C57BL/10J is a substrain of C57BL, and shares a common origin with C57BL/6J (Stock No. <a href="https://www.jax.org/strain/000664">000664</a>), which is one of the most widely used inbred strains. Coat color is black (non-agouti), a/a. The C57BL/10J substrain is similar to the C57BL/6J substrain, but allelic variants have been described at the H9, Igh2 and Lv loci. C57BL/10J mice have a long life-span (826 +/-29 days in males, 693 +/- 31 days in females). Overall tumor incidence is 33% in males and 31% in females, most of which is due to lymphoma. C57BL/10J mice are prone to dermatitis, which is a common problem in the C57BL strain. C57BL/10J mice are a valuable immunological research tool. They have a high lymphocyte phytohaemagglutinin response, a good immune response to ovalbumin, a poor response to DNP-keyhole limpet haemocyanin and are resistant to induction of passive cutaneous anaphylaxis (IgG1- and IgE- mediated). They are susceptible to immunosuppression of contact hypersensitivity by ultraviolet light, highly susceptible to TNBS-induced colitis and moderately susceptible to experimental allergic encephalomyelitis.

The C57BL/10J substrain is similar to the C57BL/6J substrain, but allelic variants have been described at the H9, Igh2 and Lv loci. C57BL/10J mice are a valuable immunological research tool. They have a high lymphocyte phytohaemagglutinin response, a good immune response to ovalbumin, a poor response to DNP-keyhole limpet haemocyanin and are resistant to induction of passive cutaneous anaphylaxis (IgG1- and IgE- mediated). They are susceptible to immunosuppression of contact hypersensitivity by ultraviolet light, highly susceptible to TNBS-induced colitis and moderately susceptible to experimental allergic encephalomyelitis

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