JAX Mouse Strain Datasheet - 000670

DBA/1J

Stock No:: 000670

Inbred Strain

Readily Available

Overview

Also Known As: D1, DBA1

DBA/1J mice are widely used as a model for rheumatoid arthritis: immunization with type II collagen leads to the development of severe polyarthritis mediated by an autoimmune response. DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet. In response to challenge, DBA/1J mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease.

Genetic overview

Genetic Background	Generation
	F201pF205 (14-AUG-14)

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Research Applications

Immunology, Inflammation and Autoimmunity Research
Neurobiology Research
Research Tools
Sensorineural Research
Dermatology Research

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Base Price

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Details

Important Note

This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

Detailed Description

DBA/1J mice are widely used as a model for rheumatoid arthritis: immunization with type II collagen leads to the development of severe polyarthritis mediated by an autoimmune response. The incidence of collagen induced arthritis varies by experimental protocol, but is less than 100%. Similar to the human condition, mice with collagen-induced arthritis display synovitis and erosions of cartilage and bone. In addition, susceptibility in both humans and mice is linked to the expression of specific MHC class II molecules. DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet. In response to challenge, DBA/1J mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004). There is high incidence of calcified lesions of the tongue with age. This strain is among the least responsive to phytohemagglutinin (Heiniger et al., 1975).

Development

The DBA inbred strain is the oldest of all inbred strains of mice. Dr. CC Little began inbreeding in 1909 from a mouse colony segregating for coat color. During 1929 and 1930 crosses were made among substrains, and several new substrains were established including DBA/1 and DBA/2. DBA/1 and DBA/2 differ at a large number of loci (including the MHC H2 haplotype) which most likely results from residual heterozygosity in the strain when the substrains were separated.

Selected References

Kato F; Nomura M; Nakamura K. 1996. Arthritis in mice induced by a single immunisation with collagen. Ann Rheum Dis 55(8):535-9. PubMed: 8774181 MGI: J:109907
Lories RJ; Derese I; Luyten FP. 2005. Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest 115(6):1571-9. PubMed: 15902307 MGI: J:109831
Lories RJ; Matthys P; de Vlam K; Derese I; Luyten FP. 2004. Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis. Ann Rheum Dis 63(5):595-8. PubMed: 15082495 MGI: J:109840
Matthys P; Lories RJ; De Klerck B; Heremans H; Luyten FP; Billiau A. 2003. Dependence on interferon-gamma for the spontaneous occurrence of arthritis in DBA/1 mice. Arthritis Rheum 48(10):2983-8. PubMed: 14558106 MGI: J:106277
McIndoe RA; Bohlman B; Chi E; Schuster E; Lindhardt M; Hood L. 1999. Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc Natl Acad Sci U S A 96(5):2210-4. PubMed: 10051620 MGI: J:53356
Myers LK; Rosloniec EF; Cremer MA; Kang AH. 1997. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci 61(19):1861-78. PubMed: 9364191 MGI: J:109904
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. PubMed: 15067087 MGI: J:122988

View All References

Genetics

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	Cdh23^753A; mdfw
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	4930542A03Rik; 4930542A03Rik; CDHR23; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; ahl; bob; bob; bobby; bus; bustling; mdfw; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf112; nmf181; nmf181; nmf252; nmf252; sals; sals; salsa; v; waltzer
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Gpr84^del

Allele Symbol: Gpr84^del

Allele Name	deletion
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name	Gpr84, G protein-coupled receptor 84
Gene Synonym(s)	EX33; GPCR4
Strain of Origin	multiple strains
Chromosome	15
Molecular Note	This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

Myo5a^d

Allele Symbol: Myo5a^d

Allele Name	dilute
Allele Type	Spontaneous
Allele Synonym(s)	Maltese dilution; blue dilution; d; d^v
Gene Symbol and Name	Myo5a, myosin VA
Gene Synonym(s)	9630007J19Rik; 9630007J19Rik; AI413174; AI661011; D; Dbv; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myh12; Myo5; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flail; flailer; flr; myosin V; nmf244
Strain of Origin	old mutant of the mouse fancy
Chromosome	9
Molecular Note	This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.

P2rx7^P451L

Allele Symbol: P2rx7^P451L

Allele Name	P451L
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	P2rx7, purinergic receptor P2X, ligand-gated ion channel, 7
Gene Synonym(s)	AI467586; P2X(7); P2X7; P2X7 receptor; P2X7R; expressed sequence AI467586
Strain of Origin	various
Chromosome	5
Molecular Note	A proline to leucine change at amino acid residue 451 is caused by a T to C transition at nucleic acid base 1352. This mutation is found in C57BL/6, C57BL/10, DBA/1, and DBA/2 and contrasts with the condition in BALB/c, NZW, NOD, 129, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein.

Rmcf^r

Allele Symbol: Rmcf^r

Allele Name	MCF resistant
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The dominant r (resistance) allele is found in strains DBA/1, DBA/2 and CBA/Ca.

Tyrp1^b

Allele Symbol: Tyrp1^b

Allele Name	brown
Allele Type	Spontaneous
Allele Synonym(s)	b
Gene Symbol and Name	Tyrp1, tyrosinase-related protein 1
Gene Synonym(s)	B; CAS2; CATB; GP75; OCA3; Oca3; TRP; TRP-1; TRP1; TYRP; Tyrp; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; isa; tyrosinase-related protein
Strain of Origin	old mutant of the mouse fancy
Chromosome	4
Molecular Note	A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype.

a

Allele Symbol: a

Allele Name	nonagouti
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)	AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor
Strain of Origin	old mutant of the mouse fancy
Chromosome	2
Molecular Note	Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - collagen induced arthritis
- Inflammation
  - collagen induced arthritis
Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Research Tools
- General Purpose
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Genotype: Myo5a^d related

Dermatology Research
- Color and White Spotting Defects

Genotype: Tyrp1^b related

Dermatology Research
- Color and White Spotting Defects

Mammalian Phenotype Terms by Genotype

immune system phenotype

decreased susceptibility to viral infection

craniofacial phenotype

abnormal tongue morphology
- DBA inbred sublines have a frequent occurance of spontaneous polypoid or slightly elevated lesions of granulation tissue with focal calcification on the tongue, mainly on the dorsum linguae near the margo linguae

digestive/alimentary phenotype

abnormal tongue morphology
- DBA inbred sublines have a frequent occurance of spontaneous polypoid or slightly elevated lesions of granulation tissue with focal calcification on the tongue, mainly on the dorsum linguae near the margo linguae

growth/size/body region phenotype

abnormal tongue morphology
- DBA inbred sublines have a frequent occurance of spontaneous polypoid or slightly elevated lesions of granulation tissue with focal calcification on the tongue, mainly on the dorsum linguae near the margo linguae

homeostasis/metabolism phenotype

calcinosis
- at 20 weeks of age approximately 30% of DBA/1J have calcified lesions of the tongue

Genotype: Rmcf^r/Rmcf^r
DBA/1J

immune system phenotype

decreased susceptibility to viral infection
- resistant to N- and NB-tropic mink cell focus-forming (MCF) viruses

Phenotype Information

Festing Inbred Strain Characteristics: DBA

References

Kato F; Nomura M; Nakamura K. 1996. Arthritis in mice induced by a single immunisation with collagen. Ann Rheum Dis 55(8):535-9. PubMed: 8774181 MGI: J:109907
Lories RJ; Derese I; Luyten FP. 2005. Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest 115(6):1571-9. PubMed: 15902307 MGI: J:109831
Lories RJ; Matthys P; de Vlam K; Derese I; Luyten FP. 2004. Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis. Ann Rheum Dis 63(5):595-8. PubMed: 15082495 MGI: J:109840
Matthys P; Lories RJ; De Klerck B; Heremans H; Luyten FP; Billiau A. 2003. Dependence on interferon-gamma for the spontaneous occurrence of arthritis in DBA/1 mice. Arthritis Rheum 48(10):2983-8. PubMed: 14558106 MGI: J:106277
McIndoe RA; Bohlman B; Chi E; Schuster E; Lindhardt M; Hood L. 1999. Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. Proc Natl Acad Sci U S A 96(5):2210-4. PubMed: 10051620 MGI: J:53356
Myers LK; Rosloniec EF; Cremer MA; Kang AH. 1997. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci 61(19):1861-78. PubMed: 9364191 MGI: J:109904
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. PubMed: 3841001 MGI: J:109950
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. PubMed: 15081119 MGI: J:89298
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. PubMed: 15067087 MGI: J:122988

Additional References

Courtenay JS; Dallman MJ; Dayan AD; Martin A; Mosedale B. 1980. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 283(5748):666-8. PubMed: 6153460 MGI: J:24763
Hartley JW; Yetter RA; Morse HC 3rd. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. PubMed: 6306133 MGI: J:7108
Heiniger HJ; Taylor BA; Hards EJ; Meier H. 1975. Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res 35(3):825-31. PubMed: 163691 MGI: J:22608
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. PubMed: 14945054 MGI: J:166288
Le AD; Ko J; Chow S; Quan B. 1994. Alcohol consumption by C57BL/6, BALB/c, and DBA/2 mice in a limited access paradigm. Pharmacol Biochem Behav 47(2):375-8. PubMed: 8146231 MGI: J:17161
Matsushima Y; Imai T; Watanabe O; Kawahara H; Ohne M; Takai H. 1984. Spontaneous calcified tongue lesions in DBA mice. Jikken Dobutsu 33(4):539-42. PubMed: 6519193 MGI: J:166811
Vied C; Ray S; Badger CD; Bundy JL; Arbeitman MN; Nowakowski RS. 2016. Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests a basis for sex-specific susceptibility and severity of neurological disorders. J Comp Neurol 524(13):2696-710. PubMed: 26917114 MGI: J:235042
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107. PubMed: 10320101 MGI: J:54812

Additional - a related

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Additional - Cdh23^ahl related

Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. PubMed: 22952717 MGI: J:191663
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Hurd EA; Adams ME; Layman WS; Swiderski DL; Beyer LA; Halsey KE; Benson JM; Gong TW; Dolan DF; Raphael Y; Martin DM. 2011. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hear Res 282(1-2):184-95. PubMed: 21875659 MGI: J:220430
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Johnson KR; Tian C; Gagnon LH; Jiang H; Ding D; Salvi R. 2017. Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains. Sci Rep 7:44450. PubMed: 28287619 MGI: J:241137
Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. Hear Res 268(1-2):85-92. PubMed: 20470874 MGI: J:163035
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Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. Hear Res 188(1-2):21-8. PubMed: 14759567 MGI: J:87783
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Additional - Gpr84^del related

Perez CJ; Dumas A; Vallieres L; Guenet JL; Benavides F. 2013. Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84. J Hered 104(4):565-71. PubMed: 23616478 MGI: J:237405

Additional - Myo5a^d related

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Moore KJ; Swing DA; Rinchik EM; Mucenski ML; Buchberg AM; Copeland NG; Jenkins NA. 1988. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln. Genetics 119(4):933-41. PubMed: 3410303 MGI: J:9309
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Rachel RA; Nagashima K; O'Sullivan TN; Frost LS; Stefano FP; Marigo V; Boesze-Battaglia K. 2012. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS One 7(9):e42446. PubMed: 22984402 MGI: J:191882
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. PubMed: 17247200 MGI: J:148463
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. PubMed: 17247280 MGI: J:148462
Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. PubMed: 17247308 MGI: J:12958
Sweet HO. 1983. Dilute suppressor, a new suppressor gene in the house mouse. J Hered 74(4):305-6. PubMed: 6886377 MGI: J:7171
Yoshimura A; Fujii R; Watanabe Y; Okabe S; Fukui K; Takumi T. 2006. Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr Biol 16(23):2345-51. PubMed: 17141617 MGI: J:117928

Additional - P2rx7^P451L related

Adriouch S; Dox C; Welge V; Seman M; Koch-Nolte F; Haag F. 2002. Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor. J Immunol 169(8):4108-12. PubMed: 12370338 MGI: J:79540
Le Stunff H; Auger R; Kanellopoulos J; Raymond MN. 2004. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem 279(17):16918-26. PubMed: 14761980 MGI: J:89513
Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin JS; Zaykin DV; Meulen HV; Costigan M; Herbert TA; Yarkoni-Abitbul M; Tichauer D; Livneh J; Gershon E; Zheng M; Tan K; John SL; Slade GD; Jordan J; Woolf CJ; Peltz G; Maixner W; DiatchenkoL; Seltzer Z; Salter MW; Mogil JS. 2012. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med 18(4):595-9. PubMed: 22447075 MGI: J:183554

Additional - Rmcf^r related

Buller RS; Ahmed A; Portis JL. 1987. Identification of two forms of an endogenous murine retroviral env gene linked to the Rmcf locus. J Virol 61(1):29-34. PubMed: 3023705 MGI: J:8497
Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med 167(5):1535-46. PubMed: 2835418 MGI: J:27618
Frankel WN; Stoye JP; Taylor BA; Coffin JM. 1989. Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63(9):3810-21. PubMed: 2547997 MGI: J:9925
Hartley JW; Yetter RA; Morse HC 3rd. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. PubMed: 6306133 MGI: J:7108
Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. PubMed: 12134027 MGI: J:78083
Kozak CA. 1985. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. J Virol 55(3):690-5. PubMed: 2991590 MGI: J:7951
Rowe WP; Hartley JW. 1983. Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids. J Exp Med 158(2):353-64. PubMed: 6224881 MGI: J:7175

Additional - Tyrp1^b related

Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. PubMed: 16827931 MGI: J:128215
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. PubMed: 18402690 MGI: J:134670
Barabas P; Huang W; Chen H; Koehler CL; Howell G; John SW; Tian N; Renteria RC; Krizaj D. 2011. Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 52(9):6766-73. PubMed: 21757588 MGI: J:181395
Brooks BP; Larson DM; Chan CC; Kjellstrom S; Smith RS; Crawford MA; Lamoreux L; Huizing M; Hess R; Jiao X; Hejtmancik JF; Maminishkis A; John SW; Bush R; Pavan WJ. 2007. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48(9):3905-13. PubMed: 17724166 MGI: J:124886
Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. PubMed: 13877379 MGI: J:160128
Center EM; Hunter RL; Dodge AH. 1967. Effects of the luxoid gene (lu) on liver esterase isozymes of the mouse. Genetics 55(2):349-58. PubMed: 6067640 MGI: J:109970
Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. PubMed: 13880466 MGI: J:12173
Gajewska M; Krysiak E; Wirth-Dziecialowska E. 2010. New coat color mutation mapped in distal part MMU10 MGI Direct Data Submission :. MGI: J:162146
Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague. MGI: J:30758
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. PubMed: 4634048 MGI: J:5346
Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. PubMed: 18158332 MGI: J:131073
Hunsicker PR. 1969. White-based brown, B<W> Mouse News Lett 40:41. MGI: J:13492
Kelly EM. 1957. Beige, bg Mouse News Lett 16:36. MGI: J:29744
Kobayashi T; Imokawa G; Bennett DC; Hearing VJ. 1998. Tyrosinase stabilization by Tyrp1 (the brown locus protein). J Biol Chem 273(48):31801-5. PubMed: 9822646 MGI: J:51301
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. PubMed: 11277491 MGI: J:103803
Little CC. 1916. The occurrence of three recognized coat mutations in mice Am Naturalist 1:335-349. MGI: J:150254
Manor U; Disanza A; Grati M; Andrade L; Lin H; Di Fiore PP; Scita G; Kachar B. 2011. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr Biol 21(2):167-72. PubMed: 21236676 MGI: J:171832
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. PubMed: 17247639 MGI: J:12970
Matheu A; Pantoja C; Efeyan A; Criado LM; Martin-Caballero J; Flores JM; Klatt P; Serrano M. 2004. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev 18(22):2736-46. PubMed: 15520276 MGI: J:93879
Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/03/01 MGI Direct Data Submission :. MGI: J:180879
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. PubMed: 5902512 MGI: J:5001
Murray WS. 1934. The breeding behavior of the dilute brown stock of mice (Little dba) Am J Cancer 20:573-593. MGI: J:2464
Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :. MGI: J:100221
RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/) :. MGI: J:133634
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. PubMed: 18117146 MGI: J:148461
Raymond S; Jackson IJ. 1994. Molecular characterization of the mouse B<w> mutation causing premature melanocyte death - melanocytes and early development Genet Res 63(2):155 (Abstr). MGI: J:18590
Rittenhouse E. 1968. Genetic effect on fine structure and development of pigment granules in mouse hair bulb melanocytes. I. The b and d loci. Dev Biol 17(4):351-65. PubMed: 5650006 MGI: J:5068
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. PubMed: 17247200 MGI: J:148463
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. PubMed: 17247280 MGI: J:148462
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. MGI: J:78801
Smyth IM; Wilming L; Lee AW; Taylor MS; Gautier P; Barlow K; Wallis J; Martin S; Glithero R; Phillimore B; Pelan S; Andrew R; Holt K; Taylor R; McLaren S; Burton J; Bailey J; Sims S; Squares J; Plumb B; Joy A; Gibson R; Gilbert J; Hart E; Laird G; Loveland J; Mudge J; Steward C; Swarbreck D; Harrow J; North P; Leaves N; Greystrong J; Coppola M; Manjunath S; Campbell M; Smith M; Strachan G; Tofts C; Boal E; Cobley V; Hunter G; Kimberley C; Thomas D; Cave-Berry L; Weston P; Botcherby MR; White S; Edgar R; C. 2006. Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A 103(10):3704-9. PubMed: 16505357 MGI: J:107243
Sweet SE; Quevedo WC Jr. 1968. Role of melanocyte morphology in pigmentation of mouse hair. Anat Rec 162(2):243-54. PubMed: 5726144 MGI: J:5095
Trantow CM; Cuffy TL; Fingert JH; Kuehn MH; Anderson MG. 2011. Microarray analysis of iris gene expression in mice with mutations influencing pigmentation. Invest Ophthalmol Vis Sci 52(1):237-48. PubMed: 20739468 MGI: J:171565
Zdarsky E; Favor J; Jackson IJ. 1990. The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics 126(2):443-9. PubMed: 2245916 MGI: J:44435

Also Known As: D1, DBA1

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Important Note

Detailed Description

Development

Selected References

Cdh23ahl

Allele Symbol: Cdh23ahl

Gpr84del

Allele Symbol: Gpr84del

Myo5ad

Allele Symbol: Myo5ad

P2rx7P451L

Allele Symbol: P2rx7P451L

Rmcfr

Allele Symbol: Rmcfr

Tyrp1b

Allele Symbol: Tyrp1b

a

Allele Symbol: a

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Genotype: Myo5ad related

Genotype: Tyrp1b related

Mammalian Phenotype Terms by Genotype

immune system phenotype

craniofacial phenotype

digestive/alimentary phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

Genotype: Rmcfr/RmcfrDBA/1J

immune system phenotype

Phenotype Information

References

Additional References

Additional - a related

Additional - Cdh23ahl related

Additional - Gpr84del related

Additional - Myo5ad related

Additional - P2rx7P451L related

Additional - Rmcfr related

Additional - Tyrp1b related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

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Citation

Animal Health Reports

Live Mouse

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Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Gpr84^del

Allele Symbol: Gpr84^del

Myo5a^d

Allele Symbol: Myo5a^d

P2rx7^P451L

Allele Symbol: P2rx7^P451L

Rmcf^r

Allele Symbol: Rmcf^r

Tyrp1^b

Allele Symbol: Tyrp1^b

Genotype: Cdh23^ahl related

Genotype: Myo5a^d related

Genotype: Tyrp1^b related

Genotype: Rmcf^r/Rmcf^r
DBA/1J

Additional - Cdh23^ahl related

Additional - Gpr84^del related

Additional - Myo5a^d related

Additional - P2rx7^P451L related

Additional - Rmcf^r related

Additional - Tyrp1^b related