Overview

Also Known As: Brown cd, C57 Brown, BR

C57BR/cdJ mice show variable incidence of spinal cord epidermoid cysts, primarily in the leptomeninges adjacent to the posterior horn and lateral/anterior columns. Mice of this strain show several behavioral differences from many other inbred strains.

Genetic overview

Genetic Background	Generation

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Research Applications

Metabolism Research
Research Tools
Neurobiology Research
Sensorineural Research
Cardiovascular Research

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Details

Important Note

This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss.

Detailed Description

C57BR/cdJ mice develop early-onset hearing loss that is moderate at seven weeks of age, is severe by 20 weeks and progresses with increasing age (Henry 1982; Zheng et al. 1999). The loss is greatest in the higher frequency range; at seven weeks, Henry reported 50% of the mice showed no 64 kHz auditory brainstem response (ABR), and by 100 days both the 2 kHz and 32 kHz responses were absent. Both labs found this strain to be least vulnerable to loss of the16 kHz response, which persisted through 200 days but was lost before 300 days of age (Henry 1982). C57BR/cdJ did not exhibit aberrant ABR wave patterns, suggesting that the hearing loss results from defects of the peripheral, rather than central auditory system (Zheng et al. 1999). F1 hybrid progeny from matings with the good-hearing strain CAST/Ei exhibited good hearing even at advanced ages, indicating that the allele(s) responsible for hearing loss in C57BR/cdJ are recessive. An allelism test between C57BR/cdJ and NOD.NON-H2^nb1 showed the mutations responsible for hearing loss in these two strains not to be allelic; NOD.NON-H2^nb1 shares the deafness allele(s) of A/J, ALR/LtJ and DBA/2J (Zheng et al. 1999).

C57BR/cdJ mice showed variable incidence of spinal cord epidermoid cysts, primarily in the leptomeninges adjacent to the posterior horn and lateral/anterior columns. The cysts comprised "a whorled mass of keratinized cells surrounded by polygonal epithelial cells," some of which contained keratohyaline granules. No basal cells were present. (Stroop 1884).

EEG studies demonstrated that although C57BR/cd mice spend less time sleeping, a greater proportion of their sleep time is spent in paradoxical sleep (PS)(equivalent to human rapid eye movement, or REM sleep) than is true of mice of six other inbred strains tested (Pagel et al. 1973). Whereas C57BL/6 mice learn slowly, gradually improving their performance at a rate dependent upon the number of training trials, C57BR/cd mice fail to improve during the initial training, but show improvement after a delay of at least eight to 10 hours; overall, C57BR/cd mice are fast learners. PS deprivation has no effect on either discriminatory or active avoidance learning in C57BL/6, BALB/c or SEC mice. In contrast, PS deprivation for 24 hours impairs learning of discriminatory tasks by C57BR/cd mice, and six hours' PS deprivation immediately following the initial training abolishes their time-dependent improvement in avoidance learning. Continuous PS deprivation causes C57BR/cd mice to learn at the same rate as C57BL/6 mice. Interestingly, although BALB/c mice show a time-delayed improvement in learning acquisition for an appetitive task similar to that of C57BR/cd mice for avoidance learning, neither C57BR/cd nor C57BL/6 exhibit show such time-dependent improvement in appetitive learning (Kitahama et al. 1981 and references cited therein).

Development

Created by C.C. Little from a cross that gave rise to C57BL, C57BR/a, and C57L. Black and brown lines were separated in the first generation. Subline cd was established in generation 13 from a cross of two brown lines, one of which had previously given rise to C57BR/a. Obtained by The Jackson Laboratory from W. E. Heston at F66.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Selected References

Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. Genome Biol 17(1):167PubMed: 27480531 MGI: J:262923
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62PubMed: 9148789 MGI: J:41130
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8PubMed: 7106865 MGI: J:6828
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

View All References

Genetics

Rmcf^s

Allele Symbol: Rmcf^s

Allele Name	MCF sensitive
Allele Type	Spontaneous
Allele Synonym(s)	Rmcf^s; MCF sensitive
Gene Symbol and Name	Rmcf, resistance to MCF virus
Gene Synonym(s)
Strain of Origin	multiple strains
Chromosome	5
General Note	This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcf^r determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcf^s determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1, a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcf^r protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxv^s/Sxv^r mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcf^r increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcf^r allele contains an endogenous MCF gp70 env gene and that the Rmcf^s allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note	This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Allele Name	age related hearing loss 1
Allele Type	Spontaneous
Allele Synonym(s)	age related hearing loss 1; Cdh23^ahl
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)	bob; bustling; bobby; nmf112; nmf252; nmf252; 4930542A03Rik; ahl; 4930542A03Rik; W; sals; mdfw; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; modifier of deaf waddler; age related hearing loss 1; v; USH1D; nmf181; RIKEN cDNA 4930542A03 gene; CDHR23; sals; waltzer; nmf112; nmf181; mdfw; neuroscience mutagenesis facility, 112; bus; ahl; bob; salsa; PITA5
Strain of Origin	multiple strains
Chromosome	10
Molecular Note	Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7, which is predicted to delete part of the 2nd and 3rd ectodomains, and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

Ahr^b-1

Allele Symbol: Ahr^b-1

Allele Name	b-1 variant
Allele Type	Not Applicable
Allele Synonym(s)	Ahr^b-1; b-1 variant
Gene Symbol and Name	Ahr, aryl-hydrocarbon receptor
Gene Synonym(s)	bHLHe76; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; Ahh; dioxin receptor; In; Ah; Ahre; inflammatory reactivity; RP85
Strain of Origin	C57BL/6J
Chromosome	12
General Note	C57BL/6 carries the responsive Ahr^b allele; DBA/2 carries nonresponsive Ahr^d. Heterozygotes (Ahr^b/Ahr^d) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahr^b-1; Ahr^b-2 is carried by BALB/cBy, A, and C3H; and Ahr^b-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahr^b-1 and Ahr^d have been determined (J:17460). Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains
Molecular Note	This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

Cox7a2l^l

Allele Symbol: Cox7a2l^l

Allele Name	long
Allele Type	Not Applicable (Not Specified)
Allele Synonym(s)	Cox7a2l^l; long
Gene Symbol and Name	Cox7a2l, cytochrome c oxidase subunit 7A2 like
Gene Synonym(s)	COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1
Strain of Origin	multiple strains
Chromosome	17
General Note	Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T⁺ Itpr3^tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.
Molecular Note	This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahr^b-1 related

Metabolism Research
Research Tools
- Toxicology Research

Genotype: Cdh23^ahl related

Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Cardiovascular Research
- Diet-Induced Atherosclerosis
  - Susceptible
Research Tools
- General Purpose
- Neurobiology Research
Neurobiology Research
- Hearing Defects
  - Age related hearing loss
Sensorineural Research
- Hearing Defects
  - Age related hearing loss

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Rmcf^s/Rmcf^s
C57BR/cdJ

immune system phenotype

increased susceptibility to viral infection
- susceptible to infection with N- and NB-tropic mink cell focus-forming (MCF) viruses

Phenotype Information

Festing Inbred Strain Characteristics: C57BR

References

Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295
Doran AG; Wong K; Flint J; Adams DJ; Hunter KW; Keane TM. 2016. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations. Genome Biol 17(1):167PubMed: 27480531 MGI: J:262923
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62PubMed: 9148789 MGI: J:41130
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8PubMed: 7106865 MGI: J:6828
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11PubMed: 15081119 MGI: J:89298

Additional References

Zheng QY; Tong YC; Alagramam KN; Yu H. 2007. Tympanometry assessment of 61 inbred strains of mice. Hear Res 231(1-2):23-31PubMed: 17611057 MGI: J:123543
Xing S; Tsaih SW; Yuan R; Svenson KL; Jorgenson LM; So M; Paigen BJ; Korstanje R. 2009. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296(6):H1907-13PubMed: 19395551 MGI: J:150867
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13PubMed: 14945054 MGI: J:166288
Sinke AP; Caputo C; Tsaih SW; Yuan R; Ren D; Deen PM; Korstanje R. 2011. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics 43(5):265-70PubMed: 21177381 MGI: J:171768
Yuan R; Meng Q; Nautiyal J; Flurkey K; Tsaih SW; Krier R; Parker MG; Harrison DE; Paigen B. 2012. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. Proc Natl Acad Sci U S A 109(21):8224-9PubMed: 22566614 MGI: J:184775
Lightfoot JT; Leamy L; Pomp D; Turner MJ; Fodor AA; Knab A; Bowen RS; Ferguson D; Moore-Harrison T; Hamilton A. 2010. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J Appl Physiol 109(3):623-34PubMed: 20538847 MGI: J:185928
Harrill AH; Desmet KD; Wolf KK; Bridges AS; Eaddy JS; Kurtz CL; Hall JE; Paine MF; Tidwell RR; Watkins PB. 2012. A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models. Toxicol Sci 130(2):416-26PubMed: 22940726 MGI: J:192655
Leduc MS; Hageman RS; Meng Q; Verdugo RA; Tsaih SW; Churchill GA; Paigen B; Yuan R. 2010. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell 9(5):823-36PubMed: 20735370 MGI: J:201869
Jonczyk MS; Simon M; Kumar S; Fernandes VE; Sylvius N; Mallon AM; Denny P; Andrew PW. 2014. Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection. PLoS One 9(3):e89831PubMed: 24594938 MGI: J:214701
Yuan R; Tsaih SW; Petkova SB; Marin de Evsikova C; Xing S; Marion MA; Bogue MA; Mills KD; Peters LL; Bult CJ; Rosen CJ; Sundberg JP; Harrison DE; Churchill GA; Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8(3):277-87PubMed: 19627267 MGI: J:216124
Roderick TH. 1963. The response of twenty-seven inbred strains of mice to daily doses of whole-body x-irradiation Radiat Res 20:631-39PubMed: 14102482 MGI: J:22617
Storer JB. 1966. Longevity and gross pathology at death in 22 inbred mouse strains. J Gerontol 21(3):404-9PubMed: 5944803 MGI: J:22621
Henry KR. 1982. Age-related auditory loss and genetics: an electrocochleographic comparison of six inbred strains of mice. J Gerontol 37(3):275-82PubMed: 7069150 MGI: J:22724
RUSSELL ES; NEUFELD EF; HIGGINS CT. 1951. Comparison of normal blood picture of young adults from 18 inbred strains of mice. Proc Soc Exp Biol Med 78(3):761-6PubMed: 14912022 MGI: J:22753
Pagel J; Pegram V; Vaughn S; Donaldson P; Bridgers W. 1973. The relationship of REM sleep with learning and memory in mice. Behav Biol 9(3):383-8PubMed: 4355184 MGI: J:23519
Wiltshire T; Ervin RB; Duan H; Bogue MA; Zamboni WC; Cook S; Chung W; Zou F; Tarantino LM. 2015. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains. Genes Brain Behav 14(3):271-80PubMed: 25727211 MGI: J:235925
Sundberg JP; Berndt A; Sundberg BA; Silva KA; Kennedy V; Bronson R; Yuan R; Paigen B; Harrison D; Schofield PN. 2011. The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice. Pathobiol Aging Age Relat Dis 1PubMed: 22953031 MGI: J:236844
Andrews E; Velupillai P; Sung CK; Beier DR; Benjamin T. 2012. Production of a natural antibody to the mouse polyoma virus is a multigenic trait. G3 (Bethesda) 2(3):353-5PubMed: 22413089 MGI: J:244969
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of water and sodium intake. Physiol Behav 91(5):620-31PubMed: 17490693 MGI: J:269806
Tordoff MG; Bachmanov AA; Reed DR. 2007. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav 91(5):632-43PubMed: 17493644 MGI: J:272216
Reed DR; Bachmanov AA; Tordoff MG. 2007. Forty mouse strain survey of body composition. Physiol Behav 91(5):593-600PubMed: 17493645 MGI: J:272217
Frick A; Fedoriw Y; Richards K; Damania B; Parks B; Suzuki O; Benton CS; Chan E; Thomas RS; Wiltshire T. 2015. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med 8:81-98PubMed: 25897258 MGI: J:275938
Benton CS; Miller BH; Skwerer S; Suzuki O; Schultz LE; Cameron MD; Marron JS; Pletcher MT; Wiltshire T. 2012. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl) 221(2):297-315PubMed: 22113448 MGI: J:275939
Schoenrock SA; Oreper D; Young N; Ervin RB; Bogue MA; Valdar W; Tarantino LM. 2016. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiol Behav 167:404-412PubMed: 27693591 MGI: J:275944
Wooley CM; Xing S; Burgess RW; Cox GA; Seburn KL. 2009. Age, experience and genetic background influence treadmill walking in mice. Physiol Behav 96(2):350-61PubMed: 19027767 MGI: J:275950
Metten P; Crabbe JC. 2005. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci 119(4):911-25PubMed: 16187819 MGI: J:276057
Avila JJ; Kim SK; Massett MP. 2017. Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains. Front Physiol 8:974PubMed: 29249981 MGI: J:276478
Berndt A; Leme AS; Williams LK; Von Smith R; Savage HS; Stearns TM; Tsaih SW; Shapiro SD; Peters LL; Paigen B; Svenson KL. 2011. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics 43(1):1-11PubMed: 20823217 MGI: J:276536
Leme AS; Berndt A; Williams LK; Tsaih SW; Szatkiewicz JP; Verdugo R; Paigen B; Shapiro SD. 2010. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics 283(4):317-26PubMed: 20143096 MGI: J:276589
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12PubMed: 2169579 MGI: J:34840
Belknap JK; Riggan J; Cross S; Young ER; Gallaher EJ; Crabbe JC. 1998. Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains Pharmacol Biochem Behav 59(2):353-60PubMed: 9476981 MGI: J:46034
Crabbe JC; Gallaher EJ; Cross SJ; Belknap JK. 1998. Genetic determinants of sensitivity to diazepam in inbred mice. Behav Neurosci 112(3):668-77PubMed: 9676982 MGI: J:48988
Zheng QY; Johnson KR; Erway LC. 1999. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130(1-2):94-107PubMed: 10320101 MGI: J:54812
Daniel WL; Harrison BW; Nelson K. 1982. Genetic regulation of murine hepatic arylsulfatase B activity during development. J Hered 73(1):24-8PubMed: 7069188 MGI: J:6740
Crabbe JC; Metten P; Gallaher EJ; Belknap JK. 2002. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology (Berl) 161(4):408-16PubMed: 12073169 MGI: J:77863
Dobelis P; Marks MJ; Whiteaker P; Balogh SA; Collins AC; Stitzel JA. 2002. A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol Pharmacol 62(2):334-42PubMed: 12130686 MGI: J:78831

Additional - Ahr^b-1 related

Additional - Cdh23^ahl related

Additional - Cox7a2l^l related

Additional - Rmcf^s related

Technical Support

Contact Technical Support

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

This inbred strain is maintained by sibling mating.
- Additional Breeding and Husbandry Support
Mating System
- Sibling x Sibling
Appearance
- brown
  Related Genotype: a/a Tyrp1^b/Tyrp1^b
Citation
When using the C57BR/cdJ mouse strain in a publication, please include JAX stock #000667 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

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Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Inbred, 1 pair minimum will be supplied

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: Brown cd, C57 Brown, BR

Genetic overview

Research Applications

Base Price

Important Note

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Rmcfs

Allele Symbol: Rmcfs

Cdh23ahl

Allele Symbol: Cdh23ahl

Ahrb-1

Allele Symbol: Ahrb-1

Cox7a2ll

Allele Symbol: Cox7a2ll

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ahrb-1 related

Genotype: Cdh23ahl related

Mammalian Phenotype Terms by Genotype

Genotype: Rmcfs/RmcfsC57BR/cdJ

immune system phenotype

Phenotype Information

References

Additional References

Additional - Ahrb-1 related

Additional - Cdh23ahl related

Additional - Cox7a2ll related

Additional - Rmcfs related

Genotyping Protocols

Breeding Considerations

Mating System

Appearance

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Rmcf^s

Allele Symbol: Rmcf^s

Cdh23^ahl

Allele Symbol: Cdh23^ahl

Ahr^b-1

Allele Symbol: Ahr^b-1

Cox7a2l^l

Allele Symbol: Cox7a2l^l

Genotype: Ahr^b-1 related

Genotype: Cdh23^ahl related

Genotype: Rmcf^s/Rmcf^s
C57BR/cdJ

Additional - Ahr^b-1 related

Additional - Cdh23^ahl related

Additional - Cox7a2l^l related

Additional - Rmcf^s related