&nbsp;&nbsp;&nbsp;This strain was developed by MacDowell in 1921 from litter mates 58 and 52 of Miss Lathrop's stock. A mating of the same male but a different female gave rise to the commonly used C57BL group of strains. C58/J mice exhibit a high incidence of leukemia (&gt;90% by one year of age). C58/J mice also exhibit an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). &nbsp;&nbsp;&nbsp;Bone marrow cells of C58/J mice (and mice of 9 other strains, excluding closely derived C57 strains) carry the interleukin 3 receptor, alpha chain; mutation 1 allele (Il3ram1) which confers non-responsiveness to Interleukin-3 (IL-3). IL-3 normally stimulates colony formation of multiple lineages of hematopoietic cells. &nbsp;&nbsp;&nbsp;Other characteristics include: low social preference, poor performance in the T-maze, and overt motoric stereotypy. C58/J mice are homozygous for the high affinity aryl-hydrocarbon receptor; b-1 variant (Ahrb-1). 
 From 2014-2020, The Jackson Laboratory Repository Stock No. 000669 live colony had ~14% nonproductive breeding units (33 of 236 breeding units failed to produce offspring). Therefore, researchers are encouraged to order more than one breeding unit.

 C58/J inbred mice develop leukemia at one year of age, and are susceptible to diet-induced atherosclerotic aortic lesions. They may also be useful in inflammation and immunology studies due to their lack of IL-3R. 

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.