG; Shankar-Sinha S; Mickiewicz M; Brinkman AS; Valencia GA; Sarma JV; Younkin EM; Standiford TJ; Zetoune FS; Ward PA. 2003. Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia.. In: . . MGI: J:94613
Zal T; Volkmann A; Stockinger B. 1994. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.. In: . . MGI: J:111649
Zal T; Weiss S; Mellor A; Stockinger B. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.. In: . . MGI: J:151753
Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury.. In: . . MGI: J:120567
de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5.. In: . . MGI: J:185883

Additional - Myo5a^d related

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse.. In: . . MGI: J:160128
Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin.. In: . . MGI: J:12173
Copeland NG; Hutchison KW; Jenkins NA. 1983. Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs.. In: . . MGI: J:7092
Engle LJ; Kennett RH. 1994. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene.. In: . . MGI: J:16915
Goodwins IR; Vincent MAC. 1955. Further data on linkage between short-ear and Maltese dilution in the house mouse. In: . . MGI: J:259
Grobman AB; Charles DR. 1947. Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus.. In: . . MGI: J:13058
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse.. In: . . MGI: J:5346
Hutchison KW; Copeland NG; Jenkins NA. 1984. Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles.. In: . . MGI: J:7751
Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus.. In: . . MGI: J:6844
Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1981. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.. In: . . MGI: J:6587
Libby RT; Lillo C; Kitamoto J; Williams DS; Steel KP. 2004. Myosin Va is required for normal photoreceptor synaptic activity.. In: . . MGI: J:92181
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.. In: . . MGI: J:12970
Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/05. In: . . MGI: J:178968
Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/18. In: . . MGI: J:179353
Mercer JA; Seperack PK; Strobel MC; Copeland NG; Jenkins NA. 1991. Novel myosin heavy chain encoded by murine dilute coat colour locus [published erratum appears in Nature 1991 Aug 8;352(6335):547]. In: . . MGI: J:11005
Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285]. In: . . MGI: J:29467
Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1994. The murine dilute suppressor gene encodes a cell autonomous suppressor.. In: . . MGI: J:20796
Moore KJ; Swing DA; Rinchik EM; Mucenski ML; Buchberg AM; Copeland NG; Jenkins NA. 1988. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln.. In: . . MGI: J:9309
MouseBook^TM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK.. In: . . MGI: J:169366
Murray WS. 1934. The breeding behavior of the dilute brown stock of mice (Little dba). In: . . MGI: J:2464
O'Sullivan TN; Wu XS; Rachel RA; Huang JD; Swing DA; Matesic LE; Hammer JA 3rd; Copeland NG; Jenkins NA. 2004. dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice.. In: . . MGI: J:94728
PIERRO LJ; CHASE HB. 1963. Slate--a new coat color mutant in the mouse.. In: . . MGI: J:25388
Pastural E; Barrat FJ; Dufourcq-Lagelouse R; Certain S; Sanal O ; Jabado N ; Seger R ; Griscelli C ; Fischer A ; de Saint Basile G. 1997. Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene.. In: . . MGI: J:41253
Provance DW Jr; Wei M; Ipe V; Mercer JA. 1996. Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distribution.. In: . . MGI: J:37976
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice.. In: . . MGI: J:13094
RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC. In: . . MGI: J:133634
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes.. In: . . MGI: J:148461
Rachel RA; Nagashima K; O'Sullivan TN; Frost LS; Stefano FP; Marigo V; Boesze-Battaglia K. 2012. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.. In: . . MGI: J:191882
Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series.. In: . . MGI: J:12958
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment.. In: . . MGI: J:148462
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules.. In: . . MGI: J:148463
Sweet HO. 1983. Dilute suppressor, a new suppressor gene in the house mouse.. In: . . MGI: J:7171
Yoshimura A; Fujii R; Watanabe Y; Okabe S; Fukui K; Takumi T. 2006. Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.. In: . . MGI: J:117928

Additional - Phka1^I/FnLn related

LYON JB Jr; PORTER J. 1963. The relation of phosphorylase to glycogenolysis in skeletal muscle and heart of mice.. In: . . MGI: J:37921
Lyon JB Jr. 1970. The X-chromosome and the enzymes controlling muscle glycogen: phosphorylase kinase.. In: . . MGI: J:5156
Lyon JB Jr; Porter J; Robertson M. 1967. Phosphorylase b kinase inheritance in mice.. In: . . MGI: J:163154
Schneider A; Davidson JJ; Wullrich A; Kilimann MW. 1993. Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform.. In: . . MGI: J:15833
Wehner M; Clemens PR; Engel AG; Kilimann MW. 1994. Human muscle glycogenosis due to phosphorylase kinase deficiency associated with a nonsense mutation in the muscle isoform of the alpha subunit.. In: . . MGI: J:42850

Additional - vic1 related

Golovkina TV. 2000. A novel mechanism of resistance to mouse mammary tumor virus infection.. In: . . MGI: J:60602
Kane M; Case LK; Wang C; Yurkovetskiy L; Dikiy S; Golovkina TV. 2011. Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry.. In: . . MGI: J:174379
Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies.. In: . . MGI: J:81554

Also Known As: I Lyon, I/FnLn, I/Lyn

Genetic overview

Research Applications

Base Price

Detailed Description

Selected References

Ahrd

Allele Symbol: Ahrd

Ednrbs

Allele Symbol: Ednrbs

Gpr84del

Allele Symbol: Gpr84del

Hc0

Allele Symbol: Hc0

Myo5ad

Allele Symbol: Myo5ad

Phka1I/FnLn

Allele Symbol: Phka1I/FnLn

vic1

Allele Symbol: vic1

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrd related

Genotype: Ednrbs related

Genotype: Hc0 related

Genotype: Myo5ad related

Genotype: vic1 related

Mammalian Phenotype Terms by Genotype

Genotype: Phka1I/FnLn/Phka1I/FnLnI/FnLn

homeostasis/metabolism phenotype

muscle phenotype

Genotype: Phka1I/FnLn/YI/FnLn

homeostasis/metabolism phenotype

muscle phenotype

Genotype: vic1/vic1I/LnJ

immune system phenotype

neoplasm

Phenotype Information

References

Additional References

Additional - Ahrd related

Additional - Ednrbs related

Additional - Gpr84del related

Additional - Hc0 related

Additional - Myo5ad related

Additional - Phka1I/FnLn related

Additional - vic1 related

Genotyping Protocols

Dietary Information

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Related Products and Services

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Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Ahr^d

Allele Symbol: Ahr^d

Ednrb^s

Allele Symbol: Ednrb^s

Gpr84^del

Allele Symbol: Gpr84^del

Hc⁰

Allele Symbol: Hc⁰

Myo5a^d

Allele Symbol: Myo5a^d

Phka1^I/FnLn

Allele Symbol: Phka1^I/FnLn

Genotype: Ahr^d related

Genotype: Ednrb^s related

Genotype: Hc⁰ related

Genotype: Myo5a^d related

Genotype: Phka1^I/FnLn/Phka1^I/FnLn
I/FnLn

Genotype: Phka1^I/FnLn/Y
I/FnLn

Genotype: vic1/vic1
I/LnJ

Additional - Ahr^d related

Additional - Ednrb^s related

Additional - Gpr84^del related

Additional - Hc⁰ related

Additional - Myo5a^d related

Additional - Phka1^I/FnLn related