JAX
Mouse Strain Datasheet - 000673
HRS/J
Mice homozygous for the hr spontaneous mutation have a higher incidence and earlier onset of leukemia, reducible by virus-specific antibody. Deficiency of splenic T helper cells (Ly-1+) may account for low cellular immune response of homozygous mutant mice. The coat is normal on hr/hr mice up to 10 days but then hair is lost from the follicle. Waves of hair growth with few thin fuzzy hairs ocur at monthly intervals for some time but homozygotes eventually become continuously hairless. Vibrissae are repeatedly regrown and shed, becoming more abnormal with age. Toenails are long and curved. There is hyperkeratosis of stratified epithelium and the upper part of hair canals beginning at 14 days. Hair club formation is abnormal. Cysts form from the hyperkeratotic upper part of hair canals and sheaths of abnormal follicles stranded in dermis. Some cysts also form from sebaceous glands. All cysts undergo sebaceous transformation and later keratinization. HRS/J mice, fed an ather...
Read More +Research Applications
- Cancer Research
- Cardiovascular Research
- Dermatology Research
- Immunology, Inflammation and Autoimmunity Research
- Research Tools
Detailed Description
Mice homozygous for the hr spontaneous mutation have a higher incidence and earlier onset of leukemia, reducible by virus-specific antibody. Deficiency of splenic T helper cells (Ly-1+) may account for low cellular immune response of homozygous mutant mice. The coat is normal on hr/hr mice up to 10 days but then hair is lost from the follicle. Waves of hair growth with few thin fuzzy hairs ocur at monthly intervals for some time but homozygotes eventually become continuously hairless. Vibrissae are repeatedly regrown and shed, becoming more abnormal with age. Toenails are long and curved. There is hyperkeratosis of stratified epithelium and the upper part of hair canals beginning at 14 days. Hair club formation is abnormal. Cysts form from the hyperkeratotic upper part of hair canals and sheaths of abnormal follicles stranded in dermis. Some cysts also form from sebaceous glands. All cysts undergo sebaceous transformation and later keratinization. HRS/J mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687).
Development
The hairless mutation (Hrhr) was found in a mouse caught in an aviary in London in 1924. It was brought to The Jackson Laboratory in 1956 by Dr. E. L. Green who had received it from Dr. H. Chase at Brown University in 1952. Dr. Green crossed it to a BALB/c female and the stock was sibling mated. The genotype was fixed homozygous for brown (Tyrp1b), albino (Tyrc), dilute (Myo5ad) and kept segregating for hairless. Since the hairless females do not nurse their litters it was bred hairless males x haired females. In 1964 at generation F24 the strain was named HRS/J. Embryos were cryopreserved in 1992 from haired females mated to hairless males at F90.
Control Suggestions
Ahrb-2
Allele Symbol: Ahrb-2
| Allele Name | b-2 variant |
|---|---|
| Allele Type | Not Applicable |
| Allele Synonym(s) | Ahb-2; Ahh |
| Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor |
| Gene Synonym(s) | Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity |
| Strain of Origin | BALB/cBy |
| Chromosome | 12 |
| General Note | C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains |
| Molecular Note | This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cBy allele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele). |
Hrhr
Allele Symbol: Hrhr
| Allele Name | hairless |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | SKH-1; hr |
| Gene Symbol and Name | Hr, hairless |
| Gene Synonym(s) | ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1; N; ba; baldy; bldy; bldy; hr; rh; rh-bmh; rh-bmh; rhino-bald Mill Hill |
| Strain of Origin | Not Specified |
| Chromosome | 14 |
| Molecular Note | The hr allele is the result of a retroviral integration. Insertion of murine leukemia proviral sequences into intron 6 results in aberrant splicing of the gene. |
Myo5ad
Allele Symbol: Myo5ad
| Allele Name | dilute |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | Maltese dilution; blue dilution; d; dv |
| Gene Symbol and Name | Myo5a, myosin VA |
| Gene Synonym(s) | 9630007J19Rik; 9630007J19Rik; AI413174; AI661011; D; Dbv; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myh12; Myo5; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flail; flailer; flr; myosin V; nmf244 |
| Strain of Origin | old mutant of the mouse fancy |
| Chromosome | 9 |
| Molecular Note | This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5ad gene. Reversions of Myo5ad to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Hrhr related
- Cancer Research
- Increased Tumor Incidence
- Leukemia
- Leukemia: lymphocytic
- Lymphomas
- Lymphomas: thymic
- Skin Cancers
- Skin Cancers: Induced
- Toxicology
- Increased Tumor Incidence
- Cardiovascular Research
- Diet-Induced Atherosclerosis
- Relatively Resistant
- Diet-Induced Atherosclerosis
- Dermatology Research
- Skin and Hair Texture Defects
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
- Research Tools
- Toxicology Research
- drug/compound testing
- Toxicology Research
Genotype: Myo5ad related
- Dermatology Research
- Color and White Spotting Defects
Mammalian Phenotype Terms by Genotype
Genotype: Hrhr/Hrhr
HRS/J
hearing/vestibular/ear phenotype
- absent linear vestibular evoked potential
- VESPs are absent at the maximum stimulus intensity used (MGI Ref ID J:116914)
neoplasm
- increased leukemia incidence
hematopoietic system phenotype
- decreased T cell number
- of CD5+ T cells (MGI Ref ID J:6087)
- decreased T cell proliferation
- to alloantigens by T helper cells (MGI Ref ID J:6375)
- increased macrophage cell number
- although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes (MGI Ref ID J:150402)
immune system phenotype
- decreased T cell number
- of CD5+ T cells (MGI Ref ID J:6087)
- decreased T cell proliferation
- to alloantigens by T helper cells (MGI Ref ID J:6375)
- increased macrophage cell number
- although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes (MGI Ref ID J:150402)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Hrhr/Hrhr
Not Specified
endocrine/exocrine gland phenotype
- abnormal mammary gland morphology
- sebaceous gland atrophy
- (MGI Ref ID J:2409)
behavior/neurological phenotype
- abnormal nursing
- failure (MGI Ref ID J:2409)
integument phenotype
- abnormal dermis reticular layer morphology
- cystic (MGI Ref ID J:2409)
- abnormal mammary gland morphology
- abnormal skin morphology
- thickened cutis (MGI Ref ID J:2409)
- deformed nails
- curved (MGI Ref ID J:2409)
- dermal cysts
- (MGI Ref ID J:14889)
- epidermal hyperplasia
- (MGI Ref ID J:14940)
- hairless
- hyperkeratosis
- (MGI Ref ID J:14940)
- sebaceous gland atrophy
- (MGI Ref ID J:2409)
References
Additional References
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- Morrissey PJ; Parkinson DR; Schwartz RS; Waksal SD. 1980. Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. J Immunol 125(4):1558-62. PubMed: 6447727MGI: J:6375
- Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579MGI: J:34840
- Reske-Kunz AB; Scheid MP; Boyse EA. 1979. Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. J Exp Med 149(1):228-33. PubMed: 310859MGI: J:6087
Additional - Ahrb-2 related
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- Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. PubMed: 2169579MGI: J:34840
- Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. PubMed: 2823093MGI: J:8895
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- Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. PubMed: 4750810MGI: J:5387
Additional - Hrhr related
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