Overview

Also Known As:C57 Leaden, L, Leaden

C57L/J mice are used widely in research as a general purpose strain. Mice have a high incidence of Hodgkin's-like reticulum cell neoplasm at 18 months of age and pituitary tumors in old multiparous females. C57L/J mice are highly susceptible to experimental allergic encephalomyelitis and highly responsive to phytohemagglutinin. In addition, C57L/J mice are highly susceptible to developing atherosclerotic aortic lesions following 14 weeks on an atherogenic diet. On a lithogenic diet, C57L/J mice develop gallstones as a result of abnormal regulation of cholesterol synthesis.

Genetic overview

Genetic Background	Generation
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Research Applications

Dermatology Research
Cardiovascular Research
Cancer Research
Research Tools
Neurobiology Research
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research
Metabolism Research

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Base Price

Starting at:

$124.43 Domestic price for female 4-week

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Details

Important Note

This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset prior to three months of age.

Detailed Description

C57L/J mice are used widely in research as a general purpose strain. Mice have a high incidence of Hodgkin's-like reticulum cell neoplasm at 18 months of age and pituitary tumors in old multiparous females. C57L/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE) and highly responsive to phytohemagglutinin. In addition, C57L/J mice are highly susceptible to developing atherosclerotic aortic lesions (4500 to 8000 um² atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat) (Paigen et al. 1990). On a lithogenic diet, C57L/J mice develop gallstones as a result of abnormal regulation of cholesterol synthesis (Xua et al. 2004). C57L/J mice carry no detectable endogenous ecotropic MuLV DNA sequences.

Development

C57L/J mice were inbred following a mutation in a now extinct substrain of C57BR at F22. Inbreeding was carried out by J Murray at The Jackson Laboratory beginning in 1933. They were transferred to the production facility in 1947 at F45. The current generation of inbreeding is F203+.

Selected References

Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73PubMed: 3841001 MGI: J:109950
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605PubMed: 8355588 MGI: J:13267
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77PubMed: 1971301 MGI: J:15484
Heiniger HJ; Taylor BA; Hards EJ; Meier H. 1975. Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res 35(3):825-31PubMed: 163691 MGI: J:22608
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23PubMed: 2317166 MGI: J:22615
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462SPubMed: 7625360 MGI: J:28248
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8PubMed: 7106865 MGI: J:6828
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

View All References

Genetics

Obq3^C57L/J

Allele Symbol: Obq3^C57L/J

Allele Name	C57L/J
Allele Type	QTL
Allele Synonym(s)	C57L/J; Obq3^C57L/J
Gene Symbol and Name	Obq3, obesity QTL 3
Gene Synonym(s)
Strain of Origin	C57L/J
Chromosome	2
General Note	Obq3 exhibits additive inheritance.

Rmcf^s

Allele Symbol: Rmcf^s

Allele Name	MCF sensitive
Allele Type	Spontaneous
Allele Synonym(s)	Rmcf^s; MCF sensitive
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	age related hearing loss 1; Cdh23^ahl
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Mx1^s1

Allele Symbol: Mx1^s1

Allele Name	myxovirus susceptibility 1
Allele Type	Spontaneous
Allele Synonym(s)	Mx1^s1; myxovirus susceptibility 1
Gene Symbol and Name	Mx1, MX dynamin-like GTPase 1
Gene Synonym(s)	Mx; Mx-1; Mx; Mx-1; AI893580; myxovirus (influenza) resistance 1 polypeptide; expressed sequence AI893580; IFI-78K; MxA; MX; IFI78; MXB; lncMX1-215
Strain of Origin	multiple strains
Chromosome	16
General Note	The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Resistance is specific for the orthomyxoviruses (J:6265). It is dependent on the presence of interferon-alpha and -beta but not -gamma (J:7365). The resistance allele at the Mx1 locus, under induction by alpha/beta interferon, produces the 75 kDa protein MX-1, which confers resistance to the influenza virus, in the nuclei of cells carrying the allele. Susceptibility alleles do not produce the protein (J:8273). The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). The MX-1 protein is a GTPase containing a GTP binding domain (J:1417) and this binding core is also necessary (J:21243). Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1^r. The Mx1^r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1^s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1^r allele. This large deletion apparently renders the protein incapable of providing resistance to influenza. The CBA/J, CE/J, I/LnJ, and PERA/Ei strains, also susceptible to the virus, have another form of the Mx1^s2 allele in which there is a nonsense mutation (J:9452). Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). Although some interferon-induced genes respond directly to virus invasion as well as indirectly through induction by virus-induced interferon, this primary response is very weak for the MX-1 protein in response to either influenza or Newcastle disease viruses (J:1892).
Molecular Note	Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi.

Obq4^C57L/J

Allele Symbol: Obq4^C57L/J

Allele Name	C57L/J
Allele Type	QTL
Allele Synonym(s)	C57L/J; Obq4^C57L/J
Gene Symbol and Name	Obq4, obesity QTL 4
Gene Synonym(s)
Strain of Origin	C57L/J
Chromosome	17
General Note	Obq4 may also be consistent with an additive mode of inheritance.
Molecular Note	This allele confers increased adiposity in male animals compared to AKR/J, and accounts for 11.7% of the phenotypic variance in male inguinal fat pad weight (percentage).

Ahr^b-1

Allele Symbol: Ahr^b-1

Allele Name	b-1 variant
Allele Type	Not Applicable
Allele Synonym(s)	Ahr^b-1; b-1 variant
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity; RP85
Strain of Origin	C57BL/6J
Chromosome	12
General Note	C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460). Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains
Molecular Note	This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Mlph^ln

Allele Symbol: Mlph^ln

Allele Name	leaden
Allele Type	Spontaneous
Allele Synonym(s)	Mlph^ln; leaden
Gene Symbol and Name	Mlph, melanophilin
Gene Synonym(s)	AW228792; DNA segment, Chr 1, Wayne State University 84, expressed; leaden; expressed sequence AW228792; ln; Slac-2a; 5031433I09Rik; SLAC2-A; D1Wsu84e; 2210418F23Rik; D1Wsu84e
Strain of Origin	C57BR
Chromosome	1
Molecular Note	This allele has a C to T transition at mRNA nucleotide position 266. This introduces a stop codon in the sequence of the normally spliced transcript and it also creates a new splice donor site in exon 2. Use of this alternative splice site yields a transcript with an in-frame 21 base pair deletion that deletes 7 amino acids from the translated protein. Northern blots failed to detect this size difference and did not find any change from normal in transcript expression level.

Cox7a2l^l

Allele Symbol: Cox7a2l^l

Allele Name	long
Allele Type	Not Applicable (Not Specified)
Allele Synonym(s)	Cox7a2l^l; long
Gene Symbol and Name	Cox7a2l, cytochrome c oxidase subunit 7A2 like
Gene Synonym(s)	COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1
Strain of Origin	multiple strains
Chromosome	17
General Note	Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T⁺ Itpr3^tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.
Molecular Note	This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Dermatology Research
- Color and White Spotting Defects
Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Susceptible
Cancer Research
- Increased Tumor Incidence
  - Leukemia
  - Other Tissues/Organs: pituitary, reticulum cell neoplasm, type B
  - Other Tissues/Organs
Research Tools
- General Purpose
Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimental allergic encephalomyelitis (EAE)

Genotype: Cdh23^ahl related

Sensorineural Research
- Hearing Defects
  - Age related hearing loss
Neurobiology Research
- Hearing Defects
  - Age related hearing loss

Genotype: Mlph^ln related

Dermatology Research
- Color and White Spotting Defects

Genotype: Ahr^b-1 related

Metabolism Research
Research Tools
- Toxicology Research

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
C57L/J

integument phenotype

abnormal coat/hair pigmentation

diluted coat color
- due to clumping of pigment

pigmentation phenotype

abnormal coat/hair pigmentation

abnormal melanocyte morphology
- results in clumping rather than even distribution of pigment during hair development

diluted coat color
- due to clumping of pigment

Genotype: Rmcf^s/Rmcf^s
C57L/J

immune system phenotype

increased susceptibility to viral infection
- susceptible to infection with N- and NB-tropic mink cell focus-forming (MCF) viruses

Phenotype Information

Festing Inbred Strain Characteristics: C57L

References

Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73PubMed: 3841001 MGI: J:109950
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605PubMed: 8355588 MGI: J:13267
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77PubMed: 1971301 MGI: J:15484
Heiniger HJ; Taylor BA; Hards EJ; Meier H. 1975. Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res 35(3):825-31PubMed: 163691 MGI: J:22608
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23PubMed: 2317166 MGI: J:22615
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462SPubMed: 7625360 MGI: J:28248
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8PubMed: 7106865 MGI: J:6828
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

Wahlsten D; Bachmanov A; Finn DA; Crabbe JC. 2006. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A 103(44):16364-9PubMed: 17053075 MGI: J:115640
Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32PubMed: 1621856 MGI: J:1348
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20PubMed: 16971002 MGI: J:138682
Milner LC; Crabbe JC. 2008. Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav 7(4):496-505PubMed: 18182070 MGI: J:149042
Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13PubMed: 14945054 MGI: J:166288
Sinke AP; Caputo C; Tsaih SW; Yuan R; Ren D; Deen PM; Korstanje R. 2011. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics 43(5):265-70PubMed: 21177381 MGI: J:171768
Yuan R; Meng Q; Nautiyal J; Flurkey K; Tsaih SW; Krier R; Parker MG; Harrison DE; Paigen B. 2012. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A 109(21):8224-9PubMed: 22566614 MGI: J:184775
Lightfoot JT; Leamy L; Pomp D; Turner MJ; Fodor AA; Knab A; Bowen RS; Ferguson D; Moore-Harrison T; Hamilton A. 2010. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol 109(3):623-34PubMed: 20538847 MGI: J:185928
Leduc MS; Hageman RS; Meng Q; Verdugo RA; Tsaih SW; Churchill GA; Paigen B; Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9(5):823-36PubMed: 20735370 MGI: J:201869
Yuan R; Tsaih SW; Petkova SB; Marin de Evsikova C; Xing S; Marion MA; Bogue MA; Mills KD; Peters LL; Bult CJ; Rosen CJ; Sundberg JP; Harrison DE; Churchill GA; Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8(3):277-87PubMed: 19627267 MGI: J:216124
Hui ST; Parks BW; Org E; Norheim F; Che N; Pan C; Castellani LW; Charugundla S; Dirks DL; Psychogios N; Neuhaus I; Gerszten RE; Kirchgessner T; Gargalovic PS; Lusis AJ. 2015. The genetic architecture of NAFLD among inbred strains of mice. Elife 4:e05607PubMed: 26067236 MGI: J:223755
Roderick TH. 1963. The response of twenty-seven inbred strains of mice to daily doses of whole-body x-irradiation Radiat Res 20:631-39PubMed: 14102482 MGI: J:22617
RUSSELL ES; NEUFELD EF; HIGGINS CT. 1951. Comparison of normal blood picture of young adults from 18 inbred strains of mice. Proc Soc Exp Biol Med 78(3):761-6PubMed: 14912022 MGI: J:22753
Wiltshire T; Ervin RB; Duan H; Bogue MA; Zamboni WC; Cook S; Chung W; Zou F; Tarantino LM. 2015. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains. Genes Brain Behav 14(3):271-80PubMed: 25727211 MGI: J:235925
Sundberg JP; Berndt A; Sundberg BA; Silva KA; Kennedy V; Bronson R; Yuan R; Paigen B; Harrison D; Schofield PN. 2011. The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice. Pathobiol Aging Age Relat Dis 1PubMed: 22953031 MGI: J:236844
Dunn TB; Deringer MK. 1968. Reticulum cell neoplasm, type B, or the Hodgkin's-like lesion of the mouse. J Natl Cancer Inst 40(4):771-821PubMed: 4869134 MGI: J:2417
Liu JL; Wang TS; Zhao M. 2016. Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda) 6(9):2929-35PubMed: 27449513 MGI: J:244239
Levine S; Sowinski R. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J Immunol 110(1):139-43PubMed: 4631068 MGI: J:24660
Gillespie A; Lee H; Robertson C; Cabot M; Brown MG. 2017. Genome-Wide Exome Analysis of Cmv5-Disparate Mouse Strains that Differ in Host Resistance to Murine Cytomegalovirus Infection. G3 (Bethesda) 7(6):1979-1984PubMed: 28450376 MGI: J:251745
Gubner NR; Wilhelm CJ; Phillips TJ; Mitchell SH. 2010. Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcohol Clin Exp Res 34(8):1353-62PubMed: 20491731 MGI: J:266371
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Bumgardner SA; Zhou Y; Jiang Z; Coe EJ; Yakaitis CL; Xiao Y; Pazdro R. 2018. Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. Exp Gerontol 104:9-16PubMed: 29355703 MGI: J:272690
Chella Krishnan K; Kurt Z; Barrere-Cain R; Sabir S; Das A; Floyd R; Vergnes L; Zhao Y; Che N; Charugundla S; Qi H; Zhou Z; Meng Y; Pan C; Seldin MM; Norheim F; Hui S; Reue K; Lusis AJ; Yang X. 2018. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6(1):103-115.e7PubMed: 29361464 MGI: J:272734
Ananda G; Takemon Y; Hinerfeld D; Korstanje R. 2014. Whole-genome sequence of the C57L/J mouse inbred strain. G3 (Bethesda) 4(9):1689-92PubMed: 25053706 MGI: J:274173
Zimmerman H; Yin Z; Zou F; Everett ET. 2019. Interfrontal Bone Among Inbred Strains of Mice and QTL Mapping. Front Genet 10:291PubMed: 31001328 MGI: J:275176
Geuther BQ; Deats SP; Fox KJ; Murray SA; Braun RE; White JK; Chesler EJ; Lutz CM; Kumar V. 2019. Robust mouse tracking in complex environments using neural networks. Commun Biol 2:124PubMed: 30937403 MGI: J:275426
Vinyard CJ; Payseur BA. 2008. Of mice and mammals: utilizing classical inbred mice to study the genetic architecture of function and performance in mammals. Integr Comp Biol 48(3):324-37PubMed: 21669795 MGI: J:275940
Tomasini-Johansson B; Mosher DF. 2009. Plasma fibronectin concentration in inbred mouse strains. Thromb Haemost 102(6):1278-80PubMed: 19967162 MGI: J:275941
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Wooley CM; Xing S; Burgess RW; Cox GA; Seburn KL. 2009. Age, experience and genetic background influence treadmill walking in mice. Physiol Behav 96(2):350-61PubMed: 19027767 MGI: J:275950
Metten P; Crabbe JC. 2005. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci 119(4):911-25PubMed: 16187819 MGI: J:276057
Chen YG; Tsaih SW; Serreze DV. 2012. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes Immun 13(2):164-74PubMed: 21938016 MGI: J:276531
Berndt A; Leme AS; Williams LK; Von Smith R; Savage HS; Stearns TM; Tsaih SW; Shapiro SD; Peters LL; Paigen B; Svenson KL. 2011. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics 43(1):1-11PubMed: 20823217 MGI: J:276536
Leme AS; Berndt A; Williams LK; Tsaih SW; Szatkiewicz JP; Verdugo R; Paigen B; Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics 283(4):317-26PubMed: 20143096 MGI: J:276589
Deschepper CF; Olson JL; Otis M; Gallo-Payet N. 2004. Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains. J Appl Physiol (1985) 97(1):369-76PubMed: 15047670 MGI: J:276748
Gillespie AL; Teoh J; Lee H; Prince J; Stadnisky MD; Anderson M; Nash W; Rival C; Wei H; Gamache A; Farber CR; Tung K; Brown MG. 2016. Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection. PLoS Pathog 12(2):e1005419PubMed: 26845690 MGI: J:278477
Fujiwara M; Cinader B. 1974. Cellular aspects of tolerance. IV. Strain variations of tolerance induceability. Cell Immunol 12(1):11-29PubMed: 4142413 MGI: J:280896
Hutton JJ; Gross SR. 1970. Chemical induction of hepatic porphyria in inbred strains of mice. Arch Biochem Biophys 141(1):284-92PubMed: 5480116 MGI: J:280906
Beamer WG; Donahue LR; Rosen CJ; Baylink DJ. 1996. Genetic variability in adult bone density among inbred strains of mice. Bone 18(5):397-403PubMed: 8739896 MGI: J:33789
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12PubMed: 2169579 MGI: J:34840
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7PubMed: 8753860 MGI: J:35147
Srivastava RA; Bhasin N; Srivastava N. 1996. Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen. Biochem Mol Biol Int 38(1):91-101PubMed: 8932523 MGI: J:36349
Taylor BA; Phillips SJ. 1997. Obesity QTLs on mouse chromosomes 2 and 17. Genomics 43(3):249-57PubMed: 9268627 MGI: J:39947
Carter CP; Howles PN; Hui DY. 1997. Genetic variation in cholesterol absorption efficiency among inbred strains of mice. J Nutr 127(7):1344-8PubMed: 9202089 MGI: J:41891
Belknap JK; Riggan J; Cross S; Young ER; Gallaher EJ; Crabbe JC. 1998. Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains Pharmacol Biochem Behav 59(2):353-60PubMed: 9476981 MGI: J:46034
Crabbe JC; Gallaher EJ; Cross SJ; Belknap JK. 1998. Genetic determinants of sensitivity to diazepam in inbred mice. Behav Neurosci 112(3):668-77PubMed: 9676982 MGI: J:48988
Daniel WL; Harrison BW; Nelson K. 1982. Genetic regulation of murine hepatic arylsulfatase B activity during development. J Hered 73(1):24-8PubMed: 7069188 MGI: J:6740
Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol 43(1):26-36PubMed: 6287001 MGI: J:6844
Crabbe JC; Metten P; Gallaher EJ; Belknap JK. 2002. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology (Berl) 161(4):408-16PubMed: 12073169 MGI: J:77863
Bachmanov AA; Beauchamp GK; Tordoff MG. 2002. Voluntary consumption of NaCl, KCl, CaCl2, and NH4Cl solutions by 28 mouse strains. Behav Genet 32(6):445-57PubMed: 12467342 MGI: J:80489
Bachmanov AA; Reed DR; Beauchamp GK; Tordoff MG. 2002. Food intake, water intake, and drinking spout side preference of 28 mouse strains. Behav Genet 32(6):435-43PubMed: 12467341 MGI: J:80495
Rustay NR; Wahlsten D; Crabbe JC. 2003. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A 100(5):2917-22PubMed: 12584362 MGI: J:82386
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9PubMed: 12884964 MGI: J:83104
Wahlsten D; Metten P; Crabbe JC. 2003. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res 971(1):47-54PubMed: 12691836 MGI: J:83159

Additional - Ahr^b-1 related

Additional - Cdh23^ahl related

Additional - Cox7a2l^l related

Additional - Mlph^ln related

Additional - Mx1^s1 related

Additional - Obq3^C57L/J related

Additional - Obq4^C57L/J related

Additional - Rmcf^s related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

This strain is a challenging breeder.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- leaden (grey)
  Related Genotype: a/a Tyrp1^b/Tyrp1^b Mlph^ln/Mlph^ln
Citation
When using the Leaden mouse strain in a publication, please include JAX stock #000668 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MP13 (Maximum)

Pricing & Availability

Available Now

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Inbred, 1 pair minimum will be supplied

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As:C57 Leaden, L, Leaden

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Selected References

Obq3C57L/J

Allele Symbol: Obq3C57L/J

Rmcfs

Allele Symbol: Rmcfs

Cdh23ahl

Allele Symbol: Cdh23ahl

Mx1s1

Allele Symbol: Mx1s1

Obq4C57L/J

Allele Symbol: Obq4C57L/J

Ahrb-1

Allele Symbol: Ahrb-1

Mlphln

Allele Symbol: Mlphln

Cox7a2ll

Allele Symbol: Cox7a2ll

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23ahl related

Genotype: Mlphln related

Genotype: Ahrb-1 related

Mammalian Phenotype Terms by Genotype

Genotype: a/a Mlphln/Mlphln Tyrp1b/Tyrp1bC57L/J

integument phenotype

pigmentation phenotype

Genotype: Rmcfs/RmcfsC57L/J

immune system phenotype

Phenotype Information

References

Additional References

Additional - Ahrb-1 related

Additional - Cdh23ahl related

Additional - Cox7a2ll related

Additional - Mlphln related

Additional - Mx1s1 related

Additional - Obq3C57L/J related

Additional - Obq4C57L/J related

Additional - Rmcfs related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Obq3^C57L/J

Allele Symbol: Obq3^C57L/J

Rmcf^s

Allele Symbol: Rmcf^s

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Mx1^s1

Allele Symbol: Mx1^s1

Obq4^C57L/J

Allele Symbol: Obq4^C57L/J

Ahr^b-1

Allele Symbol: Ahr^b-1

Mlph^ln

Allele Symbol: Mlph^ln

Cox7a2l^l

Allele Symbol: Cox7a2l^l

Genotype: Cdh23^ahl related

Genotype: Mlph^ln related

Genotype: Ahr^b-1 related

Genotype: a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
C57L/J

Genotype: Rmcf^s/Rmcf^s
C57L/J

Additional - Ahr^b-1 related

Additional - Cdh23^ahl related

Additional - Cox7a2l^l related

Additional - Mlph^ln related

Additional - Mx1^s1 related

Additional - Obq3^C57L/J related

Additional - Obq4^C57L/J related

Additional - Rmcf^s related